Unusual Ferromagnetic Band Evolution and High Curie Temperature in Monolayer 1T-CrTe on Bilayer Graphene.

2D van der Waals ferromagnets hold immense promise for spintronic applications due to their controllability and versatility. Despite their significance, the realization and in-depth characterization of ferromagnetic materials in atomically thin single layers, close to the true 2D limit, has been scarce. Here, a successful synthesis of monolayer (ML) 1T-CrTe is reported on a bilayer graphene (BLG) substrate via molecular beam epitaxy.

Efficacy and Safety Analysis of Transarterial Chemoembolization Combined with Sintilimab Plus Bevacizumab Biosimilar in the Treatment of Unresectable Hepatocellular Carcinoma.

Background: Transarterial chemoembolization (TACE) remains a cornerstone for unresectable hepatocellular carcinoma (uHCC) but is limited by tumor progression. Combining TACE with systemic therapies may enhance efficacy. Notably, sintilimab combined with bevacizumab biosimilar has shown synergistic effects in tumor control and has been incorporated into the first-line treatment regimen in China.

Atraric acid attenuates chronic intermittent hypoxia-induced lung injury by inhibiting ferroptosis through activation of the NRF2 pathway.

Chronic Intermittent Hypoxia (CIH) is a central pathological feature of diseases such as obstructive sleep apnea hypopnea syndrome (OSAHS), which induces oxidative stress in lung tissues and leads to lung injury. Atraric acid (AA), a lichen-derived compound, has been reported to possess anti-inflammatory and antioxidant activities. In this study, we investigated the functions and mechanisms of AA in CIH-induced lung injury by constructing a CIH mouse model and an in vitro hypoxia/reoxygenation model in MLE-12 cells.

Discovering robust biomarkers of psychiatric disorders from resting-state functional MRI via graph neural networks: A systematic review.

Graph neural networks (GNN) have emerged as a popular tool for modeling functional magnetic resonance imaging (fMRI) datasets. Many recent studies have reported significant improvements in disorder classification performance via more sophisticated GNN designs and highlighted salient features that could be potential biomarkers of the disorder. However, existing methods of evaluating their robustness are often limited to cross-referencing with existing literature, which is a subjective and inconsistent process.

Poricoic Acid A, an Active Ingredient Extracted From Poria cocos, Inhibits Lung Cancer Cell Growth by Suppressing MEK/ERK Signaling Pathway.

Lung cancer continues to be a significant clinical challenge, highlighting the urgent need for effective therapeutic strategies to improve patient outcomes. Poricoic acid A (PAA), an active compound derived from the traditional Chinese medicinal mushroom Poria cocos (Fuling), has gained attention for its potential antitumor effects. Although prior studies have suggested its efficacy in vitro, the therapeutic potential, mechanism of action, and safety of PAA in inhibiting cancer growth have yet to be thoroughly investigated.

Assessment of heavy metal ecotoxicity on phytoplankton photosynthesis in oligotrophic tropical ocean.

Deep-sea mining (DSM) poses ecological risks through the release of heavy metals. To study the potential impact of heavy metal from DSM wastewater, we evaluated the acute (4-hour) and chronic (4-day) effects of copper (Cu), nickel (Ni), chromium (Cr), zinc (Zn), and manganese (Mn) on the photosynthesis of phytoplankton in two proposed DSM regions: the Philippine Sea (PHS) and the western Pacific seamount regions (WPSM). In-situ experiments measured photosynthetic parameters, including the maximum photochemical efficiency (Fv/Fm), chlorophyll a (Chl a) fluorescence, and maximum electron transport rate (ETR).

Discovery of an intermediate nematic state in a bilayer kagome metal ScVSn.

Nematicity, spontaneous breaking of rotational symmetry, is a ubiquitous phenomenon in correlated quantum matter. Here we show a phase transition in high-quality ScVSn bilayer kagome metal at a temperature , occurring seven Kelvins below the charge density wave transition at , as indicated by thermodynamic, transport, and optical measurements. This emerging intermediate phase does not exhibit spontaneous time-reversal-symmetry breaking, as evidenced by zero-field Sagnac interferometry.

