The Transformation of Pigment in Fruit Wine, Precise Control of Pigment Formation, and Their Effect on Product Quality.

Global fruit production is excessive, and fruit wine is a significant outcome of fruit processing. The pigment in fruit wine gives it a vibrant color and affects its quality, taste, and marketing. The pigments in fruit wines are commonly divided into three categories: anthocyanins, carotenoids, and chlorophylls.

Loss of riparian canopy cover reduces the transfer of polyunsaturated fatty acid (PUFA) and simplifies the trophic links in stream food webs.

Stream ecosystems have been impacted by multiple anthropogenic stressors including the loss of riparian canopy cover. However, it remains unclear how these stressors shape the profiles and transfer of fatty acids in basal resources, and subsequently affect the trophic linkages in stream food webs. We collected 158 food web samples including three basal resources (periphyton, fine benthic organic matter (FBOM) and seston), two primary consumers (macroinvertebrate and omnivorous fish), and one secondary consumer (carnivorous fish) together with water quality samples across an anthropogenic disturbance gradient in a small catchment (Laoguan River) of the Yangtze River, China.

Rechallenge of anti-PD-1 antibody combined with chemotherapy shows promising efficacy in the treatment of advanced metastatic hepatocellular carcinoma: A case report.

This report presents the case of a 53-year-old man who was diagnosed with hepatocellular carcinoma and developed lung metastasis after undergoing surgery and interventional treatment. The lung metastasis progressed multiple times while the patient was undergoing successive treatments with Lenvatinib, Apatinib combined with Camrelizumab and Regorafenib. Eventually, a positive response was achieved with Tislelizumab combined with Xelox.

Comparative study on the alleviating effect of neohesperidin dihydrochalcones and its synthetic precursor neohesperidin on ovalbumin-induced food allergy.

The biological activities of natural flavonoids are structure-dependent. To investigate the structure-dependent activities of neohesperidin dihydrochalcone (NHDC) and neohesperidin (NH), which have the same basic skeletal structure, we systematically compared their roles in alleviating ovalbumin-induced food allergies in mice. Our results indicate that NHDC is superior to NH in ameliorating allergic symptoms, especially in restoring T helper 1 and T helper 2 cells (Th1 and Th2, respectively)balance and inhibiting splenic NOTCH/nuclear factor kappa-B (NF-κB) activation by enhancing binding to Hes1, which was validated by molecular docking.

Impact of Potentially Antioxidant Probiotic Strains on Fermentation Quality and Antioxidant Status in Alfalfa Silage.

The study aimed to characterize the antioxidant properties of isolated lactic acid bacteria (LAB) and assess their impacts on fermentation quality and antioxidant status in alfalfa silage. Two LAB strains of XY15 and XY20 and a reference strain of J17 were subjected to antioxidant property evaluation. This was followed by inoculation into alfalfa silage.

Earth-Abundant Spinel LiMnO Cathode for Lithium-Ion Batteries: Challenges, Strategies, and Perspectives.

Recently, lithium-ion batteries (LIBs) have gained extensive applications in electric vehicles and energy storage systems due to their high energy density and long service life. In LIBs, the energy density and overall cost highly depend on the cathode material. Therefore, low-cost Mn-based spinel LiMnO (LMO) has emerged as an outstanding candidate and attracted the attention of many scientific researchers.

Warming degrades nutritional quality of periphyton in stream ecosystems: evidence from a mesocosm experiment.

Periphyton, which is rich in polyunsaturated fatty acids (PUFA), serves as an indispensable high-quality basal resource for consumers in stream food webs. However, with global warming, how fatty acid composition of periphyton changes and consequent effects on their transfer to higher trophic level consumers remain unclear. By carrying out a manipulative mesocosm experiment with a 4°C increase, warming led to a significant decrease in the proportions of PUFA and Long-chain PUFA (LC-PUFA, >20 C) in periphyton from 13.

Exploring the use of mindfulness for prevention of burnout in allied health professionals in Singapore.

BackgroundBurnout is becoming increasingly prevalent among healthcare professionals where it impacts quality of care and staff turnover, especially in the wake of the COVID-19 pandemic. One promising strategy to reduce burnout is the use of mindfulness-based programs, which may aid allied health professionals (AHPs).ObjectiveTo explore the usefulness of a 10-week mindfulness program on reducing burnout symptoms in AHPs in Singapore, as well as to identify AHPs' attitudes and perceptions towards adopting mindfulness in practice.

Does periphyton turn less palatable under grazing pressure?

Periphyton acts as an important primary producer in stream food webs with bottom-up grazing pressure and is also subject to effects of top-down grazing pressure. However, the underlying mechanisms of these interactions remain unclear. In this study we conducted a mesocosm experiment to explore the periphyton response to grazing pressure by the freshwater snail in relation to food quality indicated by polyunsaturated fatty acid (PUFA) biomarkers, including eicosapentaenoic acid (20:5n3) and the 22C fatty acid docosahexaenoic acid (22:6n3), which are essential for cell growth and reproduction and cannot be synthesized by most consumers of periphyton.

Bite-sized structured learning: a preferred self-paced approach that enhanced learning of muscle physiology for allied health students.

Muscle physiology is often perceived as a complex topic by students because of the hierarchical concepts and the need for integrative understanding. Breaking down content in a structured manner allows for segmented bite-sized learning that may enhance students' learning beyond conventional online lectures. We compared the effectiveness of ) bite-sized structured learning (BSL) and ) synchronous Zoom lecture (SZL) in teaching muscle physiology to first-year allied health undergraduates.

