Not all type of lepidic pattern is useful for distinguishing whether metachronous multiple lung adenocarcinomas are separate primary lung cancers.

Our research aims to ascertain the value of precursor and outgrowth lepidic in aiding the confirmation of multiple lung adenocarcinomas as separate primary lung cancers (SPLC). A total of 151 patients with metachronous multiple invasive adenocarcinomas were included in this study. Driver mutation tests（at least five genes: EGFR, ALK, KRAS, BRAF, and ROS1） were conducted on 302 tumors collected from 151 patients.

Compensatory retinal blood flow enhancement in cognitively normal ApoE ε4 carriers.

This study aims to compare retinal vascular characteristics between ApoE ε4 carriers and non-carriers in healthy individuals. A total of 84 cognitively healthy subjects-64 non-carriers and 20 carriers of the ApoE ε4 allele-were analyzed using swept-source optical coherence tomography angiography (SS-OCTA). In the retinal vascular layer of OCTA images, parameters such as foveal avascular zone (FAZ) area, vessel perimeter, acircularity index (AI), and vascular density (FD) were quantified.

The burden of thyroid cancer and its association with national development levels in Asia: evidence from 47 countries (1990-2021).

Objective: This study examines the trends in thyroid cancer incidence and mortality and explores their relationship with national development levels.

Methods: Data on thyroid cancer from 47 countries were sourced from the Global Burden of Disease 2021 study, covering the years 1990-2021. National development was measured using the Human Development Index (HDI), Social Progress Imperative (SPI), Nutrition and Medical Care (NMC), the Density of Doctors per 100,000 population (DOD), and Personal Healthcare Spending (PHS).

Measurement Properties of Surface Topography for Scoliosis Assessment: A Systematic Review and Meta-Analysis.

Objective: To comprehensively evaluate the validity, responsiveness, and feasibility of surface topography (ST) indices and provide insights into their potential integration into clinical scoliosis assessment.

Data Sources: A systematic literature search was performed in PubMed and Web of Science for studies published between January 2010 and April 2024.

Study Selection: Studies reporting on the validity, responsiveness, and feasibility of ST indices were screened and selected by two independent researchers.

Photoinduced Amination of Endocyclic 1-Azaallyl Radicals.

A catalyst-free method has been discovered based on photoexcited electron donor-acceptor complexes to generate an iminyl radical and endocyclic 1-azaallyl radicals, elusive intermediates that have never been reported in synthesis. The two radicals then combine and, following reduction, ultimately provide unprotected 2-(hetero)aryl-3-aminopiperidines. This reaction expands the knowledge and synthetic application of endocyclic 1-azaallyl synthons with an intrinsic ring strain.

Utility of novel composite index in predicting the prognosis of total neoadjuvant therapy for locally advanced rectal cancer: A multicenter real-world cohort study.

Objective: C-reactive protein-albumin-lymphocyte (CALLY) is a novel composite index. Total neoadjuvant therapy (TNT) has become one of the standard treatments for locally advanced rectal cancer (LARC). It remains unclear whether CALLY can predict the prognosis for LARC patients.

Development of a host-signature-based machine learning model to diagnose bacterial and viral infections in febrile children.

Background: Early aetiological diagnosis is critical for the management of febrile children with infectious illness, as it strongly influences the choice of appropriate medication and can affect a child's complications and outcome. New diagnostic strategies based on host genes have recently been developed and have achieved high accuracy and clinical practicability. In this study, through integrative bioinformatics analysis, we aimed to construct artificial neural network (ANN, multilayer perceptron) and random forest (RF) models based on host gene signatures to diagnose bacterial or viral (B/V) infection in febrile children.

Neoadjuvant chemoimmunotherapy versus neoadjuvant chemoradiotherapy in patients with borderline resectable esophageal squamous cell carcinoma.

Background: The optimal treatment strategy for patients with borderline resectable (cT3br) esophageal squamous cell carcinoma (ESCC) remains unclear. Thus, the aim of this study was to compare the perioperative outcomes and prognoses between neoadjuvant chemotherapy combined with immunotherapy (NACI) and neoadjuvant chemoradiotherapy (NCRT) in cT3br ESCC patients.

