MXene-Based Peroxidase-Like Nanozymes: Interfacial Effects for Biomedical Applications.

MXene-based peroxidase (POD)-like nanozymes demonstrate significant potential in biomedical applications due to their 2D structure, tunable catalytic activity, and interfacial effects. This review summarizes recent advances in MXene-POD nanozyme design, focusing on interfacial effects modulation via external stimuli (e.g.

In vitro formation and growth of glycogen: experimental verification of theoretical predictions.

Glycogen is a complex branched glucose polymer that serves as energy reservoir in animals and some bacteria; it has also been synthesized in vitro. It comprises small β particles linked in large aggregates termed α particles. Theory, based on the evolutionary processes which cause these particles to be formed, suggests that if all ingredients for in vitro particle synthesis were added to a suspension of α particles, then these will grow to a steady-state size distribution, after which new particles will be formed.

Analysis of paper types based on three dimensional fluorescence spectroscopy combined with Resnet34.

Printing paper represents one of the most prevalent forms of physical evidence in document forensics, where accurate brand and model identification provides critical investigative leads. To enable rapid, precise identification of commercial printing paper brands, we propose a novel method combining 3D fluorescence spectroscopy with an enhanced ResNet34 network. First, 3D fluorescence contour maps of diverse paper brands were acquired across excitation (280-420 nm) and emission (300-592 nm) wavelengths.

mediates the sensitivity to irinotecan toxicity via tryptophan catabolites.

Background: Late-onset diarrhoea remains a poorly managed concern for clinical irinotecan therapy. Although bacterial β-glucuronidases (β-GUS) mediated SN-38 production is prevailingly thought to mediate intestinal toxicity, β-GUS inhibitors confer limited benefits in the clinic.

Objective: This study aimed to explore the role and mechanism of endogenous bacterial metabolites in susceptibility to irinotecan toxicity.

Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial.

Commercial autologous anti-CD19 chimeric antigen receptor-T cell therapies are effective in B cell malignancies and autoimmune diseases but are limited by personalized manufacturing, high costs and the risk from random chimeric antigen receptor insertion into the genome. To overcome these challenges, we developed YTS109, a hypoimmune allogeneic T cell product engineered using CRISPR-Cas9 to knock out TRAC, PD1, HLA-A, HLA-B and CIITA, with a CD19-targeting synthetic TCR and antigen receptor (STAR) precisely integrated into the TRAC locus to enable physiological, TCR-like signaling. As part of a multi-disease cohort trial, this article includes all enrolled five patients with severe, refractory systemic lupus erythematosus (SLE) complicated by lupus nephritis, who received lymphodepletion followed by YTS109 at 3 × 10 STAR⁺ T cells per kg body weight.

Student Perspectives on the Efficacy of Hybrid Simulation Laboratory Teaching-Practicing Modules.

Introduction: This study examined dental students' perspectives on a hybrid simulation-laboratory (sim-lab) course for ultrasonic supragingival scaling.

Materials And Methods: An interactive online system facilitated the course for second-year dental students from 23 colleges. The curriculum encompassed demonstrations of ultrasonic scaling techniques, coupled with opportunities for students to pose inquiries and engage in remotely guided practice sessions.

Integrated Analysis of Bulk and Single-Cell Transcriptomics Identifies Prognostic Biomarkers in Breast Cancer Metastasis.

Breast cancer (BC) remains one of the leading causes of cancer-related mortality among women worldwide, with distant metastasis being the primary contributor to poor prognosis. However, the molecular mechanisms driving BC metastasis are not yet fully understood. We integrated three public microarray datasets (GSE14776, GSE103357, and GSE32489) to identify the differentially expressed genes (DEGs) associated with breast cancer metastasis.

Non-contact ultrasound to assist laser additive manufacturing.

In ultrasound-aided laser melting processes such as additive manufacturing, it is generally believed that acoustic cavitation is essential for grain refinement during solidification while acoustic streaming plays a negligible role. We propose a non-contact ultrasound approach to provide low-intensity ultrasound, i.e.

Time from waking to first cigarette, accelerated biological aging, and risk of premature mortality.

Background: The relationship between the time from waking to first cigarette (TWFC) and premature mortality remains unclear. This study aims to assess the association between TWFC and the risk of premature mortality, and to explore the role of accelerated biological aging in this relationship.

Methods: A total of 309,308 participants from the UK Biobank were included in this study.

Study of microbubble defects in high-NA silicate-glass multi-core imaging fibers fabricated by the stack-and-draw method.

The fabrication of multicore imaging fiber (MCIF)/fiber bundle by the stack-and-draw method is favorable to achieve a hyperfine spatial imaging resolution without the rise of lattice defectw, such as core breakage and dislocation. MCIFs made of silicate glasses as host materials usually present a high numerical aperture (NA), lower bend loss, and low inter-core crosstalk, giving an excellent imaging capability. In this paper, we focus on the microbubble defect (MD) in the high-NA silicate-glass MCIF fabricated by the stack-and-draw method.

MR Promotes Ferroptosis in Gastric Cancer by Regulating FANCD2 Expression Mediated by m6A Modification.

Our previous work points out that methionine restriction (MR) treatment inhibits gastric cancer progression. Ferroptosis is a new form of cell death, and induction of ferroptosis has an inhibitory effect on tumors. Silencing of the ferroptosis inhibitory molecule FA complementation group D2 protein (FANCD2) has been reported to inhibit tumor growth.

Age-stratified diagnostic value of high-resolution anorectal manometry in women with severe rectocele: interactions between anal relaxation rate and maximum anal resting pressure.

