Integrated DNA methylome and transcriptome analysis reveals the epigenetic regulatory mechanisms underlying maize response to copper stress.

DNA methylation plays a crucial role in plants' adaptation to environmental stresses. However, the precise role of DNA methylation in regulating the response of maize (Zea mays L.) to copper stress remains incompletely understood.

Changes in pathogenicity of gut microbiota during fasting-induced molting in laying hens and their impact on spleen immune function.

Fasting-induced molting (FIM) leverages the natural molting mechanism of aging laying hens to enhance their egg production and egg quality. However, fasting may also increase the risk of pathogen infection and activate immune regulation in the spleen. Understanding the specific types of pathogen infections triggered during FIM and their impacts on the spleen's immune regulation mechanisms is crucial for enhancing the immunological resilience of poultry.

Resveratrol attenuates hepatic inflammation and oxidative stress in collagen-induced arthritis (CIA) mice via the Nrf2/Keap1 pathway.

Background: Rheumatoid arthritis can affect extra-articular organs such as the liver, and the problem of drug-induced liver injury caused by traditional antirheumatic drugs for improving the condition cannot be ignored. This study aims to investigate the therapeutic effects of resveratrol (Res) on hepatic inflammation and oxidative stress in mice with collagen-induced arthritis (CIA) and to elucidate the relationship between the regulatory mechanisms of the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) signaling pathway.

Methods: In this study, we used chicken type II collagen in combination with complete Freund's adjuvant to induce arthritis in a mouse model, and Res was administered by tube feeding to detect the serum biochemical liver function and inflammation levels, oxidative stress, and apoptosis in the livers of mice.

The LncRNA STEAP3-AS1 promotes liver metastasis in colorectal cancer by regulating histone lactylation through chromatin remodelling.

Introduction: Liver metastasis is a common cause of death in patients with colorectal cancer (CRC); however, its molecular mechanism remains unclear. Here, we aimed to reveal the role of the lncRNA STEAP3-AS1 in regulating chromatin remodelling and histone lactylation and explore the mechanism by which the lncRNA STEAP3-AS1 promotes CRC liver metastasis. This study provide new research ideas and a theoretical basis for the clinical treatment of cancer.

Reconstructing zinc anode interface for enhanced aqueous zinc-ion batteries using a trace-amount CHO additive.

Aqueous zinc-ion batteries (AZIBs) have emerged as a promising candidate for next-generation energy storage technologies due to their inherent safety, environmental compatibility, and cost-effectiveness. However, the propensity for concomitant hydrogen evolution reaction (HER), corrosion, and zinc dendrite formation at the zinc anode significantly impede their widespread adoption. To overcome the limitations, we propose using a trace-amount low-cost additive, dihydroxyacetone (CHO) with 20 mM, to improve the reversibility of zinc plating/stripping for high-performance AZIBs.

The promotion of liver vitamin metabolism is of great significance for laying hens during fasting.

Background: Induced molt is an effective measure to reduce the introduction cost, cope with the continuous rise of feed cost, and realize the prolonged rearing of laying hens as well. Vitamins are beneficial to the antioxidant capacity and reproductive performance of laying hens, however, studies on vitamin metabolism during fasting are rarely reported.

Results: We analyzed the association between cecal metabolome and liver transcriptome of laying hens during molt.

Increased plasma GPNMB levels in patients with parkinson's disease and cognitive impairment.

Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a glycosylated type I transmembrane protein that forms soluble GPNMB upon maturation. This study aimed to explore the relationship between plasma GPNMB levels in patients with Parkinson's disease (PD) and their clinical manifestations, as well as their correlations with specific brain regions identified through imaging analysis. This study included patients with PD and healthy control subjects whose plasma GPNMB levels measured by enzyme-linked immunosorbent assay (ELISA).

A Thiopurine-like Mutagenic Process Defines TGCT Subtypes.

Testicular germ cell tumors (TGCTs) are the most common malignancy in young men, exhibit a unique developmental origin and exceptional chemosensitivity. However, the molecular distinctions between TGCT subtypes remain poorly understood. Here we present a comprehensive genomic analysis of 252 treatment-naive primary TGCTs, integrating deep whole-genome sequencing with matched transcriptomic and epigenomic data.

The dynamics of wild species in response to climate change facilitate the breeding of grapevine and its rootstocks with climate resilience.

Climate change presents significant challenges to agricultural suitability and food security, largely due to the limited adaptability of domesticated crops. However, crop wild relatives maintain greater diversity and are well adapted to various environments. This study evaluates the potential distributional responses of grapevine ( L.

Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson's disease patients with depression.

Background: Depression is a common nonmotor symptom in patients with Parkinson's disease (PD). Currently, few studies have investigated the relationships between serum markers and neuroimaging changes associated with depression in PD patients.

Objective: To explore the correlations among depression, serum SIRT3 levels, and brain structural and functional alterations in PD patients.

Regulation of intestinal health by Lactobacillus rhamnosus GG during fasting-induced molting in laying hens.