Methods: In this retrospective cohort study, patients with cT3br ESCC who received either NACI or NCRT followed by surgery between January 2016 and December 2022 were identified.

Demonstration of Interoperability Between MIDRC and N3C: A COVID-19 Severity Prediction Use Case.

Interoperability between data sources, one of the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data management, can enable multi-modality research. The purpose of our study was to investigate the potential for interoperability between an imaging resource, the Medical Imaging and Data Resource Center (MIDRC), and a clinical record resource, the National COVID Cohort Collaborative (N3C). The use case was the prediction of COVID-19 severity, defined as evidence for invasive ventilatory support, extracorporeal membrane oxygenation, death, or discharge to hospice in the N3C clinical record.

Association between uric acid and aortic aneurysms: A two-sample Mendelian randomization study.

Objective: Based on Mendelian randomization (MR) methods, this study aims to explore causal associations of uric acid (UA) levels with aortic aneurysms (AAs).

Methods: In this MR study, data on UA levels and gout were extracted from genome-wide association study (GWAS) meta-analysis conducted by UK Biobank (UKB) for European population and the Biobank Japan Project (BBJ) for Asian population. Summary statistics of AAs were obtained from different databases.

Sodium Glucose Transporter 2 Inhibitor Protects Against Heart Failure With Preserved Ejection Fraction: Preclinical "2-Hit" Model Reveals Autophagy Enhancement Via AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Complex 1 Pathway.

Background: Heart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome with high morbidity and mortality. Empagliflozin, an SGLT2 (sodium-glucose cotransporter 2) inhibitor, reduces adverse events in patients with HFpEF regardless of glycemic control. However, the precise cardioprotective mechanisms of SGLT2 inhibitor in HFpEF remain underexplored.

Leveraging low-frequency components for enhanced high-frequency steady-state visual evoked potential based brain computer interface in fast calibration scenario.

High-frequency steady-state visual evoked potential-based brain-computer interface (SSVEP-BCI) systems offer improved user comfort but suffer from reduced performance compared to their low-frequency counterparts, limiting their practical application. To address this issue, we propose a transfer learning-based method that leverages low-frequency SSVEP data to enhance high-frequency SSVEP performance. A filtering mechanism is designed to extract informative components from low-frequency signals, and the least squares algorithm is employed to generate high-quality synthetic high-frequency data.

Selective Crystallization Delay in Wide-Bandgap Perovskites Enables Initial Homogeneous Phase for Square Centimeter Perovskite/Organic Tandem Solar Cells.

Mixed halide wide-bandgap (WBG) perovskites, used in high-performance perovskite/organic tandem solar cells (TSCs), are prone to phase segregation under light irradiation. Particularly, the initial inhomogeneous halide phase distribution in WBG perovskites can accelerate the phase segregation under operational stressors, thus hindering scaling of TSCs that require high phase homogeneity. Here, a selective delayed crystallization strategy is proposed in which a functional agent (3-amino-5-fluorobenzamide; AFBA) is used to regulate the initial halide phase distribution.

Multimodal data curation via interoperability: use cases with the Medical Imaging and Data Resource Center.

Interoperability (the ability of data or tools from non-cooperating resources to integrate or work together with minimal effort) is particularly important for curation of multimodal datasets from multiple data sources. The Medical Imaging and Data Resource Center (MIDRC), a multi-institutional collaborative initiative to collect, curate, and share medical imaging datasets, has made interoperability with other data commons one of its top priorities. The purpose of this study was to demonstrate the interoperability between MIDRC and two other data repositories, BioData Catalyst (BDC) and National Clinical Cohort Collaborative (N3C).

A Multimodal Semantic-Enhanced Attention Network for Fake News Detection.

The proliferation of social media platforms has triggered an unprecedented increase in multimodal fake news, creating pressing challenges for content authenticity verification. Current fake news detection systems predominantly rely on isolated unimodal analysis (text or image), failing to exploit critical cross-modal correlations or leverage latent social context cues. To bridge this gap, we introduce the SCCN (emantic-enhanced ross-modal o-attention etwork), a novel framework that synergistically combines multimodal features with refined social graph signals.

