Loneliness is associated with unstable and distorted emotion transition predictions.

Loneliness is associated with disruptions in socio-cognitive processes, including altered self-other representations and atypical processing of external stimuli. Here, we examine whether loneliness is characterized by altered expectations of emotion transitions for both oneself and others, which may contribute to the observed disruptions in socio-cognitive processes and pose challenges for social connection. Drawing on data from seven studies (total N = 1730; N = 113; N = 185; N = 376; N = 91; N = 68; N = 41; N = 856) using a validated emotion transition task, we found that lonely individuals hold atypical expectations about both their own and others' likelihoods to transition between emotions and are less accurate at predicting others' emotion transitions.

Sex-specific body fat distribution predicts cardiovascular ageing.

Background And Aims: Cardiovascular ageing is a progressive loss of physiological reserve, modified by environmental and genetic risk factors, that contributes to multi-morbidity due to accumulated damage across diverse cell types, tissues, and organs. Obesity is implicated in premature ageing, but the effect of body fat distribution in humans is unknown. This study determined the influence of sex-dependent fat phenotypes on human cardiovascular ageing.

Case Report: From coma to genetic insights: identification of a novel pathogenic variant in Chinese neonatal CTLN1.

Citrullinemia type I (CTLN1) is an autosomal recessive disorder caused by variants in the arginine succinate synthase gene (). These variants result in arginine succinate synthase deficiency, leading to a disruption of the urea cycle and hyperammonemia. To date, only a handful of CTLN1 cases have been reported in China.

Correction: Psychological Inoculation for Credibility Assessment, Sharing Intention, and Discernment of Misinformation: Systematic Review and Meta-Analysis.

[This corrects the article DOI: 10.2196/49255.].

Consumer or Decomposer? Behavioral and Morphological Diagnosis of White Grubs.

Determining the ecological role of insect larvae is crucial for pest control and resource utilization, which usually relies on accurate species identification. White grubs, the larvae of Scarabaeoidea, exhibit highly diverse behaviors but share a similar morphology, making identification challenging. In this study, an improved six-armed olfactometer was used to test the feeding preferences of two sympatric white grubs, and .

Systems metabolic engineering of for the bioproduction of biliverdin and phycoerythrobilin.

Phycobiliprotein is an important co-pigment in photosynthesis, which is composed of the covalent combination of apoprotein and phycobilin. Biliverdin IXα and phycoerythrobilin are both important substances in the phycobiliprotein biosynthesis pathway. As an economic red seaweed, has a high content of phycoerythrin.

Characterization of stability and shell elasticity of monodisperse microbubbles with different pegylated-lipid content using pressure-dependent attenuation spectra.

The stability and acoustic-induced oscillation of microbubbles strongly depend on their shell properties. Determining the relationships between the shell composition and bubble stability and shell elasticity is crucial for improving microbubble-based ultrasound imaging and therapy. We used a flow-focusing microfluidic to fabricate monodisperse microbubbles with a primary lipid and pegylated-lipid at different molar ratios.

Experiences and Role Adaptation of Nursing PhDs in Hospital Settings: A Qualitative Study.

Aims: To explore the experiences, perceptions, and role adaptation of nursing PhDs in hospital settings in China.

Design: A descriptive phenomenological qualitative study.

Methods: Individual in-depth interviews were conducted with eight female nursing PhD holders from eight tertiary hospitals across five provinces between November 2024 and February 2025.

Correlation Between Retinal Vascular Oxygen Saturation, Red Blood Cell Parameters and Hemorheology Parameters in Healthy Adults.

Purpose: Investigate the correlation between retinal vascular oxygen saturation and red blood cell parameters, hemorheology parameters in healthy adults.

Methods: The study recruited 120 healthy volunteers, and their elbow venous blood was drawn for examination of RBC parameters and hemorheology. The retinal oximeter measured the retinal vascular oxygen saturation, including retinal arteriolar oxygen saturation (SaO), venous oxygen saturation (SvO) and arteriovenous oxygen saturation Difference (AVD).