This study aims to investigate the regulatory effects of adding Lactobacillus rhamnosus GG (LGG) during the fasting-induced molting (FIM) process on the intestinal mucosal barrier and microbiota of laying hens. A total of 288 houdan chickens of 420 days of age were randomly divided into four groups, with nine replicates in each group and each replicate containing eight chickens: NC group (no LGG added); TB group (LGG was added during the pre-fasting period (F0 period)); TF group (LGG was added during the fasting period (F15 period)); TBF group (LGG was added during both the pre-fasting and fasting periods). The FIM experiment focused on four key time points: F0, F15, the 5th day (R5), and the 30th day (R30) of refeeding.

Potentially disabling factors of newly diagnosed leprosy patients in southwest China: a retrospective observational study.

Background: With the prevalence of leprosy dramatically declining, the focus of leprosy control has gradually shifted from the implementation of multidrug therapy (MDT) to accelerating the reduction of the disease burden and preventing disability. Southwestern China currently bears the highest leprosy burden in China and more than half of the disability cases reported every year are from this region. However, the potential risk factors of leprosy disability in this area remain unknown.

Artificial intelligence for modelling infectious disease epidemics.

Infectious disease threats to individual and public health are numerous, varied and frequently unexpected. Artificial intelligence (AI) and related technologies, which are already supporting human decision making in economics, medicine and social science, have the potential to transform the scope and power of infectious disease epidemiology. Here we consider the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data science.

High-Performance Zinc Halogen Aqueous Battery Exploiting [BrCl] Storage in Ketjenblack by Reconstructing Electrolyte Structure.

Halogen redox couples offer distinct merits due to high redox potential and low cost, but they usually suffer from poor reversibility. Here, we report highly reversible [BrCl]/Br and [BrCl]/Cl redox couples via harnessing interhalogen chemistry within nanoporous Ketjenblack (KB) carbon as a host for zinc-based aqueous batteries. The tunable halogen reactions are facilitated by controllable coordinating chemistry of [ZnClBr] in a hydrated deep eutectic solvent electrolyte comprising ZnCl, ZnBr, and choline chloride (CHClNO).

Corrigendum: Specific detection of duck adeno-associated virus using a TaqMan-based real-time PCR assay.

[This corrects the article DOI: 10.3389/fvets.2024.

Specific detection of duck adeno-associated virus using a TaqMan-based real-time PCR assay.

Duck adeno-associated Virus (DAAV) is a novel pathogen that was recently discovered in ducks. To establish a molecular detection assay for DAAV for further epidemiological investigation and pathogenic mechanism. Here, we designed specific primers and probes according to the sequence characteristics of the newly discovered DAAV and then established a TaqMan real-time PCR method (TaqMan-qPCR) for the detection of DAAV.

Specific detection of pigeon parvovirus with TaqMan real-time PCR technology.

The viruses of the Parvoviridae family can infect both vertebrate and invertebrate animals. Recently, pigeon parvovirus (PiPV) was detected in the feces of wild urban pigeons. Owing to no specific detection platform for PiPV, studies on the epidemiology of PiPV are still a research gap.

Comparative transcriptome analysis of maize ( L.) seedlings in response to copper stress.

Copper (Cu) is considered one of the major heavy metal pollutants in agriculture, leading to reductions in crop yield. To reveal the molecular mechanisms of resistance to copper stress in maize ( L.) seedlings, transcriptome analysis was conducted on the hybrid variety Zhengdan 958 exposed to 0 (control), 5, and 10 mM Cu stress using RNA-seq.

Iodine/Chlorine Multi-Electron Conversion Realizes High Energy Density Zinc-Iodine Batteries.

Aqueous zinc-iodine (Zn-I) batteries are promising energy storage devices; however, the conventional single-electron reaction potential and energy density of iodine cathode are inadequate for practical applications. Activation of high-valence iodine cathode reactions has evoked a compelling direction to developing high-voltage zinc-iodine batteries. Herein, ethylene glycol (EG) is proposed as a co-solvent in a water-in-deep eutectic solvent (WiDES) electrolyte, enabling significant utilization of two-electron-transfer I/I/I reactions and facilitating an additional reversibility of Cl/Cl redox reaction.

Transmission network of Hepatitis C virus subtype 2a in Huazhou County, Shaanxi Province, China.

Background: Huazhou County has one of the highest rates of hepatitis C virus (HCV) infection incidence and prevalence in Shaanxi Province, northwest China. Understanding the characteristics of HCV transmission patterns in this area could help guide targeted prevention strategies. This study employed phylogenetic analysis and the construction of a molecular transmission network of HCV-infected people in Huazhou County to describe the predominant strains of HCV and identify factors associated with onward transmission.

Characterization of maltose-binding protein-fused heparinases with enhanced thermostability by application of rigid and flexible linkers.

Heparinases, including heparinases I-III (HepI, HepII, and HepIII, respectively), are important tools for producing low-molecular-weight heparin, an improved anticoagulant. The poor thermostability of heparinases significantly hinders their industrial and laboratory applications. To improve the thermostability of heparinases, we applied a rigid linker (EAAAK) (R) and a flexible linker (GGGGS) (F) to fuse maltose-binding protein (MBP) and HepI, HepII, and HepIII from Pedobacter heparinus, replacing the original linker from the plasmid pMAL-c2X.