Size-Dependent Restructuring of Supported Platinum Cluster Catalysts.

Supported metal clusters have reactivities that depend on their nuclearity and structure. Herein, we present a strategy for precisely controlling the nuclearity of platinum clusters and demonstrate their size-dependent restructuring behavior and catalytic properties. The clusters are located on isolated CeO nanoislands on high-area SiO, and the isolation facilitates control of the migration of the platinum.

Isolable Arylphosphinidene Chalcogenides and their Radical Anions.

We report the synthesis, characterization, and reactivity of isolable arylphosphinidene chalcogenides (Ar─P═E; 2 (E = S), 3 (E = Se), 4 (E = Te)), prepared via chalcogen atom transfer from tris(dimethylamino)phosphine chalcogenides (MeN)P═E (E = S, Se, Te) to a phosphanorcaradiene. The compounds crystallize at ambient temperature and feature P═E double bonds, as confirmed by structural and computational studies. Compounds 2-4 undergo [4+2] cycloaddition with 2,3-dimethyl-1,3-butadiene to furnish six-membered heterocyclic products, demonstrating their π-bond reactivity.

Utility of novel composite index in predicting the prognosis of total neoadjuvant therapy for locally advanced rectal cancer: A multicenter real-world cohort study.

Objective: C-reactive protein-albumin-lymphocyte (CALLY) is a novel composite index. Total neoadjuvant therapy (TNT) has become one of the standard treatments for locally advanced rectal cancer (LARC). It remains unclear whether CALLY can predict the prognosis for LARC patients.

Targeting Aquaporins for Renal Fibrosis Therapy: Mechanisms and Translational Potential.

Chronic kidney disease (CKD) is a global health problem characterized by renal fibrosis (RF). Aquaporins (AQPs) are key regulators of water transport across membranes. Key members of this family (such as AQP1, AQP2, etc.

ARHGAP4/MYH9/β-catenin/c-Jun positive feedback loop promotes colorectal cancer stemness.

Rho GTPase-activating protein 4 (ARHGAP4) is implicated in poor prognosis across multiple malignancies. However, its role in driving stemness in colorectal cancer (CRC) remains unclear. In this study, we demonstrate that ARHGAP4 drives CRC stemness through a positive feedback loop involving MYH9/β-catenin/c-Jun, as validated by integrated bioinformatics analysis, in vitro and in vivo tumor stemness assays, co-immunoprecipitation, chromatin immunoprecipitation, and fluorescence recovery after photobleaching.

Single-cell transcriptomics combined with spatial transcriptomics reveals a fibrotic microenvironment in hyperuricemic nephropathy.

Background: Hyperuricemia nephropathy (HN) is a kidney disease caused by hyperuricemia, with renal fibrosis as its hallmark lesion. Renal fibrosis involves diverse cell populations and complex intercellular communication, but its cellular composition and molecular mechanisms remain unclear.

Methods: We employed single-cell RNA sequencing and spatial transcriptomics to analyze kidney tissues from HN rats, identifying cell populations, gene expression patterns, and intercellular interactions.

A single-dose mRNA vaccine encoding the classical swine fever virus E2-ECD induces durable protective immunity in rabbits.

Classical swine fever virus (CSFV) spreads in domestic and wild pig populations, causing significant economic losses in the swine industry. Despite the global implementation of live attenuated vaccines, CSFV remains a persistent threat, with sporadic outbreaks reported annually. A major limitation of the current vaccines is safety concerns and the inability to differentiate infected from vaccinated animals (DIVA).

TGF-β inhibitors: the future for prevention and treatment of liver fibrosis?

Liver fibrosis is a core pathological process in the progression of chronic liver diseases to cirrhosis and hepatocellular carcinoma, characterized by abnormal deposition of extracellular matrix. Transforming growth factor-β (TGF-β), through classical small mothers against decapentaplegic (Smad)-dependent and non-Smad-dependent pathways, activates hepatic stellate cells to transdifferentiate into myofibroblasts, promotes extracellular matrix synthesis, and regulates immunity, serving as a key driver of fibrogenesis. This review systematically summarizes the role of TGF-β in liver fibrosis and details the research progress of TGF-β-targeted inhibitors.

Visceral adipose tissue predicts perioperative complications of total neoadjuvant therapy for locally advanced rectal cancer: A multicenter real-world study.

