UBE2C promotes pancreatic tumorigenesis by KRAS stabilization via APC/C-mediated WDR76 degradation.

Bioinformatics-based association study revealed a strong positive correlation between UBE2C, an E2 ubiquitin-conjugating enzyme, and pancreatic cancer and patient survival. However, whether and how UBE2C plays a causal role in pancreatic tumorigenesis remains elusive. Here, we report that UBE2C functions as a promoter in this process.

The Design and Validation of an Intensity-Modulated Multipoint Fiber-Optic Liquid-Level Sensor.

This study introduces a cost-effective solution and sensor arrays for the multipoint liquid-level measuring sensor based on an intensity modulation technique. The sensor structure is based on the twisting of two fibers and creates cascading to achieve a multipoint detection. Three sensors are fabricated on a single illuminated polymer optical fiber.

Clinical effect of Nd:YAG laser-assisted non-surgical periodontal treatment on stage II/III periodontitis.

Background: The aim of this study was to investigate the clinical effect of Nd:YAG laser-assisted non-surgical periodontal treatment on patients with stage II/III periodontitis.

Methods: A total of 599 teeth from 22 patients with stage II/III periodontitis were included in this study. A split-mouth design randomly assigned one side to the laser group (subgingival instrumentation + Nd:YAG laser) and the other to the control group (subgingival instrumentation alone).

Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization.

Background: The etiology of depressive disorder, the leading cause of global mental disability, is characterized by systemic metabolic dysregulation. However, the causal metabolites and their mechanistic networks remain elusive.

Methods: We combined untargeted LC/GC-MS metabolomics (N=98 Chinese elderly), weighted gene co-expression network analysis (WGCNA), and two-sample Mendelian randomization (MR) using GWAS data (59,333 depression cases with 434,831 controls) to identify depression-associated metabolites and pathways.

Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.

Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely absorbing dye molecules, which created transparency in the red spectrum while blocking shorter-wavelength photons. In this paper, we extend this capability to achieve optical transparency across the entire visible spectrum by employing molecules with strong absorption in the ultraviolet spectrum and sharp absorption edges that rapidly decline upon entering the visible spectrum.

A new digital biomarker of blepharitis: energy curve of the meibomian edge.

Purpose: To develop and validate a novel digital biomarker, the energy curve of the meibomian gland (MG) edge, to assess MG uneven atrophy and aid in diagnosing blepharitis.

Methods: A retrospective study enrolled 76 dry eye patients (42 with blepharitis, 34 controls). Segmentation of upper eyelid meibography images was accomplished via a convolutional neural network (CNN)-based artificial intelligence (AI) model.

Dedifferentiated liposarcoma with low-grade fibromyxoid sarcoma and inflammatory myofibroblastic tumor: A case report and literature review.

Rationale: Dedifferentiated liposarcoma (DDLPS) is a subtype of sarcoma that originates from atypical lipomatous tumor/well-differentiated liposarcoma and undergoes varying degrees of dedifferentiation. DDLPS can occur either concurrently with or after atypical lipomatous tumor/well-differentiated liposarcoma, with the dedifferentiated component predominantly consisting of high-grade sarcomas. Notably, only approximately 10% of DDLPS cases present as purely low-grade sarcomas.

Predation effects of flupyradifurone on Orius strigicollis (Poppius) (Heteroptera: Anthocoridae), a potential natural enemy of Asian citrus psyllid.

Diaphorina citri is a globally significant pest of citrus. A pest management strategy integrating flupyradifurone with Orius strigicollis has the potential to enhance control efficacy against D. citri, but its success depends on the predation efficiency of O.

Preoperative structural networks based on DTI predicts initial subthalamic nucleus stimulation outcome in parkinson's disease.

Deep brain stimulation (DBS) is widely used to treat Parkinson's disease (PD), but its efficacy varies. This study aimed to investigate how preoperative structural network influences subthalamic nucleus deep brain stimulation (STN-DBS) outcome in Parkinson's disease (PD). This study retrospectively collected 93 patients, and divided them into a low improvement group (LIG) and a high improvement group (HIG).

Arctigenin relieves inflammation and remodels the nasal epithelial barrier function in allergic rhinitis via the KLF5/BIRC3/NFκB axis.

