Fatigue trajectory and its associated factors in patients after pituitary adenoma surgery: a longitudinal study.

Purpose: One of the most often reported symptoms in postoperative pituitary adenoma patients is fatigue, which frequently results in decreased mobility and activity, negatively affecting their quality of life. Identify subgroups of patients after pituitary adenoma surgery with distinct fatigue trajectories and analyze the differences in their characteristics.

Methods: This longitudinal study enrolled patients with pituitary adenoma undergoing transsphenoidal surgery.

Self-Assembly of Amphiphilic Comb-like Copolymers into Micelles and Vesicles in Solution.

Combining Brownian dynamics simulations and self-consistent field theory, we demonstrate that stable assembled structures, such as vesicles, toroidal micelles, bowl-like micelles, sheet-like micelles, non-spherical vesicles, and cylindrical micelles, are dependent on the molecular parameters of amphiphilic comb-like copolymers. Importantly, we find that vesicle formation involves two intermediate states, sheet-like and bowl-like micelles, and the difference in their free energies is minimal, which illustrates the coexisting phase between them. Moreover, the assembled vesicles can be modulated in the membrane thickness with overall size, unchanged only by adjusting the backbone length.

SIRT5 inhibition impairs mitochondrial metabolism and enhances venetoclax-induced elimination of acute myeloid leukemia cells.

Metabolic reprogramming is a key focus of targeted therapies in acute myeloid leukemia (AML). The mitochondrial sirtuin SIRT5 removes succinyl groups from specific lysines and impacts cell metabolism, but its role in AML tumorigenesis has not been extensively explored. A recent study highlighted that SIRT5 regulates AML cell activity by modulating glutamine metabolism, but its molecular targets in AML remain unclear.

Methyl-functionalized anionic MOFs for charge- and shape-selective adsorption of dyes in water remediation.

A methyl-functionalized MOF exhibits dual-selective adsorption of linear cationic dye molecules electrostatic attraction and steric discrimination, which are based on the anionic framework and methyl-induced pore confinement of the MOF. Its capacity to adsorb methylene blue is as high as 232.98 mg g, surpassing that of the parent MOF.

Deceleration of polymer translocation through a nanopore polymer brushes.

This work employs Brownian dynamics simulations to study the deceleration of polymer translocation through grafting nanopores. The study found that both grafting density and length positively correlate with the translocation time. The translocation time increases slowly when the grafted chains have not yet formed a blocking layer.

Engineering Spores to Display Nicotine Oxidase: In Situ Specific and Sensitive Nicotine Detection.

Nicotine exposure poses a significant public health challenge, necessitating highly sensitive and real-time detection methods. This study presents a novel live electrochemical biosensor (EN@FeSe@MHCS/GCE) by integrating synthetic biology and materials engineering. A genetically engineered NOX mutant-with 9.

Expression of Tim-3 on neutrophils as a novel indicator to assess disease activity and severity in ankylosing spondylitis.

Objective: To investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis (AS) patients and its correlation with disease activity, severity, and inflammatory markers.

Methods: Sixty-two AS patients from Guangdong Second Provincial General Hospital and 38 healthy controls (HC) were enrolled. Clinical data, physical exams, and laboratory measurements were recorded.

Dual-driven selenium Janus single-atom nanomotors for autonomous regulating mitochondrial oxygen imbalance to catalytic therapy of rheumatoid arthritis.

O deficiency and excessive reactive oxygen and nitrogen species (RONS) in macrophage mitochondria is a key factor causing oxygen imbalance in rheumatoid arthritis microenvironment (RAM). Although nanocatalytic therapy that simultaneously produce O and eliminate RONS offer a novel strategy for RA therapy, the therapeutic efficacy of nanozymes is limited by the lack of autonomous targeting into mitochondria. Herein, we constructed a Janus-structured nanomotor (Pd@MSe) with autonomous targeting ability by embedding Pd single-atom nanozymes into mesoporous selenium (MSe) nanozymes, and obtained a composite nanomotor (Pd@MSe-TPP) with dual-driven forces by modifying with triphenylphosphine (TPP) in MSe hemisphere.

A stable HOF-embedded alginate hydrogel membrane for selective adsorption of cationic dyes.

