Comparative analysis of clinical features in diffuse and focal enlargement of IgG4-related autoimmune pancreatitis: a single-center retrospective study.

Background: IgG4-related autoimmune pancreatitis (IgG4-AIP) is a rare inflammatory pancreatic disorder mediated by autoimmune mechanisms, primarily characterized by two forms of presentation: diffuse enlargement and focal enlargement. This study aims to analyze the clinical characteristics of diffuse and focal enlargement in IgG4-AIP, thereby enhancing clinicians' understanding of the differences between these two patient groups and ultimately improving patient outcomes.

Methods: This study conducted a retrospective analysis of the clinical data from 40 patients with IgG4-AIP admitted to Yichang Central People's Hospital between January 2019 and December 2024.

Comparative Analysis of Clinical Characteristics in Multi-organ and Single-organ Involvement of IgG4-Related Disease: A Single-center Retrospective Study.

Background: Immunoglobulin G4-related disease (IgG4-RD) is a rare, chronic inflammatory condition characterized by fibrosis and tendency for multi-organ involvement. This study aims to analyze the clinical characteristics associated with multi-organ versus single-organ involvement in IgG4-RD, thereby enhancing clinicians' understanding of the differences between these two patient groups and ultimately improving patient prognosis.

Methods: We performed a retrospective analysis of clinical data from 82 patients diagnosed with IgG4-RD admitted to Yichang Central People's Hospital between January 2019 and December 2024.

Enhancement of Tumor Necrosis Factor-α-Mediated Hepatic Apoptosis and Liver Injury by Hepatitis B Virus Surface Antigen.

Tumor necrosis factor-α (TNF-α) is a highly pleiotropic cytokine with a variety of biological functions, such as cell proliferation, metabolic activation, inflammatory response, and cell death. TNF-α can induce a variety of mechanisms to initiate hepatocyte apoptosis, resulting in subsequent liver damage. Hepatitis B virus surface antigen (HBsAg) is the most abundant hepatitis B virus protein in the hepatocyte during chronic virus infection.

Clinical features and risk factors of abdominal IgA vasculitis in adults.

Background: Adult-onset abdominal IgA vasculitis (A-IgAV) presents with abdominal pain as the initial symptom, which is a relatively rare condition that is frequently misdiagnosed.

Methods: This retrospective study utilized clinical data from 125 adult patients diagnosed with IgA vasculitis (IgAV), retrieved from the electronic medical records of the First College of Clinical Medical Science, China Three Gorges University. The study comprehensively investigated the clinical manifestations, evaluated the diagnostic significance of various laboratory markers, and identified features from abdominal CT and endoscopy.