Babinet-Inverted GaP Suspended Fishnet Membrane Enables Long-Lasting Unshifted Gigahertz Hypersonic Waves Generation.

Nanostructured dielectric optomechanical platforms have facilitated the efficient generation and precise control of hypersonic waves. However, substantial energy losses have thus far prevented the realization of nanoresonators with long-lasting signals and high quality factors. In this study, we propose suspended all-dielectric fishnet structures made of gallium phosphide, which exhibit up to five odd-order resonant modes with an exceptionally low isotropic loss factor (η = 0.

Gallium maltolate and cisplatin co-treatment effectively targets triple-negative breast cancer in spheroid and mouse models.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks targeted therapies and is characterized by high invasiveness and metastatic potential. Our previous work demonstrated that GaM (gallium maltolate) blocks cell cycle progression and impairs ribosomal synthesis in TNBC cells. Moreover, GaM treatment promotes ferroptosis activation, and its combination with cisplatin exhibits synergistic effects.

The association between secondhand smoke exposure and accelerated biological aging: A population-based study and Mendelian randomization analysis.

Introduction: Aging is an irreversible biological process significantly influenced by oxidative stress, which smoking exacerbates. While the impact of direct smoking on aging is well-documented, the association between secondhand smoke (SHS) exposure and biological aging remains less explored. This study examines the connection between SHS exposure in populations and biological aging, highlighting diabetes as a potential mediator due to its established links to both SHS exposure and accelerated aging through mechanisms such as oxidative stress and chronic inflammation.

Antibody-Drug Conjugates (ADCs): current and future biopharmaceuticals.

Antibody-drug conjugates (ADCs) represent a novel class of biopharmaceuticals comprising monoclonal antibodies covalently conjugated to cytotoxic agents via engineered chemical linkers. This combination enables targeted delivery of cytotoxic agents to tumor site through recognizing target antigens by antibody while minimizing off-target effects on healthy tissues. Clinically, ADCs overcome the limitations of traditional chemotherapy, which lacks target specificity, and enhance the therapeutic efficacy of monoclonal antibodies, providing higher efficacy and fewer toxicity anti-tumor biopharmaceuticals.

Pharmacokinetics and Physiological Effects of a Single Oral Dose of Oxycodone in Healthy Dogs: A Pilot Study.

Oxycodone, a full mu opioid receptor agonist prescribed for moderate-to-severe pain in people, could provide outpatient analgesia for dogs with post-operative or cancer pain. To determine the pharmacokinetic profile and physiological side effects of a single oral (PO) dose, five healthy, 2-year-old, castrated male hounds were administered a standard amount of food, with or without immediate-release oxycodone (1 mg/kg), in random order, separated by 1 month. At intervals between 0.

A review of gallium phosphide nanophotonics towards omnipotent nonlinear devices.

Gallium phosphide (GaP) has been increasingly prioritized, fueled by the enormous demands in visible light applications such as biomedical and quantum technologies. GaP has garnered tremendous attention in nanophotonics thanks to its high refractive index, indirect bandgap width of 2.26 eV, lattice perfectly matched with silicon, and omnipotent and competitive nonlinear optical properties.

Asymmetric χ-translated optical frequency combs assisted by avoided mode crossing in concentric ring resonators.

χ-translated microcomb generation in microresonators that possess both χ and χ nonlinear responses opens the door for ultra-broadband integrated comb sources. The interplay between the second- and third-order nonlinearities within a fixed coupling coefficient fertilizes complicated cavity dynamics which is of paramount scientific and technological potential. However, this coupling coefficient can be drastically wavelength-dependent, which is lack of consideration in previous studies.

[Ginsenoside Rg_1 protects PC12 cells against Aβ-induced injury through promotion of mitophagy by PINK1/parkin activation].

Amyloid β-protein(Aβ) deposition in the brain is directly responsible for neuronal mitochondrial damage of Alzheimer's disease(AD) patients. Mitophagy, which removes damaged mitochondria, is a vital mode of neuron protection. Ginsenoside Rg_1(Rg_1), with neuroprotective effect, has displayed promising potential for AD treatment.

Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy.

Ethnopharmacological Relevance: Panax notoginseng (Burk) F. H. Chen is a well-known traditional Chinese medicine with a long history and is widely used in the treatment of cerebrovascular disease.

High performance liquid chromatography associated with resonance Rayleigh scattering for synchronous determination of three antihistamines and mechanism study.

A highly sensitive and selective method of high performance liquid chromatography (HPLC) combined with resonance Rayleigh scattering (RRS) spectra was developed for the detection of three antihistamine drugs, including pyrilamine (PY), carbinoxamine (CAR) and tripelennamine (TRI). The three antihistamines were separated by a C18 column. The mobile phase contained 25% acetonitrile (ACN) and 75% phosphate buffered solution (pH 3.

High-performance liquid chromatography study of gatifloxacin and sparfloxacin using erythrosine as post-column resonance Rayleigh scattering reagent and mechanism study.

Herein, a highly selective high-performance liquid chromatography (HPLC) coupled with resonance Rayleigh scattering (RRS) method was developed to detect gatifloxacin (GFLX) and sparfloxacin (SPLX). GFLX and SPLX were first separated by HPLC, then, in pH 4.4 Britton-Robinson (BR) buffer medium, protonic quaternary ammonia cation of GFLX and SPLX reacted with erythrosine (ERY) to form 1:1 ion-association complexes, which resulted in a significant enhancement of RRS signal.

The fluorescence and resonance Rayleigh scattering spectra study on the interactions of palladium (II)-Nootropic chelate with Congo red and their analytical applications.

A highly sensitive detection approach of resonance Rayleigh scattering spectra (RRS) is firstly applied to analyzing nootropic drugs including piracetam (PIR) and oxiracetam (OXI). In HCl-NaAc buffer solution (pH=3.0), the OXI chelated with palladium (II) to form the chelate cation [Pd·OXI], and then reacted with Congo red (CGR) by virtue of electrostatic attraction and hydrophobic force to form binary complex [Pd·OXI].

Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application.

A novel, highly selective, and sensitive resonance light scattering (RLS) detection approach coupled with high performance liquid chromatography (HPLC) was researched and developed for the synchronous analysis of three kinds of benzimidazole anthelmintics, including mebendazole (MBZ), albendazole (ABZ), and fenbendazole (FBZ) for the first time. In the pH range of 3.5-3.

Poly[(acetato-κO,O')aqua-(μ(4)-1H-benzimidazole-5,6-dicarboxyl-ato-κN:O,O:O,O:O)praseodymium(III)].

In the title complex, [Pr(C(9)H(4)N(2)O(4))(C(2)H(3)O(2))(H(2)O)](n), the Pr(III) ion is coordinated by five O atoms and one N atom from four benzimidazole-5,6-dicarboxyl-ate ligands, two O atoms from an acetate ligand and one water mol-ecule, giving a tricapped trigonal-prismatic geometry. The benzimidazole-5,6-dicarboxyl-ate and acetate ligands connect the Pr(III) ions, forming a layer in the ac plane; the layers are further linked by N-H⋯O and O-H⋯O hydrogen bonding and π-π stacking inter-actions between neighboring pyridine rings [the centroid-centroid distance is 3.467 (1) Å], assembling a three-dimensional supra-molecular network.