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia.

Respiratory syncytial virus (RSV) is a ubiquitous respiratory virus that affects individuals of all ages; however, there is a notable lack of targeted treatments. RSV infection is associated with a range of respiratory symptoms, including bronchiolitis and pneumonia. Baicalin (BA) exhibits significant therapeutic effects against RSV infection through mechanisms of viral inhibition and anti-inflammatory action.

Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.

Glioblastoma stem cells (GSCs) exhibit remarkable metabolic and epigenetic adaptability, contributing to therapeutic resistance and tumor recurrence. The mechanisms underlying this plasticity represent potential targetable vulnerabilities to improve glioblastoma treatment. Here, we identified a critical metabolic-epigenetic axis centered on the mitochondrial calcium uniporter (MCU) that governs GSC survival and tumor initiation.

Multiple ctDNA- based biomarkers predict benefit from selective RET Inhibition in non-small cell lung cancer patients: exploratory analysis of a prospective study.

Selective RET inhibitors such as pralsetinib have become the standard of care for patients with RET fusion-positive non-small cell lung cancer (NSCLC). Serial analysis of circulating tumor DNA (ctDNA) has proven effective in monitoring disease control/progression and therapeutic response in NSCLC. In this prospective study, we analyzed longitudinal ctDNA profiles (at baseline, week 8, and at progression) in Chinese patients with advanced RET fusion-positive NSCLC treated with pralsetinib (NCT03037385), utilizing allele frequency-based, cfDNA quantity-normalized, and methylation-based metrics.

The mediating effects of psychological capital and career success in the relationship between leadership styles and job satisfaction among nurse managers: a cross-sectional study.

Background: Nursing managers' leadership styles significantly influence their job satisfaction, yet the underlying mechanisms remain unclear. This study explores the mediating roles of psychological capital and career success in the relationship between leadership styles-transformational (TFL), transactional (TSL), and passive/avoidant (PAL)-and job satisfaction (JS).

Methods: A cross-sectional study was conducted in May 2024 with nurse managers from 20 hospitals in Henan Province, China.

Genomics-driven discovery of superior alleles and genes for yellow rust resistance in wheat.

Yellow rust (YR), caused by Puccinia striiformis f. sp. tritici, poses a significant threat to wheat production worldwide.

The impact of perceived stress on job satisfaction among nurse managers: a moderated mediation model of job burnout and psychological capital.

Background: While the relationship between perceived stress and job satisfaction is well-established, the underlying mechanisms, particularly the roles of job burnout and psychological capital, have not been thoroughly examined in nurse managers.

Objective: This study aims to examine how job burnout (emotional exhaustion, depersonalization, and personal accomplishment) mediates the relationship between perceived stress and job satisfaction, and to assess the moderating role of psychological capital in these pathways.

Methods: A cross-sectional study was conducted with nurse managers from 20 hospitals in Henan Province, China.

Older children's third-party punishment decisions are more sensitive to severity than younger children's.

Maintaining cooperation requires responding to wrongdoing by, for example, punishing transgressors. However, we do not respond to all transgressions similarly: as adults, we are more likely to pursue the punishment of certain transgressions compared to others. This study ( = 213) looked at how presenting different transgressions may shape the developmental trajectory of third-party punishment behavior in children.

Cascade Energy Transformation in Hybrid Nanosensitizer Enables Ultrasound-Activated Luminescence Imaging and Enhanced Sonodynamic Therapy.

Optical imaging plays a pivotal role in the diagnosis and management of cancer, yet conventional techniques often suffer from limitations such as tissue autofluorescence, insufficient imaging depth, and signal persistence. Here, we introduce a hybrid nanosensitizer, SPNs(SP1)@CoOOH, that leverages cascade energy transformation (ultrasonic → chemical → photonic energy) to enable ultrasound-activated luminescence imaging concomitant with enhanced sonodynamic therapy (SDT). By integrating semiconducting polymer nanoparticles (SPNs) with cobalt oxide hydroxide (CoOOH), our platform facilitates dual-pathway reactive oxygen species (ROS) generation under acidic and ultrasound costimulation.

