Cancer beliefs, risk perceptions, and health protective behaviors among people living with diabetes in the United States: Results from the Health Information National Trends Survey.

Objective: Diabetes and cancer share common preventable risk factors, including obesity, physical inactivity, and poor diet. People with diabetes have an increased risk of developing cancer. The objective of our study was to compare cancer risk perceptions, beliefs about cancer, and cancer protective behaviors among people with and without diabetes in the United States.

Ultrabroadband UV-IR Self-Power Full-Stokes Polarization Photodetection and Imaging Based on the CsPbBrI/Si Heterojunction.

Silicon has become a leading material in photoelectric detection, owing to its distinct advantages in both response speed and photoelectric conversion efficiency. However, due to the lack of intrinsic polarization selectivity, silicon still faces major challenges in achieving polarization detection in the broadband ultraviolet (UV) to infrared (IR) range. In this paper, we have successfully developed an ultrabroadband UV-IR polarization photodetector with a Ag/CsPbBrI/Si/Ag vertical structure based on the CsPbBrI and N-type pyramid-silicon composite structure, which is designed to achieve full Stokes polarization detection.

Attention residual network for medical ultrasound image segmentation.

Ultrasound imaging can distinctly display the morphology and structure of internal organs within the human body, enabling the examination of organs like the breast, liver, and thyroid. It can identify the locations of tumors, nodules, and other lesions, thereby serving as an efficacious tool for treatment detection and rehabilitation evaluation. Typically, the attending physician is required to manually demarcate the boundaries of lesion locations, such as tumors, in ultrasound images.

Retrospective study of leptomeningeal metastasis: unveiling the indolent and rapid progression phases.

Purpose: Leptomeningeal metastasis (LM) is a severe cancer complication with poor prognosis and inconsistent treatment. Most studies are from Western countries, limiting understanding of LM in the Chinese population. This study aims to explore LM characteristics in Chinese patients and develop tailored treatment strategies.

Inferring kinase-phosphosite regulation from phosphoproteome-enriched cancer multi-omics datasets.

Phosphorylation in eukaryotic cells plays a key role in regulating cell signaling and disease progression. Despite the ability to detect thousands of phosphosites in a single experiment using high-throughput technologies, the kinases responsible for regulating these sites are largely unidentified. To solve this, we collected the quantitative data at the transcriptional, protein, and phosphorylation levels of 10 159 samples from 23 tumor datasets and 15 adjacent normal tissue datasets.

Suitability of Rosaceae fruit tree species for Panonychus citri (McGregor) (Acari: Tetranychidae).

The citrus red mite (CRM), Panonychus citri (McGregor) (Acari: Tetranychidae), a worldwide pest chiefly infesting Citrus plants, has spread from Southern China to Northern China. Little information is known about the population performance of CRM on the plants except for citrus trees and pear trees. In order to evaluate the extent of damage might caused by CRM to the fruit trees cultivated in Northern China, the performance of CRM on four Rosaceae species, including three main fruit tree species (pear-Pyrus pyrifolia Nakai cv.

A cost-effective adaptive repair strategy to mitigate DDoS-capable IoT botnets.

Distributed denial of service (DDoS) is a type of cyberattack in which multiple compromised systems flood the bandwidth or resources of a single system, making the flooded system inaccessible to legitimate users. Since large-scale botnets based on the Internet of Things (IoT) have been hotbeds for launching DDoS attacks, it is crucial to defend against DDoS-capable IoT botnets effectively. In consideration of resource constraints and frequent state changes for IoT devices, they should be equipped with repair measures that are cost-effective and adaptive to mitigate the impact of DDoS attacks.

Increased matrix stiffness in pituitary neuroendocrine tumors invading the cavernous sinus is activated by TAFs: focus on the mechanical signatures.

Purpose: Pituitary neuroendocrine tumors (PitNETs) with invasion of the cavernous sinus (CS) are particularly challenging to treat. Tumor associated fibroblasts (TAFs) are recognized for their pivotal role in reprogramming extracellular matrix (ECM). Herein, we aimed to explore the potential involvement of TAFs in ECM reprogramming and elucidate the underlying mechanism involved.

DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress.

Post-traumatic stress disorder (PTSD) is a severe stress-dependent psychiatric disorder characterized by impairment of fear memory extinction; however, biological markers to determine impaired fear memory extinction in PTSD remain unclear. In male mice with PTSD-like behaviors elicited by single prolonged stress (SPS), 19 differentially expressed proteins in the hippocampus were identified compared with controls. Among them, a biological macromolecular protein named deleted in colorectal cancer (DCC) was highly upregulated.

Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses.

Ethnopharmacological Relevance: Anshen Dingzhi prescription (ADP), documented in "Yi Xue Xin Wu", is a famous prescription for treating panic-related mental disorders such as post-traumatic stress disorder (PTSD). However, the underlying mechanism remains unclear.

Aim Of The Study: This study aimed to investigate the mechanisms by which ADP intervened in PTSD-like behaviors.

Gibberellic acid targeting ZBTB16 reduces NF-κB dependent inflammatory stress in sepsis-induced neuroinflammation.

Objective: Sepsis is frequently complicated by neuroinflammation. Gibberellic acid (GA3) is recognized for its anti-inflammatory properties. In this study, our objective was to investigate whether GA3 could alleviate Nuclear factor-kappa B (NF-κB) -dependent inflammatory stress in sepsis-induced neuroinflammation.

Comparison of Financial Hardship and Healthcare Utilizations Associated with Cancer in the United States Medicare Programs during the COVID-19 Pandemic.

Background: In the United States, Medicare beneficiaries diagnosed with cancer often face significant financial challenges due to the expensive nature of cancer treatments and increased cost-sharing responsibilities. However, there is limited knowledge regarding the financial hardships and healthcare utilizations faced by those enrolled in Medicare Advantage (MA) compared to those in traditional fee-for-service Medicare (TM) during the COVID-19 pandemic. Our study aims to investigate the subjective financial hardships experienced by individuals enrolled in TM and MA and to determine whether these two Medicare programs exhibit differences in healthcare utilization during the pandemic.

Chiral BINOL-phosphate assembled single hexagonal nanotube in aqueous solution for confined rearrangement acceleration.

Creating microenvironments that mimic an enzyme's active site is a critical aspect of supramolecular confined catalysis. In this study, we employ the commonly used chiral 1,1'-bi-2-naphthol (BINOL) phosphates as subcomponents to construct supramolecular hollow nanotube in an aqueous medium through non-covalent intermolecular recognition and arrangement. The hexagonal nanotubular structure is characterized by various techniques, including X-ray, NMR, ESI-MS, AFM, and TEM, and is confirmed to exist in a homogeneous aqueous solution stably.

A Framework for Detecting False Data Injection Attacks in Large-Scale Wireless Sensor Networks.

False data injection attacks (FDIAs) on sensor networks involve injecting deceptive or malicious data into the sensor readings that cause decision-makers to make incorrect decisions, leading to serious consequences. With the ever-increasing volume of data in large-scale sensor networks, detecting FDIAs in large-scale sensor networks becomes more challenging. In this paper, we propose a framework for the distributed detection of FDIAs in large-scale sensor networks.

Observation on Short-Term Therapeutic Effect of Electroacupuncture on Compensatory Hypertrophy Of Gastrocnemius Muscle: A Retrospective Cohort Study.

Objective: In Oriental women, having thick and short legs is a common posture problem, and having an imperfect lower leg shape is one of the factors that can cause feelings of inferiority. To address this issue, a retrospective cohort study was conducted to investigate the effectiveness of electroacupuncture in improving compensatory hypertrophy of the gastrocnemius muscle while also reducing side effects. The goal of this study is to improve the clinical treatment plan for this type of problem.

Naturally aged polylactic acid microplastics stunted pakchoi (Brassica rapa subsp. chinensis) growth with cadmium in soil.

