Imaging indicators and fusion analysis of percutaneous endoscopic posterior lumbar interbody fusion and modified posterior lumbar interbody fusion for the treatment of lumbar degenerative diseases.

Background: Although numerous studies have confirmed percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF) as a safe and effective minimally invasive technique for lumbar degenerative diseases (LDDs), existing research primarily focuses on clinical outcomes and involves limited imaging analysis. This study aimed to quantitatively compare PE-PLIF and modified posterior lumbar interbody fusion (MPLIF) through comprehensive radiographic evaluation and clinical outcomes.

Methods: We conducted a retrospective analysis of 75 consecutive LDD patients who underwent surgical treatment at our institution between January 2018 and October 2023.

Analysis of factors influencing the fusion rate in lumbar interbody fusion surgery: A Systematic Review.

This systematic review evaluates critical factors influencing lumbar interbody fusion success by analyzing clinical evidence from multiple studies. The findings demonstrate that smoking significantly reduces fusion rates, while autograft use shows superior outcomes compared to synthetic alternatives. The evidence supports implementing comprehensive preoperative optimization, refined surgical techniques, and standardized postoperative protocols to enhance fusion success.

Predation effects of flupyradifurone on Orius strigicollis (Poppius) (Heteroptera: Anthocoridae), a potential natural enemy of Asian citrus psyllid.

Diaphorina citri is a globally significant pest of citrus. A pest management strategy integrating flupyradifurone with Orius strigicollis has the potential to enhance control efficacy against D. citri, but its success depends on the predation efficiency of O.

Overexpression of CYP6CY36 and CYP380C34 contributes to metabolic resistance of Myzus persicae (Sulzer) to flupyradifurone.

Flupyradifurone is a novel butenolide insecticide widely applied to control a broad range of sucking pests, including Myzus persicae. However, resistance monitoring has revealed that several Chinese populations have developed moderate resistance to flupyradifurone. Therefore, we investigated the risk and underlying mechanisms of flupyradifurone resistance in M.

Lirispirolides A-L, a new class of sesquiterpene-monoterpene heterodimers with anti-neuroinflammatory activity from the rare medicinal plant Liriodendron chinense.

Lirispirolides A-L (1-12), twelve novel sesquiterpene-monoterpene heterodimers featuring distinctive carbon skeletons, were isolated from the branches and leaves of Chinese tulip tree [Liriodendron chinense (L. chinense)], a rare medicinal and ornamental plant endemic to China. The structural elucidation was accomplished through comprehensive spectroscopic analyses, quantum-chemical calculations, and X-ray crystallography.

Bletistrosides M-X, Anti-Alzheimer's Disease Compounds from the Tubers of .

Twelve new compounds, bletistrosides M-X (-), including five glucosyloxybenzyl 2-isobutylmalates (-), along with four neolignan glycosides (-), two phenanthrene derivatives (-), and one bibenzyl derivative (), were isolated from the tubers of (). The structures and absolute configurations of the undescribed compounds were elucidated on the basis of spectroscopic data analysis, experimental and calculated electronic circular dichroism data, chiroptical analysis, and chemical derivatizations. In silico, compounds , , and bound well to Aβ.

Hyperspectral Imaging for Predicting Bladder Cancer Grading: A Novel Diagnostic Approach.

Bladder cancer is a common malignancy of the urinary system, where accurate grading plays a key role in guiding personalized treatment and improving patient outcomes. Traditional grading methods rely on manual assessment of pathological slides, which are prone to subjective bias. This paper proposes a deep learning-based multimodal fusion model, named RVCK-net, which integrates hyperspectral imaging (HSI) and pathological images to achieve precise bladder cancer grading.

BRD4 regulates PAI-1 expression in tumor-associated macrophages to drive chemoresistance in colorectal cancer.

