The microstructure of metastatic bone lesions suggests tumor mediated alterations in bone mineralization.

Breast, prostate and lung cancer cells frequently metastasize to bone, leading to disruption of the bone microstructure. This study utilized mechanical testing with micro-CT imaging, digital volume correlation (DVC), and atomic force microscopy (AFM) nanomechanical testing to examine the mechanical property variations in mouse long bones (tibia) with metastatic lung cancer cell involvement, spanning from the whole-bone scale to the microstructural level. In addition, we also investigated how metastatic invasion alters the morphology of hydroxyapatite nanocrystals in bone at the nanometer scale.

Pooled data from phase 3 clinical trials comparing the clinical activity of ceftolozane/tazobactam versus meropenem for the treatment of complicated intra-abdominal infections.

Background: Ceftolozane/tazobactam (C/T) in combination with metronidazole is an active antimicrobial therapy used to treat complicated intra-abdominal infections (cIAIs).

Methods: A comparison of the clinical efficacy of C/T plus metronidazole vs. meropenem for the treatment of cIAIs using pooled data from four phase 3 clinical studies (CXA-cIAI-10-08, CXA-cIAI-10-09, NCT02739997 and NCT03830333).

C/EBP-β/MeCP2/Wnt Axis Participates in the Testicular Injury in Rats Under Simulated Microgravity Conditions.

Background And Objective: As space exploration advances, the effects of the microgravity environment on testicular injury and spermatogenic function in astronauts have attracted widespread attention, but the underlying mechanisms remain unclear.

Methods: In this study, testicular morphometry and Johnsen score were used to evaluate the degree of testicular injury. Then the upstream transcription factors of MeCP2 were verified using the dual-luciferase reporter assay.

A generalist foundation model and database for open-world medical image segmentation.

Vision foundation models have demonstrated vast potential in achieving generalist medical segmentation capability, providing a versatile, task-agnostic solution through a single model. However, current generalist models involve simple pre-training on various medical data containing irrelevant information, often resulting in the negative transfer phenomenon and degenerated performance. Furthermore, the practical applicability of foundation models across diverse open-world scenarios, especially in out-of-distribution (OOD) settings, has not been extensively evaluated.

Tumors hijack macrophages for iron supply to promote bone metastasis and anemia.

Bone marrow is both a primary site for hematopoiesis and a fertile niche for metastasis. The mechanism of the common occurrence of anemia among patients with bone metastasis remains poorly understood. Here, we show that a specialized population of VCAM1CD163CCR3 macrophages, normally essential for erythropoiesis by transporting iron to erythroblasts, are highly enriched in the bone metastatic niche in mouse models.

Tricontinuous Sponge-like LiFePO Cathode with Ultrahigh Areal Capacity for Flexible Lithium-Ion Batteries.

Increasing the mass loading of active materials offers significant potential for enhancing the energy density of flexible lithium-ion batteries on the system scale. However, this approach is hindered by the impeded Li diffusion kinetics and insufficient mechanical flexibility. To address this, we developed a tricontinuous sponge-like LiFePO-based flexible cathode using an ethanol-induced phase separation technique.

A concept reflecting relative visual acuity insufficiency among low and moderate myopia students in east of China: Yicheng Myopia Study.

Background: Myopia has shown a sharp upward trend worldwide and has become a global public health concern. However, there were insufficient correction rates all over the world. This study aimed to investigate the prevalence of myopia and spectacle-wearing rate in primary and high school students in Yicheng, as well as analyze the risk factors of myopia onset and development.

Recent Advances in Metasurfaces: From THz Biosensing to Microwave Wireless Communications.

In recent years, important progress has been made in the field of biosensing and wireless communications by using metamaterials and metasurfaces. These technologies enable efficient manipulation of electromagnetic waves through judiciously designed subwavelength structural units. This review begins by focusing on the design and optimization of terahertz metasurface sensors, emphasizing their unique advantages in biomedical diagnostics.

A novel hypomorphic mutation in associated with severe interstitial lung disease.

In individuals with hypomorphic mutations of , inflammatory or autoimmune disorders are rare. We present a child with prolonged and severe interstitial lung disease, Omenn-like syndrome, and a novel frameshift variant in .

