Design of a Distributed Passive Micro-Magnetic Stimulator for Targeted Multi-Brain Region Neuromodulation.

The multi-channel synchronous stimulator, aimed at achieving efficient and precise neural regulation, typically utilizes a monolithic microelectrode array structure. However, this structure limits the flexibility of electrode placement and the expansion to a large number of nodes, particularly in discontinuous locations. To address this, this paper designs a distributed passive micro-magnetic stimulation (DP-μMS) neuro-regulation device with multi-brain region collaborative stimulation functionality.

The Humanistic and Economic Burden of COPD Patients in Urban China: A Propensity Score Matching Study.

Purpose: Chronic obstructive pulmonary disease (COPD) is a leading cause of death in China. However, few national surveys have comprehensively evaluated the health and economic outcomes among COPD patients in China. The objective of this study was to examine and compare the humanistic and economic burden of COPD patients with a control group.

The cation channel Trpa1 and chemokine Cxcl1 mediate axonal degeneration in spared nerve injury-induced neuropathic pain.

Demyelination of peripheral nerve injury is a vital cause of neuropathic pain. Schwann cells play an important role in supporting and maintaining the removal and regeneration of myelin debris from neuronal axons in the peripheral nervous system. Creating a good immune microenvironment would promote the Schwann cells to repair the injured nerve and reverse the allodynia of neuropathic pain.

Thermoregulating phase-change composite separators with thermal runaway suppression for safe and high-performance lithium-ion batteries.

Lithium-ion batteries(LIBs)have been widely used and its safety has attracted much attention. Separators are an essential part of ensuring the safety of LIBs by both allowing ion transport and preventing direct electrical contact between the cathode and anode, Herein, a unique temperature-regulating separator that is thermally stimuli-responsive is designed. A thermosensitive composite separator was ingeniously crafted by filling hollow halloysite that followed by encapsulation with a phase change materials (PCMs) and a bio-adhesive polydopamine with a high-temperature-resistant poly (arylene ether nitriles) polymer.

Effects of Multi-Generational Rearing on Job's Tears on the Performance and Host Plant Preference of (Lepidoptera: Noctuidae).

The fall armyworm (FAW), , is a highly polyphagous pest posing a major threat to Poaceae crops, particularly corn (), in China. However, its ability to adapt to Job's tears (), an edible and medicinal Poaceae species, under continuous rearing remains insufficiently understood. In this study, FAW survival, development, and reproduction were assessed over eight generations on two cultivars of Job's tears, 'Cuiyi 1' and 'Puyi 6'.

Supramolecular Self-assembly of Tanshinone IIA to Construct an Antitumor Drug Delivery Platform.

has been reported to exhibit significant antitumor effects, primarily due to its active ingredient, Tanshinone IIA (TSA). However, its low solubility and bioavailability pose challenges for its application. This study employed the antisolvent precipitation method to explore the self-assembly potential of TSA molecules for developing possible soluble nanomedicine.

Caffeic acid tablets plus high-dose dexamethasone versus placebo plus high-dose dexamethasone in patients with newly diagnosed immune thrombocytopenia: A multicenter, double-blind, randomized, controlled, phase 2 trial.

Background: Standard initial therapy with intensive glucocorticoids requires further optimization due to high relapse rates and unsatisfying long-term outcomes in patients with primary immune thrombocytopenia (ITP). Caffeic acid (CA) has been reported to increase platelet counts in thrombocytopenia. This study investigated the efficacy and safety of CA tablets plus high-dose dexamethasone (HD-DXM) as a novel initial treatment for adults with newly diagnosed ITP.

Immunosuppressive spirocyclic labdane diterpenoids from Holocheila longipedunculata.

Phytochemical study on Holocheila longipedunculata has revealed twenty previously undescribed spirocyclic labdane diterpenoids, named hololabdanes (1-20). Their chemical structures were elucidated through comprehensive spectroscopic analysis, and the absolute configuration of hololabdane A (1) was determined via single-crystal X-ray diffraction. Notably, hololabdane I (17) and 16-epi-hololabdane I (18) feature a rare pyrrolo [2,1-b] oxazolidinone moiety, while hololabdane J (19) and 2'-epi-hololabdane J (20) possess a distinctive peroxide bridge.

Tuning water dissociation at oxide-electrolyte interfaces with electric fields.

Understanding how electric fields influence water dissociation at heterogeneous interfaces is crucial for controlling interfacial chemical reactions and advancing next-generation energy technologies. Herein, ab initio-based machine learning simulations show that even small electric field changes can significantly alter the water dissociation fraction at planar TiO-electrolyte interfaces. The resulting free energy difference between undissociated and dissociated interfacial water exhibits a linear dependence on the field change with a slope of 1.

Impact of black carbon exposure on length of hospital stay in asthma patients: a retrospective cohort study in yulin, China.

Objective: BACKGROUND: While PM₂.₅ exposure is linked to asthma exacerbations, components-specific effects on healthcare burden remain understudied. Hospital length of stay (LOS), a critical indicator of disease severity and healthcare costs, has received limited attention in black carbon (BC) research.

Protective Effects of Pectin From Honey-Processed Hawthorn on Acute Myocardial Ischemia.

Previous studies have shown that both hawthorn and honey-processed hawthorn (HH) can prevent heart injury in acute myocardial ischemia (AMI). Hawthorn pectin (HP) and stir-fried hawthorn pectin (FHP) have been identified as protective agents against AMI, with the effects closely related to their structural characteristics. This study aims to investigate the effects of pectin of HH (HHP) in preventing AMI.

