Edge-centric Brain Connectome Representations Reveal Increased Brain Functional Diversity of Reward Circuit in Patients with Major Depressive Disorder.

Background: Major depressive disorder (MDD) has been increasingly understood as a disorder of network-level functional dysconnectivity. However, previous brain connectome studies have primarily relied on node-centric approaches, neglecting critical edge-edge interactions that may capture essential features of network dysfunction.

Methods: This study included resting-state functional MRI data from 838 MDD patients and 881 healthy controls (HC) across 23 sites.

Multiple Lignocellulosic Inhibitor-Tolerant Strains Developed by Evolutionary Engineering and CRISPR/Cas9 Gene Editing Technology.

Through evolutionary engineering strategies, scientists have successfully cultivated multiple strains of with enhanced tolerance, demonstrating significant potential in improving resistance. In this study, was continuously cultured for 80 days in a medium containing lignocellulosic inhibitors (furfural, acetic acid, and vanillin). The evolved strain, , exhibited 12 h reduction in lag phase under multiple stress conditions and 17% increase in the ethanol conversion rate.

Targeting FAM111B attenuates mitophagy and increases the sensitivity to lenvatinib treatment by increasing MFN2 stability in hepatocellular carcinoma.

Lenvatinib resistance significantly limits its clinical efficacy and application in the treatment of hepatocellular carcinoma (HCC). Mitofusin 2 (MFN2) is an important GTPase involved in mitochondrial fusion, energy balance and mitophagy. The role and regulatory mechanism of MFN2 in HCC progression and lenvatinib resistance remain unclear.

Toll-like receptor 4-mediated inflammatory stimulation in Kupffer cell enhances arsenite-induced liver fibrosis by triggering hepatic stellate cell activation.

As a metalloid element with toxic properties, arsenic (As) has been shown to induce liver fibrosis (LF). Activation of hepatic stellate cell (HSC) is a pivotal factors in the progression of LF, yet the key sentinel cells of the liver tissue, Kupffer cell (KC), also exert a central regulatory role in driving LF. However, the specific functions of these cells in As-induced LF remain to be elucidated.

HBV reactivation and prognosis after systemic therapy in HCC with undetectable HBV DNA: a multicenter retrospective study.

There is a lack of research on hepatitis B virus (HBV) reactivation and prognosis in hepatocellular carcinoma (HCC) patients with undetectable HBV DNA after systemic therapy. This study aims to compare HBV reactivation (HBVr) and prognosis between patients treated with tyrosine kinase inhibitor (TKI) monotherapy and those receiving TKI combined with programmed cell death protein‑1 (PD-1) inhibitors. The retrospective study comprised 877 advanced HCC patients from two medical centers with undetectable HBV DNA, receiving TKI monotherapy (n = 419) or TKI plus PD-1 inhibitors (n = 458).

Fermentation quality improvement of cigar wrapper inoculated with exogenous strain Staphylococcus capitis S1.

The cigar wrapper leaves (CWLs), as a symbol of the intrinsic quality and appearance of cigars, reflects the overall quality of the cigar. The Shaoxing-flavored T3 Jiuqu used in Shaoxing wine production contains a large number of high-quality microorganisms, such as molds and yeasts, which play a significant role in enhancing flavor and quality. Among these microorganisms, several positively promote the fermentation of CWLs.

Current status and influencing factors of kinesiophobia in elderly patients with chronic obstructive pulmonary disease: A cross-sectional study.

Background: Kinesiophobia is an important psychological barrier that prevents chronic obstructive pulmonary disease(COPD) patients from participating in activities, and there is a lack of research on kinesiophobia in elderly COPD patients.

Objective: This study aimed to investigate the current situation of kinesiophobia in elderly COPD patients and to analyze its related influencing factors.

Methods: A cross-sectional survey was conducted on 271 elderly patients with COPD recruited from a tertiary hospital in Guangzhou, China.

Hypoxia-Induced Creatine Uptake Reprograms Metabolism to Antagonize PARP1-Mediated Cell Death and Facilitate Tumor Progression in Hepatocellular Carcinoma.

