Multi-Omics Profiling Unveils Antifungal Secondary Metabolites Mediating LQ's Biocontrol Efficacy Against .

is a significant phytopathogen in both pre- and postharvest stages of fruit development and storage. The development of environmentally-friendly biological control agents has attracted increasing research interest. In this study, we characterized a fungal strain ( LQ) that strongly inhibits .

Deep learning-based quantitative assessment of renal chronicity indices in lupus nephritis.

Renal chronicity indices (CI) have been identified as strong predictors of long-term outcomes in lupus nephritis (LN) patients. However, assessment by pathologists is hindered by challenges such as substantial time requirements, high interobserver variation, and susceptibility to fatigue. This study aims to develop an effective deep learning (DL) pipeline that automates the assessment of CI and provides valuable prognostic insights from a disease-specific perspective.

Adolescent Dietary Intake and Breast Cancer in Adulthood: A Systematic Review and Meta-Analysis.

Adolescence represents a key opportunity for breast cancer prevention, as the rapid proliferation of breast tissue during puberty creates a critical window of vulnerability for the development of cancerous cells. With increasing research on adolescent dietary factors and breast cancer risk, we conducted a systematic review and meta-analysis to summarize the associations between adolescent diet and risk of breast cancer in adulthood, as well as benign breast disease (BBD) and high mammographic breast density, which are markers for breast cancer. We searched Web of Science, Ovid MEDLINE, Cochrane CENTRAL and Embase for epidemiological studies assessing dietary intakes in adolescent girls (aged 10-18 years), published through 16 October 2024, with no language or time restrictions.

Advances in PD-1/PD-L1 pathway inhibitors in the treatment of thyroid cancer: mechanisms and clinical therapeutic perspectives.

Cancer of the thyroid is a endocrine cancer. Although most patients achieve favorable outcomes with surgical resection, radioactive iodine (RAI) ablation, and thyroid-stimulating hormone (TSH) suppression therapy, a subset progresses to advanced or refractory disease. Immune checkpoint inhibitors (ICIs) blocking the PD-1/PD-L1 pathway reactivate T cells, enabling them to identify and eradicate malignant cells, thus reinstating immune surveillance against tumors.

Breaking the Efficiency-Stability-Sustainability Trilemma in all-perovskite Tandem Solar Modules via Oxidative Blockchain Molecular Engineering.

Narrow-bandgap (NBG) tin-lead (Sn-Pb) perovskites are vital for all-perovskite tandem solar modules (TSMs), yet their commercialization remains limited by challenges in balancing efficiency, stability, and sustainability. Here, we presented an oxidation-triggered blockchain molecular (BCM) interface engineering strategy, which modified the poly (3,4-ethylenedioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) surface and constructed a dynamic functional layer at the buried PEDOT:PSS/Sn-Pb perovskite interface through synergistic effects of biocompatible rutin molecules and their oxidation derivatives. This approach enabled full-cycle optimization from film formation to operational longevity via sequential regulation of crystallization and carrier dynamics, along with persistent defect passivation through synergistic coordination and hydrogen bonding.

miRNA-204-5p acts as a tumor suppressor in gastric cancer by inhibiting cell migration, invasion, and glycolysis via the RAB22A/PI3K/AKT axis.

Gastric cancer (GC) is a highly prevalent and lethal malignancy worldwide. Accumulating evidence has shown that microRNAs (miRNAs) play essential roles in the development and progression of GC. In this study, we aimed to investigate the expression, functions, and molecular mechanisms of miRNA-204-5p in GC.

Granular Cell Tumours of the Breast: A Case Series and Literature Review.

Granular cell tumours (GCTs) are rare tumours that can occur in any part of the body but are commonly observed in the skin, digestive tract, and subcutaneous tissues, with the oral cavity being the most common anatomical location. Breast involvement has been reported in a small proportion of cases and is commonly benign. However, some of these lesions can be malignant.

Comparative efficacy of one-hole split endoscope versus unilateral biportal endoscopy in the treatment of lumbar disc herniation: a retrospective analysis.

