Controlled synthesis of Zn-doped MnO nanoplates for MRI-guided metal ion interference synergistic therapy for breast cancer.

Manganese dioxide (MnO) nanomaterials have emerged as a promising class of nanoplatform for the therapeutic management of tumors due to their regulable physicochemical properties and good biocompatibility. However, the rational design of MnO nanomaterials often decreased the therapeutic efficacy of tumors due to the inherent protective mechanisms of eliminating the imbalance of Mn in cells. Herein, we firstly prepared a novel Zn ion doped MnO nanoplate (Zn-MnO) employing different zeolitic imidazolate framework 8 (ZIF8) precursors as Zn ion source, which possessed enhanced T1-weighted magnetic resonance imaging (MRI) signal, reactive oxygen species (ROS) generation capacity and efficient photothermal conversion.

The rare hemoglobin variants Hb O-Arab and Hb D-Punjab identified in population-based genetic screening throughout Guangxi, China.

Background: Hemoglobinopathies are a group of autosomal recessive disorders characterized by a high degree of clinical and genetic heterogeneity. Comprehensive genetic screening for hemoglobin variants is crucial for prevention and treatment of these conditions. Single-molecule real-time (SMRT) sequencing enables efficient and reliable analysis of common and complex or rare hemoglobin variants.

Electron Redistribution via LDH-to-DACs Coupling Enhances d-Band Regulation and Stability for Zinc-Air Battery Electrocatalysis.

The limited activity and poor long-term stability of oxygen electrocatalysts remain major obstacles to the practical deployment of zinc-air batteries (ZABs). Herein, a heterostructure catalyst, FeNi-LDH@DACs, was constructed by anchoring ultrasmall FeNi layered double hydroxide (LDH) nanodots onto polyhedral FeNi dual-atomic catalysts (DACs), forming a "sesame-ball-like" architecture. This spatial arrangement enables interfacial coupling, where electron transfer from LDH to DACs modulates the d-band center of the FeNi atomic sites and adjusts the adsorption energies of oxygen intermediates.

The impact of maternal chronic stress on spontaneous preterm birth: evidence from a Chinese cohort study.

Background: This study aimed to examine the relationship between maternal chronic stress, measured as allostatic load (AL), and the subsequent risk of spontaneous preterm birth (sPTB).

Methods: This analysis was based on a prospective, single-center cohort study conducted in China. Eligible women were recruited during their second trimester and followed up until giving birth.

Subsoiling-Induced Shifts in Nitrogen Dynamics and Microbial Community Structure in Semi-Arid Rainfed Maize Agroecosystems.

Global agricultural intensification has exacerbated soil compaction and nitrogen (N) inefficiency, thereby threatening sustainable crop production. Sub-soiling, a tillage technique that fractures subsurface layers while preserving surface structure, offers potential solutions by modifying soil physical properties and enhancing microbial-mediated N cycling. This study investigated the effects of subsoiling depth (0, 20, and 40 cm) on soil microbial communities and N transformations in a semi-arid maize system in China.

Tandem Dual CAR-T Cells Targeting HER2 and Mesothelin Enhance anti-Tumor Effects in Pancreatic Cancer.

The therapeutic application of T cells engineered to express chimeric antigen receptors (CARs) is hindered by the risk of antigen escape in single-target CAR constructs, particularly in the treatment of solid tumors. Pancreatic cancer cells frequently overexpress tumor-associated antigens, such as human epidermal growth factor receptor 2 (HER2) and Mesothelin (Meso). In this study, we therefore investigated the therapeutic effect of tandem dual CAR-T cells co-targeting Her2 and Meso single-targeted CAR-T cells in pancreatic cancer models.

2D Molybdenum Disulfide Embedded Photonic Crystal Fiber for all-Fiber Phase Retarder.

The integration of 2D materials with optical fibers enables multifunctional fiber devices, such as polarizers, modulators, and sensors. Recent advances in direct vapor deposition growth further enhance light-2D material interactions to centimeter-scale lengths, overcoming the micrometer-scale limitations of transferred 2D materials. However, conventional methods for growing 2D materials in fibers typically produce isotropic material architectures due to uniform precursor deposition, limiting applications that require birefringence, such as a phase retarder.

Identifying therapeutic targets for erectile dysfunction in the European population using genome-wide Mendelian randomization.