Recently, a PARP1-dependent cell-death process termed "parthanatos" that is driven by DNA damage has emerged as a crucial regulator of tissue homeostasis and tumorigenesis. Hypoxia is a hallmark of solid tumors and profoundly affects the malignant phenotypes of cancer cells. Here, we investigated the crosstalk between parthanatos and hypoxia.

Global trends and cross-country inequalities in laryngeal cancer: A systematic analysis of the 2021 Global Burden of Disease study represented by China.

Introduction: Laryngeal cancer is one of the most common malignant tumors in the upper respiratory tract, accounting for approximately 4.5% of all malignant tumors. Smoking, drinking alcohol and occupational exposure are its main risk factors.

Association of Prepregnancy Cardiovascular Risk Factors Clusters With Stillbirth Risk Across Racial and Ethnic Groups: A Nationwide Population-Based Study of 31.4 Million Singleton Births and 131 047 Stillbirths.

Background: The relationship between specific clusters of prepregnancy cardiovascular risk factors and stillbirth, particularly across racial and ethnic groups, remains understudied. We aimed to evaluate the association between 16 distinct cardiovascular risk clusters and stillbirth, emphasizing racial disparities.

Methods: We conducted a nationwide, population-based study using Centers for Disease Control and Prevention Natality and Fetal Death Data Files (2014-2022), including 31 408 776 singleton births and 131 047 stillbirths (≥20 weeks' gestation).

SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma.

Introduction: Recently, contrary to attacking cancer cells, the tumor microenvironment (TME) with genomic stability and vulnerable nature has emerged as promising therapeutic targets in hepatocellular carcinoma (HCC). Within TME ecosystem, tumor-associated macrophages (TAMs) play a pivotal role in tumor evasion and progression of HCC. However, their clinical and therapeutic implications remain unexplored.

Feasibility of laparoscopic-endoscopic rendezvous technology in high-risk cholecystocholedocholithiasis patients.

The feasibility of one-stage laparoscopic-endoscopic rendezvous (LER) strategy in high-risk cholecystocholedocholithiasis (CCL) requires exploration. Prior to the study, 16 items were approved by hospital administrative and clinical departments to address logistic challenges. A total of 51 Patients were analyzed, median operation time, intraoperative bleeding, duration of nasobiliary drainage tube (NBDT), and posthospital stay were 210 min, 20 ml, 8 days and 10 days, respectively.

Study on elongation master curve of thermal aging composite modified double base propellant.

In order to predict the maximum elongation of composite modified double base (CMDB) propellants under different aging time, temperature and strain rate, systematic uniaxial tensile characterization was performed across six controlled temperatures (233.15 K, 253.15 K, 273.

Prevalence and changes of childhood overweight across China and its provinces from 2000 to 2030.

Objectives: Childhood obesity has emerged as a significant public health challenge and there is an urgent need to improve the effectiveness of local government governance to curb its growth. We aimed to estimate the prevalence and changes of childhood overweight (including obesity) across China and its provinces from 2000 to 2019 and to project the prevalence by 2030, stratified by sex.

Methods: This study utilized data from the Institute for Health Metrics and Evaluation (IHME), which generated local-, administrative-, and national-level estimates of overweight prevalence among children under 5 years of age at a 5 × 5 km resolution for several low- and middle-income countries (LMICs) between 2000 and 2019 using a model-based geostatistical approach.

Immune System Alterations in the Development of Three Urological Cancers: Insights from Large-Sample Mendelian Randomization.

Urological cancers (UCs) greatly impact global public health. While immunity plays an important role, the contribution of specific immune cell traits to the development of UCs remains unclear. In our study, we employed Mendelian randomization (MR) to elucidate the causal relationship between 731 immune cell traits and three common UCs, namely kidney cancer (KC), bladder cancer (BC), and prostate cancer (PC).

Pretreatment Multi-sequence Contrast-Enhanced MRI to Predict Response to Immunotherapy in Unresectable Hepatocellular Carcinoma Using Transformer: A Multicenter Study.

Targeted combined immunotherapy (TCI) has shown certain antitumor effects in patients with unresectable hepatocellular carcinoma(uHCC), but only a subset of patients benefit. This study aims to develop a Transformer-based radiomics model to predict the objective response to combined therapy in patients with uHCC. This multicenter, retrospective study involved 264 HCC patients who underwent contrast-enhanced MRI prior to immunotherapy.