Effectiveness of virtual, group cough modulation therapy for chronic refractory cough.

https://bit.ly/4ltwNul.

Synthesis of PPy-BiVO-Cu heterojunction and its visible-light-driven photocatalytic degradation of 2,4-dichlorophenol.

2,4-Dichlorophenol (2,4-DCP) as a persistent organic pollutant, poses significant health risks to humans through chronic exposure. Photocatalysis is an efficient and green treatment technology, which has great advantages in the degradation of organic pollutants in wastewater. In this study, the PPy-BiVO-Cu photocatalyst - modified with both transition metal copper ions (Cu) doping and conductive polypyrrole (PPy) composite - was synthesized via a two-step process combining sol-gel method and chemical oxidative polymerization method.

Ginsenoside (20)S-APPT induces ferroptosis in hepatocellular carcinoma and cholangiocarcinoma by targeting FSP1.

Triggering ferroptosis has recently been recognized as a promising approach for cancer treatment. However, current ferroptosis inducers, such as glutathione peroxidase 4 (GPX4) inhibitors, face limitations in terms of druggability and safety. In this study, we performed a phenotypic screen of a 180-compound natural product library and identified (20S)-protopanaxatriol ((20)S-APPT), a ginsenoside derivative, as a potent ferroptosis inducer with a favorable safety profile both in vitro and in vivo.

Tracking the spatial and temporal evolution of salt marsh vegetation based on UAV sampling and seasonal phenology from Landsat data.

Salt marshes, valued for their ecological importance, have been increasingly degraded in recent decades. Preserving salt marshes necessitates a critical approach that involves monitoring vegetation distribution and species composition. This study presents a high-precision salt marsh mapping framework for the Yellow River Delta (YRD), integrating Unmanned Aerial Vehicle (UAV), machine learning and seasonal phenological features from Landsat data.

Surface-area-dependent viscoelastic property characterization of monodisperse microbubbles with different phospholipid shells.

The acoustic response of microbubbles is strongly dependent on the viscoelasticity of the shell. Accurately characterizing viscoelastic properties is crucial for tailoring phospholipids for ultrasound imaging and therapy. However, the current understanding of the nonlinear surface-area dependent shell viscoelasticity is limited.

Aberrant prefrontal-hippocampal connectivity of cross-modal associative memory impairment in schizophrenia.

Objective: Associative memory (AM) impairment is considered as a core cognitive dysfunction and indicative of poor function in schizophrenia. Despite the robust findings of abnormalities in prefrontal-hippocampal network, yet the specific regions and definitive patterns have remained elusive. We adopted an innovative AM paradigm to disentangle the contributions of prefrontal-hippocampal network.

Rechallenge with immune-checkpoint inhibitors in patients with advanced-stage lung cancer.

Lung cancer remains the leading cause of cancer-related mortality globally, with many patients diagnosed with advanced-stage disease. Treatment in this setting relies on systemic therapies, including chemotherapy, targeted therapy and immunotherapy. Immune-checkpoint inhibitors (ICIs), which promote or restore antitumour immunity by inhibiting immunosuppressive signalling pathways, are currently the most widely used immunotherapies in these patients.

Robust Plasmonic Structures Fabricated by Femtosecond Laser-Assisted Anisotropic Intaglio Engraving on Quartz for High-Sensitivity Surface Plasmon Resonance Sensing.

Fabrication of plasmonic structures on a gold film is a well-established approach to improve the performance of surface plasmon resonance (SPR) sensors. However, traditional fabrication techniques, such as photolithography, electron beam lithography (EBL), and focused ion beam (FIB) milling, often involve complex procedures and costly equipment. In this study, we present a mask-free, convenient method to fabricate robust plasmonic structures on the surface of z-cut α-quartz by combining femtosecond laser-induced modification with chemical etching for high-sensitivity Kretschmann configuration SPR sensing.