Tumor-associated macrophages (TAMs) in the tumor microenvironment play a key role in drug resistance, but the mechanisms underlying TAM polarization and its role in drug resistance remain unclear. Here, we identified BRD4 as a critical factor in TAM polarization and drug resistance in colorectal cancer (CRC). BRD4 deficiency in macrophages impaired M2-like TAM polarization, and tumors from myeloid-lineage specific Brd4 conditional knockout (Brd4-CKO) mice displayed a reduction in infiltrating M2-like TAMs and an enhanced anti-tumor microenvironment.

Diterpene-phenylpropanoid hybrids and structurally diverse diterpenoid monomers from the endangered conifer Podocarpus annamiensis and their bioactivities.

In this phytochemical investigation, a total of 16 previously undescribed and 27 known diterpene-related compounds were isolated from the endangered Chinese endemic conifer Podocarpus annamiensis. Podoannamiacids A (1) and B (2) represent the first examples of a new chemical class of diterpene-phenylpropanoid hybrids characterized by a unique 7'-phenyl-7',8'-dihydrobenzofuran unit. This structure is hypothesized to be biogenetically derived through the formation of newly generated C-12-C-8' and C-13-O-C-7' bonds via a free radical coupling reaction between a totarane unit and a phenylpropanoid moiety.

Structurally diverse sesquiterpenes with anti-leukemia activity from the rare medicinal plant Liriodendron chinense.

A further phytochemical investigation on the branches and leaves of Liriodendron chinense, a rare medicinal and ornamental plant endemic to China, yielded thirty-four sesquiterpenes with diverse skeletons. The isolated compounds comprise 12 new naturally occurring sesquiterpenoids (1-12) and 22 known analogues (13-34). The new structures were elucidated by spectroscopic data analyses, and their absolute configurations (except for 10) were determined by electronic circular dichroism spectra, quantum-chemical calculations, and X-ray crystallography.

An eco-friendly water-soluble CuO@His for efficient control of citrus canker.

Background: Citrus canker, a bacterial disease caused by Xanthomonas citri subsp. citri (Xcc), is one of the major threats to the citrus industry. Inorganic copper (Cu) formulations such as Bordeaux mixture and Kocide 3000 are currently used to control citrus canker; however, they are poorly water-soluble and have negligible plant transport, making the systemic treatment of citrus canker difficult.

pH-Activated NIR fluorescent probe for sensitive mitochondrial viscosity detection.

Understanding mitochondrial viscosity is crucial for comprehending cellular health and function. Therefore, accurate and sensitive measurement of mitochondrial viscosity is essential for advancing medical diagnostics and treatment strategies. In this study, a novel near-infrared (NIR) fluorescent probe SSN was developed, based on the dual mechanisms of Excited-State Intramolecular Proton Transfer (ESIPT) and Twisted Intramolecular Charge Transfer (TICT).

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XLIV. Integrated NMR/EI-MS/LC-PDA-ESIMS approach for dereplication and targeted isolation of fortunefuroic acids from Keteleeria fortunei across diverse geographical origins.

Secondary metabolites in plants of the same species, though originating from distinct geographical regions, frequently display both similarities and notable variations. A prior study on the vulnerable Chinese endemic conifer Keteleeria fortunei, collected from Yunnan province (KFYN), led to the isolation of fortunefuroic acids (FFAs) A-I. These compounds represent a unique class of triterpenoids characterized by a rare furoic acid moiety within the lateral chain.

Prediction of Potential Risk for Ten Azole and Benzimidazole Fungicides with the Aryl Hydrocarbon Receptor Agonistic Activity to Aquatic Ecosystems.

Azole and benzimidazole fungicides are widely used agrochemicals to prevent and treat fungal growth and are frequently detected in aquatic environments. Here, we aimed to assess the aquatic ecological risks of ten currently used azole and benzimidazole fungicides, which with the aryl hydrocarbon receptor (AhR) agonistic activity, and their transformation products (TPs). We obtained over 400 types of aerobic TPs for ten fungicides.

Bis-Iridoid Glycosides and Triterpenoids from and Their Potential as Inhibitors of ACC1 and ACL.

