Characterization of the Flavors and Organoleptic Attributes of Petit Manseng Noble Rot Wines from the Eastern Foothills of Helan Mountain in Ningxia, China.

To investigate the effect of infection severity on the flavor characteristics of Petit Manseng noble rot wine, this study analyzed wines produced from Petit Manseng grapes grown in the eastern foothills of Helan Mountain, Ningxia, China. The grapes were categorized into three groups based on infection status: uninfected, mildly infected, and severely infected with . Headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS) and an electronic nose were employed to detect and analyze the aroma components of wines under the three infection conditions.

Effect of Hyperbaric Oxygen Treatment on Lipid Metabolism and Neurovascular Microenvironment in an Apolipoprotein E Knockout Mouse Model.

Background: Dyslipidemia during midlife represents a significant risk factor for neuropathological alterations associated with cognitive decline. Given the currently incurable nature of dementia, implementation of preventive strategies and early therapeutic interventions prior to disease progression are paramount. Emerging evidence suggests that hyperbaric oxygen (HBO) therapy exhibits neuroprotective properties in various neurological conditions.

Hydrogen-Bonded Perovskite Heterojunction Photocatalytic Membrane with Efficient Proton Supply for Boosting CO Methanation.

Efficient proton supply and enhanced *CO intermediate adsorption are crucial strategies for boosting CO methanation. Herein, we construct a hydrogen-bonded (H-bonded) photocatalytic membrane by integrating a MAPbBr/cyano-g-CN (MPB/CN-g-CN) heterojunction with ethyl cellulose (ECE) binder through a simple sol-gel process, achieving significantly enhanced CO methanation efficiency. ECE functions as a novel proton source, with hydroxyl (-OH) groups that are readily oxidized by photogenerated holes, resulting in efficient proton supply compared to HO.

Effectiveness of fermentation broth of for primary insomnia: a randomized clinical trial with digital health tool.

Background: is widely used in Traditional Chinese Medicine and dietary supplements to tonify the kidney, lung, and heart, as well as to calm the mind. The fermentation broth of (FBCS), containing cordycepin, has shown potential in various healthcare applications.

Methods: Ninety patients with primary insomnia were divided into two groups: the FBCS group ( = 45) and the control group ( = 45).

Orchestrating Gut Disorders by Oral Delivery of a Living-Synthetic Hybrid Hydrogel.

Elevated intestinal inflammation, reactive oxygen species (ROS), and gut microbiota dysbiosis are prominent features of various intestinal disorders. In this work, we develop an oral inulin-based hydrogel delivery system (LICH) containing living probiotics and hyaluronic acid (HA)-modified carbon dot (CD) nanoenzymes to orchestrate gut disorders. Utilizing the hydrophobic properties of HA under acidic conditions, LICH contracts its network to safeguard probiotics during gastric transit.

Magnetic field-regulated glow discharge sputtering for enhanced depth-profiling and antibacterial analysis of Ag-doped TiN coating.

A novel satellite-like magnetic field-regulated (SLM) configuration is developed to enhance the depth-profiling and antibacterial analysis of Ag-doped TiN coating on Al substrate (Ag:TiN/Al) using glow discharge mass spectrometry (GDMS). COMSOL simulations reveal that the SLM configuration produces a unique magnetic field distribution through an antiparallel pole arrangement with six-fold symmetry. This creates a distinctive central circular magnetic field, which effectively controls electron motion, enhances central sputtering, and minimizes the edge effect, thereby improving depth-profiling performance.

Global, regional, and national burden of sudden infant death syndrome, 1990-2021: a comprehensive analysis of GBD 2021 data with insights into the impact during the COVID-19 pandemic.

Background: Sudden infant death syndrome (SIDS) remains a leading cause of infant mortality globally. Although the global burden has generally declined over recent decades, the COVID-19 pandemic may have influenced these trends. This study investigates whether the global SIDS burden has changed, particularly during the COVID-19 pandemic.

Prognostic predictive value of the preoperative systemic immunoinflammatory index combined with the neutrophil-to-lymphocyte ratio in patients with primary liver cancer undergoing transarterial chemoembolization.

Primary liver cancer (PLC) is a common type of malignant tumor, characterized by high morbidity and mortality worldwide, a poor prognosis, and a lack of reliable and effective prognostic predictors. The systemic immunoinflammatory index (SII) and the neutrophil-to-lymphocyte ratio (NLR) are key indicators of immunoinflammation in the body, and their combined clinical utility has not been fully explored in patients with PLC undergoing transarterial chemoembolization. In the present study, the association between the preoperative SII combined with the NLR and the prognosis of patients with PLC undergoing percutaneous hepatic artery chemoembolization was investigated.

