Qualitative Study on Cognitive Load in Epilepsy Specialist Nurse Training in Northeast China: A Phenomenological Study Among Ten Trained Nurses.

Background: Although cognitive load theory has been applied in general nursing education, its role in epilepsy specialist training remains unexplored, particularly in resource-constrained regions such as Northeast China, where medical disparities intensify learning barriers.

Objective: To investigate the cognitive load experienced by epilepsy specialist nurses (ESNs) during training in Northeast China.

Methods: The research participants were 10 nurses who underwent epilepsy training between December 2023 and February 2024, all from tertiary hospitals within the province.

The efficacy of lactobacillus reuteri in conjunction with racecadotril in managing pediatric rotavirus enteritis and its impact on intestinal mucosa and immune function.

Background: This study aimed to evaluate the effectiveness of combining Lactobacillus reuteri with racecadotril in treating pediatric rotavirus enteritis, focusing on its impact on intestinal mucosa and immune function.

Methodology: Eighty-five children diagnosed with pediatric rotavirus enteritis were randomly divided into two groups: the control group (43 cases) receiving racecadotril alone and the observation group (42 cases) treated with both Lactobacillus reuteri and racecadotril. Evaluation of the RV conversion rate and treatment efficacy was conducted at 3d, 5d, and 7d post-treatment.

Clinicopathological significance of histological diversity in gastric adenocarcinoma with primitive enterocyte phenotype: A methylation-driven aggressive entity.

Background: Gastric adenocarcinoma with primitive phenotypes has recently attracted increasing attention due to its aggressive nature and challenging diagnosis. Gastric adenocarcinoma with enteroblastic differentiation (GAED) and hepatoid adenocarcinoma (HAC) were previously regarded as gastric adenocarcinoma with primitive enterocyte phenotype (GAPEP). GAPEP is known for its poor prognosis, and the accurate diagnosis of GAPEP directly affects therapeutic decision-making.

The impact of rifampin on the efficacy of implant retention and prosthesis removal in staphylococcal periprosthetic joint infection.

Objectives: The purpose of this study was to evaluate the impact of adjunctive rifampicin therapy on the outcomes of prosthesis retention versus removal in patients with staphylococcal prosthetic joint infection (PJI) undergoing antibacterial treatment.

Methods: A retrospective study was conducted on 227 patients diagnosed with Staphylococcal PJI from March 2014 to September 2023 who underwent debridement, antibiotics, and implant retention (DAIR) or explantation and revision surgery. Based on antimicrobial susceptibility testing, we used an effective baseline antibiotic regimen.

Biomineralization-driven simultaneous carbon/phosphorus recovery and membrane fouling control in anaerobic membrane bioreactor for swine wastewater treatment.

The high phosphorus (P) containing in swine wastewater (SW) presents as both an environmental hazard and a potential source of high-value phosphorus resource. This study presents a biomineralization-driven Fe-P crystals (FePs) metabolism to facilitate simultaneous pollutant removal, energy recovery, and membrane fouling mitigation in SW treatment. The approach enhanced methane production from 0.

[Mechanism of Qingrun Decoction in alleviating hepatic insulin resistance in type 2 diabetic rats based on amino acid metabolism reprogramming pathways].

This study aims to investigate the mechanism of Qingrun Decoction in alleviating hepatic insulin resistance in type 2 diabetes mellitus(T2DM) rats through the reprogramming of amino acid metabolism. A T2DM rat model was established by inducing insulin resistance through a high-fat diet combined with intraperitoneal injection of streptozotocin. The model rats were randomly divided into five groups: model group, high-, medium-, and low-dose Qingrun Decoction groups, and metformin group.

The antitumor effects of lupenone on colon cancer and its mechanistic insights.

Background: Lupenone, a natural constituent derived from medicinal plants and fruits, is classified as a lupane-type triterpenoid and is known for its diverse biological activities, including anti-diabetic, anti-cancer, and anti-inflammatory effects. However, the specific impact of lupenone on colon cancer has not been fully elucidated.

Purpose: The purpose of this research was to explore the anti-cancer effects of lupenone monotherapy and in combination with chemotherapy agents in colon cancer.

Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa.

Background: Hidradenitis suppurativa (HS) is a common, chronic, and debilitating inflammatory disease that most commonly affects intertriginous skin. Despite its high heritability, the genetic underpinnings of HS remain poorly understood.