A comprehensive phytochemical investigation of the twigs/leaves and flower buds of , a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (- and -), 20 triterpenoids (, , and -), and 8 phenylpropanoids (-). Among these, amabiliosides A () and B () represent previously undescribed bis-iridoid glycosides, while amabiliosides C () and D () feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro--carboline-5-carboxylic acid moiety.

Function Analysis of Heme Peroxidase Genes, MpPxd2 and MpPxd4, Under Thiacloprid Exposure in the Neonicotinoid-Resistant (Sulzer).

The green peach aphid, , is a notorious pest worldwide. We collected a field population of the pest (FZQ-F) that exhibited high resistance to neonicotinoids. Exposure to neonicotinoids can induce oxidative damage in animals; however, it remains unclear whether antioxidant enzymes contribute to the innate immune response of neonicotinoid-resistant pests against high doses of insecticides.

Brd4 modulates metabolic endotoxemia-induced inflammation by regulating colonic macrophage infiltration in high-fat diet-fed mice.

High-fat diet (HFD) induces low-grade chronic inflammation, contributing to obesity and insulin resistance. However, the precise mechanisms triggering obesity-associated metabolic inflammation remain elusive. In this study, we identified epigenetic factor Brd4 as a key player in this process by regulating the expression of Ccr2/Ccr5 in colonic macrophage.

Bone histology and growth curve of the earliest ceratopsian from the Upper Jurassic of Junggar Basin, Northwest China.

, the earliest known ceratopsian, is represented by dozens of specimens of different sizes collected from the Upper Jurassic of the Junggar Basin, northwestern China. Here, we present the first comprehensive study on the bone histology of based on ten specimens varying in size. Four ontogenetic stages are recognized: early juvenile, late juvenile, subadult, and adult.

ZnO quantum dots reduce acquisition of huanglongbing pathogen by Diaphorina citri.

Background: Diaphorina citri Kuwayama is the main vector of the Huanglongbing (HLB) pathogen Candidatus Liberibacter asiaticus (CLas). Therefore, reducing CLas acquisition by D. citri is crucial for controlling the spread of HLB.

The Altered Lipid Composition and Key Lipid Metabolic Enzymes in Thiacloprid-Resistant , with Special Attention Paid to the Function of .

Neonicotinoid resistance is increasingly prevalent in the agricultural pest . Lipids play a critical role in insect defense systems, but their contribution to insect neonicotinoid resistance is disregarded. We conducted metabolomics and transcriptomics studies on thiacloprid-resistant (THG-R) and -susceptible (FFJ-S) populations.

Solanapyrone analogues from endophytic Nigrospora sphaerica MZW-A associated with the endangered conifer Pinus wangii.

Eight previously undescribed solanapyrone analogues, sphasolanapyrones A-H (1-8), together with four structurally related known compounds (9-12) were obtained from the solid fermentation of Nigrospora sphaerica MZW-A, an endophytic fungus isolated from the fresh branches of the endangered conifer Pinus wangii. This study represents the first investigation on the secondary metabolites of endophytic fungus associated with this precious plant. The structures and absolute configurations of compounds 1-8 were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations.

Benzofurans and dibenzofurans from galls on twigs of the endangered Chinese endemic tree Parrotia subaequalis and their inhibitory properties against Staphylococcus aureus and ATP-citrate lyase.

Parrotia subaequalis, an endangered Tertiary relict tree native to China and a member of the Hamamelidaceae family, is one of several host plant species in this family that exhibit unique ecological habits, such as gall formation. Tree galls are the results of complex interactions between gall-inducing insects and their host plant organs. The formation of galls may serve to protect other regions of the plant from potential damage, often through the production of phytoalexins.

An outbreak associated with in a junior high school, China.

is an emerging foodborne enteropathogen associated with infectious diarrhoea in humans. In February 2023, an outbreak of acute gastroenteric cases was reported in a junior high school located in Hangzhou, Zhejiang province, China. Twenty-two investigated patients presented diarrhoea (22/22, 100%), abdominal pain (21/22, 95.