Biomimetic GNPs-interwoven photonic molecularly imprinted polymer for the colored determination of trace 17β-estradiol.

A new biomimetic film was developed for the detection of 17β-estradiol (E2), drawing inspiration from the hydrophilic and hydrophobic (HI-HO) pattern of the beetle's back. The film had a non-densely packed face-centered cubic (FCC) structure of interwoven hydrophobic gold nanoparticles (GNPs) and hydrophilic poly ionic liquid methyl methacrylate (PILMMA) spheres. The film exhibited reflection (RE) and fluorescence (FL) emissions.

Consumer or Decomposer? Behavioral and Morphological Diagnosis of White Grubs.

Determining the ecological role of insect larvae is crucial for pest control and resource utilization, which usually relies on accurate species identification. White grubs, the larvae of Scarabaeoidea, exhibit highly diverse behaviors but share a similar morphology, making identification challenging. In this study, an improved six-armed olfactometer was used to test the feeding preferences of two sympatric white grubs, and .

Parameterize Structure With Differentiable Template for 3D Shape Generation.

Structural representation is crucial for reconstructing and generating editable 3D shapes with part semantics. Recent 3D shape generation works employ complicated networks and structure definitions relying on hierarchical annotations and pay less attention to the details inside parts. In this paper, we propose the method that parameterizes the shared structure in the same category using a differentiable template and corresponding fixed-length parameters.

Cynarin Counteracts Lipotoxicity in Pancreatic β-Cells Via Inhibiting Palmitate-Induced Apoptosis and Linoleic Acid-Provoked Ferroptosis.

Lipotoxicity has raised intense public concerns for its cytotoxicity and associated chronic diseases. Pancreatic β-cells are highly susceptible to lipotoxicity, since the excessive lipids may produce massive reactive oxygen species (ROS), cause severe oxidative stress, induce the dysfunction of endoplasmic reticulum (ER), damage lipid membranes and trigger the eventual cell death. This study explored the mechanism of cynarine (CYN) in preventing rat pancreatic cells (RINm5F) from the cytotoxicity induced by representative fatty acids, palmitate (PA, physiologically abundant) and linoleic acid (LA, prevalent in Western-style diets).

Pro-inflammatory diet and the risk of depression and anxiety: A prospective study based on the dietary inflammatory index.

Background: Foods contain pro-inflammatory and anti-inflammatory components that may influence mood. This study aims to investigate the association between dietary inflammation, assessed by the Dietary Inflammatory Index (DII), and anxiety and depression.

Methods: DII was calculated from 29 food items in a 24-h diet recall questionnaire from the UK Biobank.

Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis.

Background: Recent studies emphasize the significance of copper dyshomeostasis in neurodegenerative diseases, such as Alzheimer's and Parkinson's, thereby highlighting the role of copper in neurotoxicity. Cuproptosis, a novel mechanism of copper-dependent cell death, remains underexplored, particularly concerning environmental pollutants like polystyrene nanoplastics (PS-NPs). While PS-NPs are recognized for inducing neurotoxicity through various forms of cell death, including apoptosis and ferroptosis, their potential to trigger neuronal cuproptosis has not yet been investigated.

Impact of kernel breakage and storage conditions on mildew growth in grain piles.

Grain storage is vital in today's world, however the annual grain losses due to mycotoxin contamination reach 250 million tons all over the world. During harvesting, processing and storage (damping and compression), mechanical damage to kernels inevitably creates fracture/breakage and thereafter mildew in the grain silo. One issue that the effect of breakage type and position on mildew under one dimensional (1D) loading was not fully understood up to date.

Role of thyroid function in non-basal ganglia intracerebral hemorrhage prognosis.

Purpose: Thyroid function disorders serve as unfavorable prognosis predictors for numerous diseases. However, their role in predicting intracerebral hemorrhage outcome is unclear. This study investigated the prognostic potential of thyroid function parameters for intracerebral hemorrhage.

The association between secondhand smoke exposure and accelerated biological aging: A population-based study and Mendelian randomization analysis.

Introduction: Aging is an irreversible biological process significantly influenced by oxidative stress, which smoking exacerbates. While the impact of direct smoking on aging is well-documented, the association between secondhand smoke (SHS) exposure and biological aging remains less explored. This study examines the connection between SHS exposure in populations and biological aging, highlighting diabetes as a potential mediator due to its established links to both SHS exposure and accelerated aging through mechanisms such as oxidative stress and chronic inflammation.

Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice.

Ozone (O) and nanoplastics (NPs) are pervasive environmental pollutants that frequently co-occur in our heavily industrialized era. While it has been documented that exposure to O or NPs individually has neurotoxic effects, studies investigating their combined impact and the hazardous mechanisms resulting from co-exposure are limited. In this study, we established a mouse model co-exposure to polystyrene nanoparticles (PS-NPs) and O, focusing on the prefrontal cortex (PFC), a brain region crucial for cognition and emotion.

Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients.

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that remains incurable. Although the etiologies of ALS are diverse and the precise pathogenic mechanisms are not fully understood, approximately 20% of ALS cases are caused by genetic factors. Therefore, advancing targeted gene therapies holds significant promise, at least for the 20% of ALS patients with genetic etiologies.

Association of Early Blood Pressure Levels and Outcomes in Ischemic Stroke Treated With Intravenous Thrombolysis: A Prospective Cohort Study.

Background And Purpose: Current guidelines for acute ischemic stroke (AIS) treatment recommend a lenient upper blood pressure (BP) threshold of 185/110 mmHg. However, stricter BP control has been reported to improve prognosis. This study aims to identify the optimal BP range following thrombolysis.

Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.

In recent years, there has been a notable increase in the concentration of air pollutants in the troposphere, especially ozone. However, limited research has gone beyond examining histopathological alterations in the olfactory bulb (OB) to explore the effects of ozone exposure on olfactory and cognitive functions. In our study, we exposed nine-month-old C57BL/6 mice to ozone at a concentration of 1.

Ages-specific beverage consumption and its association with depression and anxiety disorders: A prospective cohort study in 188,355 participants.

Background: Diet habit is associated with mental health which has been suggested to be an independent risk factor. Nevertheless, evidence concerning the association between beverage consumption and age-specific mental health remains limited. Here we estimate the association between six types of beverages and depression and anxiety disorders.

What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study.

Background: Post-stroke stress can trigger instant survival but its influence on long-term ischemic stroke outcomes remains controversial. Thus, we sought to explore the associations of acute post-stroke stress evidenced by endocrine and metabolic changes, with long-term ischemic stroke outcomes.

Methods: Admissions for acute ischemic stroke within seven days of onset were prospectively recruited to determine acute endocrine and metabolic variations measured by thyroid parameters and the stress hyperglycemia ratio (SHR).

Unlocking the Gates: Therapeutic Agents for Noninvasive Drug Delivery Across the Blood-Brain Barrier.

The blood-brain barrier (BBB) is a highly selective network of various cell types that acts as a filter between the blood and the brain parenchyma. Because of this, the BBB remains a major obstacle for drug delivery to the central nervous system (CNS). In recent years, there has been a focus on developing various modifiable platforms, such as monoclonal antibodies (mAbs), nanobodies (Nbs), peptides, and nanoparticles, as both therapeutic agents and carriers for targeted drug delivery to treat brain cancers and diseases.

Multifunctional pressure and humidity sensor modulated by electrostatic interactions and hydrogen bonds for wearable health monitoring.

Breathing and urination, are vital physiological activities of the human body, continuous real-time monitoring of these physiological behaviors could offer timely feedback on an individual's health status. However, current monitoring techniques predominantly rely on cumbersome and intricate medical apparatuses, posing challenges in adapting to the diverse requirements of multi-scenario detection. Consequently, there is a growing interest in developing wearable devices capable of monitoring breathing and urination.

Research on accident early warning of metallurgical enterprises based on grey DEMATEL/ISM and Bayesian network.

To clarify the complex relationship between the factors causing safety accidents in metallurgical enterprises and predict the risk of accidents in enterprises, a correlation analysis model of the factors causing safety accidents in metallurgical enterprises based on grey Decision-Making Trial and Evaluation Laboratory/Interpretative Structural Modeling (DEMATEL/ISM) was established, and a Bayesian network early warning model was constructed on this basis. The relationship and action path of accident-causing factors in metallurgical enterprises were clarified. The factors were hierarchically divided and a multi-layer hierarchical structure model was established to obtain the neighboring cause, transitional cause, and essential cause of the accident.

Bioinspired High-Linearity, Wide-Sensing-Range Flexible Stretchable Bioelectronics Based on MWCNTs/GR/NdFeB/PDMS Nanocomposites for Human-Computer Interaction and Biomechanics Detection.

In recent years, flexible and stretchable strain sensors have emerged as a prominent area of research, primarily due to their remarkable stretchability and extremely low strain detection threshold. Nevertheless, the advancement of sensors is currently constrained by issues such as complexity, high costs, and limited durability. To tackle the aforementioned issues, this study introduces a lepidophyte-inspired flexible, stretchable strain sensor (LIFSSS).

Enhancing the activation of T cells through anti-CD3/CD28 magnetic beads by adjusting the antibody ratio.

The utilization of anti-CD3/CD28 magnetic beads for T cell expansion in vitro has been investigated for adoptive cell transfer therapy. However, the impact of the CD3/CD28 antibody ratio on T cell differentiation and function remains incompletely elucidated. This study seeks to address this knowledge gap.