Relationship between baseline platelet-to-red blood cell distribution width ratio and all-cause mortality in non-traumatic subarachnoid hemorrhage: A retrospective analysis of the MIMIC-IV database.

Objective: The study aimed to evaluate the relationship between baseline platelet-to-red blood cell distribution width ratio (PRR) and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage (SAH).

Methods: This cohort study of adults with non-traumatic SAH used Medical Information Mart for Intensive Care (MIMIC-IV) data from 2008-2022 admissions at the Intensive Care Unit (ICU). We collected the PRR levels at admission and determined the all-cause death rates for the ICU and hospital.

Association Between Health-Related Quality of Life and Willingness of COVID-19 Vaccination: A Cross-sectional Study in China.

Objectives: This study aims to explore the association between Health-Related Quality of Life (HRQoL) and people's willingness to receive the coronavirus disease 2019 (COVID-19) vaccination.

Methods: This survey was conducted in November 2020. 1461 participants (convenient sampling method) completed the online questionnaire.

Broad-spectrum antiviral peptide targets infectious bronchitis virus S2 subunit to attenuate viral infection and transmission.

Blocking the membrane fusion function mediated by the S2 subunit 6-helix bundle (6-HB) structure is an effective strategy for treating coronavirus infections. However, the 6-HB structure of infectious bronchitis virus (IBV) remains unclear, hindering the development of targeted drugs. In this study, we predicted the 6-HB structure of IBV via in silico and designed an antiviral peptide HR2P based on this structure.

Transcriptome Combined with Mendelian Randomization to Identify and Validate Biomarkers Associated with Parthanatos in Sepsis.

Purpose: Sepsis, which is triggered by infection and characterized by a systemic inflammatory response, has been associated with the diagnosis of sepsis, although the detailed molecular basis remains unclear. This study explores parthanatos-related genes (PRGs) as potential biomarkers for sepsis diagnosis and treatment.

Patients And Methods: Data from GSE65682, GSE167363, and GSE95233 were analyzed.

Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography.

Aim: To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiography (OCTA) techniques.

Methods: In this retrospective and observational case series, patients were classified into type 1 or type 2 MNV groups. A comprehensive panel of OCT and OCTA metrics was evaluated, including CMT, MNV area, VT, and VDisp.

Whether Adjuvant TACE Plus TKI Therapy is More Effective Than TACE Alone in HCC Patients at High Risks of Recurrence Following Radical Hepatectomy.

Purpose: To compare the efficacy and safety of postoperative adjuvant therapy with transarterial chemoembolization (TACE) plus tyrosine kinase inhibitor (TKI) (TPT) versus TACE alone in hepatocellular carcinoma (HCC) patients at high risks of recurrence after radical hepatectomy.

Patients And Methods: We retrospectively analyzed 264 HCC patients who underwent radical hepatectomy (R0 resection) between August 2016 and August 2023. To mitigate selection bias, propensity score matching (PSM) was employed.

Disentangling shared and unique brain functional changes associated with clinical severity and cognitive phenotypes in schizophrenia via deep learning.

Individuals with schizophrenia experience significant cognitive impairments and alterations in brain function. However, the shared and unique brain functional patterns underlying cognition deficits and symptom severity in schizophrenia remain poorly understood. We design an interpretable graph-based multi-task deep learning framework to enhance the simultaneous prediction of schizophrenia illness severity and cognitive functioning measurements by using functional connectivity, and identify both shared and unique brain patterns associated with these phenotypes on 378 subjects from three datasets.

Diode-pumped microchip laser from neodymium doped calcium borosilicate glass.

Calcium borosilicate glass doped with 0.6 atomic percent (at.%) of Nd ions (NdCBS06) was fabricated using the high-temperature melting method.

Exosomal LncRNA SCAMP1-AS1 enhances osteosarcoma malignancy by regulating the LKB1-AMPK signaling pathway.

Exosomes are extracellular vesicles that facilitate communication among cells by exchanging signaling biomolecules with adjacent cells. Among the diverse signaling biomolecules, long noncoding RNAs (lncRNAs) can be selectively packaged into exosomes to influence cancer onset and progression through various mechanisms. This study aimed to explore the role of exosomal lncRNA SCAMP1-AS1 in osteosarcoma (OS).

