Qualitative Study on Cognitive Load in Epilepsy Specialist Nurse Training in Northeast China: A Phenomenological Study Among Ten Trained Nurses.

Background: Although cognitive load theory has been applied in general nursing education, its role in epilepsy specialist training remains unexplored, particularly in resource-constrained regions such as Northeast China, where medical disparities intensify learning barriers.

Objective: To investigate the cognitive load experienced by epilepsy specialist nurses (ESNs) during training in Northeast China.

Methods: The research participants were 10 nurses who underwent epilepsy training between December 2023 and February 2024, all from tertiary hospitals within the province.

Enhanced non-radical activation of peroxymonosulfate by the P-doped CoO nanoparticles confined in SiO aerogel.

P-doped strategy exhibits remarkable advantages in the field of environmental catalytic materials due to its excellent charge modulation ability and enhanced chemical stability. Although the current SiO-based aerogel materials have outstanding high specific surface area properties, their lack of stability and poor electrical conductivity limit their application potential. Herein, the SiO aerogel confined material with P-doped CoO nanoparticles (P-Co@SiO2 aerogel) was constructed for the removal of tetracycline (TC) from water by the activation of peroxymonosulfate (PMS).

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment.

Efficient elimination of intestinal reactive oxygen species (ROS) and accelerated alleviation of proinflammatory microenvironment are considered as a direct approach for the management of inflammatory bowel disease (IBD). Although promising, current treatments focusing on the intestinal inflammation resolution are still unsatisfactory and far from their practical applications. To address these limitations, novel polydopamine nanodots (PDA NDs) are rationally designed and developed as an efficient oral formulation for the targeted IBD treatment by regulating intestinal oxidative stress and proinflammatory microenvironment.

Mitophagy: A key regulator of radiotherapy resistance in the tumor immune microenvironment.

Cancer remains a leading global cause of mortality, with radiation therapy (RT) as a cornerstone of treatment despite frequent radioresistance. Emerging evidence indicates that mitophagy activation contributes to adaptive radioresistance of cancer cells within the tumor microenvironment (TME). In this review, we highlight the dual role of mitophagy in modulating RT resistance and shaping the immune landscape of the TME.

In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase-Like Catalytic Activity for Oral Disease Detection.

As a series of attractive nanomaterials, nanozymes with great catalytic activity and specificity are well developed in the field of biosensors. Although promising, the lack of appropriate structural design strategy and limitation of sensing performance in the clinical samples remain challenging for the practical application of nanozymes. Herein, a novel copper silicate nanozyme (CSHSs-Ar) with enhanced peroxidase-like catalytic activity is synthesized through a facile in situ valence-engineered approach.

Targeting CCR5 with miltefosine as a therapeutic strategy for thrombocytopenia.

Thrombocytopenia remains a challenging clinical condition with limited treatment options. Here, we demonstrated that miltefosine stimulated megakaryocyte (MK) differentiation . Miltefosine significantly accelerated platelet recovery, enhanced platelet function, and boosted MK production and differentiation in irradiated mice.

Electrical Control of Magnetic Order Transition in 2D Antiferromagnetic Semiconductor FePS.

Manipulating the magnetic order transition of 2D magnetic materials is an important way for the application of spintronic devices, and carrier concentration modulation is a commonly used effective regulation method. Here the magnetic ground state of FePS is tuned from antiferromagnetic (AFM) to ferrimagnetic (FIM) and back to AFM by electron doping, which is achieved via the intercalation of various organic cations. The doped FePS with FIM order exhibits a Curie temperature T of ≈110 K, a strong out-of-plane magnetic anisotropy, and particularly an unusual hysteresis loop, where with increasing temperature, the area of magnetic hysteresis loop increases below 50 K, then decreases above 50 K and eventually disappears.

Efficacy and safety of danshen class injections in the treatment of coronary heart disease: a network meta-analysis.

Background: Danshen [Salvia miltiorrhiza Bunge (Lamiaceae; Salviae miltiorrhizae radix et rhizoma)] class injections (DSCIs) are widely used in the treatment of coronary heart disease (CHD). However, there are various types of DSCIs available on the market, and it remains uncertain which DSCI has the best clinical efficacy, as well as which one is most effective in regulating inflammatory markers and oxidative stress indicators. The aim of this network meta-analysis (NMA) is to compare the therapeutic effects of different DSCIs to identify the optimal DSCI for the treatment of CHD.

Active cytomegalovirus infection in mechanically ventilated patients with sepsis.

Background: Active cytomegalovirus (CMV) infection is associated with poor prognosis in septic patients with critical illness. Patients of septic category are highly likely to benefit from prophylactic antiviral therapy. Nevertheless, the clinical characteristics for CMV reactivation are lacking among septic patients requiring mechanical ventilation.

Gratitude Experience in Ten Patients with Spinal Muscular Atrophy: A Qualitative Study.

Objective: This study aimed to investigate the gratitude experience of young and middle-aged patients with spinal muscular atrophy (SMA) during hospitalisation to provide a theoretical basis for medical professionals to develop gratitude intervention programs.

Methods: Patients with SMA who were treated with nusinersen in the Department of Neurology of the First Hospital of Jilin University between April 20 and May 20, 2024 were selected using the purposive sampling method, and semi-structured interviews were conducted. The interview data were analysed using Colaizzi's 7-step analysis method.