Targeted at organic dye pollutants, a stable HOF was combined with an alginate (SA) hydrogel to enhance the affinity for cationic dyes. The as-obtained HOF@SA membrane (weight ratio: 1/1) shows a high adsorption capacity (729.21 mg g), adsorption selectivity and good recycling performance towards methylene blue.

Enhanced UV-Visible Absorption of Silicon Solar Cells Utilizing YAG:Ce and BaSiOCl: Eu Based on Spectral Down-Shifting.

Spectral down-shifting materials can convert the less utilized photons in the solar spectrum into the portion that solar cells can fully utilize, providing an effective means of improving the efficiency of solar cells. In this work, the spectral down-shifting material BaSiOCl: Eu (BSOC) was prepared by a high-temperature solid-state method. The fluorescence spectra indicate that the absorption spectrum of BSOC can cover the range of 210-500 nm, and has a strong emission spectrum with a broadband of 410-650 nm.

Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia.

Acute myeloid leukemia (AML) patients with the FMS-related receptor tyrosine kinase 3 internal tandem duplication (FLT3/ITD) mutation have a poorer prognosis, and treatment with FLT3 tyrosine kinase inhibitors (TKIs) has been hindered by resistance mechanisms. One such mechanism is known as adaptive resistance, in which downstream signaling pathways are reactivated after initial inhibition. Past work has shown that FLT3/ITD cells undergo adaptive resistance through the reactivation of extracellular signal-regulated kinase (ERK) signaling within 24 h of sustained FLT3 inhibition.

Unveiling spatiotemporal distribution, partitioning, and transport mechanisms of tire additives and their transformation products in a highly urbanized estuarine region.

Numerous tire additives are high-production volume chemicals that are used extensively worldwide. However, their presence and partitioning behavior remain largely unknown, particularly in marine environments. This study is the first to reveal the spatiotemporal distribution, multimedia partitioning, and transport processing of 22 tire additives and their transformation products (TATPs) in a highly urbanized estuary (n = 166).

"Three-dimensional environment-friendly" amino acid functionalized chitosan: Uranium adsorption performance and mechanism research.

To achieve the goals of "carbon peak and carbon neutrality" and sustainable development, we propose "Three-Dimensional Environment-Friendly" materials to balance the urgent need for the development of clean energy and the reduction of secondary environmental pollution during adsorbent preparation. In this study, three novel chitosan adsorbents (CMNSC-Leu, CMNSC-Pro, CMNSC-Phe) for uranium adsorption were designed on the basis of molecular level and successfully synthesized with three different amino acids (leucine, proline, phenylalanine) through amidation reaction in an aqueous environment using a sustainable green chitosan material. The uranium adsorption capacity of the three adsorbents was evaluated by batch adsorption, selectivity and recyclability studies.

Broadband sensitized near-infrared emission in Eu-Nd co-doped BaAlO as a potential spectral modulator for silicon solar cells.

The near-infrared (NIR) down-conversion process for broadband sensitization has been studied in Eu-Nd co-doped BaAlO. This material has a broad absorption band of 200-480 nm and can convert photons in the visible region into NIR photons. The NIR emission at 1064 nm, attributed to the Nd:F → I transition, matches the bandgap of Si, allowing Si solar cells to utilize the solar spectrum better.

Bis-substituted amino acid functionalized chitosan aerogels: High uranium adsorption capacity and antibacterial properties.

Based on the goal of "carbon neutralization and carbon peaking", it is still challenging to develop a high adsorption performance and environmentally friendly material for uranium extraction. We proposed a new idea of "Three-Dimensional Environmental-Friendly". A series of amino acid bis-substituted chitosan aerogels (C-1, C-2, C-3, C-4 and C-5) were prepared by ice template method and selective substitution reaction in water environment.

Associations of blood pressure in the third trimester and risk of venous thromboembolism postpartum.

Studies on the associations of blood pressure (BP) and the risk of venous thromboembolism (VTE) had been performed neither among pregnant women nor in Chinese population. This study included participants of pregnant women from a retrospective multicenter cohort, between May 2020 and April 2023. Systolic BP (SBP) and diastolic BP (DBP) of the participants were measured in the third trimester.

Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition.

Internal tandem duplication mutations of FLT3 (FLT3/ITD) confer poor prognosis in AML. FLT3 tyrosine kinase inhibitors (TKIs) alone have limited and transient clinical efficacy thus calling for new targets for more effective combination therapy. In a loss-of-function RNAi screen, we identified NOTCH4 as one such potential target whose inhibition proved cytotoxic to AML cells, and also sensitized them to FLT3 inhibition.

Construction of oxime-functionalized PCN-222 based on the directed molecular structure design for recovering uranium from wastewater.

The directed construction of productive adsorbents is essential to avoid damaging human health from the harmful radioactive and toxic U(VI)-containing wastewater. Herein, a sort of Zr-based metal organic framework (MOF) called PCN-222 was synthesized and oxime functionalized based on directed molecular structure design to synthesize an efficient adsorbent with antimicrobial activity, named PCN-222-OM, for recovering U(VI) from wastewater. PCN-222-OM unfolded splendid adsorption capacity (403.

A convenient functionalization strategy of polyimide covalent organic frameworks for uranium-containing wastewater treatment and uranium recovery.

The purpose of this research was to design and synthesize an adsorbent based on polyimide covalent organic frameworks (PICOFs) for uranium-containing wastewater treatment and uranium recovery. A modified solvothermal method was innovatively proposed to synthesize PICOFs with high specific surface area (1998.5 m g) and regular pore structure.

Single-crystal ZrCo nanoparticle for advanced hydrogen and H-isotope storage.

Hydrogen-isotope storage materials are essential for the controlled nuclear fusion. However, the currently used smelting-ZrCo alloy suffers from rapid degradation of performance due to severe disproportionation. Here, we reveal a defect-derived disproportionation mechanism and report a nano-single-crystal strategy to solve ZrCo's problems.

Season of delivery and risk of venous thromboembolism during hospitalization among pregnant women.

Background: Seasons were found to be related to the occurrences of venous thromboembolism (VTE) in hospitalized patients. No previous study has explored whether seasons were associated with VTE risk in pregnant women. This study aimed to investigate the relationships between the season of delivery and VTE risk during hospitalization among pregnant women.

Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides.

Atropisomerism is a type of conformational chirality that plays a critical role in various fields of chemistry, including synthetic, medicinal and material chemistry, and its impact has been widely recognized. Although chiral atropisomerism in rotationally restricted aryl-aryl bonds has garnered substantial interest and led to important discoveries in chiral catalysts and drug development, the exploration of non-aryl atropisomers has fallen behind. Here we reveal a previously unexplored form of non-aryl atropisomerism by linking a sterically congested olefin to a sulfoxonium ylide.

Effect of Enhanced Recovery After Surgery on the Prognosis of Patients With Hip Fractures: A Systematic Review and Meta-Analysis.

Background: Hip fractures, predominantly occurring in the elderly, are a significant public health concern due to associated morbidity, disability, and mortality. Prolonged bed rest following the fracture often leads to complications, further threatening patient health. Enhanced recovery after surgery, a modern approach to postoperative care, is being explored for its potential to improve outcomes and quality of life in hip fracture patients.

Label-free colorimetric detection of tetracycline using gold nanoparticles with different surface charge.

Visual detection assay based on aptamer unmodified gold nanoparticles shows great potential in biotechnology. Here, we reported a visible, salt-free and highly sensitive tetracycline (TC) assay based on a colloidally stable mixture of AuNPs that contains poly (diallyl dimethylammonium chloride) capped AuNPs ((+)AuNPs) and tetracycline-specific aptamer capped AuNPs (Apt-capped AuNPs). This reported TC assay was visible and salt-free that did not need any salt during TC detection.

Association between serum alkaline phosphatase levels in late pregnancy and the incidence of venous thromboembolism postpartum: a retrospective cohort study.

Background: Two previous studies found alkaline phosphatase (ALP) levels were related with the development of venous thromboembolism (VTE) in hospitalised patients. VTE is a leading cause of death during pregnancy and postpartum. No prior study has investigated the associations of ALP levels and VTE postpartum, and the related mechanisms remain unclear.