Host-guest supramolecular approach for the preparation of a F MRI-guided theranostic agent with long relaxation times and its synergetic performances.

The construction of highly efficient theranostic materials is critical for accurate lesion diagnosis and treatment. Among various diagnostic modalities, magnetic resonance imaging (MRI) is gaining attention due to its safety and precision. This study presents a novel theranostic agent, TPZ@TSF, that integrates F MRI for diagnostic imaging with photodynamic therapy (PDT) and hypoxia-activated tirapazamine (TPZ) as therapeutic modalities.

Identification of clinical diagnostic and immune cell infiltration characteristics of acute myocardial infarction with machine learning approach.

Acute myocardial infarction (AMI) is a serious heart disease with high fatality rates. The progress of AMI involves immune cell infiltration. However, suitable clinical diagnostic biomarkers and the roles of immune cells in AMI remain unknown.

Effects of renal denervation at BP-elevation/reduction sites guided by renal nerve stimulation on atrial neural and structural remodeling in a hypertensive canine model.

Hypertension is a common condition in cardiovascular medicine, and can lead to atrial enlargement, atrial fibrosis, and even the development of atrial fibrillation. Renal denervation (RDN) causes reduction in blood pressure (BP), but its effects on hypertension-related atrial remodeling remain unclear. This study aimed to explore the effects of RDN at BP-elevation/reduction sites guided by renal nerve stimulation (RNS) on atrial neural and structural remodeling in a hypertensive canine model.

Proton orbital coupling induced magnetic anisotropy in perovskite single crystals: Demonstration with Faraday rotation effect in deuterated crystals.

In this report, eight halide-based perovskite single crystals high in crystallinity with cations of methylammonium, formamidinium, and cesium are grown at low temperature via a modified solvent evaporation method or an inverse temperature crystallization technique to investigate the Faraday rotation effect. The crystals are examined using various techniques to ensure the pure single crystal phase. Among the crystals investigated, only the MAPbCl3 and MAPbBr3 crystals display the Faraday rotation effect in a broad visible range.

A transformer-based network with second-order pooling for motor imagery EEG classification.

. Electroencephalography (EEG) signals can reflect motor intention signals in the brain. In recent years, motor imagery (MI) based brain-computer interfaces (BCIs) have attracted the attention of neuroinformatics researchers.

The silent spread: uncovering the diversity and evolution of poxviruses in ticks across Western China's host landscapes.

Background: Poxviruses are a diverse group of pathogens with significant implications for both human and animal health. Ticks, as hematophagous arthropods, are capable of switching hosts during their life cycle. Although previous research has suggested the potential for parapoxviral transmission via ticks, the poxviral transmission dynamics remain poorly understood, particularly regarding the role of ticks as vectors.

Insights into immune-related adverse events in colorectal cancer patients receiving neoadjuvant immunotherapy: findings from a multicenter registry study.

Background: The growing use of immune checkpoint inhibitors (ICIs) in the neoadjuvant treatment of colorectal cancer (CRC) has highlighted immune-related adverse events (irAEs) as a major concern. This study aimed to investigate the characteristics of irAEs.

Methods: This study was a retrospective, multicenter, registry-based investigation conducted in China, including 148 patients who developed irAEs after neoadjuvant immunotherapy between September 2020 and March 2024.

Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy.

Objective: To investigate the changes in cone photoreceptors in patients with non-arteritic anterior ischemic optic neuropathy (NAION).

Methods: Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) was performed in patients with NAION and healthy participants. Acute NAION was defined as a disease duration of <2 months, whereas chronic NAION was defined as a duration of >2 months.

TgMYBS1-TgSUS1 regulatory module mediates sucrose metabolism in Torreya grandis kernels.

Sucrose synthase (SUS) is a key enzyme in sucrose metabolism, catalyzing the reversible synthesis and degradation of sucrose. It plays a crucial role in plant growth and development. Previous studies have shown that SUS-mediated sucrose metabolism is essential during various developmental stages in plants like Arabidopsis.