Pseudo-4D Printing of Microbubble Arrays in Quantum Dot-Doped Polymer Films for Effective Light Extraction.

Quantum dots (QDs) with excellent optical properties are rapidly emerging as promising materials for the construction of photonic devices and systems. However, the light generated within QD-based devices always suffers from limited light out-coupling efficiency due to photon trapping effects caused by successive total internal reflection and waveguide losses at the edge. This study introduces a pseudo-4D printing strategy to construct microbubble arrays to tackle light trapping in QDs films.

Carbon dots assemblies with zinc as activable fluorescence probe for local glucose monitoring in traumatic wounds.

Hyperglycemic microenvironment is a major cause of impaired wounds healing in diabetes. Real-time and rapid monitoring of the local glucose is essential for effective caring and intervening in diabetic wounds. Herein, an activatable fluorescence nanoprobe (Zn-CDs) was developed for rapid response to glucose.

Electron donor-acceptor complex of aryl sulfonium salt enabling hydrogen/halogen atom transfer: C(sp)-H alkylation of glycine derivatives and late-stage modification of peptides.

Disclosed herein is the first example of visible-light-promoted C(sp)-C(sp) bond formation a radical-radical coupling strategy, enabled by a sequential intermolecular charge transfer and atom transfer steps, for synthesizing unnatural amino acids and modifying peptides.

Carbon-Dot-Zn Assembly Hybrid Multifunctional Hydrogels for Synergistically Monitoring Local Glucose and Repairing Diabetic Wound.

The prolonged healing period and increased rates of amputation and mortality are significant challenges for diabetic patients' wound care in clinical practice. Therefore, there is an urgent need to develop timely and efficient wound management strategies to monitor the local glucose while promoting rapid wound healing. In this study, a multifunctional hydrogel (PF127@Zn/C-G) was constructed by coloading the monitoring and therapeutic carbon dot (CD)-based agents (Zn/C) and glucose oxidase (GOx).

Study on the correlation between hsCRP/HDL-C ratio and the severity and prognosis of ischemic stroke.

Objective: Inflammatory and lipid biomarkers are increasingly recognized for their role in acute ischemic stroke (AIS). This study evaluated the predictive value of composite indicators, focusing on the hsCRP/HDL-C ratio.

Methods: A prospective study included 183 AIS patients and 194 controls from Sichuan Provincial People's Hospital (July 2023-July 2024).

Time-Reversal Enhanced Dynamic Causality Distribution Learning and Its Application in Identifying Dynamic ECNs in MCI Patients.

Objective: Dynamic causal influences between brain regions are crucial for understanding the temporal variation and fluctuation of the interaction in human brain. However, recent causal discovery approaches often focus on fixed causality under directed acyclic graph constraints, and do not infer the dynamic and fluctuating nature of causality, which commonly exists in the brain.

Methods: We propose a causality learning framework with evolving distribution for non-stationary and non-linear systems.

Recent progress of carbon dots in the theranostics of cardiovascular and cerebrovascular diseases.

Cardiovascular and cerebrovascular diseases (CCVDs) remain the leading cause of human death worldwide, therefore their early, highly sensitive diagnosis and effective treatment are key to reducing related mortality. With the development of biotechnology, various nanomaterials have been applied to the management of CCVDs. Among them, carbon dots (CDs) are considered promising candidates for bioimaging and CCVD therapy due to their unique properties, including excellent biocompatibility, good optical stability, abundant surface functional groups, high surface area, oxidation resistance, enzyme-like activity, and potential photoacoustic/fluorescence/magnetic resonance imaging capabilities.

Multi-omics integration reveals Vha68-3 as a testicular aging-specific factor that coordinates spermatid elongation through mitochondrial metabolic homeostasis.

Background: Testicular aging has profound effects on spermatogenesis, sperm function, and the spermatogenic microenvironment, contributing to reduced male fertility. However, the precise molecular mechanisms by which mitochondria influence spermiogenesis during aging still remain largely unclear.

Methods: Vha68-3 KO flies were generated using the CRISPR/Cas9 technique.

Research on the supply-demand balance evaluation and driving mechanism of community public service facilities.

The configuration level of community-level public service facilities is an important indicator for assessing the completeness of the urban public service system, and its spatial equilibrium directly impacts residents' quality of life. This study takes 400 living circles in Changsha as samples and, based on the theory of "spatial equilibrium," applies CRITIC method, system coordination model, and geographic detector to systematically evaluate the "supply-demand" equilibrium of community-level public service facilities. The study finds that: (1) The supply of public service facilities exhibits spatial agglomeration characteristics, while the demand distribution is significantly dispersed, with regional heterogeneity in the supply-demand matching; (2) There is a "Matthew effect" in the configuration of facilities, with significant equilibrium differences between the central urban areas and suburban regions; (3) The coverage of bus stops, farmers' markets, and multifunctional sports fields are key driving factors, and transportation convenience and daily demand satisfaction are the core pathways to improving equilibrium.