Mediastinal drainage combined with upper mediastinal re-tunneling vs. mediastinal drainage alone in McKeown esophagectomy of esophageal cancer: a retrospective study.

Background: Although mediastinal drainage may lower the risk of anastomotic leakage, the incident rate of anastomotic leakage is still high. The current study aimed to compare the effects of mediastinal drainage combined with upper mediastinal re-tunneling with mediastinal drainage only on anastomotic leakage after McKeown esophagectomy for esophageal cancer.

Methods: From October 2018 to March 2021, 52 patients diagnosed as esophageal carcinoma were included in the study.

Nutritional Quality of Basal Resource in Stream Food Webs Increased with Light Reduction-Implications for Riparian Revegetation.

Biofilms are considered a basal resource with high nutritional quality in stream food webs, as periphytic algae are abundant of polyunsaturated fatty acids (PUFAs). PUFAs are essential for growth and reproduction of consumers who cannot or have very limited capacity to biosynthesize. Yet, how the nutritional quality based on PUFA of basal food sources changes with light intensity remains unclear.

Optimization Design of a Multi-String Standing Wave Electrospinning Apparatus Based on Electric Field Simulations.

The mass production of uniform, high-quality polymer nanofibers remains a challenge. To enhance spinning yield, a multi-string standing wave electrospinning apparatus was developed by incorporating a string array into a standing wave electrospinning device. The process parameters such as string spacing, quantity, and phase difference were optimized, and their effects on the electric field distribution within the spinning area were analyzed using electric field simulations.

TONSL promotes lung adenocarcinoma progression, immune escape and drug sensitivity.

Purpose: The tonsoku-like DNA repair protein (TONSL) encoded by the TONSL gene, located on chromosome 8q24.3, is crucial for repairing DNA double-strand breaks through homologous recombination. However, TONSL overexpression in lung adenocarcinoma (LUAD) promotes tumor development, leading to a poor prognosis.

Fecal fermentation behaviors of Konjac glucomannan and its impacts on human gut microbiota.

Dietary fiber targets the regulation of the intestinal flora and thus affects host health, however, the complex relationship between these factors lacks direct evidence. In this study, the regulatory effects of Konjac glucomannan (KGM) on key metabolites of host intestinal flora were examined by using fermentation. The results showed that KGM could be utilized by the intestinal flora, which inhibited the relative abundance of , , , and and enriched the relative abundance of , Fermentation is accompanied by the production of short-chain acids, including acetic and propionic acids.

Colonization of microbiota derived from s, Bama miniature pigs, beagle dogs, and C57BL/6J mice alleviates DSS-induced colitis in germ-free mice.

Fecal microbiota transplantation (FMT) is an innovative and promising treatment for inflammatory bowel disease (IBD), which is related to the capability of FMT to supply functional microorganisms to improve recipient gut health. Numerous studies have highlighted considerable variability in the efficacy of FMT interventions for IBD. Several factors, including the composition of the donor microorganisms, significantly affect the efficacy of FMT in the treatment of IBD.

Lithology constrains the origination of autochthonous carbon in river ecosystems.

Dissolved inorganic carbon (DIC) provides a substrate for primary production in the lotic ecosystems, yet carbon's biogeochemical origination in the lotic food webs is still poorly constrained. Here, we assembled a global dataset of isotopic composition (i.e.

Pre-exercise hot water immersion increased circulatory heat shock proteins but did not alter muscle damage markers or endurance capacity after eccentric exercise.

Pre-exercise passive heating attenuates muscle damage caused by eccentric exercise in rats where the induction of heat shock proteins (HSPs) confers a myoprotective effect. We investigated whether pre-exercise hot water immersion (HWI) confers similar benefits in humans. Eleven recreational male athletes were immersed in 41°C water up to 60 min or until rectal temperatures reached 39.

Efficacy of first-line dual oral pyrotinib plus capetabine therapy in HER2-positive metastatic breast cancer: A real-world retrospective study.

Background: The combination of dual-targeted human epidermal growth factor receptor 2 (HER2) therapy and chemotherapy is the standard first-line regimen for recurrent/metastatic breast cancer (mBC). However, the toxicity of such combination therapy can lead to some patients being unable to tolerate adverse events or bear treatment costs. As a novel irreversible pan-ErbB receptor TKI (pyrotinib), can the dual oral administration of pyrotinib plus capetabine (PyroC) provide first-line survival benefits and serve as a more affordable treatment option?

Methods: This real-world retrospective study included patients diagnosed with HER2-positive mBC who received PyroC as a first-line treatment at West China Hospital between May 2018 and July 2023.

Mapping of technological strategies for reducing social isolation in homebound older adults: A scoping review.

Background: Homebound older adults (HOAs) are particularly vulnerable to social isolation and loneliness, which engender a poorer physical and mental health, and greater cognitive decline. The purpose of this review is to map the literature to identify potential technological strategies that reduce social isolation in HOAs, and to understand facilitators and barriers for adoption and implementation.

Methods: Six databases including PubMed (MEDLINE), Google Scholar, Cochrane Database, EBSCOHost, National Library ProQuest, Web of Science, and the Journal of Medical Internet Research were searched for relevant articles.

Progress on early diagnosing Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions. The disease follows a continuum, starting with preclinical stages, progressing to mild cognitive and behavioral impairment, ultimately leading to dementia. Early detection of AD is crucial for better diagnosis and more effective treatment.