Stable zero-dimensional hybrid indium-based halides with yellow to orange light emission.

Low-dimensional organic-inorganic hybrid materials (OIHMs) in the field of luminescence have been occupying promising application prospects, but the toxicity and instability of lead-based halides are huge obstacles to the industrial utilization of these materials. Developing lead-free halides with low-toxicity and high stability have become important topics of research in recent years. Herein, we report three 0D In-based OIHMs (ABI)(InBr)Br (ABI = 2-aminium benzo-imidazole) 1, (DMA)(InBr)Br (DMA = dimethylammonium) 2, and (BAPP)(InBr)Br·6HO (BAPP = 1,4-bis(3-aminopropyl)piperazine) 3, which show maximum emission peaks within 605-622 nm, with a photoluminescence quantum yield (PLQY) of 60.

Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.

Glioblastoma stem cells (GSCs) exhibit remarkable metabolic and epigenetic adaptability, contributing to therapeutic resistance and tumor recurrence. The mechanisms underlying this plasticity represent potential targetable vulnerabilities to improve glioblastoma treatment. Here, we identified a critical metabolic-epigenetic axis centered on the mitochondrial calcium uniporter (MCU) that governs GSC survival and tumor initiation.

Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat syndrome.

Background: Da-Yuan-Yin Decoction (DYY), used since the early Qing Dynasty in China for damp-heat syndrome, was evaluated for its comprehensive protective effects.

Materials And Methods: Rats received a high-fat/high-sugar diet for 14 days, then daily exposure to high temperature/humidity (31.0 ± 0.

Intelligent pH-responsive films based on natural blueberry anthocyanins: A non-destructive monitoring system for the freshness of aquatic products with prospective smartphone compatibility.

Packaging plays a pivotal role in preserving food quality throughout processing and storage. This study developed a smart hydroxypropyl methylcellulose- κ-carrageenan- gelatin (H-K-G-B) film containing blueberry anthocyanins (BA) for freshness monitoring. The incorporation of BA significantly enhanced the film's antioxidant properties, with DPPH and ABTS radical scavenging capacities reaching 82.

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU-EMRE Assembly.

The mitochondrial calcium uniporter (MCU) complex mediates Ca entry into mitochondria, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases, and cancer. Despite its importance, developing specific and clinically viable MCU inhibitors is challenging.

Transoral endoscopic thyroid lobectomy and ipsilateral central neck lymph node dissection vestibular approach: analysis of the learning curve and clinical outcomes evaluation.

Purpose: The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is distinguished by its ability to leave no visible scars on the body's surface. Currently, there is still a lack of single-center large sample size analysis on the learning curve of TOETVA, especially for the treatment of thyroid cancer. This study aims to fill this void by presenting a comprehensive analysis of the learning curve and assessing the procedure's feasibility in managing thyroid cancer.

A double cross-linked film based on carboxymethyl chitosan binding with L-cysteine/ oxidized konjac glucomannan with slow-release of nisin for food preservation.

In order to address the issue of food contamination by microorganisms and effectively harness the antibacterial properties of nisin, we attempted to incorporate nisin into natural polymer films while addressing its inherent instability. An antibacterial food packaging film based on carboxymethyl chitosan (CCS) binding with L-cysteine (CYS) and oxidized konjac glucomannan (OKG) was developed through both Schiff base reaction and addition reaction of thiol aldehyde. To analyze the effect of addition reaction of thiol aldehyde on the CCS-CYS/OKG films' physicochemical properties, the CCS-CYS was prepared with different CYS combination rates, which were further used to fabricate composite films.

Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.

Prior to the generation of hematopoietic stem cells (HSCs) from the hemogenic endothelial cells (HECs) mainly in the dorsal aorta in midgestational mouse embryos, multiple hematopoietic progenitors including erythro-myeloid progenitors and lymphoid progenitors are generated from yolk sac HECs. These HSC-independent hematopoietic progenitors have recently been identified as major contributors to functional blood cell production until birth. However, little is known about yolk sac HECs.

Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta-Gonad-Mesonephros Region.

In the aorta of mid-gestational mouse embryos, a specialized endothelial subpopulation termed hemogenic endothelial cells (HECs) develops into hematopoietic stem and progenitor cells (HSPCs), through a conserved process of endothelial-to-hematopoietic transition (EHT). EHT is tightly controlled by multiple intrinsic and extrinsic mechanisms. Nevertheless, the molecular regulators restraining this process remain poorly understood.

Surface control approach for growth of cerium oxide on flower-like molybdenum disulfide nanosheets enables superior removal of uremic toxins.

Due to the high incidence of kidney disease, there is an urgent need to develop wearable artificial kidneys. This need is further exacerbated by the coronavirus disease 2019 pandemic. However, the dialysate regeneration system of the wearable artificial kidney has a low adsorption capacity for urea, which severely limits its application.

Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling.

The communication between glioblastoma stem cells (GSCs) and the surrounding microenvironment is a prominent feature accounting for the aggressive biology of glioblastoma multiforme (GBM). However, the mechanisms by which GSCs proactively drive interactions with microenvironment is not well understood. In this study, we interrogated metabolites that are preferentially secreted from GSCs and found that GSCs produce and secrete histamine to shape a pro-angiogenic tumor microenvironment.

Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment.

Acute kidney injury (AKI) can lead to loss of kidney function and a substantial increase in mortality. The burst of reactive oxygen species (ROS) plays a key role in the pathological progression of AKI. Mitochondrial-targeted antioxidant therapy is very promising because mitochondria are the main source of ROS in AKI.

MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2.

Background: The mechanism of recurrence and metastasis of hepatocellular carcinoma (HCC) is complex and challenging. Methyl-CpG binding domain protein 3 (MBD3) is a key epigenetic regulator involved in the progression and metastasis of several cancers, but its role in HCC remains unknown.

Methods: MBD3 expression in HCC was detected by immunohistochemistry and its association with clinicopathological features and patient's survival was analysed.

A Photoelectrochemical Platform Based on Polyaniline-Modified Titanium Dioxide Facet Heterostructure.

A photoelectrochemical (PEC) electrode for glucose detection was built based on polyaniline (PANI) modified titanium dioxide heterojunction (FH-TiO) structures. Ultrathin titanium dioxide (TiO) nanosheets are assembled onto rutile nanorods (TiO NRs). Experiments show that the main exposed faces of these nanosheets are (101) or (111) crystal planes.

Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice.

Koolen-de Vries syndrome (KdVS) is a rare disorder caused by haploinsufficiency of KAT8 regulatory NSL complex subunit 1 (KANSL1), which is characterized by intellectual disability, heart failure, hypotonia, and congenital malformations. To date, no effective treatment has been found for KdVS, largely due to its unknown pathogenesis. Using siRNA screening, we identified KANSL1 as an essential gene for autophagy.

Tumor evolution selectively inactivates the core microRNA machinery for immune evasion.

Cancer cells acquire genetic heterogeneity to escape from immune surveillance during tumor evolution, but a systematic approach to distinguish driver from passenger mutations is lacking. Here we investigate the impact of different immune pressure on tumor clonal dynamics and immune evasion mechanism, by combining massive parallel sequencing of immune edited tumors and CRISPR library screens in syngeneic mouse tumor model and co-culture system. We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity.

Mitochondrial Ca and cell cycle regulation.

It has been demonstrated for more than 40 years that intracellular calcium (Ca) controls a variety of cellular functions, including mitochondrial metabolism and cell proliferation. Cytosolic Ca fluctuation during key stages of the cell cycle can lead to mitochondrial Ca uptake and subsequent activation of mitochondrial oxidative phosphorylation and a range of signaling. However, the relationship between mitochondrial Ca and cell cycle progression has long been neglected because the molecule responsible for Ca uptake has been unknown.

1T- and 2H-mixed phase MoS nanosheets coated on hollow mesoporous TiO nanospheres with enhanced photocatalytic activity.

Recently, photocatalysts with a hollow mesoporous structure have drawn increasing interest owing to their extensive application in environmental protection. Herein, we prepared hollow mesoporous TiO nanospheres decorated with few layer 1T- and 2H- mixed phase MoS nanosheets via a template-based method and a hydrothermal reaction. The as-synthesized samples are of hollow mesoporous structure and high specific surface area, providing abundant mass transport and active sites for photocatalytic reaction.

AMPK-mediated activation of MCU stimulates mitochondrial Ca entry to promote mitotic progression.

The capacity of cells to alter bioenergetics in response to the demands of various biological processes is essential for normal physiology. The coordination of energy sensing and production with highly energy-demanding cellular processes, such as cell division, is poorly understood. Here, we show that a cell cycle-dependent mitochondrial Ca transient connects energy sensing to mitochondrial activity for mitotic progression.

Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer.

Purpose: The aberrantly upregulated Friend leukemia virus integration 1 () is closely correlated with the malignant phenotype of small cell lung cancer (SCLC). It is interesting to note that the CRISPR gene knockout by Cas9 gRNAs that target the coding region and the posttranscriptional knockdown by shRNAs that target the 3' region of mRNA yielded distinct antimetastasis effects in SCLC cells. This study attempts to examine if exonic circular RNAs (FECR) function as a new malignant driver that determines the metastatic phenotype in SCLC.

Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing.

Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other aging-related diseases. However, the molecular mechanisms of mitophagy are not fully understood.

Synthesis of hierarchically meso-macroporous TiO/CdS heterojunction photocatalysts with excellent visible-light photocatalytic activity.

Photocatalysts with a hierarchically porous structure have attracted considerable attention owing to their wide pore size distribution and high surface area, which enhance the efficiency of transporting species to active sites. In this study, hierarchically meso-macroporous TiO photocatalysts decorated with highly dispersed CdS nanoparticles were synthesized via hydrolysis, followed by a hydrothermal treatment. The textural mesopores and interconnected pore framework provided more accessible active sites and efficient mass transport for the photocatalytic process.

JMJD1C Ensures Mouse Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming through Controlling MicroRNA Expression.

The roles of histone demethylases (HDMs) for the establishment and maintenance of pluripotency are incompletely characterized. Here, we show that JmjC-domain-containing protein 1c (JMJD1C), an H3K9 demethylase, is required for mouse embryonic stem cell (ESC) self-renewal. Depletion of Jmjd1c leads to the activation of ERK/MAPK signaling and epithelial-to-mesenchymal transition (EMT) to induce differentiation of ESCs.

The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes.

The unique properties of embryonic stem cells (ESCs), including unlimited self-renewal and pluripotent differentiation potential, are sustained by integrated genetic and epigenetic networks composed of transcriptional factors and epigenetic modulators. However, the molecular mechanisms underlying the function of these regulators are not fully elucidated. Chromodomain helicase DNA-binding protein 4 (Chd4), an ATPase subunit of the nucleosome remodeling and deacetylase (NuRD) complex, is highly expressed in ESCs.