Dissolution Inhibition via Intramolecular N···I Halogen Bond Enables High-Loading Zn-Organic Battery.

The development of aqueous zinc-ion batteries faces persistent challenges in reconciling high mass-loading capabilities with extreme tolerance, particularly for organic cathodes prone to dissolution in aqueous electrolyte. Here, we present a halogen-bonded azo-based cathode material, 4,4'-azopyridine-iodide (AZPY-I), engineered through iodine-mediated molecular stabilization of pyridinic nitrogen sites. Analyses reveal that AZPY-I adopts a robust π-π conjugated framework stabilized by directional N···I halogen bonds, achieving ultralow solubility (<0.

The relationship between the expression of serum asprosin and miR-21 in patients with osteoporosis and delayed healing after OVCF surgery.

To explore the relationship between serum asprosin, microRNA-21 (miR-21) expression, and delayed healing after surgery in patients with osteoporotic vertebral compression fractures (OVCF), and to construct a nomogram model. A prospective study inducted 300 OVCF patients treated with percutaneous vertebroplasty (PVP) from June 2022 to June 2024. Serum asprosin and miR-21 were measured preoperatively, and fracture healing was assessed via X-ray 3 months post-surgery.

MicroRNA-410-3p modulates chondrocyte apoptosis and inflammation by targeting high mobility group box 1 (HMGB1) in an osteoarthritis mouse model.

Background: Osteoarthritis (OA) is the most prevalent type of arthritis, which commonly involves inflammation in the articular cartilage in OA pathogenesis. MicroRNAs (miRNAs) play essential roles in the regulation and pathophysiology of various diseases including OA. MiR-410-3p has been demonstrated to mediate inflammatory pathways, however, the regulatory functions of miR-410-3p in OA remain largely unknown.