Ligand-Engineered Metal-Organic Frameworks of 3D Infinite Trinuclear Zinc Units for Photocatalytic Monooxygenation of Sulfenamides.

Metal-organic frameworks (MOFs) composed of infinite metal units exhibit enhanced electron transport and charge migration capabilities compared to discrete metal units. Herein, three underdeveloped isomorphic MOFs featuring 3D infinite zinc units are designed and synthesized. The Lewis acidity and photocatalytic activity of these MOFs are fine-tuned through atomic-level engineering of nitrogen atoms of ligands and the resultant change of charge transfer modes.

Targeting SAMD1 enhances the effect of anti-PD-1 plus lenvatinib therapy in hepatocellular carcinoma by increasing ferroptosis sensitivity and immune response.

Background: Combination therapy of anti-PD-1 plus lenvatinib has shown effective anti-tumour effects for unresectable hepatocellular carcinoma (HCC), but the overall prognosis of HCC is still unsatisfactory. Elucidating the molecular mechanism underlying HCC progression contributes to develop new effective treatment in order to enhances the response of anti-PD-1 plus lenvatinib therapy and improve the patients prognosis.

Method And Results: Here, we reported that targeting SAMD1 in HCC cells via small interference RNA-containing ZIF-90@HA (ATP/acid-responsive) Nanoparticles (ZIF-90@siRNA@HA NPs, ZSH NPs) significantly enhanced the anti-tumour effects of anti-PD-1 plus lenvatinib in vivo.

Maternal pre-pregnancy diabetes and risk of all-cause and cause-specific infant mortality.

Background: Maternal pre-pregnancy diabetes is associated with a higher risk of adverse pregnancy outcomes. Few large, cohort studies have assessed associations with a wide large range of causes of infant death.

Methods: This retrospective cohort study included all singleton live births to women aged 18-49 years in the US National Vital Statistics System from 2011 to 2020.

Impact of Upper Airway Comorbidities and Tonsil/Adenoid Synergistic Effects on Pediatric OSA Severity.

Purpose: To investigate the factors influencing the severity of obstructive sleep apnea (OSA) in children and to elucidate the synergistic effects of upper airway comorbidities (chronic rhinosinusitis, nasal septum deviation and malocclusion) with tonsillar and adenoid hypertrophy on ventilation efficiency.

Patients And Methods: A total of 404 pediatric patients with OSA aged 6-10 years diagnosed between January 2022 and January 2025 were included in this retrospective cohort study and underwent logistic regression analysis to identify the risk factors for pediatric OSA. Three-dimensional upper airway models under various comorbidity states were constructed via cone‒beam computed tomography (CBCT), and postoperative airway resistance changes were calculated via computational fluid dynamics (CFD) simulation and simulated surgery.

New-onset diabetes worsens prognosis of patients with pancreatic ductal adenocarcinoma after R0 resection: A multicenter study.

Background: The risk of pancreatic ductal adenocarcinoma (PDAC) is increased in patients with diabetes mellitus (DM), particularly in new-onset diabetes (NOD). This study aimed to analyze the effect of NOD on the outcomes of patients with PDAC after R0 resection.

Methods: PDAC patients from six centers in China undergoing R0 resection from 2015 to 2022 were included.

Configurable kinetics of polarization switching via ion migration in ferroionic CuInPS.

Ferroelectric materials are promising for developing non-volatile memory, neuromorphic computing, and photovoltaic technologies. Taking advantage of variable switching kinetics provides an important strategy for designing multifunctional ferroelectric devices. However, the conventional ferroelectrics due to the unmovable atomic species generally own a single switching kinetics, thus versatile and configurable switching kinetics still remain challenging.

IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance.

Background: Myocardial ischemia/reperfusion injury (MIRI) is a critical problem in cardiovascular medicine, often occurring after coronary revascularization procedures or cardiopulmonary bypass. The characters of MIRI are both energy metabolism disturbances and severe myocardium insulin resistance (IR), which exacerbated myocardial damage and cell death. Isoliquiritigenin (ISL), a flavonoid derived from licorice roots ( spp.