Epidemiological and molecular investigation of a norovirus GII.17 outbreak in a kindergarten in Shanghai, China.

Introduction: Norovirus (NoV) is among the most prevalent pathogens responsible for non-bacterial acute gastroenteritis (AGE) in humans on a global scale.

Methodology: In September 2024, an epidemiological investigation and etiological analysis of a norovirus outbreak at a kindergarten in Shanghai Municipality of China was conducted to provide insights for preventing and controlling similar incidents in the future.

Results: A total of nine cases of vomiting and diarrhea were reported in the outbreak, involving eight students and one teacher in the same class.

The silent spread: uncovering the diversity and evolution of poxviruses in ticks across Western China's host landscapes.

Background: Poxviruses are a diverse group of pathogens with significant implications for both human and animal health. Ticks, as hematophagous arthropods, are capable of switching hosts during their life cycle. Although previous research has suggested the potential for parapoxviral transmission via ticks, the poxviral transmission dynamics remain poorly understood, particularly regarding the role of ticks as vectors.

Detection of KPC-Producing Carbapenem-Resistant Based on CRISPR Cas12a.

To develop a detection system for carbapenemase (KPC) and provide a reference for clinical prevention and control of nosocomial infections caused by multidrug-resistant . The KPC resistance gene was amplified by PCR. Guided by crRNA, Cas12a specifically identified the resistance gene and activated its trans-cleavage activity.

Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China.

On January 30, 2024, China announced the first human case of H10N5 influenza infection. Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution and future epidemiological trends of the H10 and N5 subtypes of avian influenza viruses (AIVs).

Study on sentinel hosts for surveillance of future COVID-19-like outbreaks.

The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host.

Study on Sensor Fault-Tolerant Control for Central Air-Conditioning Systems Using Bayesian Inference with Data Increments.

A lack of available information on heating, ventilation, and air-conditioning (HVAC) systems can affect the performance of data-driven fault-tolerant control (FTC) models. This study proposed an in situ selective incremental calibration (ISIC) strategy. Faults were introduced into the indoor air (Ttz1) thermostat and supply air temperature (Tsa) and chilled water supply air temperature (Tchws) sensors of a central air-conditioning system.

Case Study: Impacts of Air-Conditioner Air Supply Strategy on Thermal Environment and Energy Consumption in Offices Using BES-CFD Co-Simulation.

Due to energy constraints and people's increasing requirements for indoor thermal comfort, improving energy efficiency while ensuring thermal comfort has become the focus of research in the design and operation of HVAC systems. This study took office rooms with few people occupying them in Wuhan as the research object. The EnergyPlus-Fluent co-simulation method was used to study the impact of 12 forms of air distribution on the thermal environment and air-conditioner energy consumption.

Antibiotic residues of drinking-water and its human exposure risk assessment in rural Eastern China.

Trace levels of antibiotics were frequently found in drinking-water, leading a growing concern that drinking-water is an important exposure source to antibiotics in humans. In this study, we investigated antibiotics in tap water and well water in two rural residential areas in Eastern China to assess the related human health exposure risks in drinking-water. Twenty-seven antibiotics were analyzed using ultra performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UPLC-MS/MS).

Mapping rabies distribution in China: a geospatial analysis of national surveillance data.

Objectives: Dog-mediated human rabies remains an important public health problem in China. In this study, we aimed to understand the spatiotemporal variation of rabies and examine its nonmedical ecological factors.

Methods: In this study, we used the annual incidence data for rabies at the province level in China to describe the incidence trends for the period 2004-2019 and used a Bayesian hierarchical spatiotemporal model to determine the impacts of environmental, economic, and demographic factors.

Avian influenza A virus H7N9 in China, a role reversal from reassortment receptor to the donator.

Reassortment can introduce one or more gene segments of influenza A viruses (IAVs) into another, resulting in novel subtypes. Since 2013, a new outbreak of human highly pathogenic avian influenza has emerged in the Yangtze River Delta (YRD) and South-Central regions of China. In this study, using Anhui province as an example, we discuss the possible impact of H7N9 IAVs on future influenza epidemics through a series of gene reassortment events.