Serum tumor markers and outcomes in lung cancer patients with brain metastases: a retrospective longitudinal cohort study.

Background: Serum tumor markers (STMs) are recommended for cancer diagnosis and surveillance. However, their role in lung cancer with brain metastases (BM) is not yet clear. We aim to analyze the roles of baseline levels of STMs or ongoing STM surveillance on survival.

Artificial Bacteriophages for Treating Oral Infectious Disease via Localized Bacterial Capture and Enhanced Catalytic Sterilization.

With the rapid emergence of antibiotic-resistant pathogens, nanomaterial-assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating the level of reactive oxygen species including hydroxyl radical (·OH). Although promising, the ultra-short lifetime and limited diffusion distance of ·OH severely limit their practical antibacterial usage. Herein, the rational design and preparation of novel virus-like copper silicate hollow spheres (CSHSs) are reported, as well as their applications as robust artificial bacteriophages for localized bacterial capture and enhanced catalytic sterilization in the treatment of oral infectious diseases.

Cancer-associated fibroblasts mediate resistance to anti-EGFR therapies in cancer.

Over the last decade, epidermal growth factor receptor (EGFR)-targeted therapies have transformed the treatment landscape for patients with advanced solid tumors. Despite these advances, resistance to anti-EGFR therapies is still a significant clinical challenge. While cell-autonomous mechanisms of resistance are well-documented, they do not fully elucidate the complexity of drug resistance.

Efficacy of first-line dual oral pyrotinib plus capetabine therapy in HER2-positive metastatic breast cancer: A real-world retrospective study.

Background: The combination of dual-targeted human epidermal growth factor receptor 2 (HER2) therapy and chemotherapy is the standard first-line regimen for recurrent/metastatic breast cancer (mBC). However, the toxicity of such combination therapy can lead to some patients being unable to tolerate adverse events or bear treatment costs. As a novel irreversible pan-ErbB receptor TKI (pyrotinib), can the dual oral administration of pyrotinib plus capetabine (PyroC) provide first-line survival benefits and serve as a more affordable treatment option?

Methods: This real-world retrospective study included patients diagnosed with HER2-positive mBC who received PyroC as a first-line treatment at West China Hospital between May 2018 and July 2023.

Highly Crystalline Copper Aluminum-Layered Double Hydroxides with Intrinsic Fenton-Like Catalytic Activity for Robust Oral Health Management.

As the main challenge of dental healthcare, oral infectious diseases are highly associated with the colonization of pathogenic microbes. However, current antibacterial treatments in the field of stomatology still lack a facile, safe, and universal approach. Herein, we report the controllable synthesis of copper aluminum-layered double hydroxides (CuAl-LDHs) with high Fenton-like catalytic activity, which can be utilized in the treatment of oral infectious diseases with negligible side effects.

Short Prewarming at 41°C to Correct the Interference in Samples with the Presence of Cold Agglutination.

Background: Cold agglutinins (CAs) in blood samples can cause a reversible agglutination of red blood cell (RBC) which result in an incorrect complete blood count (CBC). So, it is important to explore new simple and feasible treatment conditions for clinical work.

Methods: The CAs group included 32 samples with CAs.

Scoping review of obesity interventions: Research frontiers and publication status.

Obesity and overweight are significant global health issues, and numerous obesity intervention studies have been conducted. Summarizing current knowledge of interventions aims to inform researchers and policymakers to keep up-to-date with the latest scientific advancements and trends. In this review, we comprehensively retrieved and screened 4,541 studies on obesity intervention published between 2018 and 2022 in the Web of Science Core Collection, and objectively presented research frontiers using bibliometric analysis.

The crucial role of age and site in incidence and prognosis of female neuroendocrine neoplasms in the United States: a population-based study from 2000 to 2018.

Background: As the incidence continues to rise, global concern about neuroendocrine neoplasms (NENs) is mounting. However, little is known about how NENs affect women patients.

Methods: The annual percentage change (APC) was calculated to describe the incidence.

A cretaceous frog with eggs from northwestern China provides fossil evidence for sexual maturity preceding skeletal maturity in anurans.

Mesozoic fossils of frogs are rare in the palaeontological record, particularly those exhibiting soft tissues that offer limited insights into early life-history characteristics. Here we report on a skeletally immature frog from the Lower Cretaceous of northwest China, with egg masses in the body and eggs in the oviduct, indicative of a gravid female. CT reconstruction of the specimen allows referral to and we assign it as a paratype complementing the diagnosis of the type species The new fossil, which might represent a younger individual than the holotype of , shows that sexual maturation occurred before full adulthood in this frog and provides evidence of death linked to mating behaviour.

A bibliometric and knowledge-map analysis of bispecific antibodies in cancer immunotherapy from 2000 to 2023.

Background: Bispecific antibody (BsAb)-based cancer immunotherapy has provided new avenues for the treatment of various malignancies. The approval of Blinatumomab has encouraged further investigation into these treatments, and a series of preclinical and clinical trials have been conducted, together with the publication of numerous articles. Here, the knowledge structure of BsAb-based cancer immunotherapy is summarized using bibliometric analysis to provide in-depth insight into current research trends and foci.