Low-Energy Femtosecond Laser Lens Fragmentation Techniques for Cataract.

Femtosecond laser has become an important tool in cataract surgery due to its precision and minimally invasive nature. However, the strong scattering properties of the lens limit surgical efficiency, especially when it comes to effectively cutting highly opaque and hard cataracts with femtosecond laser. This study proposes a method for achieving optical transparency in opaque lenses through tartrazine treatment.

Enhancing Sugarcane Yield and Weed Control Sustainability with Degradable Film Mulching.

A two-year field study evaluated biodegradable plastic film (BPF; thicknesses: 0.006, 0.008, and 0.

Sialic Acid-Loaded Nanoliposomes with Enhanced Stability and Transdermal Delivery for Synergistic Anti-Aging, Skin Brightening, and Barrier Repair.

: Sialic acid (SA), a naturally occurring compound abundantly found in birds' nests, holds immense promise for skincare applications owing to its remarkable biological properties. However, its low bioavailability, poor stability, and limited skin permeability have constrained its widespread application. : To overcome these challenges, SA was encapsulated within nanoliposomes (NLPs) by the high-pressure homogenization technique to develop an advanced and efficient transdermal drug delivery system.

Optimization of mixed strain co-cultures and regulatory mechanisms for combustible gas metabolism in goaf environments.

Coal mine goafs are prone to the accumulation of combustible gases such as methane (CH) and carbon monoxide (CO), posing significant risks of thermodynamic disasters. The present study developed a co-culture system comprising CH-oxidizing bacteria Methylophilus S2 and Methylobacter T7, alongside CO-oxidizing bacteria Comamonas M13, to mitigate these hazards. Optical density at 600 nm (OD) and gas metabolism rates served as performance indicators, and the concentrations of principal components (HPO, NO, Mg) and trace elements (Fe, Cu) in the co-culture medium were optimized.

Structural equation modeling for influencing factors on behavioral intention to adopt medical AI among Chinese nurses: a nationwide cross-sectional study.

Background: Artificial intelligence (AI) shows great potential to improve clinical nursing practices. However, concerns and challenges related to its implementation have led to resistance among nurses, hindering the widespread use of AI tools in healthcare. This study aimed to apply the Unified Theory of Acceptance and Use of Technology (UTAUT) model to medical AI in Chinese nursing and to examine the relationships specified within the established theoretical framework.

YBX1: an RNA/DNA-binding protein that affects disease progression.

YBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNA-binding protein characterized by a highly conserved cold shock domain (CSD). YBX1 is localized in both the cytoplasm and nucleus, where it participates in various biological processes such as transcription, translation, and DNA damage repair. YBX1 is upregulated in numerous malignant tumors and is closely associated with tumor progression and poor prognosis, making it a recognized target for cancer therapy.

Acryloyl Gelatin as Polymer Additive to Droplet Digital LAMP for DNA Quantification.

Absolute quantification of target nucleic acids is essential for life analysis and can be achieved through droplet digital microfluidic nucleic acid quantification (droplet digital NAQ). Recent advancements in this field have incorporated polymers into droplets to form microgel particles, which add new functionalities to the droplets and offer opportunities for tandem analysis. However, the range of materials available for microgel-based droplet digital NAQ remains limited.

Clinical analysis of ultrasound-guided "tract without bleeding vessel requiring embolization (TBVE)" in reducing bleeding during percutaneous nephrolithotomy.

Objective: To compare the efficacy of ultrasound-guided tract without bleeding vessel requiring embolization (TBVE) versus conventional minimally invasive access in mini-percutaneous nephrolithotomy (Mini-PCNL) for reducing postoperative bleeding.

Methods: This retrospective study analyzed 188 patients who underwent Mini-PCNL by a single surgeon between June 2021 and July 2023. Patients scheduled for mini-PCNL were assigned to two groups based on access technique.

Relationships between different components of intolerance of uncertainty and symptoms of obsessive-compulsive disorder: a network analysis.

Background: Previous studies have shown that intolerance of uncertainty (IU) and obsessive-compulsive disorder (OCD) are closely interrelated. This reliance on scale totals to measure symptom severity obscures the distinctions and connections between different symptoms. In the present study, we explored the relationships between different components of IU and symptoms of OCD.