Corrigendum: Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.

[This corrects the article DOI: 10.3389/fcell.2021.

Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19.

The total number of cumulative cases and deaths from the COVID-19 pandemic caused by SARS-CoV-2 is still increasing worldwide. Although many countries have actively implemented vaccination strategies to curb the epidemic, there is no specific efficient therapeutic drug for this virus to effectively reduce deaths. Therefore, the underappreciated macromolecular compounds have become the spotlight of research.

Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.

Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored stem-cell-based therapy that can aid in viral clearance and rescue liver cells from further damage during dengue infection.

Achieving High Thermoelectric Performance of n-Type BiTeSe Sintered Materials by Hot-Stacked Deformation.

Bismuth telluride has been the only commercial thermoelectric candidate, but the n-type sintered material lags well behind the p-type one in the value, which severely limits the further development of thermoelectrics. Here, we report a promising technique named hot-stacked deformation to effectively improve the thermoelectric properties of n-type BiTeSe + 0.067 wt % BiCl materials based on zone-melting ingots.

Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19.

Cardiac injury is a common complication of the coronavirus disease 2019 (COVID-19), and is associated with adverse clinical outcomes. In this study, we aimed to reveal the association of cardiac injury with coagulation dysfunction. We enrolled 181 consecutive patients who were hospitalized with COVID-19, and studied the clinical characteristics and outcome of these patients.

Impact of the Inflow Population From Outbreak Areas on the COVID-19 Epidemic in Yunnan Province and the Recommended Control Measures: A Preliminary Study.

COVID-19 developed into a global pandemic in 2020 and poses challenges regarding the prevention and control capabilities of countries. A large number of inbound travelers from other regions could lead to a renewed outbreak of COVID-19 in the local regions. Globally, as a result of the imbalance in the control of the epidemic, all countries are facing the risk of a renewed COVID-19 outbreak brought about by travelers from epidemic areas.

Enhanced Thermoelectric Properties of p-Type BiSbTe/SbTe Composite.

Constructing a nanocomposite to introduce a coherent interface is an effective way to improve the property of thermoelectric material. Here, a series composites of BiSbTe- wt % SbTe ( = 0, 0.3, 0.

Novel Blood Cytokine-Based Model for Predicting Severe Acute Kidney Injury and Poor Outcomes After Cardiac Surgery.

Background Alterations in serum creatinine levels delay the identification of severe cardiac surgery-associated acute kidney injury. To provide timely diagnosis, novel predictive tools should be investigated. Methods and Results This prospective observational study consists of a screening cohort (n=204) and a validation cohort (n=198) from 2 centers from our hospital.

Surface electrocardiographic characteristics in coronavirus disease 2019: repolarization abnormalities associated with cardiac involvement.

Aims: The coronavirus disease 2019 (COVID-19) has spread rapidly around the globe, causing significant morbidity and mortality. This study aims to describe electrocardiographic (ECG) characteristics of COVID-19 patients and to identify ECG parameters that are associated with cardiac involvement.

Methods And Results: The study included patients who were hospitalized with COVID-19 diagnosis and had cardiac biomarker assessments and simultaneous 12-lead surface ECGs.

Phonon Engineering for Thermoelectric Enhancement of p-Type Bismuth Telluride by a Hot-Pressing Texture Method.

Phonon engineering is a core stratagem to improve the thermoelectric performance, and multi-scale defects are expected to scatter a broad range of phonons and compress the lattice thermal conductivity. Here, we demonstrate obviously enhanced thermoelectric properties in BiSbTe alloy by a hot-pressing texture method along the axial direction of a zone-melted ingot. It is found that a plastic deformation of grain refinement and rearrangement occurs during the textured pressing process.

The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study.

The new type of pneumonia caused by the SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) has been declared as a global public health concern by WHO. As of April 3, 2020, more than 1,000,000 human infections have been diagnosed around the world, which exhibited apparent person-to-person transmission characteristics of this virus. The capacity of vertical transmission in SARS-CoV-2 remains controversial recently.

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.

A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients.