Numerical study on bearing performance of rock socketed pile anchored by inclined anchors under uplift and horizontal combined load.

Rock-socketed pile anchored by inclined anchors (RPIA) is a novel pile-anchor composite foundation developed to address the challenges of transmission tower installations in mountainous areas. This study investigates the bearing performance of RPIA under uplift-horizontal combined load using a nonlinear numerical model validated through full-scale field tests. Parametric analyses were conducted to examine the effects of inclined anchor length, angle and diameter, as well as connection node depth, on RPIA performance.

Is employment status associated with baseline symptoms, engagement, and outcomes in naturalistic psychotherapy? Evaluation in a large community mental health agency.

Employment status, an essential socioeconomic factor, may be an important driver of disparities in mental health and access to treatment. However, prior research has been inconclusive and utilized broad employment categories. The present study investigated the associations between various types of employment status and baseline symptomology, psychotherapy engagement, and psychotherapy outcomes.

Prioritization of legacy and emerging halogenated organic contaminants in humpback dolphins from northern South China Sea.

Marine mammals are prone to accumulating elevated levels of halogenated organic contaminants (HOCs) due to their long lifespans, high trophic positions, and substantial lipid stores. However, which HOCs are of greatest concern in these apex predators remain largely unknown. Here, we constructed a toxicological prioritization index (ToxPi) model that integrates detection frequency, persistence, bioaccumulation, and endocrine-disrupting potential to evaluate priority HOCs in Indo-Pacific humpback dolphins (Sousa chinensis, n = 70) from the northern South China Sea (NSCS) between 2008 and 2018.

Developing meditation practice in individuals with elevated psychological distress via a meditation app intervention: An implementation science-informed qualitative investigation of barriers and facilitators.

In recent decades, depression and anxiety have worsened among American adults. Meditation apps may provide an accessible route for reducing these symptoms. However, many users experience barriers to persisting in their use of these apps.

Integrating machine learning and bioinformatics approaches to identify novel diagnostic gene biomarkers for diabetic mice.

Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding the molecular mechanisms of diabetes has become an important direction in bioinformatics research. The aim of this study is the identification of diagnostic genes associated with streptozotocin (STZ)-induced diabetic mice.

Spider Webs as Noninvasive Indicators of Biomagnification and Tissue Partitioning of Halogenated Organic Contaminants in Mangrove Ecosystems.

Mangrove ecosystems are increasingly threatened by halogenated organic contaminants (HOCs), posing a significant threat to resident arthropods, including spiders and insects. Spider webs, due to their distinctive chemical composition and adsorption properties, have emerged as promising tools for monitoring environmental pollutant. This study quantified 58 HOCs in insects, spider tissues, and webs of across mangroves with varying pollution levels, using quantitative fatty acid signature analysis (QFASA) to estimate spider diets.

Fatty acids as biomarkers of organohalogen contaminant exposure in mangrove insects from the Pearl River Estuary, South China.

Insects are critical indicators of environmental health, providing a valuable insight into pollutant dynamics within mangrove ecosystems. Despite the recognized use of fatty acids (FAs) as biomarkers in various organisms, the effects of organohalogen contaminants (OHCs) on FA profiles in insects have not been extensively investigated. This study analyzed 54 OHCs and 36 FAs across 16 insect species from the Pearl River Estuary to assess the viability of FAs as biomarkers for OHC exposure.

Prompting Vision-Language Model for Nuclei Instance Segmentation and Classification.

Nuclei instance segmentation and classification are a fundamental and challenging task in whole slide Imaging (WSI) analysis. Most dense nuclei prediction studies rely heavily on crowd labelled data on high-resolution digital images, leading to a time-consuming and expertise-required paradigm. Recently, Vision-Language Models (VLMs) have been intensively investigated, which learn rich cross-modal correlation from large-scale image-text pairs without tedious annotations.

Focusing on the working range of two dimensions in purely endoscopic posterior interhemispheric approach: a series of 23 cases of lateral ventricular lesions.

The lateral ventricle, located deep within the intracranial space, poses significant surgical challenges due to its complex anatomy and proximity to critical neural structures. The purely endoscopic posterior interhemispheric approach, leveraging the natural corridor of the interhemispheric fissure, offers a promising alternative. A retrospective review was conducted on 23 cases of lateral ventricle lesions treated with the purely endoscopic posterior interhemispheric approach between January 2013 and December 2024.

Expanding the reach of mental health apps among college students.

This letter builds upon McCarthy and Horwitz's study published in , which examined first-year college students' attitudes and barriers to mental health apps. The letter highlights key areas for further research, including considering the role of international student status in mental health app use, incorporating pharmacological treatment history into mental health treatment measures, and expanding the application of the Health Belief Model to capture additional constructs pertinent to college students' attitudes toward mental health apps. It advocates for longitudinal studies to assess relationships between prior mental health care use and mental health app engagement.

Cytotoxic Mechanism and Exposure Risk Assessments of Banned Organochlorine Pesticides in Indo-Pacific Humpback Dolphins.

The persistent detrimental effects of banned organochlorine pesticide (dichlorodiphenyltrichloroethanes (DDTs)) exposure are a concern for cetaceans, yet their toxicological effects and risks have been difficult to handle due to technical and ethical issues. Here, we measured the concentrations of DDTs in the blubber of Indo-Pacific humpback dolphin () ( = 128) collected from the Pearl River Estuary (PRE) during 2003-2020 and studied by an assay that used the skin fibroblasts to answer questions about the cytotoxicity mechanism and risks of DDTs. DDT levels in humpback dolphins exceed those reported in other marine mammal studies.

