Multi-level validation of high expression of PLAUR, FOSL2, and SLC11A1 in aortic dissection and their clinical implications.

Macrophages, pivotal orchestrators of the immune system, are integral to the initiation of specific immune responses and exert profound influence on the pathogenesis, progression, and therapeutic landscape of aortic dissection (AD). Leveraging the precision of single-cell RNA sequencing (scRNA-seq), this study aimed to dissect the heterogeneity of macrophages within the AD microenvironment. We identified a unique macrophage subpopulation, termed AD-associated macrophages (AD-mac), which is predominantly implicated in the early stages of AD pathogenesis.

Insights into the Genomic Architecture and Improvement of the Capabilities of for the Biodegradation of Petroleum Hydrocarbons.

Petroleum-contaminated terrestrial ecosystems require effective bioremediation strategies. In this study, genomic analysis revealed key biodegradation genes on the 21# chromosome: alkane hydroxylases (, , ) and aromatic ortho-cleavage pathway genes (). Phylogenetic and multiple sequence alignment analyses of the gene in strain 21# revealed the presence of signature motifs characteristic of Baeyer-Villiger monooxygenase.

Tumor microenvironment signatures enhances lung adenocarcinoma prognosis prediction: Implication of intratumoral microbiota.

The interaction between intratumoral microbiome and the tumor microenvironment (TME) has furthered our understanding of tumor ecology. Yet, the implications of their interaction for lung cancer management remain unclear. In the current work, we collected host transcriptome samples and matched intratumoral microbiome samples, as well as detailed clinical metadata from The Cancer Genome Atlas (TCGA) of 478 patients with lung adenocarcinoma (LUAD).

Antidepressant-like actions of lanifibranor and its related mechanisms in mouse models of depression: Involvement of hippocampal PPARα and BDNF.

Current commercial antidepressants worldwide are mainly developed according to the monoaminergic hypothesis of depression and have various limitations. Thus, exploring new antidepressants with better therapeutic efficacy and fewer adverse effects remain a hot topic in the field of neuropsychiatric research. Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to closely participate in the pathophysiology of depression, and here we assume that lanifibranor, a novel pan-PPAR agonist for α, δ, and γ, may induce antidepressant-like actions by PPARs activation.

Evaluation of cerium oxide nanoparticles' effects on pakchoi (Brassica chinensis L.) based on metabolomics analysis.

Nanotechnology holds significant potential for agricultural applications, yet plant response mechanisms to nanoparticle exposure remain poorly characterized. Cerium oxide nanoparticles (CeO NPs), prevalent in commercial products, were investigated using soil-grown pakchoi (Brassica chinensis L.) exposed to 0.

Pathologically Responsive Au@Ag Nanocomposite Spray-Coated Hydrogel Dressing for Accelerated Healing of Infected Wounds.

Infected wounds present a major clinical challenge due to the increasing prevalence of antibiotic resistance and the complex interplay of factors that impede tissue regeneration. To address this, we developed a pathologically responsive, sprayable hydrogel dressing incorporating gold-core silver-shell nanorod (Au@Ag NR) nanocomposites to accelerate infected wound healing. The hydrogel, composed of poly(vinyl alcohol) (PVA) and carboxylated chitosan (CCS), responds to elevated hydrogen peroxide (HO) levels characteristic of infected wound microenvironments.

Prevalence and Genomic Characterization of Isolated from a Vast Amount of Aquatic Products in Huzhou, China.

is the leading bacterial cause of gastroenteritis associated with aquatic food consumption globally. This study aimed to determine the prevalence of in aquatic foods from Huzhou and to identify the serotypes, antimicrobial resistance, virulence factors, and genetic relatedness of the strains. A total of 306 isolates were detected from 1314 aquatic food samples from 2022 to 2024.

Pathologic complete response after neoadjuvant chemotherapy for HER-2 negative breast cancer with HRR mutation.