Orthogonally polarized dual-wavelength Sm:YAP orange laser with the balanced output power.

A diode-pumped continuous-wave (CW) orthogonally polarized dual-wavelength (OPDW) Sm: YAlO (Sm: YAP) orange laser with the balanced output power (i.e. equal power for both wavelengths) on G→ H transition was studied for the first time.

[Qiwei No.3 combined with sildenafil inhibits Rho kinase activity and increases AKT/eNOS expressions in the penile cavernosum of rats with diabetic erectile dysfunction].

Objective: To explore the effects of Qiwei No.3 combined with sildenafil on Rho kinase activity and AKT/eNOS pathways in the penile cavernous tissue of male rats with diabetic erectile dysfunction (DED).

Methods: We constructed a model of DED in 24 SD male rats by intraperitoneal injection of streptozotocin solution and injecting apomorphine into the neck after 8 weeks of feeding, equally randomized the model rats into a model control (MC), a sildenafil (S), a low-dose Qiwei No.

A secondary data analysis on hypotheses generated by inexperienced clinical researchers: Cases from a randomized controlled study.

To obtain insights about inexperienced clinical researchers' hypothesis quality and associated factors. The findings inform the development of informatics tools to aid the hypothesis generation process. We analyzed an existing dataset collected through a randomized controlled study, focusing on individual hypotheses and participants.

Biofilm-triggered interfacial assembly of dual-porphyrin heterojunctions for chemo-/sonodynamic treatment of pyomyositis.

Sonodynamic therapy (SDT) indicates advantages in combating antibiotics-resistant bacteria and deep tissue infections, but challenges remain in the development of highly efficient, infection-responsive, and biocompatible sonosensitizers. Herein, tetrakis (4-hydroxyphenyl) porphyrin (TH) and tetrakis (4-carboxyphenyl) zinc porphyrin (ZnTC) are proposed to construct dual-porphyrin heterojunctions (TH/ZnTC), and their matched interface and strong interfacial electric field (IEF) enhance charge density and transfer for selective and efficient SDT. Specifically, metal organic frameworks were constructed through coordination of Fe and ZnTC and simultaneously loading TH to prepare TH@FeM.

Mitophagy: A key regulator of radiotherapy resistance in the tumor immune microenvironment.

Cancer remains a leading global cause of mortality, with radiation therapy (RT) as a cornerstone of treatment despite frequent radioresistance. Emerging evidence indicates that mitophagy activation contributes to adaptive radioresistance of cancer cells within the tumor microenvironment (TME). In this review, we highlight the dual role of mitophagy in modulating RT resistance and shaping the immune landscape of the TME.

Earlier finish of motor planning in the premotor cortex predicts faster motor command in the primary motor cortex: Human intracranial EEG evidence.

The human motor system operates under hierarchical control during finger movements. The non-primary motor cortex (premotor cortex, PM, and supplementary motor area, SMA) organizes motor planning, while the primary motor cortex (M1) is responsible for motor execution. We utilized the high temporal and spatial resolution of intracranial EEG (iEEG) to investigate how the temporal dynamics of high-gamma oscillations in these hierarchically organized motor sub-regions, during both pre-movement planning and motor execution, correlated with reaction times (RTs) in a cued finger movement task.

CO hydrogenation to HCOOH catalyzed by aqueous Pd needle assembly.

Carbon dioxide (CO) conversion to liquid fuels has attracted great attention due to the current environmental concerns and energy crisis. However, the selective conversion of CO to target liquids is formidably challenging due to the chemical inertness of CO. We theoretically and experimentally confirm that the bending of Pd-Pd bond can breaks the asymmetric potential well and facilitate CO adsorption.

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior.

The cell nucleus is a soft composite material with a shell-like nuclear cortex enclosing chromatin, comprised of roughly 2 meters of DNA and associated proteins. Assembling on and around chromatin are droplet-like structures known as biomolecular condensates, which form via phase separation, and facilitate vital roles in gene expression. From studies in non-living materials, the driving forces for phase separation are expected to be sensitive to the local mechanical environment, which often exhibits significant spatial heterogeneity.