Background: Erectile dysfunction (ED) is a prevalent condition with current treatments limited by suboptimal efficacy and adverse effects. Mendelian randomization (MR) offers a promising approach to identify potential genetic targets for novel therapies.

Aim: We performed a genome-wide MR study on druggable genes to find ED therapies.

The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies.

Background: The therapeutic potential of stem cell-derived extracellular vesicles (EVs) for intrauterine adhesions (IUA) has attracted increasing preclinical investigation, yet a comprehensive and up-to-date meta-analysis is currently lacking. Before moving forward with clinical applications, it is essential to fully understand the impact of stem cell-derived EVs on IUA.

Methods: PubMed, EMBASE, Cochrane Library, Web of Science were searched up to May 19th 2025.

Trehalose supplementation ameliorates heat stress-induced intestinal barrier dysfunction by suppressing endoplasmic reticulum stress and modulating gut microbiota in mice.

Heat stress (HS) compromises intestinal barrier integrity and microbiota homeostasis. Trehalose, a nonreducing disaccharide, is well known as a molecular chaperone to prevent protein misfolding under stress. However, whether trehalose supplementation can affect intestinal barrier integrity and microbiota under HS remains unknown.

CMOS-compatible high-performance silicon photodetector by femtosecond-laser hyperdoping and nanosecond-laser annealing.

Femtosecond-laser hyperdoped silicon has emerged as a promising material for the preparation of photodetectors, because of its ultraviolet-near-infrared response spectrum that transcends the bandgap limitations of monocrystalline silicon, along with superior spectral responsivity at low bias and an exceptionally high dynamic range. However, the dependence on thermal annealing post-processing limits the consistency of femtosecond-laser hyperdoping with the trends toward low thermal budget and miniaturization in semiconductor fabrication. Developing high-performance hyperdoped silicon photodetectors compatible with complementary metal-oxide-semiconductor (CMOS) processes and other silicon-based device technologies has consistently been a considerable challenge.

Specific effect of inserted sham acupuncture and its impact on the estimation of acupuncture treatment effect in randomized controlled trials: A systematic survey.

Background: The use of inserted sham acupuncture as a placebo in randomized controlled trials (RCTs) is controversial, because it may produce specific effects that cause an underestimation of the effect of acupuncture treatment.

Objective: This systematic survey investigates the magnitude of insert-specific effects of sham acupuncture and whether they affect the estimation of acupuncture treatment effects.

Search Strategy: PubMed, Embase and Cochrane Central Register of Controlled Trials were searched to identify acupuncture RCTs from their inception until December 2022.

Robustness of perfect Laguerre-Gaussian beams for OAM multiplexing in turbulence.

This study investigates the strong robustness of perfect Laguerre-Gaussian (PLG) beams in orbital angular momentum (OAM) multiplexing systems compared to Laguerre-Gaussian (LG) beams. We demonstrate that PLG beams, with an optimal beam waist of approximately 0.07 m, exhibit superior turbulence resistance properties.

Absolute Configuration Control in Covalent Organic Frameworks.

Reticular materials constructed from chiral building blocks have garnered significant attention; however, the influence of their absolute configurations on framework structures and properties has yet to be elucidated. Herein, we report the stereoselective synthesis of covalent organic frameworks (COFs) through precise manipulation of the absolute configurations of chiral precursors. By selectively linking axially chiral binaphthalene-functionalized precursors with defined stereochemistry, we synthesized four ultrastable, highly crystalline isomeric three-dimensional COFs.

Fluorescent Three-Dimensional Covalent Organic Frameworks with pcu Topology Based on Triangular Antiprism Node.

The design of highly connected fluorescent polyhedral building blocks is essential for expanding the structural and functional diversity of three-dimensional covalent organic frameworks (3D COFs) but remains largely underexplored due to synthetic and characterization challenges. Here, we report a hexatopic fluorescent building block with triangular antiprismatic geometry, developed via steric-hindrance-directed conformational control and the integration of triphenylamine units. Its imine condensation with linear diamines afforded two crystalline 3D COFs with unambiguously resolved 6-fold Class IIa interpenetrated pcu topology, as determined by continuous rotation electron diffraction.

The Effect of Conventional and Microwave Frying on the Quality Characteristics of French Fries.

Fried foods have a widespread appeal worldwide, but consumers are cautious about their high-calorie density and oil content. We evaluated microwave frying (MF) at 2.45 and 5.