Allergic rhinitis (AR) is a significant global health issue that necessitates effective treatments. This paper investigates the mechanism of arctigenin (ATG) in alleviating AR. An AR mouse model was constructed and administered with different doses of ATG or positive control dexamethasone.

High-sensitivity Mach-Zehnder interferometer temperature sensor based on a no-core optical fiber with a large lateral offset.

We designed and experimentally demonstrated an innovative temperature sensor based on Mach-Zehnder interference, which was formed by splicing a piece of no-core fiber (NCF) between two conventional single-mode fibers (SMFs) with a core offset. The intentional misalignment formed a gap that can be filled with ethanol, and temperature sensing was realized using the mode interference between the two distinct optical paths passing through the NCF cladding and the ethanol solution. Although the NCF length barely influenced the sensor sensitivity, it produced a major impact on the free spectral range (FSR) value.

Influence of antibacterial peptides in drinking water on growth and intestinal health of European meat pigeon.

This study evaluated insect-derived antimicrobial peptides (AMPs) as sustainable alternatives to antibiotics in European meat pigeon production. Using a randomized design, 360 breeding pairs with squabs were allocated to four groups (n = 90/group; 1:1 sex ratio). Controls received untreated water, while treatment groups received 200, 400, or 600 mg/kg AMPs in drinking water for 30 days.

A Knowledge Graph-Based Intelligent Q&A System for Rare Diseases.

This study develops a knowledge graph-based intelligent Q&A system for rare diseases, integrating data from 126 diseases, 2,609 symptoms, and related departments. The Bert-BiLSTM-CRF model achieved 82.13% accuracy in entity extraction, and TextCNN achieved 94.

Three-dimensional distribution and key drivers of neonicotinoid residues in hilly agricultural areas.

Neonicotinoids (NNIs) raise global concern due to their substantial soil residues and potential health risks to animal and human health. High water solubility and low soil adsorption enhanced vertical and horizontal migration of NNIs. However, understanding of NNIs' three-dimensional distribution in soils and influencing factors remains limited, limiting accurate risk assessment and remediation strategies for agriculture ecosystems.

Limosilactobacillus fermentum M5e Attenuates Hyperuricemia and Renal Injury via Dual Modulation of Gut Microbiota and Purine Metabolic Pathways.

Hyperuricemia, associated with gout and chronic kidney disease, underscores the need for novel therapies. Recent studies suggest that the gut microbiota may play a role in the pathogenesis of HUA, with certain probiotics demonstrating potential in reducing urate levels. Notably, Limosilactobacillus fermentum M5e exhibits exceptional in vitro uric acid degradation, yet its in vivo mechanisms remain unexplored.

Dynamical analysis and solutions of coupled 4D fractional differential systems with applications to predictability limit quantification in ocean-atmosphere models.

For coupled two-dimensional fractional differential systems, a new two-step fractional-order Runge-Kutta method is proposed in this paper, which can reach a convergence order of 2α, with α being the fractional-order number. Further, we extend the two-step fractional-order Runge-Kutta algorithm to any coupled n-dimensional fractional differential system while maintaining convergence and consistency. To demonstrate the validity of the proposed method, numerical experiments are given for a four-dimensional fractional Lorenz system, and the dynamics of the four-dimensional fractional Lorenz system is analyzed using Lyapunov characteristic exponents, bifurcation diagrams, chaos diagrams, and C0 complexity.

On-Demand ER Stress Modulation in Tumor Cells and TAMs via an Adaptively Transformable Nanoplatform Enhances Photodynamic Immunotherapy.

Photodynamic therapy (PDT) induces tumor immunogenic cell death (ICD) primarily through activating endoplasmic reticulum (ER) stress in tumor cells. However, ER stress is shown to promote the activation and proliferation of the immunosuppressive tumor-associated macrophages (TAMs), which are pivotal drivers of immune evasion. Coordinating the conflicting demands of ER stress signaling pathways in tumor cells and TAMs is crucial for potentiating PDT-based immune therapy.

Psychometric properties and measurement invariance of the Perth Emotion Regulation Competency Inventory (PERCI) in the Chinese version.

Background: The Perth Emotion Regulation Competency Inventory (PERCI) evaluates an individual's capacity to regulate their positive and negative emotions. To support future cross-cultural studies on emotion regulation, a Chinese version of PERCI was created and its psychometric properties and measurement invariance among different time points, genders, and educational levels were examined in 870 college students.

Methods: The study employed confirmatory factor analysis to test the seven models from the original research and used multi-group confirmatory factor analysis to examine the measurement equivalence of the Chinese version of PERCI across different genders, time points, and educational levels.

Correlation between infection and severity of gastritis in children.

is widely recognized as the chronic infection that is most commonly observed across all age cohorts worldwide and is closely linked to chronic gastritis. In pediatric patients, we aim to examine the endoscopic and histopathological alterations in the gastric mucosa. This was a potential monocentric investigation conducted from January 2018 to August 2018, collecting 120 children who underwent gastroscopy due to symptoms of gastrointestinal distress.

Comparative outcomes of Single and Dual Proglide Strategies in Endovascular Aortic Repair: A Multi-center Cohort Study.

Objective: To evaluate the safety and efficacy of single versus dual Proglide strategies for large-bore access closure (16-24F) after endovascular aortic repair (EVAR).

Methods: A multi-center, retrospective cohort study was conducted including patients who underwent percutaneous access EVAR from March 2023 to July 2024. Patients were categorized into two groups: those using dual Proglide strategy (DP group) and those using single Proglide strategy (SP group).

Exploring the neural mechanisms of alpha-band EEG neurofeedback using portable devices: A pre-post comparative study.

Objective: This study aimed to clarify the neural mechanisms of alpha-band neurofeedback (NF) training using a portable EEG system and to evaluate its feasibility for cognitive enhancement in practical settings.

Methods: Sixteen healthy young adults (M=24.28±1.

Development and biological evaluation of novel SOS1 inhibitors featuring 5,8-dihydropyrido[4,3-d]pyrimidin-7(6H)-one scaffold.

SOS1 plays a pivotal role in RAS activation and has emerged as a promising therapeutic target for tumors driven by KRAS mutations. In this study, we designed and synthesized a novel series of SOS1 inhibitors based on the 5,8-dihydropyrido[4,3-d]pyrimidin-7(6H)-one scaffold. Biological evaluation revealed that most compounds displayed anti-proliferative activity against K562 leukemia cells.

Global Leadership Initiative on Malnutrition: a bibliometric analysis of research trends and contributions (2018-2024).

Background: The Global Leadership Initiative on Malnutrition (GLIM) criteria were officially introduced in 2018 with the aim of establishing a standardized global framework for the diagnosis of malnutrition. Synthesizing expert consensus from multiple international organizations, the GLIM criteria proposed a two-step diagnostic model integrating both phenotypic and etiologic components. Although GLIM-related research has expanded rapidly in recent years, a comprehensive bibliometric evaluation remains absent.

DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma.

The mechanisms underlying clear cell renal cell carcinoma (ccRCC) metastasis remain largely unexplored. We demonstrate that Deleted in Split hand/Split foot protein 1 (DSS1), a critical cofactor of BRCA2 in DNA repair, is upregulated in metastatic ccRCC and promotes both tumor growth and distant metastasis. Mechanistically, DSS1 interacts with LC3 and promotes its degradation via TRIM25-mediated Lys63 (K63)-linked polyubiquitination at LC3B-K51.

Resveratrol attenuates hepatic inflammation and oxidative stress in collagen-induced arthritis (CIA) mice via the Nrf2/Keap1 pathway.

Background: Rheumatoid arthritis can affect extra-articular organs such as the liver, and the problem of drug-induced liver injury caused by traditional antirheumatic drugs for improving the condition cannot be ignored. This study aims to investigate the therapeutic effects of resveratrol (Res) on hepatic inflammation and oxidative stress in mice with collagen-induced arthritis (CIA) and to elucidate the relationship between the regulatory mechanisms of the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) signaling pathway.

Methods: In this study, we used chicken type II collagen in combination with complete Freund's adjuvant to induce arthritis in a mouse model, and Res was administered by tube feeding to detect the serum biochemical liver function and inflammation levels, oxidative stress, and apoptosis in the livers of mice.