Lumbar disc herniation (LDH) is a prevalent spinal disorder affecting 20-40% of the population. This study compared the clinical efficacy of two minimally invasive techniques, one-hole split endoscopy (OSE) and unilateral biportal endoscopy (UBE), for treating single-level LDH. A retrospective analysis of 217 patients (OSE: 118; UBE: 99) treated between April 2021 and January 2025 demonstrated that while both techniques were effective, OSE offered several advantages.

Impact of large language models and vision deep learning models in predicting neoadjuvant rectal score for rectal cancer treated with neoadjuvant chemoradiation.

This study aims to explore Deep Learning methods, namely Large Language Models (LLMs) and Computer Vision models to accurately predict neoadjuvant rectal (NAR) score for locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiation (NACRT). The NAR score is a validated surrogate endpoint for LARC. 160 CT scans of patients were used in this study, along with 4 different types of radiology reports, 2 generated from CT scans and other 2 from MRI scans, both before and after NACRT.

Chromosome-level haplotype-resolved genome assembly of the giant honeycomb oyster, Hyotissa hyotis.

The giant honeycomb oyster, Hyotissa hyotis, a common bivalve inhabitant of tropical and subtropical coastal waters, holds significant ecological and economic importance due to its shell characteristics, rapid growth, and high-quality adductor muscle. However, the lack of high-quality genome has impeded the genetic study and artificial breeding of this species. In this study, we provided the first chromosomal-level haplotype-resolved assembly for the H.

High electron transfer efficiency accordion-shaped HNiZn heterostructure nanozyme for low-temperature photo-catalytic enhanced therapy of bacterial infection wounds.

Bacterial and drug-resistant bacterial infections pose significant challenges to the treatment of skin wounds. Among various non-antibiotic strategies, nanozymes which mimic the activities of natural bioenzymes and possess broad-spectrum antibacterial properties, hold promise for antibacterial therapy in infected wounds. However, the catalytic activity and biosafety of most current nanozymes remain insufficient to meet clinical requirements.

Retraction Notice to: SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury.

[This retracts the article DOI: 10.1016/j.omtn.

Chicoric acid ameliorates rat salpingitis by inhibiting the Nrf2/Notch1 signaling pathway.

Salpingitis is a challenging condition for reproductive-aged women, causing problems ranging from chronic pain to infertility. Chicoric acid, a polyphenolic acid compound obtained from plants, such as Cichorium intybus, Echinacea pallida, Taraxacum officinale, and other edible plants, exhibits antiviral, antioxidative, and anti-inflammatory activities. The potential utility of chicoric acid in the management of salpingitis warrants prompt investigation.

Development and implementation of an "Internet " integrated service model for antepartum, intrapartum, and postpartum care in maternal and child specialty hospitals: A randomized controlled trial.

Objective: This study investigates the effects of developing and implementing an integrated service model for antepartum, intrapartum, and postpartum care in maternal and child specialty hospitals under the deep integration of Internet technology. The goal is to provide practical references for addressing declining birth rate challenges and promoting the sustainable development of maternal and child specialty hospitals.

Methods: Using a convenience sampling method, 100 pregnant and postpartum women from a tertiary maternal and child health hospital in Chengdu, China, were selected as the participants for this study.

Genome Comparison Reveals a High-Resolution DNA Marker for Phylogenetic Discrimination Within the Species Complex.

The species complex (CGSC), comprising more than 50 closely-related species, constitutes a globally significant phytopathogenic group. Current species delimitation within this complex predominantly relies on multi-locus phylogeny, an approach that is time-consuming and technically demanding. To address these limitations, we screened for novel high-resolution markers by performing comparative analyses of public CGSC genomes.

Encoding Desired Postural Synergies in a Single-Actuator Soft Robotic Prosthetic Hand Through Finger Joint Stiffness Modulation.

This paper presents the design and analysis of a single-actuator robotic prosthetic hand based on soft flexure joints, enabling the encoding of desired postural synergies of fingers through their joint stiffness modulation. Finger movements are coordinated using a simple whiffletree mechanism, which simultaneously pulls all tendons, with the synergy determined by the varying stiffness of the flexure joints. A forward quasistatic model is developed to predict joint angles based on tendon displacement driven by the actuator, assuming known joint stiffness values.

Gait Adaptations Under Functional Asymmetry: Exploring the Role of Step Width, Step Length, and CoM in Lateral Stability.

Bipedal gait is inherently unstable, requiring a complex interplay between foot placement and centre of mass (CoM) movement to maintain balance. While various factors are known to impact walking balance, few studies have explored the specific effects of functional asymmetry on lateral stability. This study investigates how step length, step width, and CoM adaptations impact lateral gait stability in healthy young adults walking with and without a functional asymmetry induced by fully extending the left knee.

Can Learning From Demonstration Approaches Encode and Generalise Human Movements for Neurorehabilitation?

The use of robotic systems in Upper-Limb (UL) neurorehabilitation typically involves semi-standardised, simple movement exercises controlled by the robot. However, alternative approaches aim to support more complex movements that align with Activities of Daily Living (ADLs) and offer greater customisation of interactions tailored to individual patients by clinicians. These approaches, however, require increased therapist involvement, which underscores the need for methods that allow clinicians to teach a set of exercises to the robot.

Pd-catalyzed asymmetric (6+2) dipolar cyclization for medium-sized spirooxindoles.

Chiral spirooxindoles are privileged scaffolds in bioactive molecules, yet efficient strategies for their functionalization-especially for medium-sized spirocycles-remain scarce. We report a Pd-catalyzed asymmetric (6+2) dipolar cyclization between vinyloxetanes and 3-diazoquinoline-2,4-diones, which allows the synthesis of enantioenriched spirooxindoles with eight-membered lactones under mild conditions. This method provides 22 examples with high yields and enantioselectivities (up to 90% yield and 98% ee), facilitated by a tailored chiral phosphine ligand and photogenerated ketene dipolarophiles.

The Role of von Willebrand Factor in the Pathogenesis of C3 Glomerulopathy.

Introduction: C3 glomerulopathy (C3G) is caused by dysregulation of complement activation. Our previous study found that patients with C3G showed rare variants in von Willebrand factor (vWF). However, the role of vWF in the pathogenesis of C3G is still unclear.

Spatial microfluidic holographic integrated platform for label-free and high-dimensional analysis of cancer heterogeneity.

The combination of quantitative phase microscopy (QPM) with imaging flow cytometry (IFC) enables label-free and multi-parameter single-cell analysis. Here, we present a simple yet powerful QPM-IFC platform, the spatial microfluidic holographic integrated (SMHI) platform, which uniquely integrates spatial hydrodynamic focusing microfluidics with digital holographic microscopy (DHM) to achieve high-fidelity single-cell QPM reconstruction without digital refocusing in 0.34 seconds, accounting for only 4.

Lignin-Derived Melanin-Like Nanosheets: Modulating the Microscopic Morphology and Photothermal Conversion Property through the Substituent Effect.

Artificial melanin-like materials have attracted significant attention due to their bioactivity and photothermal conversion capability. The regulation of their morphology is essential for optimizing performance; however, this presents considerable challenges. In this study, a novel template-free approach is introduced that utilizes the Scholl reaction in conjunction with a demethylation reaction to synthesize melanin-like nanosheets.

Exploring Interference between Concurrent Skin Stretches.

Proprioception is essential for coordinating human movements and enhancing the performance of assistive robotic devices. Skin stretch feedback, which is used within natural proprioception mechanisms, presents a promising method for conveying proprioceptive information. To better understand the impact of interference on skin stretch perception and to provide insights into how to best balance between perception performance and the workload required for its understanding, we conducted a user study with 30 participants that evaluated the effect of two simultaneous skin stretches on the user's ability to perceive changes in skin stretch and the associated perceived workload.

Swertianin Suppresses M1 Macrophage Polarization and Inflammation in Metabolic Dysfunction-Associated Fatty Liver Disease via PPARG Activation.

Metabolic dysfunction-associated fatty liver disease (MASLD) is closely associated with immune dysregulation and macrophage-driven inflammation. The activation of PPARG plays a critical role in modulating macrophage polarization and lipid metabolism, suggesting its potential as a therapeutic target for MASLD. We used UPLC-Q/TOF-MS and network pharmacology to investigate the key components and targets of Swertia davidi Franch, focusing on Swertianin.