Retrospective study of leptomeningeal metastasis: unveiling the indolent and rapid progression phases.

Purpose: Leptomeningeal metastasis (LM) is a severe cancer complication with poor prognosis and inconsistent treatment. Most studies are from Western countries, limiting understanding of LM in the Chinese population. This study aims to explore LM characteristics in Chinese patients and develop tailored treatment strategies.

Risk of Residual Axillary Lymph Node Macrometastasis in Early Breast Cancer PATIENTS with One Positive Macrometastasis Sentinel Lymph Node.

Objective: To investigate the risk factors for residual axillary lymph node macro-metastasis in early-stage breast cancer patients with a single macrometastasis sentinel lymph node (SLN).

Methods: We retrospectively analyzed the clinical data of 119 breast cancer patients diagnosed between January 2018 and September 2023, each with one positive SLN stained with methylene blue, who subsequently underwent axillary lymph node dissection. The patients were divided into two groups based on the total number of SLNs identified: fewer than three and more than three.

Impact of Upper Airway Comorbidities and Tonsil/Adenoid Synergistic Effects on Pediatric OSA Severity.

Purpose: To investigate the factors influencing the severity of obstructive sleep apnea (OSA) in children and to elucidate the synergistic effects of upper airway comorbidities (chronic rhinosinusitis, nasal septum deviation and malocclusion) with tonsillar and adenoid hypertrophy on ventilation efficiency.

Patients And Methods: A total of 404 pediatric patients with OSA aged 6-10 years diagnosed between January 2022 and January 2025 were included in this retrospective cohort study and underwent logistic regression analysis to identify the risk factors for pediatric OSA. Three-dimensional upper airway models under various comorbidity states were constructed via cone‒beam computed tomography (CBCT), and postoperative airway resistance changes were calculated via computational fluid dynamics (CFD) simulation and simulated surgery.

Triglyceride-glucose index: a novel predictor of major adverse cardiovascular events and cerebrovascular events in patients with acute ST-segment elevation myocardial infarction.

Introduction: Numerous studies have indicated the association of the triglyceride-glucose index (TyG) index with coronary artery disease, particularly myocardial infarction. However, limited mention exists regarding the predictive effects of major adverse cardiovascular events (MACE) and major adverse cardiac and cerebrovascular events (MACCE) in patients with ST-segment Elevation Myocardial Infarction (STEMI). This study aimed to investigate the predictive role of the TyG index on MACE and MACCE within 30 days in patients with STEMI.

Climate change and overfishing combine to drive the population decline of the Indo-Pacific humpback dolphins in the Pearl River Estuary from the Northern South China Sea.

Overfishing and climate change pose significant threats to cetacean populations, yet the specific impacts on individual species, particularly cetaceans inhabiting complex coastal areas, are not well understood due to limited data. This study utilizes five years of field survey data, alongside fishery activity and climate change scenarios, to assess the population dynamics of the Indo-Pacific humpback dolphin in the Pearl River Estuary from the Northern South China Sea. Our results indicate a dramatic and ongoing decline in the humpback dolphin population over recent decades, decreasing from over 1000 to 742 individuals.

SCNN1A expression in triple-negative breast cancer: clinical implications for prognosis and neoadjuvant therapy response.

Background: This study aimed to identify differential genes between pathological complete response (pCR) and non-pCR following neoadjuvant chemotherapy in triple-negative breast cancer (TNBC). Additionally, the expression and clinical significance of the differential gene SCNN1A in TNBC were explored.

Methods: Differential genes related to prognosis following neoadjuvant chemotherapy in TNBC were identified using the GEO database.

Phylogenomics of the superfamily Lygaeoidea with proposals on taxonomic system (Hemiptera: Heteroptera).

Lygaeoidea, one of the largest superfamilies of the true bugs (Hemiptera: Heteroptera), currently comprises 16 families and exhibits abundant diversification in habitats, body plans, and feeding habits. The relationships within this superfamily are complex, and comprehensive molecular phylogenetic studies, particularly those focusing on subfamilies and tribes within Rhyparochromidae, have been lacking. In the present study, we sampled 125 lygaeoid species representing all 16 families of Lygaeoidea, with a focus on two subfamilies and 12 tribes within Rhyparochromidae.

Prediction of EGFR mutations in non-small cell lung cancer: a nomogram based on F-FDG PET and thin-section CT radiomics with machine learning.

Background: This study aimed to develop and validate radiomics-based nomograms for the identification of EGFR mutations in non-small cell lung cancer (NSCLC).

Methods: A retrospective analysis was performed on 313 NSCLC patients, who were randomly divided into training (n = 250) and validation (n = 63) groups. Radiomic features were extracted from F-fluorodeoxyglucose positron emission tomography (F-FDG PET) and thin-section computed tomography (CT) scans.

Optimization of synthesis conditions of [Ga]Ga-PSMA-D5 and its clinical application in prostate cancer.

Radioisotope-labeled prostate-specific membrane antigen (PSMA) PET tracers have gained popularity in diagnosing prostate cancer (PCa). Recently, a novel biphenyl-containing tracer [Ga]Ga-PSMA-D5 targeting PSMA has been developed for PET imaging of PCa. The advantages of [Ga]Ga-PSMA-D5 include high tumor uptake, simple synthesis, and convenient labeling, making it a promising PSMA PET tracer.