Purpose: This study aimed to assess the diagnostic accuracy of combining anal relaxation rate (ARR) and maximum anal resting pressure (MARP), measured by three-dimensional (3D) high-resolution anorectal manometry (HR-ARM), in identifying high-risk phenotypes of severe rectocele in women (SRW) aged ≥ 50 years compared with healthy female volunteers (HFVs).

Methods: This retrospective comparative study was conducted at the Tianjin Union Medical Center (2018-2024) and included 50 SRW scheduled for surgery and 40 age-matched HFVs aged ≥ 50 years. Log-linear regression was used to assess interaction effects, and the Hosmer-Rothman additive model evaluated qualitative and quantitative interactions.

Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.

Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues.

Retinal Vascular Occlusion Following COVID-19 Vaccination: A Comprehensive Review of Observational Study and Pathophysiological Mechanisms.

: Retinal vascular occlusion (RVO) and retinal artery occlusion (RAO) have been reported as rare adverse events following COVID-19 vaccination, raising concerns about vaccine safety. This review synthesizes cohort and case-control studies assessing the association between COVID-19 vaccines and RVO/RAO, while exploring potential pathophysiological mechanisms. : We analyzed large-scale population-based studies from South Korea, Europe, and the TriNetX database, focusing on odds ratios (OR), hazard ratios (HR), and relative risks (RR) across mRNA and adenoviral vector vaccines.

Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases.

Ocular diseases affect over 2.2 billion people globally, imposing a significant socioeconomic burden, with annual productivity losses estimated at US$411 billion. Conventional drug delivery methods-topical, local injection, and systemic administration-face challenges such as low bioavailability (<5%), rapid clearance, and physiological barriers like the cornea and blood-retinal barrier (BRB).

Analysis of the AP2/ERF transcription factor family in Eriobotrya japonica and its role in exogenous melatonin-mediated regulation of salt stress.

AP2/ERF transcription factors (TFs) are involved in various regulatory pathways related to plant growth, development, and stress responses. The growth of Eriobotrya japonica, a popular fruit and medicinal plant, is affected by salt stress. Currently, the functions of E.

Causal Link Between Gut Microbiota and Arterial Occlusive Diseases: Insights From Mendelian Randomization and Bioinformatics Analysis.

Background: Arterial occlusive diseases (AOD), including peripheral artery disease (PAD), are significant causes of morbidity and mortality worldwide. Emerging evidence suggests that gut microbiota may play a crucial role in the pathogenesis of PAD. However, causal relationships remain unclear due to limitations in observational studies.

Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization.

Gut microbiota (GM) is implicated in aging biology, yet its dual regulatory role in the distinct yet interconnected processes of lifespan extension and aging remains poorly understood. This study employed genetic approaches to identify GM taxa exerting causal effects on longevity and aging and assess the mediation role of cerebrospinal fluid (CSF) proteins. We leveraged summary statistics of the GM taxa (207 taxa, 7738 participants from the Dutch Microbiome Project), the CSF proteins (7008 aptamers, 3506 participants), and the longevity and aging phenotypes (UK Biobank, Longevity Genomics, and Edinburgh DataShare) from the largest genome-wide association studies so far.

An Improved Extracorporeal Membrane Oxygenation Blood Reinfusion Technique.

During extracorporeal membrane oxygenation (ECMO) decannulation, blood loss often occurs, leading to anemia and the need for blood transfusions. This article presents an improved ECMO pump-controlled blood reinfusion technique designed to address these challenges. The proposed method offers a simple and effective solution to minimize blood loss and reduce the need for additional blood transfusions during ECMO procedures.

Prognostic impact of multi-domain approaches and the Tilburg frailty indicator in elderly patients with heart failure.

Backgrounds: The optimal multidimensional frailty assessment approach in heart failure (HF) remains uncertain. This study aimed to compare the prognostic value of a multi-domain approach versus the Tilburg Frailty Indicator (TFI) in elderly HF patients.

Methods: This prospective single-center cohort study consecutively enrolled 461 elderly HF patients at Fuzhou University Affiliated Provincial Hospital, China.

Sociability genetically separable from social hierarchy in amniotes.

Sociability and social hierarchy are two essential features to form a social group. However, it remains unknown whether sociability and social hierarchy are genetically separable. In this study, we examined the social hierarchy, social and social novelty preference of PAS1 knock-out and knock-in mice.

Developmental expression of α- and β- synuclein in the mouse retina.

The synuclein family comprises three presynaptic proteins-alpha-synuclein (α-Syn), beta-synuclein (β-Syn), and gamma-synuclein (γ-Syn)-which are crucial for synaptic transmission. Our previous studies have detailed the precise cellular and subcellular localization of α- and β-Syn in the adult mouse retina, revealing distinct expression patterns in excitatory and inhibitory synaptic elements. The balance between excitatory and inhibitory neurotransmitters in the inner plexiform layer (IPL) is critical for neural development in the mouse retina.

Re-Boosting Self-Collaboration Parallel Prompt GAN for Unsupervised Image Restoration.

Deep learning methods have demonstrated state-of-the-art performance in image restoration, especially when trained on large-scale paired datasets. However, acquiring paired data in real-world scenarios poses a significant challenge. Unsupervised restoration approaches based on generative adversarial networks (GANs) offer a promising solution without requiring paired datasets.

Telitacicept combined with conventional therapy successfully treated MDA5-associated RPILD: A case report.

Rationale: Melanoma differentiation-associated gene 5 (MDA5)-associated rapidly progressive interstitial lung disease (RPILD) is a rare and life-threatening condition with no standardized treatment protocol. We report a case of successful treatment using a novel combination therapy.

Patient Concerns: A 69-year-old female presented with progressive dyspnea and chest tightness that had persisted for 1 year but significantly worsened over the 20 days before admission.