Hysterectomy for Benign Gynecologic Disease: A Comparative Study of Articulating Laparoscopic Instruments and Robot-Assisted Surgery in Korea and Taiwan.

: Hysterectomy is a common non-obstetric procedure. Minimally invasive techniques, such as laparoscopy and robot-assisted surgery, have replaced open surgery for benign gynecologic conditions. Robotic surgery offers reduced blood loss and shorter hospital stays but is limited by high costs.

lncRNA EBLN3P Promotes Proliferation, Metastasis and Stemness of Gastric Cancer Cells via miR-141-3p/HMGCS1.

Long non-coding RNAs (lncRNAs) have become an essential factor in gastric cancer (GC) initiation and metastasis. This study is aimed to uncover the functional significance of EBLN3P in GC. In GC, EBLN3P and HMGCS1 was significantly increased.

The Nuss and reverse Nuss procedure paradox: divergent outcomes in scoliosis risk for pectus excavatum and pectus carinatum patients.

Background: Pectus excavatum (PE) and pectus carinatum (PC), structurally opposite chest wall deformities, provides a unique opportunity to investigate the relationship between chest deformities and thoracic scoliosis.

Methods: The study collected 2014 to 2024 medical records and radiological data. Cross-sectional analysis included 1315 PE/PC patients and 5140 matched controls; retrospective cohort analysis included 549 patients.

A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1.

Gastric cancer (GC), a malignant neoplasm originating in the stomach epithelium, is characterized by substantial global incidence and mortality rates, posing a substantial threat to public health systems worldwide. The present study was designed to identify and validate a previously unannotated protein encoded by circular RNA (circRNA), with the principal objective of elucidating its functional significance and mechanistic basis in gastric carcinogenesis.CircUBE2G1 (hsa_circ_003239) was identified as a translationally active circRNA exhibiting significant downregulation in gastric cancer.

Comparison of ArtiSential and Conventional Laparoscopic Instruments in Hysterectomy for Gynecologic Cancers: A Hybrid Observational Study on Surgical Outcomes, Pain Control, and Oncologic Safety.

Objective: To evaluate the clinical and oncologic outcomes of gynecologic cancer surgeries performed using multi-joint laparoscopic instruments (ArtiSential) compared to conventional instruments, focusing on hysterectomy.

Design: A hybrid observational study combining prospective data for the ArtiSential group (n = 44) and retrospective data for the conventional group (n = 136).

Setting: International multicenter study conducted in Korea, Taiwan, and Japan.

Outcomes and surgical technique of laparoscopic hysterectomy using an articulating laparoscopic instrument: a prospective observational study.

Objective: This study aimed to evaluate the feasibility of performing laparoscopic hysterectomy using an articulating laparoscopic instrument that provides flexible and ergonomic movements similar to robotic systems and to demonstrate the surgical techniques facilitated by this advanced instrument.

Methods: This prospective observational study was performed at a single institution. We reviewed the electronic medical records of patients who underwent laparoscopic hysterectomy using an articulating laparoscopic instrument between October 2022 and May 2023.

DFO-loaded PDA nanoparticles facilitated 3D stem cell spheroids for diabetic wound repair by normalizing the pathological microenvironment.

Diabetic wounds represent a prevalent and challenging complication of diabetes, characterized by compromised immune function, chronic inflammation, oxidative stress, and impaired revascularization, all of which impede normal wound healing. Despite the high therapeutic potential of 3D stem cell spheroids, owing to their structural and functional advantages, the complex microenvironment encountered post-transplantation significantly diminishes their survival and efficacy. This study presents a novel therapeutic strategy that integrates three-dimensional adipose-derived stem cell spheroids (3D-ADSCs) with desferrioxamine-loaded mesoporous polydopamine nanoparticles (M@D), encapsulated within a gelatin methacrylamide (GelMA) hydrogel scaffold, creating a functional bio-composite.

Impact of Para-Aortic Lymphadenectomy on Clinically FIGO Stage IIIC1 High-Grade Endometrial Cancer: A Retrospective Cohort Study from Two Tertiary Centers in Korea and Taiwan.

: The therapeutic effect of para-aortic lymphadenectomy in patients with clinically para-aortic node-negative diseases remains controversial. In this study, we investigated whether combined pelvic and para-aortic lymphadenectomy has a survival benefit compared with pelvic lymphadenectomy alone in patients with clinically FIGO stage IIIC1 high-grade endometrial cancer. : We retrospectively reviewed patients with clinically FIGO stage IIIC1 high-grade endometrial cancer in the period between January 2000 and December 2020 at two tertiary centers.

Targeting SARS-CoV-2 RNA-dependent RNA polymerase with the coumarin derivative BPR2-D2: Evidence from cell-based and enzymatic studies.

The rapid mutation rate of SARS-CoV-2 highlights the urgent need for continuous drug development to enhance both efficacy and safety. BPR2-D2, an angular coumarin derivative, has previously shown notable anti-influenza activity and broad-spectrum inhibitory effects against RNA viruses. In this study, we found that BPR2-D2 exhibits potent antiviral activity against multiple SARS-CoV-2 variants, including several variants of concern, at nanomolar concentrations.

MSFusion: A multi-source hybrid feature fusion network for accurate grading of invasive breast cancer using H&E-stained histopathological images.