Revisiting the Eoarchean Akilia quartz-pyroxene rock with potassium isotopes: Implications for early-ocean sedimentation.

The Eoarchean quartz-pyroxene rock from Akilia Island in Greenland has been proposed as one of Earth's oldest banded iron formations (BIF) and a potential host for the earliest biosignatures. However, the origin of its protolith, whether it metamorphosed from an igneous or sedimentary precursor, remains debated. Here, we revisit this longstanding Akilia controversy using potassium isotope analyses, comparing Akilia samples with BIFs and black shales spanning the Eoarchean to Mesoproterozoic.

Genetic and Clinical Characteristics of Difficult-To-Treat Crohn's Disease: Trio-Based Exome Sequencing in 24 Families.

Objectives: Difficult-to-treat Crohn's disease (DTT-CD) represents a critical unmet need in inflammatory bowel disease (IBD) management. However, its genetic architectures remain poorly understood. We aimed to evaluate the genetic characteristics and clinical manifestations of DTT-CD cases through integrated trio-based whole exome sequencing (WES) and longitudinal phenotyping.

Biomimetic targeted self-adaptive nanodrug for inflammation optimization and AT2 cell modulation in precise ARDS therapy.

Acute respiratory distress syndrome (ARDS) is a lethal respiratory condition, while effective pharmacological treatments remain elusive. We identified the decreased mechanical capacity and impaired proliferation of alveolar type 2 (AT2) epithelial cells in the inflammatory environment as the primary contributors to respiratory failure of ARDS. A biomimetic, self-adaptive, 7,8-dihydroxyflavone-loaded hollow mesoporous cerium oxide coated with a platelet membrane (HCeO-D@PM) was developed for precise ARDS therapy.

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.

Ferroptosis has emerged as a novel therapeutic target in cancer treatment. RNA N6-methyladenosine (m6A) methylation, plays a critical role in regulating ferroptosis and mediating tumor progression and therapy resistance. Gambogic acid (GA), a plant-derived compound with potent antitumor activity, was investigated for its role in inducing ferroptosis in colorectal cancer (CRC).

Recent progress of [5 + 2] cycloaddition reactions in natural product synthesis.

Covering: 2013 to 2024Cycloaddition reactions, which efficiently construct polycyclic ring systems and stereocenters, are powerful tools in the total synthesis of natural products. Given the significant progress and numerous elegant applications of [5 + 2] cycloaddition reactions over the past decade, this review systematically summarizes the advances in three major types of [5 + 2] cycloaddition reactions in natural product synthesis from 2013 to 2024. The advantages of [5 + 2] cycloadditions in constructing complex natural product frameworks are illustrated through comparisons with alternative strategies for the same targets.

Prevalence, combination patterns, and quality of life factors of multimorbidity among older adults in southern China based on the health ecological model.

Background: Multimorbidity is increasingly prevalent among older adults and poses significant challenges to health and well-being. This study applied a health ecological model to investigate the prevalence, determinants, and common disease patterns of multimorbidity, as well as the factors associated with quality of life (QoL) among older adults in southern China.

Methods: A cross-sectional survey was conducted among 2404 individuals aged 60 years and older using a multi-stage random sampling method.

Recent Progress of Stereolithography-Based Additive Manufactured Electrodes for Supercapacitors: Materials, Structures, Performance, and Perspectives.

Stereolithography-based additive manufacturing techniques, leveraging their superior capability for high-precision fabrication of 3D structures with well-defined periodicity and complex geometries, have unlocked unprecedented opportunities in constructing architecturally engineered 3D electrodes for advanced supercapacitors. Over the past few years, a series of groundbreaking achievements in stereolithography-based additive manufactured 3D structural electrodes have been successively reported, fostering a comprehensive understanding of recent advances and a strategic re-evaluation of future research direction. In this review, the latest representative progress in stereolithography-based additive manufactured electrodes for supercapacitors, covering ceramic-based electrodes, carbon-based electrodes, resin-based electrodes, and carbon-ceramic-based electrodes, is first summarized.

 (Asteraceae, Senecioneae), a new species from south-eastern Xizang, China, based on morphological and molecular evidence.