Aims: This study compared pathologic complete response (pCR) rates to neoadjuvant chemotherapy (NAC) in HER2-negative early breast cancer patients with versus without homologous recombination repair (HRR) mutation, focusing on BRCA1/2.

Methods: This retrospective cohort study included HER-2-negative breast cancer patients who completed HRR genetic testing and received NAC. The primary endpoint was the pCR rate among HRR mutation carriers and noncarriers.

A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy.

Transfer RNA-derived small RNAs (tsRNAs or tDRs) perform a range of cellular functions. Here, we showed that tRNA-Asp-GTC-3'tDR, a hypoxia-induced tDR derived from the 3' end of tRNA-Asp-GTC, activated autophagic flux in kidney cells and its silencing blocked autophagic flux. Functional gain-/loss-of-function studies in murine kidney disease models demonstrated a substantial renoprotective function of tRNA-Asp-GTC-3'tDR.

The Value of Heparin-Binding Protein (HBP) in Predicting Early Pneumonia in Neurosurgical Intensive Care Unit (ICU) Patients.

Background: The high incidence of pneumonia in neurosurgical intensive care unit (NICU) patients significantly impacts their prognosis. Early identification of high-risk individuals for pneumonia is crucial for timely intervention and personalized treatment. Heparin-binding protein (HBP), an early inflammatory marker, shows promise as a predictor for early-onset pneumonia.

A Luminescent Sensor for Trace Uranyl in Nature Water Systems Using a Terbium(III)-Organic Framework.

Here, we have demonstrated a terbium(III)-organic framework ([Tb(HBTC)(BTC)(HO)]·4HO, denoted as ) synthesized from 1,2,4,5-benzenetetracarboxylic acid (HBTC) and TbCl·6HO under hydrothermal conditions. Notably, exhibits a highly efficient uranyl sensing capability in complex natural water systems such as lake water and seawater, featuring high sensitivity ( = 1.13 × 10 and 1.

Clinical value of controlling nutritional status scores in patients with hepatocellular carcinoma.

Background: Numerous studies have highlighted the significance of controlling nutritional status (CONUT) score in the prognosis of patients with hepatocellular carcinoma (HCC). However, the precise role of the CONUT scor in predicting HCC prognosis remains unclear. This study aimed to investigate the prognostic significance of the CONUT scores in patients with HCC through an updated meta-analysis.

Interventional effects of action research combined with bladder function rehabilitation methods for patients with spinal cord injury neurogenic bladder.

This study explores the influencing factors of spinal cord injury neurogenic bladder (SCINB) patients and evaluates the effect of action research combined with bladder function rehabilitation (AR-BFR) on bladder function recovery, aiming to provide clinical reference for rehabilitation nursing. A total of 92 SCINB patients admitted to the rehabilitation department from January 1, 2021, to December 31, 2023, were enrolled. Patients were divided into a control group, which received conventional medication, nursing, and neuromuscular rehabilitation, and an experimental group (EG), which received AR-BFR intervention.

Iron-silver-modified quantum dots act as efficient catalysts in anti-cancer multitherapy through controlled, ultrasound-induced oxidation.

Chemodynamic therapy and sonodynamic therapy are two promising tumour therapeutic strategies. However, lack of highly effective sonosensitizers and control over chemodynamic therapy limit their application. Here we synthesize silver-doped zinc selenide quantum dots with atomically dispersed superficial Fe and show that they act as efficient sonosensitizers, catalysers and immunoreagents.

Pseudo-4D Printing of Microbubble Arrays in Quantum Dot-Doped Polymer Films for Effective Light Extraction.

Quantum dots (QDs) with excellent optical properties are rapidly emerging as promising materials for the construction of photonic devices and systems. However, the light generated within QD-based devices always suffers from limited light out-coupling efficiency due to photon trapping effects caused by successive total internal reflection and waveguide losses at the edge. This study introduces a pseudo-4D printing strategy to construct microbubble arrays to tackle light trapping in QDs films.

Luteolin alleviates right ventricular hypertrophy in high altitude pulmonary hypertension rats by regulating PI3K/AKT/mTOR signalling pathway.