Extracellular vesicles in dairy cattle: research progress and prospects for practical applications.

Intensive dairying has diminished infectious disease resistance in dairy cattle and increased the risk of disorders affecting milk quality and productive life. Development of novel health monitoring technologies, optimization of disease treatment protocols using novel biomarkers, and development of antibiotic substitutes are necessary to further enhance the productivity of dairy cattle. Extracellular vesicles (EVs) are key mediators of cellular communication and are essential for maintaining intracellular homeostasis and regulating various physiological and pathological processes.

Elevated Neutrophil, Lymphocyte, and Platelet Counts as Early Biomarkers of Preeclampsia Risk: A Retrospective Cohort Study.

Objective: This study aimed to evaluate the association between peripheral immune markers during gestational weeks 11-28 and the risk of preeclampsia (PE), and to explore potential causal relationships using Mendelian randomization (MR).

Methods: We conducted a retrospective cohort study involving 19, 028 singleton pregnancies between January 2020 and December 2023. Peripheral immune markers, including neutrophils, lymphocytes, monocytes, and platelets, and derived indices, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), were analyzed in relation to PE incidence.

Biomechanical evaluation of percutaneous cement discoplasty combined with percutaneous vertebroplasty: a finite element analysis.

Introduction: Since the introduction of percutaneous cement discoplasty (PCD), numerous studies have confirmed its clinical efficacy in elderly patients. However, PCD is also associated with risks such as bone cement leakage and vertebral fractures. The purpose of this study was to present a biomechanical evaluation of two modified versions of PCD performed in combination with percutaneous vertebroplasty (PVP).

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections.

Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathogen encounter and consequent activation of the immune system cause tissue damage and the release of host-derived damage-associated molecular patterns, contributing to shape immunity. However, how self-derived factors are sensed by phagocytes and impact the immune response remains poorly understood.

Regulation of inflammatory responses by pH-dependent transcriptional condensates.

Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation is monitored remains largely unknown. Acidification of the tissue microenvironment is associated with inflammation.

The CST complex mediates a post-resection non-homologous end joining repair pathway and promotes local deletions in Saccharomyces cerevisiae.

The repair of a DNA double-strand break (DSB) by non-homologous end joining (NHEJ) generally leaves an intact or minimally modified sequence. Resection exposes single-stranded DNA and directs repair toward homology-dependent pathways and away from NHEJ. Here, we report that in Saccharomyces cerevisiae, the Cdc13/Stn1/Ten1 (CST) complex, characterized for its telomeric functions, acts after resection initiation to mediate a back-up NHEJ repair.

Molecular characterization of the receptor subunits of IL-10 in a perciform fish, Nibea albiflora.

The transmembrane receptor complex of Interleukin-10 (IL-10), comprising the IL-10Rα subunit and IL-10Rβ subunits, belong to the class Ⅱ cytokine receptor family. In the present study, IL-10Rα and IL-10Rβ were characterized in Nibea albiflora (referred to as NaIL-10Rα (MZ620685.1) and NaIL-10Rβ (OK149228.

Evaluation of the diagnostic efficacy of serum DR-70 and its combination with CEA in lung cancer.

Objective: To evaluate the diagnostic value of DR-70 immunoassay and its combination with carcinoembryonic antigen (CEA) measurement for detecting lung malignancies.

Methods: Serum concentrations of carcinoembryonic antigen (CEA) and DR-70 were quantitatively assessed using electrochemiluminescence immunoassay (ECLIA) and enzyme-linked immunosorbent assay (ELISA), in 110 patients diagnosed with primary lung cancer, 48 patients with pulmonary benign lesions, and 164 healthy subjects.

Results: Serum levels of both DR-70 and CEA showed statistically significant differences between lung cancer patients and healthy controls ( < 0.

A dual-targeted nano-system co-regulating macrophage ROS and fibroblast ferroptosis for rheumatoid arthritis treatment.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a marked macrophage polarization imbalance and abnormal synovial fibroblast proliferation. Herein, we developed a multifunctional drug delivery platform utilizing a glycosaminoglycan heparin derivative. This derivative combines heparin (Hep), which targets macrophages and synovial fibroblasts, with phenylboronic acid (PBA), which exhibits ROS-responsive properties, to regulate macrophage polarization and inhibit synovial fibroblast proliferation.