Lirispirolides A-L, a new class of sesquiterpene-monoterpene heterodimers with anti-neuroinflammatory activity from the rare medicinal plant Liriodendron chinense.

Lirispirolides A-L (1-12), twelve novel sesquiterpene-monoterpene heterodimers featuring distinctive carbon skeletons, were isolated from the branches and leaves of Chinese tulip tree [Liriodendron chinense (L. chinense)], a rare medicinal and ornamental plant endemic to China. The structural elucidation was accomplished through comprehensive spectroscopic analyses, quantum-chemical calculations, and X-ray crystallography.

METTL3-YTHDF1 axis drives BCL-3 m6A methylation to promote the ferroptosis of brain microvascular endothelial cells during intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) significantly impacts human health, with emerging evidence indicating that N6-methyladenosine (mA) modifications serve a critical regulatory function in ischemic stroke. However, the underlying mechanisms remain largely unexplored. This study sought to comprehensively analyze aberrant mA modification and its mechanistic implications following ICH.

Variation of Arbuscular Mycorrhizal Fungi Communities Between Root and Rhizosphere Soil of Endangered Plant Along Elevation Gradient.

Arbuscular mycorrhizal fungi (AMF) are considered crucial for the survival of many endangered plant species. However, the dynamics of AMF communities in the roots and rhizosphere soil of , particularly along elevation gradients, remain underexplored. This study investigates AMF colonization, spore density, and community structure in the root and rhizosphere soil of across an elevation range from 306 to 1028 m a.

Structurally diverse sesquiterpenes with anti-leukemia activity from the rare medicinal plant Liriodendron chinense.

A further phytochemical investigation on the branches and leaves of Liriodendron chinense, a rare medicinal and ornamental plant endemic to China, yielded thirty-four sesquiterpenes with diverse skeletons. The isolated compounds comprise 12 new naturally occurring sesquiterpenoids (1-12) and 22 known analogues (13-34). The new structures were elucidated by spectroscopic data analyses, and their absolute configurations (except for 10) were determined by electronic circular dichroism spectra, quantum-chemical calculations, and X-ray crystallography.

Integrated physiological and anatomical analyses reveal the mycorrhizal symbiosis efficiency of Heptacodium miconioides under different nitrogen conditions.

Arbuscular mycorrhizal fungi (AMF) have been shown to play a role in protecting endangered plants from environmental stresses. However, the adaption mechanisms by which AMF symbiosis influences the physiological and anatomical traits of the endangered species Heptacodium miconioides under varying nitrogen (N) conditions remain unclear. Here, we examined the effects of three types of AMF inoculation treatments-Rhizophagus intraradices, Glomus versiforme, and a mixture of the two-on the growth, photosynthesis, antioxidant enzyme activity, and stem and leaf structure of H.

Oxidation of [3]naphthylenes to cations and dications converts local paratropicity into global diatropicity.

Oxidized states of polycyclic aromatic hydrocarbons are of importance as they represent charged conductive species in organic semiconductor substrates. In this work, we investigated the properties of radical cations and dications of linear and angular [3]naphthylenes, consisting of fused aromatic naphthalenoid and antiaromatic cyclobutadienoid moieties and containing different degrees of paratropicity. Electronic absorption and vibrational Raman spectroscopies were used to describe the more relevant bonding changes.

Integrating Ultra-High-Performance Liquid Chromatography and Orbitrap High-Resolution Mass Spectrometry, Feature-Based Molecular Networking, and Network Medicine to Unlock Harvesting Strategies for Endangered Sinocalycanthus Chinensis.

Evaluating the practical utility of endangered plant species is crucial for their conservation. Nevertheless, numerous endangered plants, including Sinocalycanthus chinensis, lack historical usage data, leading to a paucity of guidance in traditional pharmacological research. This gap impedes their development and potential utilization.

In Vitro Inducted Tetraploid Nakai ex F. Maek. Alters Polyphenol Species and Synthesis.

Nakai ex F. Maek. has been employed in traditional Chinese medicine for millennia.

Benzofurans and dibenzofurans from galls on twigs of the endangered Chinese endemic tree Parrotia subaequalis and their inhibitory properties against Staphylococcus aureus and ATP-citrate lyase.

Parrotia subaequalis, an endangered Tertiary relict tree native to China and a member of the Hamamelidaceae family, is one of several host plant species in this family that exhibit unique ecological habits, such as gall formation. Tree galls are the results of complex interactions between gall-inducing insects and their host plant organs. The formation of galls may serve to protect other regions of the plant from potential damage, often through the production of phytoalexins.

Supramolecular Assembly of Fused Macrocycle-Cage Molecules for Fast Lithium-Ion Transport.

We report a new supramolecular porous crystal assembled from fused macrocycle-cage molecules. The molecule comprises a prismatic cage with three macrocycles radially attached. The molecules form a nanoporous crystal with one-dimensional (1D) nanochannels.

Major specialized natural products from the endangered plant Heptacodium miconioides, potential medicinal uses and insights into its longstanding unresolved systematic classification.

A comprehensive phytochemical investigation of the flower buds and leaves/twigs of Heptacodium miconioides, a cultivated ornamental plant native to China and categorized as 'vulnerable', has led to the isolation of 45 structurally diverse compounds, which comprise 18 phenylpropanoids (1-4, 7-20), 11 pentacyclic triterpenoids (5, 6, 21-29), eight secoiridoid glycosides (30-37), three quinic acid derivatives (38-40), and a few miscellaneous components (41-45). Among them, (+)-α-intermedianol (1), (+)-holophyllol A (2), and (-)-pseudolarkaemin A (3) represent previously unreported enantiomeric lignans, while (+)-7'(R)-hydroxymatairesinol (4) is an undescribed naturally occurring lignan. Heptacoacids A (5) and B (6) are undescribed 24-nor-urs-28-oic acid derivatives.