High altitude pulmonary hypertension (HAPH) is a chronic high-altitude disease caused by chronic hypoxia. Protecting right ventricular (RV) structure and function constitutes a key strategy for improving HAPH prognosis. Luteolin, a plant-derived flavonoid with cardiovascular protective properties, has been shown to reduce pulmonary artery pressure by improving vascular remodelling in HAPH.

Mutations in spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.

The spliceosome is a critical cellular machinery responsible for pre-mRNA splicing, essential for the proper expression of genes. Mutations in its core components are increasingly linked to neurodevelopmental disorders, such as primary microcephaly. Here, we investigated the role of SNW1, a spliceosomal protein, in splicing integrity and neurodevelopment.

Isolation and complete genome sequence of a novel Mycobacterium phage MS619.

Mycobacterium, an opportunistic pathogen, is highly prone to causing infections in humans, and its resistance to antibiotics poses a significant challenge. Phage therapy has emerged as a highly promising alternative treatment. In this study, a bacteriophage infecting Mycobacterium smegmatis was isolated from soil, named MS619, and classified within the class Caudoviricetes.

Group Typology Shapes Social Network Representations.

Efficiently representing social networks is challenging, but cognitive schemas can help address this challenge. This study examined whether network schemas related to group typology influence social network representations. In Experiment 1, participants, who were given only group-type information and the number of relationships without network structure, freely constructed friendship networks, forming more interconnected and centralized structures for task groups than social categories.

Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China.

Objective: serovar Typhimurium (. Typhimurium) and its monophasic variant, 4,[5],12:i:-, have become two of the most frequently isolated serovars worldwide, in both humans and animals. This study investigated the antimicrobial resistance and genomic characteristics of these two serovar .

A uranyl-based luminescent dosimeter for ultralow-dose tracking of UV and X-ray radiation.

Herein, we report a novel uranyl-based organic-inorganic hybrid dosimeter, designated as U-OX-PIP. Remarkably, U-OX-PIP exhibits UV/X-ray-induced fluorescence quenching responses, which are characterized by a gradual suppression of the uranyl emission signature. The pronounced fluorescence quenching behavior of U-OX-PIP enables its application as a highly sensitive radiation-responsive material.

Natural Revegetation Alters Habitat Conditions, Bacterial Components, and Polycyclic Aromatic Hydrocarbon (PAH)-Degrading Communities in Aged PAH-Polluted Soils.

The vegetation restoration of contaminated sites plays a critical role in ensuring the sustained stability and functional integrity of natural ecosystems. However, during the natural revegetation process, the variations in habitat conditions, bacterial community structure, and metabolic functions in aged, polluted soil are still unclear. In the present study, we investigated aged, polycyclic aromatic hydrocarbon (PAH)-polluted soils at closed, abandoned oil well sites from the Yellow River Delta.

CDC34 suppresses macrophage phagocytic activity and predicts poor response to immune checkpoint inhibitor in cancers.

The Cell Division Cycle 34 (CDC34) is an E2 ubiquitin-conjugating enzyme that is required for proteasomal degradation of substrate proteins, and is able to stabilize proteins including the epidermal growth factor receptor to promote lung carcinogenesis. Here, we conducted a pan-cancer analysis of CDC34 in The Cancer Genome Atlas datasets, and found its high expression in breast cancer and negative association with patient outcomes. Analysis of single-cell RNA-sequencing data revealed a negative role of CDC34 in macrophage phagocytotic activity for cancer cells.

Pathogenic mutations disrupt stress granules assembly in patients with DDX3X neurodevelopmental disorder.

DDX3X neurodevelopmental disorder (DDX3X-NDD) represents a recently identified genetic syndrome characterized by intellectual disability (ID) and developmental delays, primarily caused by pathogenic variants in the DDX3X gene. The physiological ramifications of these mutations remain largely unexplored. In this study, we reported 21 DDX3X variants from 22 Chinese patients with DDX3X-NDD by whole exome sequencing.