Mediating effect of moral resilience between good-death perception and coping with death competence of ICU nurses: a cross-sectional study.

Background: Moral resilience can help Intensive Care Unit (ICU) nurses overcome moral dilemmas caused by the death of patients, while enhancing their competence to cope with death. Death-coping competence is also related to the cognitive level of nurses about good death. However, few studies have focused on the relationships among between moral resilience, perception of good death, and death-coping competence.

Disruptions of deep medullary veins and MRI indices of glymphatic function in cerebral small vessel disease.

BackgroundDisruptions of deep medullary veins (DMV) have been associated with the radiological severity and cognitive impairment observed in cerebral small vessel disease (SVD). Glymphatic dysfunction may serve as a potential mechanism underlying these associations.ObjectiveWe aimed to clarify the associations between DMV disruptions, MRI indices previously hypothesized as related to glymphatic function, white matter hyperintensities (WMH), and cognitive impairment in SVD.

Induced Pyopneumothorax: A Rare but Serious Clinical Entity.

() is a Gram-negative, anaerobic bacterium predominantly found in the oral cavity, gastrointestinal tract, and urogenital system. It accounts for less than 1% of anaerobic bacterial infections in clinical settings and can lead to a spectrum of severe infections. This report details the case of a 55-year-old male who presented with a one-month history of productive cough, acute right-sided chest pain, dyspnea, and fever.

Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.

Little is known about maternal occupational exposure to hydrocarbons and offspring cancer risk. We aimed to estimate childhood cancer risk associated with maternal exposure to aliphatic/alicyclic, aromatic, and chlorinated hydrocarbons, and methylene chloride, trichloroethylene, 1,1,1-trichloroethane, and toluene. In this case-control study, all cancer cases (N = 10 442) diagnosed at less than 20 years (born 1968-2016) in Denmark were matched to 261 050 cancer-free controls (25 : 1 matching ratio).

Self-Warning and Self-Repairing Mechanisms in Functional Coatings: A Review.

Coatings have attracted widespread attention in the field of corrosion protection of metals because of their corrosion resistance and convenient techniques. Unfortunately, till now, traditional coatings have the shortcomings of vulnerability and passive corrosion protection, hence functional coatings progressively replace them. Endowing coatings with additional functions not only transform them into active protection mechanisms but also significantly improve life cycle of coatings.

Perirenal fat: a neglected fat depot shaping heterogeneity of obesity along with hepatic fat.

Objective: Obesity is a heterogeneous condition that leads to diverse cardiovascular and metabolic outcomes. This study aimed to identify the primary visceral fats contributing to metabolically unhealthy obesity and to investigate the characteristics of fat distribution associated with different obesity-related complications.

Methods: A retrospective analysis was conducted on fat-selective magnetic resonance images (MRI) from 319 individuals with a BMI ≥24 kg/m².

Hotspot analysis and frontier exploration of biomechanical research on knee osteoarthritis: a bibliometric study and visualization analysis.

Objective: This study employs bibliometric and visualization analysis to systematically investigate research hotspots and emerging trends in the biomechanics of knee osteoarthritis (KOA).

Methods: This study utilizes the Web of Science Core Collection (WoSCC) as the data source, employing a keyword-based search strategy to retrieve literature on the biomechanics of KOA published over the past two decades. Bibliometric analyses are conducted using tools such as CiteSpace and VOSviewer.

Fecal microbiota transplantation reveals the impact of gut microbiota dysbiosis on osteoporosis development in ovariectomized mice.

Osteoporosis is characterized by low bone mineral density and deteriorated bone microarchitecture. The gut microbiota has emerged as a potential regulator of bone metabolism through the gut-bone axis. This study investigates the role of gut microbiota dysbiosis in osteoporosis.

UFOS-Net leverages small-scale feature fusion for diabetic foot ulcer segmentation.

Diabetic Foot Ulcer (DFU) is a critical risk factor for disability and mortality among diabetic patients, posing a significant public health challenge. Existing DFU datasets are limited in capturing the diversity and complexity of ulcer manifestations, preventing advancements in medical segmentation. This paper introduces SRRSH-DF, a novel DFU dataset that comprehensively covers characteristic symptoms and lesions across different foot regions.

Energy intake and physical activity over the course of pregnancy and gestational weight gain: a systematic review and dose-response meta-analysis of data from randomized controlled lifestyle intervention trials.

Background: This systematic review and meta-analysis aimed to quantify the relationship between energy intake (EI) and physical activity (PA) during pregnancy and gestational weight gain (GWG) in randomized controlled trials (RCTs).

Methods: RCTs measuring EI and PA at least twice and total GWG during pregnancy were eligible. To synthesize PA measures reported on different scales, standardized mean change per day (SMC/day) were obtained by dividing the change in PA by the standard deviation of the change.

Novel multifunctional targeted nanozyme as an ultrasound contrast agent for real-time monitoring and treatment of congenital hydronephrosis renal fibrosis.

Background: Congenital Hydronephrosis (CH) is a common pediatric disorder that often leads to renal fibrosis (RF), significantly impairing kidney function. Oxidative stress (OS) plays a central role in the pathogenesis of RF. Current treatments lack effective monitoring and targeted therapies for CH, thus highlighting the need for innovative diagnostic and therapeutic approaches.

OmniCellAgent: Towards AI Co-Scientists for Scientific Discovery in Precision Medicine.

The convergence of large language models (LLMs), AIagents, and large-scale omic datasets-such as single-cell omics, marks the arrival of a critical inflection point in biomedical research, via autonomous data mining and novel hypothesis generation. However, there is no specifically designed agentic AI model that can systematically integrate large-scale single-cell (sc) RNAseq (covering diverse diseases and cell types), omic data analytic tools, accumulated biomedical knowledge, and literature search to facilitate autonomous scientific discovery in precision medicine. In this study, we develop a novel agentic AI, OmniCellAgent, to empower non-computational-expert users-such as patients and family members, clinicians, and wet-lab researchers-to conduct scRNA-seq data-driven biomedical research like experts, uncovering molecular disease mechanisms and identifying effective precision therapies.

Leveraging low-frequency components for enhanced high-frequency steady-state visual evoked potential based brain computer interface in fast calibration scenario.

High-frequency steady-state visual evoked potential-based brain-computer interface (SSVEP-BCI) systems offer improved user comfort but suffer from reduced performance compared to their low-frequency counterparts, limiting their practical application. To address this issue, we propose a transfer learning-based method that leverages low-frequency SSVEP data to enhance high-frequency SSVEP performance. A filtering mechanism is designed to extract informative components from low-frequency signals, and the least squares algorithm is employed to generate high-quality synthetic high-frequency data.

Associations of the Neutrophil-to-Lymphocyte Ratio(NLR), Triglyceride-Glucose Index (TyG), and TyG-derived indices with vitality decline in older adults in China: a study within the Integrated Care for Older People (ICOPE) framework.

Background/objectives: Aging populations have led to numerous health challenges. The World Health Organization (WHO) proposed "Healthy Aging" to promote elderly health by optimizing Intrinsic Capacity (IC) with vitality as a core component of metabolic homeostasis. The relationships between vitality decline and inflammatory-metabolic indicators (the NLR and TyG index) remain to be investigated.

Identification and validation of a prognostic signature of mC-related genes for esophageal cancer.

Background: Esophageal cancer (ESCA) is one of the most common malignancies, and has a poor prognosis. The role of 5-methylcytosine (mC) regulators has been linked to carcinogenesis in a number of cancers. However, the role of mC regulators in ESCA is unclear.

Disrupted Neuronal Dynamics of Reward Encoding in the Medial Prefrontal Cortex and the Ventral Tegmental Area after Episodic Social Stress.

Previous research suggests that stress predisposes individuals to develop substance use disorders by disrupting the brain processing of rewards. Yet, how stressful experiences disrupt the brain processing of reward-related cues at the neuronal level is poorly understood. Intermittent social defeat (ISD) is a stress animal model that increases reward-seeking behavior, drug self-administration, and choice impulsivity up to several weeks after stress.

Evaluation of landslide susceptibility of mountain highway based on RF and SVM models.

Geological complexities along mountain highways frequently trigger landslides, posing significant threats to transportation safety and infrastructure. This study evaluates landslide susceptibility along the Lizha-Jiezi section of China's G345 national highway using Random Forest (RF) and Support Vector Machine (SVM) models. Eleven conditioning factors including altitude, slope, aspect, plan curvature, profile curvature, lithology, distance to fault, rainfall, distance to river, normalized difference vegetation index (NDVI), and distance to road were analyzed using remote sensing and field surveys.