Physiological and Structural Changes in Leaves of Seedlings Exposed to Increasing Light Intensities.

Understanding the light adaptation of plants is critical for conservation. , an endangered deciduous shrub endemic to East Asia, possesses high ornamental and phylogeographic value. However, the weak environmental adaptability of species has limited its general growth and conservation.

Liriogerphines E-U, further unique sesquiterpene-alkaloid hybrids from the rare Chinese tulip tree.

Seventeen undescribed sesquiterpene-alkaloid hybrids (liriogerphines E-U, 1-17) were isolated and identified during a further phytochemical investigation on the branches and leaves of Chinese tulip tree (Liriodendron chinense), a rare medicinal and ornamental plant endemic to China. These unique heterodimers are conjugates of germacranolide-type sesquiterpenoids with structurally diverse alkaloids [i.e.

Near-Infrared, Organic Chiroptic Switch with High Dissymmetry Factors.

Here we unveil a chiral molecular redox switch derived from PDI-based twistacenes─ that has the remarkable attributes of high-intensity and a broadband chiral response. This material exhibits facile, stable, and reversible multistate chiroptical switching behavior over a broad active wavelength range close to 700 nm, encompassing ultraviolet, visible, and near-infrared regions. Upon reduction, exhibits a substantial increase in the amplitude of its circular dichroic response, with an outstanding |ΔΔε| > 300 M cm and a high dissymmetry factor of 3 × 10 at 960 nm.

Knockdown of BCL-3 Attenuates Inflammatory Response in Intracerebral Hemorrhage Through an rBMECs/MGs Microenvironment.

Intracerebral hemorrhage (ICH) is a severe disease with high mortality. Recently, the role of BCL-3 in ICH has started to gain attention, but its mechanism remains unclear. A collagenase injection method was used to establish an ICH model in rats, and the expression of BCL-3 were detected.

Functions of arbuscular mycorrhizal fungi in regulating endangered species Heptacodium miconioides growth and drought stress tolerance.

The important values of AMF in regulating endangered species Heptacodium miconioides growth and drought stress tolerance. The wild endangered tree Heptacodium miconioides is distributed sporadically in mountainous areas and often subjected to various abiotic stresses, such as drought. The mutualistic association between plants and arbuscular mycorrhizal fungi (AMF) is known to have a significant impact on plant growth and their ability to withstand drought conditions.

BCL-3 Promotes Intracerebral Hemorrhage Progression by Increasing Blood-Brain Barrier Permeability, Inflammation, and Cell Apoptosis via Endoplasmic Reticulum Stress.

Background: Intracerebral hemorrhage (ICH) is among the common types of stroke with high mortality and morbidity. Molecular biomarker selection is crucial for ICH diagnosis and treatment. However, the identification of ICH-related biomarkers remains inadequate.

Fusing perylene diimide with helicenes.

Incorporating perylene diimide (PDI) units into helicene structures has become a useful strategy for giving access to non-planar electron acceptors as well as a method of creating molecules with unique and intriguing chiroptical properties. This minireview describes this fusion of PDIs with helicenes.

Integrated transcriptomics and metabolomics analysis provide insight into anthocyanin biosynthesis for sepal color formation in .

Rehd., commonly known as "seven-son flower," is an ornamental species with a beautiful flower pattern and persistent sepals. Its sepals are of horticultural value, turning bright red and elongating in the autumn; however, the molecular mechanisms that cause sepal color change remain unclear.

Coaxially Conductive Organic Wires Through Self-Assembly.

Here, we describe the synthesis of the hexameric macrocyclic aniline (MA[]), which spontaneously assembles into coaxially conductive organic wires in its oxidized and acidified emeraldine salt (ES) form. Electrical measurements reveal that ES-MA[] exhibits high electrical conductivity (7.5 × 10 S·cm) and that this conductivity is acid-base responsive.

Electronic Materials: An Antiaromatic Propeller Made from the Four-Fold Fusion of Tetraoxa[8]circulene and Perylene Diimides.

The synthesis of an antiaromatic tetraoxa[8]circulene annulated with four perylene diimides (PDI), giving a dynamic non-planar π-conjugated system, is described. The molecule contains 32 aromatic rings surrounding one formally antiaromatic planarized cyclooctatetraene (COT). The intense absorption (ϵ=3.

Photosynthesis, Nitrogen Allocation, Non-Structural Carbohydrate Allocation, and C:N:P Stoichiometry of Seedlings Exposed to Different Light Intensities.

The leaf photosynthetic capacity, leaf N partitioning, non-structural carbohydrate content, C, N, and P contents of endangered seedlings exposed to different light intensities were compared in this study. The most favorable light condition for the survival and growth of seedlings in the present study was 100% full sunlight, as this induced higher , PNUE, , , , and NSC content relative to shade-treated seedlings. PNUE, , , and in seedling leaves decreased under 40% and 10% full sunlight, while increased, indicating that shade increased the light capture efficiency of photosystem (PS) II but decreased electron transfer from PSII to PSI.

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities.

A joint phytochemical investigation on the MeOH extracts of the twigs and needles of two endangered Pinaceae plants endemic to the Chinese Qinling Mountains, Picea neoveitchii (an evergreen spruce) and Larix potaninii var. chinensis (a deciduous larch), led to the isolation and characterization of 34 and 24 structurally diverse terpenoids, respectively. Among them, seven are previously undescribed, including a picane-type [i.