Objective: For locally advanced rectal cancer, total neoadjuvant therapy can improve the pathologic complete response rate. However, total neoadjuvant therapy-related adverse events and postoperative complications remain significant challenges.

Methods: A restricted cubic spline model was used to analyze the relationship between visceral adipose tissue and total neoadjuvant therapy-related adverse events, intraoperative parameters, and postoperative complications.

Wearable Electrical-impedance-tomography Armband for Noninvasive and Continuous Bone Monitoring.

Medical inspection systems such as digital radiography (DR) and computed tomography (CT) are limited in the continuous monitoring of fracture healing due to cumulative radiation exposure. This work presents a wearable 16-electrode armband incorporating electrical impedance tomography (EIT) for noninvasive, continuous monitoring of arm bones. The EIT armband applies stimulation current on the skin surface with a defined drive pattern and detects response voltages across electrodes.

Identification of core noncoding RNA-associated competing endogenous RNA networks in renal fibrosis via whole-transcriptome sequencing.

Objective: This study aimed to investigate noncoding RNA (ncRNA) expression changes in renal fibrosis (RF) models induced by three distinct etiologies using whole-transcriptome RNA sequencing, identify overlapping differentially expressed (DE) ncRNAs, construct core competing endogenous RNA (ceRNA) networks, and explore their role in RF.

Methods: Three RF rat models, 5/6 nephrectomy, adenine, and unilateral ureteral obstruction, were established. DE RNAs were identified through sequencing and validated by real-time quantitative polymerase chain reaction.

WITHDRAWN: ARHGAP4/ MYH9/ β-catenin/ c-Jun positive feedback loop regulates colorectal cancer stemness.

This article has been withdrawn at the request of the author(s) and/or editor due to an error in the publishing process. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.

Corrigendum: Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: a propensity score matching comparative study.

[This corrects the article DOI: 10.3389/fonc.2022.

Band Gap Engineering and Metastable Phase Discovery in CuBaSnSSe Nanocrystals via Topotactic Anion Exchange.

Earth-abundant multinary inorganic chalcogenides, such as CuBaSnSSe (CBTSSe), have emerged as promising absorbers for next-generation solar cells. However, accessing colloidal CBTSSe nanocrystals, including metastable polymorphs with more favorable optoelectronic properties, remains a critical synthetic challenge. Herein, we report the first use of topotactic anion exchange to access metastable crystal structures in soft chemistry syntheses.

Mechanisms and therapeutic potential of multiple forms of programmed cell death in renal fibrosis.

Programmed cell death (PCD), particularly necroptosis, ferroptosis, and pyroptosis alongside classical apoptosis has attracted considerable attention in recent years in the context of renal fibrosis (RF). Accumulating evidence indicates that these regulated cell death pathways contribute substantially to renal tissue damage and fibrosis progression by promoting inflammation and extracellular matrix (ECM) accumulation. Renal fibrosis, a common pathological process to various chronic kidney diseases (CKD), is closely intertwined with diverse forms of cell death.

Contrasting Atomically Dispersed Metal Catalysts Supported on CeO Nanoislands with Various Ligand Environments Including Chloride.

Metals that are dispersed atomically on supports offer new and potentially valuable catalytic properties associated with their high atom efficiencies and opportunities for tuning their electronic properties by choice of the support and other ligands bonded to them. Herein, we report the synthesis of atomically dispersed Pt, Rh, and Ir anchored on CeO nanoislands on a high-area SiO support. Synthesis from chloride-containing metal salts gave metal complexes chemisorbed on the supported nanoislands, with Pt being prototypical and having a structure approximated as PtClO, as shown by X-ray absorption spectroscopy and calculations at the level of density functional theory (DFT).

C-reactive protein-to-albumin ratio predicts outcome of neoadjuvant chemotherapy for colorectal liver metastases: A multicenter prediction model.

Background: Neoadjuvant chemotherapy for patients with colorectal liver metastasis often results in varying outcomes. This study aimed to develop a clinical prediction model incorporating the C-reactive protein-to-albumin ratio to determine neoadjuvant chemotherapy efficacy in patients with colorectal liver metastasis METHODS: This retrospective study included 1,335 patients with colorectal liver metastasis who received neoadjuvant chemotherapy. Patients were classified into high and low C-reactive protein-to-albumin ratio groups on the basis of an optimal cutoff value.