A Mendelian randomization study on the causal association of circulating cytokines with diabetic nephropathy.

Background: Circulating cytokines were reported to be related to diabetic nephropathy (DN) in observational studies. However, the causal relationship between them remains unknown. This study aimed to investigate the causal relationship between DN and circulating cytokines with genetic data in the frame of Mendelian Randomization (MR).

Iodine-Induced Redirection of Active Sources in Cu-Based Catalysts during Efficient and Stable Water Oxidation.

Enhancing the mechanistic regulation of the oxygen evolution reaction (OER) is crucial for developing efficient and stable electrocatalysts. However, the dynamic variation of surface structure during the electrocatalytic process limits the accurate identification of the active source and underlying reaction mechanism. Herein, we report an iodine-doping strategy to direct the reconstruction of active species in CuS catalysts toward an unconventional oxygen vacancy oxidation mechanism, thereby overcoming the activity and stability limitations.

Enhanced Backgate Tunability on Interfacial Carrier Concentration in Ionic Liquid-Gated MoS Devices.

The periodic spatial modulation potential arising from the zig-zag distribution of ions at large gate voltage in an ionic liquid-gated device may enable functionalities in a similar way as nanopatterning and moiré engineering. However, the inherent coupling between periodic modulation potential and carrier concentration in ionic liquid devices has hindered further exploration. Here, the feasibility of decoupling manipulation on periodic modulation potential and carrier density in an ionic liquid device is demonstrated by using a conventional backgate.

Chronic Intermittent Hypoxia-Induced Neural Injury: Pathophysiology, Neurodegenerative Implications, and Therapeutic Insights.

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a sleep-related respiratory disorder that poses a global threat to human health. Chronic intermittent hypoxia (CIH) is its main pathological feature. With the advancements in medical research, the study of CIH-induced neural injury has gained increasing attention.

Machine learning-based transcriptmics analysis reveals , , and as crucial biomarkers and therapeutic targets in sepsis.

Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, resulting in high mortality rates and complex clinical management. This study leverages transcriptomics and machine learning (ML) to identify critical biomarkers and therapeutic targets in sepsis. Analyzing microarray data from the Gene Expression Omnibus (GEO) datasets GSE28750, GSE26440, GSE13205, and GSE9960, we discovered three pivotal biomarkers that (bone marrow tyrosine kinase gene on chromosome X), growth factor receptor bound protein 10), and (growth arrest and DNA damage inducible alpha), exhibiting exceptional diagnostic accuracy (AUC >0.

Nitrogen-Containing Carbon-Encapsulated Platinum Electrocatalysts Supported by Single-Walled Carbon Nanotubes for Polymer Electrolyte Fuel Cells.

Platinum (Pt)-based electrocatalysts are widely regarded as the preferred choice for oxygen reduction reaction (ORR) in Polymer Electrolyte Fuel Cell (PEFC). However, their low stability remains a critical challenge. To overcome this problem, high-crystallinity and high-purity single-walled carbon nanotubes (SWCNTs), fabricated by the enhanced direct injection pyrolysis synthesis (e-DIPS) method, are utilized as support with a nitrogen introducing treatment applied to produce nitrogen-containing SWCNT (N-SWCNT).

Repurposing Vancomycin as a Potential Antiviral Agent Against PEDV via nsp13 Helicase Inhibition.

Porcine epidemic diarrhea virus (PEDV) causes a highly contagious intestinal disease with severe economic impacts on the global swine industry. The non-structural protein 13 (nsp13), a viral helicase, is essential for viral replication, making it a promising target for antiviral drug development. In this study, through virtual screening and molecular dynamics simulations, Vancomycin, a small-molecule drug also clinically used as an antibacterial agent, was identified to exhibit a stable binding affinity for PEDV nsp13.

Integrating P-Doped Carbon Nitride Dots as Active Sites on P/Mo Co-Doped BiVO Photoanodes Promotes HO Production.

The indirect anthraquinone method is currently used to produce HO, but it leads to high energy consumption and a large amount of chemical waste. Alternatively, water oxidation reactions offer a potential green approach for HO production, although it is constrained by low selectivity. Herein, the functional photoanodes are rationally designed for HO production via photocatalytic water oxidation.