Sivelestat-Loaded Neutrophil-Membrane-Coated Antioxidative Nanoparticles for Targeted Endothelial Protection in Sepsis.

: This study aims to develop and evaluate neutrophil-membrane-coated nanoparticles (Siv@NMs) encapsulating sivelestat for the treatment of sepsis-induced endothelial injury. Leveraging the intrinsic chemotactic properties of neutrophil membranes, Siv@NMs are engineered to achieve site-specific delivery of sivelestat to damaged endothelia, thereby overcoming the limitations of conventional therapies in mitigating endothelial dysfunction and multiorgan failure associated with sepsis. : Siv@NMs were synthesized through a combination of ultrasonication and extrusion techniques to encapsulate sivelestat within neutrophil-membrane-derived vesicles.

Voluntary wheel running exercise improves sleep disorder, circadian rhythm disturbance, and neuropathology in an animal model of Alzheimer's disease.

Introduction: The sleep-wake cycle and circadian rhythm disturbances are common in Alzheimer's disease (AD). However, it is not known if exercise has any benefit for the sleep disorders in AD.

Methods: We conducted a 2-month voluntary wheel running (VWR) exercise (Ex) in an animal model of AD (APP/PS1 mice).

Effects of different art therapy interventions on cognitive functions in older adults: A systematic review and network meta-analysis.

Objective: To assess the effectiveness of various art therapies on cognitive functions in elderly adults.

Methods: This study included 38 studies and 2,869 patients, using Review manager 5.4 and Stata 17 for statistical analyses.

Inflammatory Macrophage-Targeted Atherosclerosis Treatment by miRNA-Delivered, MRI-Visible, and Anti-Inflammatory Nanomedicine.

Atherosclerosis, a principal cause of fatal cardiovascular diseases, is fundamentally a chronic inflammatory disease. Addressing this, the combined regulation of oxidative stress and inflammation through synergistic modalities offers an efficient therapeutic avenue. In this work, we rationally designed and engineered a highly efficient functional nanosystem, referred to as polydopamine nanoparticles doped with arginine and gadolinium ions (AGPDAR-146a), for the targeted delivery of therapeutic oligonucleotides, specifically microRNA-146a (miR-146a), to inflammatory macrophages within atherosclerotic plaques.

Greenhouse gas emissions reduction potential by increasing aquatic food consumption in China.

Aquatic food production plays a crucial role in ensuring global food security, improving the quality of life, and reducing greenhouse gas (GHG) emissions. In this study, we have comprehensively evaluated the GHG emissions associated with China's fisheries, considering both production and consumption. Scenario analysis was used to compare the potential of GHG emissions reduction under two conditions: maintaining current protein intake levels, and increasing the consumption of aquatic foods to align with global average.

Prepubertal exposure to 17β-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus).

Studies have demonstrated that adult male fish exposed to estrogenic endocrine-disrupting compounds (EDCs) exhibit reduced sperm motility and fertility. However, the effects of prepubertal estrogenic EDC exposure on testicular development and subsequent reproductive capacity remain poorly understood. In this study, prepubertal male (XY) tilapia at 30 days after hatching (dah) were exposed to 17β-estradiol (E2) for 60 days, covering the prepubertal period, to investigate its impact on testicular development and fertility at sexual maturity.

VP-SFDA: Visual Prompt Source-Free Domain Adaptation for Cross-Modal Medical Image.

Source-free unsupervised domain adaptation (SFUDA) methods aim to address the challenge of domain shift while preserving data privacy. Existing SFUDA approaches construct reliable and confident pseudo-labels for target-domain data through denoising methods, thereby guiding the training of the target-domain model. The effectiveness of denoising approaches is influenced by the degree of domain gap between the source and target domains.

Black carp OTUD1 negatively regulates antiviral innate immunity via deubiquitination and degradation of IRF3/7.

IRF3 and IRF7 function importantly in type I interferon production. Ovarian tumor deubiquitinase 1 (OTUD1) is a critical member of OUT deubiquitinases, which has been identified as a negative regulator in IRF3-mediated interferon signaling in mammals. However, the role of teleost OTUD1 in the immunity remains unclear.