Dosimetric and Clinical Effects of Polyethylene Glycol Gel in Radical Concurrent Chemoradiotherapy for Cervical Cancer: A Phase III Prospective Multicenter Randomized Controlled Trial.

Purpose: This study evaluated the safety and efficacy of PEG hydrogels in reducing rectal radiation dose and complication during cervical cancer radical concurrent chemoradiotherapy.

Methods And Design: This phase 3, randomized, parallel-controlled trial (NCT05690906) conducted across nine centers in China (July 2022-January 2025). Participants were randomized 1:1 to receive a 10 mL PEG hydrogel injection (experimental group) or no injection (control group) after 50.

Glyphosate bioremediation using a newly isolated Bacillus albus strain F9D: mechanisms and kinetic studies.

Unlabelled: Glyphosate is widely used as an herbicide around the world. The extensive application of glyphosate, however, has serious adverse effects on living systems. Therefore, the elimination of residual glyphosate pollution has become an urgent issue worldwide.

Case Report: Is the isolated bone change in advanced colorectal cancer necessarily malignant metastasis?

Background: Radiation osteitis (RO) is a bone-related complication following radiotherapy (RT), often characterized by atypical imaging features. It is challenging to distinguish RO from early bone metastasis (BM), potentially leading to inappropriate treatment. Therefore, establishing reliable diagnostic criteria for accurately identifying RO is essential for improving treatment outcomes in advanced colorectal cancer (CRC).

Abdominal aortic spectral Doppler combined with echocardiography can improve the diagnostic sensitivity of aortic coarctation in pediatric patients.

Objectives: This study aimed to investigate the clinical value of abdominal aortic spectral Doppler combined with echocardiography in the diagnosis of aortic coarctation in pediatric patients.

Methods: Pediatric patients with aortic coarctation, diagnosed by computed tomography angiography (CTA) and surgically confirmed, were retrospectively enrolled. These patients were divided into two groups based on the availability of abdominal aortic spectral Doppler.

Association between depressive symptoms and physical exercise in college students: longitudinal mediating effects of social support and psychological resilience.

Purpose: This longitudinal study aimed to explore the bidirectional causal relationship between depressive symptoms and physical exercise among college students, with a focus on the mediating roles of social support and psychological resilience.

Methods: The Self-Rating Depression Scale (SDS) was used to assess depression. Physical activity Rating Scale (PARS-3), Perceived Social Support Scale (PSSS), Connor-Davidson Resilience Scale (CD-RISC), A longitudinal study of 1,413 college students was conducted over three months, collecting data at two time points (T1: September 15, 2024; T2: 17 December 2024).

Cancer-associated fibroblast-derived extracellular vesicles loaded with GLUT1 inhibitor synergize anti-PD-L1 to suppress tumor growth via degrading matrix stiffness and remodeling tumor microenvironment.

Cancer immunotherapy has transformed cancer treatment, demonstrating the potential for lasting responses in multiple solid and hematologic malignancies and thus has revolutionized cancer treatment in clinic. However, the intricate tumor microenvironment (TME), characterized by a rigid extracellular matrix (ECM) and robust immunosuppressive environment, presents substantial hurdles to the effectiveness of cancer immunotherapy. Thus, cancer-associated fibroblasts (CAFs), the most abundant stromal cells that mediate ECM remodeling and participate in immune suppression, represent promising therapeutic targets for combination immunotherapy.

Overexpression of ATP binding cassette transporters (ABCs) from Hydrangea macrophylla enhance aluminum tolerance.

The ATP-binding cassette (ABC) transporter family represents a large and diverse protein superfamily that plays a crucial role in responding to metal elements stresses. Hydrangea macrophylla is notable for its sepal's bright blue color caused by sequestration of an aluminum (Al) binding pigment in the sepal vacuoles. This allows the species to thrive in acidic soil with high toxic levels of Al.

Elucidating the kinetics and mechanisms of tetramethrin biodegradation by the fungal strain Neocosmospora sp. AF3.

Tetramethrin is a common pyrethroid insecticide, but there is limited knowledge about its degradation kinetics and mechanisms. In this study, a novel fungal strain, Neocosmospora sp. AF3, was obtained from pesticide-contaminated fields and was shown to be highly effective for degrading tetramethrin and other widely used pyrethroids.