Objective: To identify genetic signals associated with HS, determine genetic relationships with other diseases, and investigate potential molecular genetic mechanisms.

Isoform characterization of mA in single cells identifies its role in RNA surveillance.

The distribution of mA across various RNA isoforms and its heterogeneity within single cells are still not well understood. Here, we develop mA-isoSC-seq, which employs both Oxford Nanopore long-read and Illumina short-read sequencing on the same 10x Genomics single-cell cDNA library with APOBEC1-YTH induced C-to-U mutations near mA sites. Through mA-isoSC-seq on a pooled sample of three cell line origins, we unveil a profound degree of mA heterogeneity at both the isoform and single-cell levels.

SIRT5 inhibition impairs mitochondrial metabolism and enhances venetoclax-induced elimination of acute myeloid leukemia cells.

Metabolic reprogramming is a key focus of targeted therapies in acute myeloid leukemia (AML). The mitochondrial sirtuin SIRT5 removes succinyl groups from specific lysines and impacts cell metabolism, but its role in AML tumorigenesis has not been extensively explored. A recent study highlighted that SIRT5 regulates AML cell activity by modulating glutamine metabolism, but its molecular targets in AML remain unclear.

Regional Brain Aging Disparity Index: Region-Specific Brain Aging State Index for Neurodegenerative Diseases and Chronic Disease Specificity.

This study proposes a novel brain-region-level aging assessment paradigm based on Shapley value interpretation, aiming to overcome the interpretability limitations of traditional brain age prediction models. Although deep-learning-based brain age prediction models using neuroimaging data have become crucial tools for evaluating abnormal brain aging, their unidimensional brain age-chronological age discrepancy metric fails to characterize the regional heterogeneity of brain aging. Meanwhile, despite Shapley additive explanations having demonstrated potential for revealing regional heterogeneity, their application in complex deep learning algorithms has been hindered by prohibitive computational complexity.

A multicenter prospective clinical cohort study of pulmonary cryptococcosis in adult non-HIV-infected patients in a southeastern province of China.

Background: This study investigates the clinical presentations, diagnostic approaches, and treatment outcomes of pulmonary cryptococcosis (PC) in non-HIV patients in Fujian Province, and explores the correlation between immunological status and clinical features.

Methods: A prospective, multicenter cohort study was conducted from April 2017 to March 2022, involving 234 PC patients from 47 hospitals in nine prefecture-level cities in southeastern China's Fujian Province.

Results: The study included 145 male and 89 female PC patients, average age 50.

Effects of effort-reward imbalance on emergency nurses' health: a mediating and moderating role of emotional exhaustion and work-family conflict.

Background: Effort-reward imbalance (ERI) is a prevalent issue in the healthcare sector, particularly in the high-intensity, high-risk, and high-stress environment of the emergency department. This results in emergency department nurses bearing heavier workloads, responsibilities, and time commitments compared to their counterparts in other departments. ERI poses significant risks to their physical, psychological, and sleep quality.

Advancements and Design Strategies for Self-Supported Electrocatalysts Operating in Alkaline Conditions at High-Current-Density.

Alkaline water splitting is one of the most mature sustainable hydrogen production methods. However, the overall efficiency of alkaline water electrolysis is significantly constrained by the anode oxygen evolution reaction, where the four-electron transfer process leads to slow reaction kinetics, limiting the achievement of efficient and cost-effective hydrogen production at high-current-density. Although substantial efforts have been made in the academic community to enhance the activity of electrocatalysts, challenges remain in achieving high activity and stability of catalysts at high-current-density.

DEC1 promotes breast cancer bone metastasis through transcriptional activation of CXCR4.

Bone metastasis is the primary cause of mortality in breast cancer (BC) patients. This study elucidates the functional role of DEC1 (differentiated embryonic chondrocyte expressed gene 1) in promoting BC bone metastasis. Analysis of patient-derived samples and public databases revealed significant upregulation of DEC1 and CXCR4 in breast tumors compared to adjacent normal tissues, with elevated levels correlating with increased metastatic potential, suggesting their synergistic involvement in BC progression.

Comprehensive analysis of culture-negative periprosthetic joint infection with metagenomic next-generation sequencing.

Objective: This study aimed to identify the risk factors and microbial profiles of patients with culture-negative periprosthetic joint infection (PJI) using metagenomic next generation sequencing (mNGS) and to compare the clinical characteristics and treatment outcomes of culture-negative PJI (CN PJI) with culture-positive PJI (CP PJI).