A Deep Neural Network Trained on Congruent Audiovisual Speech Reports the McGurk Effect.

In the McGurk effect, incongruent auditory and visual syllables are perceived as a third, illusory syllable. The prevailing explanation for the effect is that the illusory syllable is a consensus percept intermediate between otherwise incompatible auditory and visual representations. To test this idea, we turned to a deep neural network known as AVHuBERT that transcribes audiovisual speech with high accuracy.

Online Neural-to-Movement Mapping Transfer for Task Switching and Retention in Brain-Machine Interfaces.

Current brain-machine interfaces (BMIs) often rely on decoders trained for single tasks, limiting their flexibility in real-world applications. We propose an online learning framework that enables the transfer of neural-to-movement (knowledge) across tasks, supporting both task switching and memory retention. In our framework, neural activity is projected into a dynamical jPCA space to effectively dissociate into variant and invariant components.

AEBP1 drives fibroblast-mediated T cell dysfunction in tumors.

T cell dysfunction enables tumor immune evasion, understanding its mechanism is crucial for improving immunotherapy. Here we show, by RNA-sequencing analysis of human colon adenocarcinoma and triple-negative breast cancer tissues, that expression of Adipocyte Enhancer-Binding Protein 1 (AEBP1) positively correlates with T cell dysfunction and indicative of unfavorable patient outcomes. Subsequent single-cell RNA sequencing identifies cancer-associated fibroblasts (CAF) as the primary AEBP1 source.

3D-Printed Fe-Ni Porous Framework Structures for Efficient and Recyclable Degradation of Azo Dyes in Wastewater.

Advanced oxidation processes offer a potent, eco-friendly solution for degrading organic wastewater. Creating high-activity and stability catalysts is crucial to addressing water pollution concerns. Nevertheless, due to constraints in their preparation, prevalent catalysts often lack satisfactory cyclic stability and pose challenges in recovery.

REEV SENSE IMUs for Gait Analysis in Stroke: A Clinical Study on Lower Limb Kinematics.

Human gait analysis is essential for clinical evaluation and rehabilitation monitoring, particularly in post-stroke individuals, where joint kinematics provide valuable insights into motor recovery. While optical motion capture (OMC) is the gold standard, its high cost and restricted use in laboratory settings limit its accessibility. This study aimed to evaluate the accuracy of REEV SENSE, a novel magnetometer-free inertial measurement unit (IMU), in capturing knee and ankle joint angles during overground walking in post-stroke individuals using assistive devices.

Effects of Outdoor and Household Air Pollution on Hand Grip Strength in a Longitudinal Study of Rural Beijing Adults.

Outdoor and household PM are established risk factors for chronic disease and early mortality. In China, high levels of outdoor PM and solid fuel use for cooking and heating, especially in winter, pose large health risks to the country's aging population. Hand grip strength is a validated biomarker of functional aging and strong predictor of disability and mortality in older adults.

Multidimensional insights into exosomes in hepatocellular carcinoma: from genesis to clinical application.

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, whose progression is intimately linked to the complex dynamics of the tumor microenvironment (TME). Exosomes, once considered mere cellular waste, have emerged as pivotal mediators of intercellular communication within the TME, actively participating in the multistep development of HCC. These nanoscale vesicles play crucial roles in the initiation of precancerous lesions and, by transporting drug resistance-related molecules such as proteins and non-coding RNAs, facilitate the acquisition of resistance to chemotherapy and targeted therapies by tumor cells.

Babinet-Inverted GaP Suspended Fishnet Membrane Enables Long-Lasting Unshifted Gigahertz Hypersonic Waves Generation.

Nanostructured dielectric optomechanical platforms have facilitated the efficient generation and precise control of hypersonic waves. However, substantial energy losses have thus far prevented the realization of nanoresonators with long-lasting signals and high quality factors. In this study, we propose suspended all-dielectric fishnet structures made of gallium phosphide, which exhibit up to five odd-order resonant modes with an exceptionally low isotropic loss factor (η = 0.

Dosimetric and Clinical Effects of Polyethylene Glycol Gel in Radical Concurrent Chemoradiotherapy for Cervical Cancer: A Phase III Prospective Multicenter Randomized Controlled Trial.

Purpose: This study evaluated the safety and efficacy of PEG hydrogels in reducing rectal radiation dose and complication during cervical cancer radical concurrent chemoradiotherapy.

Methods And Design: This phase 3, randomized, parallel-controlled trial (NCT05690906) conducted across nine centers in China (July 2022-January 2025). Participants were randomized 1:1 to receive a 10 mL PEG hydrogel injection (experimental group) or no injection (control group) after 50.

Intratumoral microbiota-driven macrophage reprogramming in pancreatic cancer via Blautia metabolite 6-hydroxyhexanoic acid.

Pancreatic ductal adenocarcinoma (PDAC) exhibits a particularly immunosuppressive microenvironment, which contributes to its poor prognosis and resistance to conventional therapies. Recent studies have highlighted the microbiome as a dynamic regulator of anti-tumor immunity, ultimately contributing to tumor suppression. The tumor microenvironment is increasingly recognized as a dynamic ecosystem where the microbiome plays a pivotal role in shaping immune responses.

Out-of-Plane Polarization in a 2D Ruddlesden-Popper Hybrid Lead Halide Perovskite Ferroelectric Semiconductor.

Lead halide hybrid perovskite ferroelectric semiconductor materials with out-of-plane polarization show great advantages in ultrathin photoelectric devices, especially vertical sandwich-type ferroelectric devices. However, out-of-plane polarization in lead halide hybrid perovskite ferroelectrics is extremely rare, even for the Ruddlesden-Popper (RP) type. Here, we report an RP lead-based hybrid perovskite ferroelectric semiconductor [3,3-difluoropyrrolidium]PbBr (DPB) with = 1.

Abnormal levels of miRNA in pancreatic cancer are linked to tumor progression by regulating the translation of tumor-associated mRNA.

Background: Pancreatic cancer remains one of the most malignant tumors, characterized by limited treatment efficacy.

Main Findings: microRNAs (miRNAs) play a crucial role in regulating the proliferation, invasion, migration, drug resistance, apoptosis, and cell cycle progression of pancreatic cancer cells by inhibiting tumor-associated proteins. Metscape analysis revealed that miRNA-targeted proteins associated with pancreatic cancer are enriched in processes such as cell proliferation, mitosis, and cell migration, and participate in multiple signaling pathways.

Prediction of Tl(I) adsorption onto metal oxides and identification of critical factors using a machine learning-based model.

Thallium is a highly toxic element, which is widely found all over the world. Adsorption is one of the most common techniques for thallium removal. Traditional adsorption studies face several limitations, such as a limited ability to predict adsorption results, inability to concurrently deal with the effects of multiple factors on adsorption outcomes, and fail to quantify the importance of these factors.

Respiratory-related safety profiles of ciprofol (cipepofol) for anesthesia/sedation in Chinese elderly patients undergoing gastroscopy: a multicenter, parallel controlled clinical trial (REST trial).

Background: A post-marketing, parallel-controlled clinical trial (REST trial) was conducted to evaluate the safety and efficacy of cipepofol versus propofol for the induction of anesthesia/sedation in Chinese elderly patients undergoing gastroscopy.

Methods: All enrolled patients aged ≥65 years were assigned randomly in a 1:1 ratio to be administered intravenous cipepofol-0.3 mg/kg or propofol-1.

Unambiguous Quantum State Discrimination in a -Symmetric System of a Single Trapped Ion.

An unambiguous quantum state discrimination of two qubit states is experimentally demonstrated under a non-Hermitian Hamiltonian with parity-time-reversal ( ) symmetry in a single trapped Ca ion. It is shown that any two non-orthogonal states can become orthogonal subjected to time evolution of a -symmetric Hamiltonian in both the -symmetry preserving and broken regimes, thus can be discriminated unambiguously. For a given pair of candidate states, it is shown that the parameters of the Hamiltonian must be confined in a proper range, within which there exists an optimal choice to realize quantum brachistochrone for the fastest orthogonalization.