Preparation of strong and tough alginate fibers through multiple Ca crosslinking structures and interpenetrating networks.

Green and low carbon development has become an unstoppable mainstream of the global and forced a trend of developing biomass fibers with high performance. Alginate fiber is an important component of marine biobased fibers that has gained widespread interest recently. However, applications of alginate fiber are facing challenges because of its limited mechanical properties.

Evaluate the clinical performance of Bio-HPP and Vitallium frameworks in free-end removable partial dentures.

Denture defects affect patients' aesthetic appearance and masticatory function, thus reducing their quality of life. There are many ways to repair denture defects, among which removable partial dentures are a basic and widely used method. The purpose of this study was to compare the clinical performance of Bio-HPP and Vitallium frameworks in the restoration of free-end removable partial dentures.

Association between dietary vitamin B1 intake and stroke risk in older patients: a retrospective cross-sectional study.

Background: Stroke is associated with vitamin B12, folate, and vitamin B1 (VitB1); however, large-scale data supporting the association between VitB1 and stroke risk are lacking. In this study, we aimed to investigate the correlation between VitB1 intake and stroke risk in U.S.

WTAP-mediated m6A modification of ARG2 mRNA Inhibits Its expression and drives prostate cancer malignant progression.

Background: Prostate cancer (PCa) incidence increases as age advances and seriously endangers men's health worldwide. Arginase 2 (ARG2) has been identified as a potential diagnostic and prognostic marker for PCa. However, the molecular mechanisms underlying its function in PCa remain undefined.

Leveraging Dynamic Bonds to Probe Equilibrium Topology in Polymer Networks.

Formation of chemically cross-linked polymer networks is a kinetically driven process leading to local topological defects such as primary loops, which decrease the elastic effectiveness of the network. Dynamic bonds in a network create possibilities for bond exchange and network rearrangement, potentially altering the topology. This work investigates how network topology changes as a result of incorporating dynamic bond rearrangements into an irreversibly cross-linked network.

Study on the astringent mechanism of .

(CF) is commonly used to make juice, porridge, and also as dietary supplements owing to anti-inflammatory and antioxidant activities. However, astringency affects the palatability and compliance. During taste masking, it is essential to identify astringent mechanism to balance masking needs and efficacy maintenance.

Bisphenol A causes melatonin biosynthesis epigenetic reprogramming of melatonin biosynthesis genes in arabidopsis thaliana.

Bisphenol A (BPA) is a widely used chemical that is commonly found in soils and surface waters worldwide and acts as an oxidative stressor on plants. Our understanding of how BPA exposure affects cellular redox homeostasis remains limited. We discovered that the epigenetic reprogramming of melatonin biosynthesis helps defend against oxidative stress induced by BPA in Arabidopsis.

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia.

Respiratory syncytial virus (RSV) is a ubiquitous respiratory virus that affects individuals of all ages; however, there is a notable lack of targeted treatments. RSV infection is associated with a range of respiratory symptoms, including bronchiolitis and pneumonia. Baicalin (BA) exhibits significant therapeutic effects against RSV infection through mechanisms of viral inhibition and anti-inflammatory action.

Effectiveness of fermentation broth of for primary insomnia: a randomized clinical trial with digital health tool.

Background: is widely used in Traditional Chinese Medicine and dietary supplements to tonify the kidney, lung, and heart, as well as to calm the mind. The fermentation broth of (FBCS), containing cordycepin, has shown potential in various healthcare applications.

Methods: Ninety patients with primary insomnia were divided into two groups: the FBCS group ( = 45) and the control group ( = 45).

Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia-Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis.

Previous studies have shown the potential of Chaihu Sanshen capsule (CHSSC) to ameliorate myocardial ischemia-reperfusion injury (MIRI), but there is yet no corresponding research on its chemical ingredients and multi-target action network. The study aims to identify the chemical composition and potential bioactive compounds of CHSSC and elucidate its underlying mechanisms in MIRI treatment. Ultra-high-performance liquid chromatography-Q exactive focus-mass spectrometry was used to analyse the chemical composition and potential bioactive compounds of CHSSC.

Long-read sequencing for NF1 gene analysis: enhancing diagnostic accuracy for Neurofibromatosis type 1.

The Clinical diagnosis of Neurofibromatosis type 1 (NF1) in pediatric patients is challenged by incomplete manifestation of age-dependent phenotypes, and molecular genetic testing is usually required to confirm the diagnosis. Early differential diagnosis is particularly crucial for children presenting solely with multiple Cafe-au-lait spots (CALMs). Here we developed a comprehensive analysis of the NF1 gene (CANF1) based on long-range PCR and long-read sequencing (LRS) for genetic testing of NF1.

A good rest makes a caring doctor: Linking physicians' nonwork time recovery to patient-centered communication with nonwork-to-work enrichment and empathy.

As an ideal form of patient-physician communication, patient-centered communication (PCC) is linked with various desired health and relationship outcomes, raising the need to promote PCC practices among physicians. However, how factors within physicians' daily work and life contexts are associated with PCC remains largely unknown. Based on the work-home resource (PCC) model, we proposed and tested a mediation path model linking nonwork time recovery-the restoration of resources during leisure time-to physicians' PCC.