Invasive breast cancer (IBC) is a prevalent malignant tumor in women, and precise grading plays a pivotal role in ensuring effective treatment and enhancing survival rates. However, accurately grading IBC presents a significant challenge due to its heterogeneous nature and the need to harness the complementary information from multiple nuclei sources in histopathology images. To tackle this critical problem, we introduce a novel multi-source hybrid feature fusion network named MSFusion.

Compression Molding Flow Behavior and Void Optimization of an Integrated Circuit Package with Shielding-Metal-Frame.

As the demand for smaller and more multifunctional integrated circuit (IC) products increases, system-in-package (SiP) has emerged as a key trend in IC encapsulation. However, the use of polymer-based materials such as epoxy molding compounds (EMCs) introduces complex flow behaviors during the encapsulation process, often leading to void formation, especially in highly integrated SiP structures. This study employs the Moldex3D 2024 R3 simulation software to perform mold-filling analyses of SiP packages using EMC as the encapsulant.

Assessment of the Phenolics Content in Epilobium angustifolium and Epilobium hirsutum Extracts and Their Pharmacological Activity.

The recent outbreak of Omicron strains of coronavirus disease urged the search for novel treatments from natural products such as Epilobium species. The present work reports a comparative HPLC-DAD study of the polyphenolic composition of the crude extracts of Epilobium angustifolium and Epilobium hirsutum. Oenothein B, gallic acid, hyperoside, and isoquercitin were the dominant phenolic compounds.

Pterostilbene Exhibits Broad-Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV-A71 Challenge.

Human enteroviruses (EVs) are a major public health issue worldwide owing to their potential to cause respiratory illnesses, hand-foot-and-mouth disease, and severe neurological complications. Currently, no effective drugs or multivalent vaccines are available. Pterostilbene (Pte), a naturally occurring compound found in blueberries and other plants, is a type of stilbene with a similar structure to resveratrol.

CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes.

Circular RNAs are associated with cardiovascular disease, including coronary artery disease, but the mechanisms have not been completely elucidated. We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563. Our results suggest that circBTBD7-420aa may inhibit the abnormal proliferation and migration of human coronary artery smooth muscle cells by promoting SLC3A2 degradation through the ubiquitin-proteasome pathway.

Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.

Spinal cord injury (SCI) presents considerable therapeutic challenges due to its complex pathophysiology, and effective treatments are currently lacking. Macelignan (Mace) has shown therapeutic effects in some neurological disorders, but its potential to enhance functional recovery in SCI and the underlying mechanisms are not well understood. This research endeavors to explore the therapeutic value of Mace in SCI and its underlying mechanism of action.

Circular RNA-Drug Association Prediction Based on Multi-Scale Convolutional Neural Networks and Adversarial Autoencoders.

The prediction of circular RNA (circRNA)-drug associations plays a crucial role in understanding disease mechanisms and identifying potential therapeutic targets. Traditional methods often struggle to cope with the complexity of heterogeneous networks and the high dimensionality of biological data. In this study, we propose a circRNA-drug association prediction method based on multi-scale convolutional neural networks (MSCNN) and adversarial autoencoders, named AAECDA.

Prognostic impact of primary surgery in human papillomavirus-independent, advanced or metastatic endocervical adenocarcinoma: A bi-institutional retrospective study.

Objective: To evaluate the prognostic impact of primary surgery on patients with HPV-independent, advanced or metastatic endocervical adenocarcinoma (EAC) who typically exhibit poor survival outcomes and resistance to conventional therapies such as chemoradiotherapy.

Methods: A bi-institutional retrospective study was conducted at Samsung Medical Center and Taiwan National University Hospital. Between 2001 and 2023, 92 patients with HPV-independent advanced or metastatic EAC were included.

Validation of 2023 FIGO Stage IA1-IIIC2 Endometrial Carcinoma: A Retrospective Analysis of Two Tertiary Centers in South Korea and Taiwan.

Purpose: As understanding of the molecular pathogenesis of endometrial carcinoma (EC) advanced, the International Federation of Gynecology and Obstetrics (FIGO) staging system was revised in 2023. This study compared EC survival outcomes using the 2009 and 2023 FIGO staging systems.

Materials And Methods: We retrospectively analyzed 3,029 patients diagnosed with 2009 FIGO stage I-III EC between 1985 and 2022 in South Korea, and between 2020 and 2022 in Taiwan.

On-demand Reprogrammable Mechanical Metamaterial Driven by Structure Performance Relations.

The physical reprogrammability of metamaterials provides unprecedented opportunities for tailoring changeable mechanical behaviors. It is envisioned that metamaterials can actively, precisely, and rapidly reprogram their performances through digital interfaces toward varying demands. However, on-demand reprogramming by integration of physical and digital merits still remains less explored.

Efficient electroreduction of carbon dioxide to formate enabled by bismuth nanosheets enriched dual V vacancy.

The electrocatalytic reduction of carbon dioxide (COER) into formate presents a compelling solution for mitigating dependence on fossil energy and green utilization of CO. Bismuth (Bi) has been gaining recognition as a promising catalyst material for the COER to formate. The performance of Bi catalysts (named as Bi-V) can be significantly improved when they possess single metal atom vacancy.

Abscisic acid-mediated autoregulation of the MYB41-BRAHMA module enhances drought tolerance in Arabidopsis.

Drought stress poses a substantial challenge to plant growth and agricultural productivity worldwide. Upon water depletion, plants activate an abscisic acid (ABA) signaling pathway, leading to stomatal closure to reduce water loss. The MYB family of transcription factors plays diverse roles in growth, development, stress responses, and biosynthesis, yet their involvement in stomatal regulation remains unclear.