Biodegradable microplastics (BMPs) and cadmium (Cd) are posing threats to agro-systems especially to plants and current studies mostly used virgin BMPs to explore their ecological effects. However, effects of naturally aged BMPs and their combined effects with Cd on pakchoi are yet to be unraveled. Therefore, this study incubated naturally aged polylactic acid (PLA) MPs through soil aging process and investigated the single and combined effects of Cd and PLA MPs (virgin and aged) on pakchoi (Brassica rapa subsp.

General anesthesia alters the diversity and composition of the lung microbiota in rat.

Background: The lung microbiome plays a crucial role in human health and disease. Extensive studies have demonstrated that the disturbance of the lung microbiome influences immune response, cognition, and behavior. The goal of this study was to investigate the effect of general anesthetics on lung microbiome.

A Novel Diagnosis Scheme against Collusive False Data Injection Attack.

The collusive false data injection attack (CFDIA) is a false data injection attack (FIDA), in which false data are injected in a coordinated manner into some adjacent pairs of captured nodes of an attacked wireless sensor network (WSN). As a result, the defense of WSN against a CFDIA is much more difficult than defense against ordinary FDIA. This paper is devoted to identifying the compromised sensors of a well-behaved WSN under a CFDIA.

The underlying mechanism of transcription factor IRF1, PRDM1, and ZNF263 involved in the regulation of NPPB rs3753581 on pulse pressure hypertension.

To investigate the correlation between NPPB gene variants and pulse pressure hypertension and the underlying regulatory mechanisms and try to confirm that NPPB may be a potential molecular target of gene therapy for pulse pressure hypertension. A total of 898 participants were recruited from the First Affiliated Hospital of Fujian Medical University and the plasmids with differential expression of NPPB were constructed. Genotype distribution of NPPB(rs3753581, rs198388, and rs198389)was analyzed and the expression of N-terminal pro-B-type natriuretic peptide(NT-proBNP) and renin-angiotensin -aldosterone system(RAAS) related indicators were identified in the groups studied.

MantaID: a machine learning-based tool to automate the identification of biological database IDs.

The number of biological databases is growing rapidly, but different databases use different identifiers (IDs) to refer to the same biological entity. The inconsistency in IDs impedes the integration of various types of biological data. To resolve the problem, we developed MantaID, a data-driven, machine learning-based approach that automates identifying IDs on a large scale.

Precise heteroatom doping determines aqueous solubility and self-assembly behaviors for polycyclic aromatic skeletons.

Developing effective strategies to improve the hydrophilicity or aqueous solubility of hydrophobic molecular scaffolds is meaningful for both academic research and industrial applications. Herein, we demonstrate that stepwise and precise N/O heteroatoms doping on a polycyclic aromatic skeleton can gradually alter these structures from hydrophobic to hydrophilic, even resulting in excellent aqueous solubility. The Hansen solubility parameters (HSP) method shows that the three partial solubility parameters are closely related to N/O doping species, numbers and positions on the molecular panel.

Engineering the Thermostability of a d-Carbamoylase Based on Ancestral Sequence Reconstruction for the Efficient Synthesis of d-Tryptophan.

Employing ancestral sequence reconstruction and consensus sequence analysis, the thermostability of a novel d-carbamoylase derived from (HyuC) was engineered through greedy-oriented iterative combinatorial mutagenesis. A mutant S202P/E208D/R277L (M4Th3) was obtained with significantly elevated thermostability. M4Th3 has a half-life of 36.

Ginsenoside Rg1 in neurological diseases: From bench to bedside.

Ginseng has been used in China as a superior medicinal material for thousands of years that can nourish the five internal organs, calm the mind and benefit wisdom. Due to its anti-inflammatory, antioxidant and neuroprotective activities, one of the active components of ginseng, ginsenoside Rg1, has been extensively investigated in the remedy of brain disorders, especially dementia and depression. In this review, we summarized the research progress on the action mechanisms of Rg1 ameliorating depression-like behaviors, including inhibition of hyperfunction of hypothalamic-pituitary-adrenal (HPA) axis, regulation of synaptic plasticity and gut flora.