, a new species belonging to Senecioneae (Asteraceae), is described and illustrated herein after being discovered during biodiversity surveys in Lhozhag County, Xizang Autonomous Region, China. This species is similar to (Wall. ex DC.

Predicting time-to-first cancer diagnosis across multiple cancer types.

Cancer causes over 10 million deaths annually worldwide, with 40.5% of Americans expected to be diagnosed in their lifetime. Early detection is critical; for liver cancer, survival rates improve from 4 to 37% when caught early.

Development and validation of the Pediatrics Functional Living Index-Emesis scale.

Background And Objective: Assessing the impact of chemotherapy-induced nausea and vomiting (CINV) on the quality of life (QoL) of cancer patients is critical. However, there is a dearth of specialized assessment tools designed specifically for pediatric cancer patients. The aim of this study was to develop and validate the Pediatrics Functional Living Index-Emesis (PFLIE) as a patient-reported outcome measure (PROM) to assess the impact of CINV on QoL in pediatric patients.

Exploring research dynamics of PDT in anti-infective applications (2004-2024): a bibliometric perspective.

Background: Photodynamic therapy (PDT) has become a popular research direction in the field of infection control; however, there is still a lack of systematic bibliometric analysis. This paper aims to fill this gap by conducting the first comprehensive bibliometric analysis of studies related to PDT in infection control over the past 20 years, in order to gain in-depth insights into its current status and emerging trends.

Methods: Publications related to PDT and infection control were collected from the Web of Science Core Collection database (WoSCC) from January 2004 to April 2024.

Impact-induced sublimation drives volatile depletion in carbonaceous meteorites.

Carbonaceous chondrites are amongst the most chemically primitive solid materials in the Solar System, yet many are depleted in moderately volatile elements. Here, we report enrichments in heavier zinc isotopes in heated carbonaceous chondrites compared to the typical ranges for chondritic meteorites. Our results indicate that impact-driven thermal metamorphism under low-pressure conditions led to partial sublimation of zinc.

Molecular Subtypes of Mixed Gastric Cancer Defined by Machine Learning for Predicting Prognosis and Treatment Response.

Background: Gastric cancer (GC) is traditionally classified into intestinal (IGC), diffuse (DGC), and mixed (MGC) types based on pathological features, with each subtype exhibiting distinct clinical outcomes. Among these, DGC is associated with poor prognosis, characterized by low cell adhesion and a high stromal component. Recent proteomic studies have revealed significant differences in extracellular matrix (ECM) composition between DGC and IGC, highlighting the critical role of ECM in tumor biology.

Innovative rapid screening for complex BCR-ABL1 kinase domain mutations in TKI-treated leukaemia patients.

Background: Screening for BCR-ABL1 kinase domain (KD) mutations is routinely implemented in cases of treatment failure for chronic myeloid leukaemia and Philadelphia-positive acute lymphoblastic leukaemia. However, timely deciphering their clonal relationship via mutation profiling that requires identification of mutation types, quantification of mutant abundance, and differentiation between compound and polyclonal mutations (CMs and PMs), remains difficult during therapy.

Methods: Herein, we established a protocol that identified mutation types and further distinguished clonal relationships by combining mini-sequencing of MeltArray with allele segregation of droplet digital PCR (ddPCR).

Birt-Hogg-Dubé syndrome - a rare genetic disorder complicated by pneumothorax: A case report.

Background: Birt-Hogg-Dubé (BHD) syndrome is a rare genetic disorder associated with mutations in the gene, which can manifest symptoms at any age, including dermatological and pulmonary complications, as well as renal tumors. This study presents a case of a BHD patient who experienced spontaneous pneumothorax, aiming to enhance the understanding of this syndrome.

Case Summary: A 42-year-old female patient presented with left-sided chest pain and tightness lasting three days.

Characterization of Spectrin Family Genes and Their Evolutionary Roles in Domestication and Breeding of the Silkworm .

The spectrin family genes play critical roles in cytoskeletal organization and cellular integrity, yet their evolutionary and functional significance in non-classical model organisms remains poorly explored. Here, we systematically identified and characterized spectrin family genes in the silkworm . Genome-wide analysis identified 17 predicted spectrin genes, which were integrated into eight optimized members through transcriptome-guided structural refinement.