Methods: A retrospective analysis was conducted on 223 patients who met the International Consensus Meeting criteria for PJI and underwent surgical treatment at our hospital between February 2013 and January 2023. Clinical and follow-up data, including microbiological culture results and mNGS findings, were collected.

Extending the culture duration could not improve the culture positivity rate and clinical outcomes of periprosthetic joint infection.

Objective: To explore the clinical value of extending the culture time for accurately diagnosing hip or knee PJI.

Methods: This retrospective study included 201 hip or knee PJI patients. All specimens were cultured using a standardized procedure.

Small Cell Neuroendocrine Carcinoma of the Ureter: A Case Evaluated by 18FFDG- PET/CT and Literature Review.

Introduction: Small cell neuroendocrine carcinoma (SCNEC) of the ureter is extremely rare, and tends to show a mixed histologic profile. Literature on its imaging features is limited.

Case Presentation: We herein report the case of a 68-year-old woman who presented with two days of left flank pain.

Paeonol Relieves Chronic Neuropathic Pain by Reducing Communication Between Schwann Cells and Macrophages in the Dorsal Root Ganglia After Injury.

This study investigated the mechanism underlying Paeonol's therapeutic efficacy against neuropathic pain. GSE158892 dataset data were used to conduct a scRNA-seq analysis. In cell experiments, Schwann cells and macrophages were utilized to examine pain pathogenesis using specific inhibitors.

Optogenetic activation of mechanical nociceptions to enhance implant osseointegration.

Orthopedic implants with high elastic modulus often suffer from poor osseointegration due to stress shielding, a phenomenon that suppresses the expression of intracellular mechanotransduction molecules (IMM) such as focal adhesion kinase (FAK). We find that reduced FAK expression under stress shielding is also mediated by decreased calcitonin gene-related peptide (CGRP) released from Piezo2 mechanosensitive nerves surrounding the implant. To activate these nerves minimally invasively, we develop a fully implantable, wirelessly rechargeable optogenetic device.

Investigating Modifiable Factors Associated with Cognitive Decline: Insights from the UK Biobank.

: Given the escalating global prevalence of age-related cognitive impairments, identifying modifiable factors is crucial for developing targeted interventions. : After excluding participants with dementia and substantial missing data, 453,950 individuals from UK Biobank (UKB) were included. Cognitive decline was assessed across four cognitive domains.

Children and adolescents' demand for psychiatric services: Insight from the a nine-year-period visits population change in Nanjing, China.

Background: The prevalence of mental health issues among children and adolescents has been increasing. The objective of this study is to delineate the evolving characteristics of psychiatric visits among this demographic, including sex differences in service utilization, and to evaluate the capacity of existing medical resources to meet their needs for such visits.

Methods: The data were sourced from Nanjing Brain Hospital and retrieved from outpatient and inpatient records of individuals aged 18 and below who visited the psychiatric department between the dates of July 2015 and June 2024.

Association between low-dose ionizing radiation and hypertension: a cohort study in China.

Objective: The association between high-dose ionizing radiation and the incidence of hypertension is well-established, whereas the impact of low-dose ionizing radiation (<20 mSv) on hypertension remains uncertain. The aim of this study is to assess the risk of hypertension among petroleum workers workers following long-term exposure to low-dose ionizing radiation (<20 mSv).

Methods: The study began in July 2013 and was followed up to December 2019.

Association of normal range of urinary albumin-to-creatinine ratio with all-cause mortality among diabetic adults with preserved kidney function: National Health and Nutrition Examination Survey (NHANES) 2003-2018.

Aim: To ascertain the connection between normal-range urinary albumin-to-creatinine ratio (UACR) and all-cause mortality (ACM) among diabetic adults with preserved eGFR.

Methods: We used data from the 2003-2018 National Health and Nutrition Examination Survey. Nationally representative cross-sectional survey data linked with mortality outcomes from the National Death Index.

Empowering diabetic foot ulcer prevention: A novel cloud-based plantar pressure monitoring system for enhanced self-care.

BackgroundThis study was prompted by the crucial impact of abnormal plantar pressure on diabetic foot ulcer development and the notable lack of its monitoring in daily life. Our research introduces a cloud-based, user-friendly plantar pressure monitoring system designed for seamless integration into daily routines.ObjectiveThis innovative system aims to enable early ulcer prediction and proactive prevention, thereby substantially improving diabetic foot care through enhanced self-care and timely intervention.