Sustainable and cost-efficient hydrogen production using platinum clusters at minimal loading.

Proton exchange membrane water electrolysis stands as a promising technology for sustainable hydrogen production, although its viability hinges on minimizing platinum (Pt) usage without sacrificing catalytic efficiency. Central to this challenge is enhancing the intrinsic activity of Pt while ensuring the stability of the catalyst. We herein present a MoTiC MXene-supported Pt nanocluster catalyst (MoTiC-Pt) that requires a minimal Pt content (36 μg cm) to function, yet remains highly active and stable.

A Causal Relationship Between Hypothyroidism and Gestational Hypertension: Results From a Two-Sample Mendelian Randomization Analysis.

Although hypothyroidism induced thyroid hormone disorders affect cardiovascular system homeostasis, whether hypothyroidism has a causal effect on gestational hypertension remains unknown. Therefore, our research aims to explore the causal relationship between hypothyroidism and gestational hypertension using Mendelian randomization (MR) analysis. Summary data genome-wide association study of hypothyroidism (30,155 cases and 379,986 controls in the discovery dataset; 26,342 cases and 59,827 controls in the replicated dataset) and gestational hypertension (14,727 cases and 196,143 controls) were used for analysis.

Cuproptosis-related gene ACAD8 inhibits the metastatic ability of colorectal cancer by inducing cuproptosis.

Background: Distant metastasis of colorectal cancer (CRC) significantly impacts patient prognosis. Cuproptosis is a new form of copper ion-dependent cell death. However, whether cuproptosis-related genes (CRGs) play a role in the metastatic potential of CRC remains unclear.

Efficient Gradient-Based Metasurface Optimization toward the Limits of Wavelength-Polarization Multiplexing.

Polarization and wavelength multiplexing are the two widely employed techniques to improve capacity in metasurfaces. While previous studies have pushed the channel numbers of each technique to its individual limits, achieving simultaneous limits of both techniques still presents challenges. Furthermore, current multiplexing methods often suffer from computational inefficiencies, hindering their applicability in computationally intensive tasks.

Low Visceral Adipose Tissue Predicts the Outcome of Neoadjuvant Chemotherapy for Colorectal Liver Metastases: A Multicentre Real-World Study.

Background: Visceral obesity (VO), associated with excessive visceral adipose tissue (VAT), has been extensively studied in cancer. However, whether low VAT can predict the prognosis of colorectal liver metastases (CRLM) undergoing neoadjuvant chemotherapy (NAC) remains unknown.

Methods: This multicentre real-world cohort study analysed data from initially resectable CRLM patients who received NAC.

Neoadjuvant chemotherapy combined with bevacizumab for resectable colorectal liver metastasis with risk factors for recurrence: a multicenter real-world study.

Background: Currently, guidelines prohibit the addition of targeted drugs in neoadjuvant chemotherapy (NAC) for initially resectable colorectal liver metastasis (CRLM).

Objective: Nevertheless, efficacy data of NAC combined with bevacizumab (Bev) for initially resectable CRLM with risk factors for recurrence (RFR) are lacking.

Designs: We conducted a multicenter real-world cohort study to retrospectively analyze the efficacy and feasibility of NAC combined with Bev for CRLM with RFR.

Crystalline Arylstibinidene Chalcogenides: Heavier Congeners of Aromatic Nitroso Compounds.

Nitroso compounds, R-N═O, containing N═O double bonds are ubiquitous and widely utilized in organic synthesis. In contrast, heavier congeners of nitroso compounds, namely pnictinidene chalcogenides R-Pn = E (Pn = P, As, Sb, Bi; E = O, S, Se, Te), are highly reactive and scarce. They have been stabilized in the coordination sphere of Lewis acid/base or by pronounced contribution from resonance structures, whereas free species with unperturbed pnictogen-chalcogen double bonds remains elusive.

Systematic analysis and prediction of the burden of Alzheimer's disease and other dementias caused by hyperglycemia.

Background: Alzheimer's disease and other dementias (ADOD) pose a significant and escalating global public health challenge, particularly among the aging populations. Emerging evidence has identified high fasting plasma glucose (HFPG) as a major modifiable risk factor for ADOD, linking impaired glucose metabolism to cognitive decline and neurodegeneration. Despite this association, the comprehensive impact of HFPG on the global burden of ADOD has not been fully elucidated.