A Multi-Center Survey of Necrotizing Enterocolitis Prevention Strategies in Very Low Birth Weight Infants.

Objective: To compare the prevention practices of necrotizing enterocolitis (NEC) across 17 neonatal intensive care units (NICUs) in China.

Methods: A web-based survey was sent to 17 level 3 NICUs in China on September 21, 2023, to evaluate the prevention strategies for NEC.

Results: All 17 Neonatal Intensive Care Units (NICUs) responded to the survey.

Discovery of homocamptothecin derivative TOP-0618 as a radiosensitive agent for the treatment of pancreatic cancer.

Background: Pancreatic cancer is one of the most lethal malignancies characterized by a complex tumor microenvironment (TME) and highly heterogeneous nature, making it resistant to radiotherapy. This study aims to evaluate the radiosensitizing effect of homocamptothecin derivative TOP-0618 on pancreatic cancer.

Methods: Clonogenic assays and cell viability assays were used to evaluate the radiosensitizing effects of TOP-0618 on pancreatic cancer cells.

Tumour-derived microparticles obtained through microwave irradiation induce immunogenic cell death in lung adenocarcinoma.

Tumour-derived microparticles (TMPs), extracellular vesicles traditionally obtained upon ultraviolet (UV) radiation of tumour cells, hold promise in tumour immunotherapies and vaccines and have demonstrated potential as drug delivery systems for tumour treatment. However, concerns remain regarding the limited efficacy and safety of UV-derived TMPs. Here we introduce a microwave (MW)-assisted method for preparing TMPs, termed MW-TMPs.

A CRISPR/Cas12a-Assisted SERS Nanosensor for Highly Sensitive Detection of HPV DNA.

The lack of timely and effective screening and diagnosis is a major contributing factor to the high mortality rate of cervical cancer in low-income countries and resource-limited regions. Therefore, the development of a rapid, sensitive, and easily deployable diagnostic tool for HPV DNA is of critical importance. In this study, we present a novel high-sensitivity and high-specificity detection method for HPV16 and HPV18 by integrating the CRISPR/Cas12a system with surface-enhanced Raman scattering (SERS) technology.

[Aluminum absorption capacity of different cultivars of seedlings under aluminum stress and the physiological and biochemical mechanisms].

exhibits strong tolerance to acid and aluminum stress. Many cultivars can absorb Al from soils, resulting in variations of their flower color from red to blue. This characteristic presents a potential avenue for the ecological remediation of aluminum-rich acidic soils.

Life cycle assessment for rare earth production from ion-adsorption deposits: A comparative study of magnesium sulfate and ammonium sulfate leaching techniques.

The production of rare earth elements, key raw materials for high-end technological innovation, is associated with considerable energy consumption and environmental pollution. This study focused on the mining of ion-adsorption deposits in southern China and examined two principal production processes: magnesium salt leaching and ammonium salt leaching. A life cycle inventory for the production of 1 kg of individual rare earth oxides and rare earth elements was compiled via field research and resource consumption allocation modeling of the hydrometallurgical system.

Application and Evaluation of Spiral CT in the Diagnosis of Congenital Heart Disease in Children.

Objective: This study aims to explore the application of spiral CT in the diagnosis of congenital heart disease in children and evaluate its clinical value.

Methods: The study included children diagnosed and treated at our hospital from January 2021 to October 2023 as research subjects. After excluding children who did not meet the complete inclusion criteria, a total of 60 cases were finally included.

Dendritic Cell Derived-Extracellular Vesicles Engineered to Express Interleukin-12 and Anti-CTLA-4 on Their Surface for Combinational Cancer Immunotherapy.

Dendritic cell (DC)-derived extracellular vesicles (DEVs) are promising candidates for cancer vaccines, but their therapeutic effects still need further optimization. In this study, we utilized neoantigens, lipopolysaccharide and IFN-γ to induce the maturation of DCs, and then isolated DEVs derived from these mature DCs. We showed that the immune checkpoint inhibitor (anti-CTLA-4 antibody, aCTLA-4) can improve the immunostimulatory function of DEVs by directly activating T cells through immune checkpoint signal blockade.

Machine learning-based risk prediction model for pertussis in children: a multicenter retrospective study.

Background: Pertussis is a highly contagious respiratory disease. Even though vaccination has reduced the incidence, cases have resurfaced in certain regions due to immune escape and waning vaccine efficacy. Identifying high-risk patients to mitigate transmission and avert complications promptly is imperative.

Multiomic traits reveal that critical irinotecan-related core regulator FSTL3 promotes CRC progression and affects ferroptosis.

Background: Irinotecan is a widely used chemotherapy drug in colorectal cancer (CRC). The evolution and prognosis of CRC involve complex mechanisms and depend on the drug administered, especially for irinotecan. However, the specific mechanism and prognostic role of irinotecan-related regulators remain to be elucidated.

Effect of probiotics on necrotizing enterocolitis in preterm infants: a network meta-analysis of randomized controlled trials.

Background: Previous studies have suggested that probiotics may have potential benefits for preterm infants. Their efficacy seems to depend on the particular species or combinations used.

Methods: To further investigate the effects of probiotics in preventing necrotizing enterocolitis (NEC) and other related outcomes in preterm infants, we conducted a network meta-analysis of 51 randomized controlled trials involving 11,661 participants.

Comorbidity Pattern in Patients with Moderate-to-Severe Plaque Psoriasis: Network Analysis of a Hospitalized Database in China.

Introduction: Psoriasis is a chronic systemic inflammatory disorder characterized by a high prevalence of comorbid conditions, profoundly affecting patient quality of life and complicating treatment strategies. This study aims to analyze demographic characteristics, prevalence, age distribution, and gender differences of psoriatic comorbidities in hospitalized patients with moderate-to-severe psoriasis at a single center. Additionally, we explore the correlation between comorbidities and psoriasis through network analysis.

Interfacial imine-bridging and charge directional migration dual regulation of ZnO/covalent organic frameworks S-scheme heterostructure for boosting photocatalytic CO reduction.

Covalent organic frameworks (COFs) equipped with controllable porosity and excellent structural stability are regarded as promising candidates for photocatalytic CO reduction, yet some inherent drawbacks including low CO activation and sluggish charge carriers' transfer properties urgently need to be addressed. Herein, we developed an imine-bridged strategy to construct ZnO/COF heterostructure by integrating donor-acceptor COF (TAPT-DMTP COF) on the surface of amino-modified ZnO for photocatalytic CO reduction. The optimal photocatalyst, NZnO/TAPT-DMTP COF-3, exhibited superior photocatalytic activity for reducing CO to CO and CH, which was significantly higher than pristine COF and non-covalently bridged ZnO/TAPT-DMTP COF.

Rapid modulation bandwidth test system of micro-LED based on photon excitation.

Modulation bandwidth is essential for micro-LED in visible light communication systems. The traditional electroluminescence-based bandwidth test system (EL-BW-Test) is time-consuming and inevitably causes irreversible damage. This paper introduces the design and construction of a novel, to the best of our knowledge, photon-excited bandwidth testing system (PL-BW-Test), capable of swiftly acquiring the bandwidth of LED epi-wafers and devices.

Transcriptome analysis provides insights into the role of TLP16 in Musa acuminata Resistance to Fusarium oxysporum f. sp. cubense wilt.

Background: Thaumatin-like proteins (TLPs) are crucial pathogenesis-related proteins that significantly contribute to plant defense rection. Fusarium oxysporum f. sp.

[Casticin inhibits proliferation of non-small cell lung cancer cells by regulating glucose metabolism through suppression of HIF-1α].

The study investigated the effect of casticin on the proliferation of non-small cell lung cancer(NSCLC) H322 cells and explored its molecular mechanism. Firstly, the cell counting kit-8(CCK-8) assay, colony formation assay, and EdU assay were used to detect the effect of casticin on the proliferation capacity of H322 cells under different concentrations and treatment durations. Then, glucose uptake, lactate production, extracellular pH, and oxygen consumption of H322 cells were measured before and after casticin treatment to analyze its impact on glycolysis in NSCLC H322 cells.