When viral myocarditis meets thrombosis tendency: deep analysis of a complex case report.

This case report presents a 43-year-old male patient with severe symptoms who was admitted due to dyspnea following physical activity, cough accompanied by fever, lower limb edema, and hemoptysis. The patient had a 20-year history of hypertension. Examinations revealed bilateral lower pulmonary artery thrombosis, a left ventricular thrombus, pulmonary infarction, and reduced left ventricular systolic function, with a lowest left ventricular ejection fraction (LVEF) of 26.

Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state.

The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In the present study, we demonstrate that dormant breast cancer cells lodged in the lungs reside in a highly mesenchymal, nonproliferative phenotypic state. The awakening of these cells is not triggered by a cancer cell-autonomous process.

Electroacupuncture therapy improves cognitive dysfunction after ischemic stroke in Sprague-Dawley rats by adjusting the lncRNA-MEG3/miR-4640-3p axis.

Background: Ischemic stroke (IS) is a common disease that can cause cognitive dysfunction. Electroacupuncture (EA) is an effective way to alleviate cognitive dysfunction, but its molecular regulatory mechanism is still unclear. Long noncoding RNA-MEG3 (MEG3) is an important factor in the incidence and progression of IS.

Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome.

Targeting CDK2 with first generation CDK2 inhibitors suffered from a reduced therapeutic index likely due to toxicity stemming from lack of selectivity against the CDK family and other kinases. Recently, CDK2 has been identified as a mediator of resistance to CDK4/6 inhibitors in the context of high levels of cyclin E expression. Discovery of highly selective CDK2 inhibitors may minimize off-target effects, reduce toxicity observed with first generation CDK2 inhibitors, and allow precise targeting of aberrant cell cycle progression and resistance mechanisms mediated by high cyclin E/CDK2 activity.

Study design and rationale of the TXL-CAP trial: a randomized, double-blind, placebo-controlled, multicenter clinical trial assessing the effect of Tongxinluo capsules on the stability of coronary atherosclerotic plaques.

Recent clinical trials have demonstrated a protective effect in using traditional Chinese medicine Tongxinluo (TXL) capsule to treat atherosclerosis. However, clinical evidence of the effects of TXL treatment on coronary plaque vulnerability is unavailable. In response, we developed this study to investigate the hypothesis that on the basis of statin therapy, treatment with TXL capsule may stabilize coronary lesions in patients with acute coronary syndrome (ACS).

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

Unlabelled: To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human microglia upregulate Glypican 4 (GPC4), a GPI-anchored heparan sulfate proteoglycan (HSPG). Glial GPC4 expression exacerbates motor deficits and reduces lifespan in a amyloidosis model, implicating GPC4 in a toxic neurodegenerative program.

Impact of Knowledge Access on Risky Sexual Behaviors Among Chinese Youths to Improve HIV Prevention: Cross-Sectional Study.

Background: HIV infection significantly challenges Chinese youth, with most infections resulting from risky sexual behaviors. Health communication is critical in preventing risky behaviors. Different HIV-related information sources exhibit unique characteristics, affecting young adults' perception of HIV and sexual behaviors.

Differences in Growth Responses to Climate of Three Conifer Species in Lugu Lake of Northwestern Yunnan, Southwestern China.

Responses of tree radial growth to climate are usually species-specific. Northwestern Yunnan has become a hotspot for the study of dendrochronology due to its sensitivity to climate change and the relative integrity of vegetation preservation. In this paper, we take three dominant conifers-, and -as the research objects and analyze their tree-ring width chronologies in order to reveal the main climate factors affecting tree growth in northwestern Yunnan and to evaluate species-specific variation in climate response.

PROTACs in Antivirals: Current Advancements and Future Perspectives.

Proteolysis-targeting chimera (PROTAC) technology has demonstrated remarkable progress in tumor therapy, attributed to its unique capability of catalytically degrading "undruggable" targets. In the context of the ongoing global health threat posed by the Coronavirus Disease 2019 (COVID-19) pandemic, the application scope of PROTAC technology has been gradually extended to the field of antiviral research. Unlike traditional small molecule inhibitors, PROTAC employs an "event-driven" mechanism to achieve ubiquitination-mediated degradation of target proteins.

The Non-Traditional Cardiovascular Culprits in Chronic Kidney Disease: Mineral Imbalance and Uremic Toxin Accumulation.

Chronic kidney disease (CKD) is associated with a significantly elevated mortality rate, primarily due to cardiovascular disease (CVD), highlighting a complex bidirectional relationship between the two conditions. Life-threatening cardiovascular events occur despite control of the traditional risk factors, emphasizing the underlying role of non-traditional risk factors. CKD, causing mineral imbalance and the accumulation of uremic toxins due to a compromised ability to excrete waste products, imposes extra pressure on the cardiovascular system.

Regioselective C7 sulfinylation of 4-aminoindoles with sulfinates.

The regioselective C7-H sulfinylation of 4-aminoindoles was achieved by exploiting the -directing ability of the amino group. This transformation utilizes readily available sulfinates as versatile sulfinyl sources, allowing facile installation of structurally diverse sulfoxide motifs at the C7 position. In addition to aryl/alkyl sulfinates, trifluoromethyl sulfinate is also viable.

Enhancing Catalysis and Sieving Polysulfides by Oxygen Vacancy-Rich Separator Modifier for High-Performance Li-S Batteries.

Lithium-sulfur (Li-S) batteries have been hindered by the low active material utilization, sluggish kinetics and Li anode corrosion caused by the dissolution of Li polysulfides (LiPSs) intermediates. To solve these problems simultaneously, Fe-doped HTiO anchored on the reduced graphene oxide (rGO/HTiO-Fe) is designed via dopant selection and doping content optimization as a novel separator modifier. Tunable Fe-doping induces the controllable generation of oxygen vacancies (OVs), endowing rGO/HTiO-Fe with suitable Lewis acid character, which causes a sieving effect via the differentiated adsorption between OVs and various LiPSs.

Assessing grassland degradation based on abrupt changes in living status of vegetation in a subalpine meadow.

Grassland degradation impacts and restoration strategies have been extensively studied in existing literature. Nevertheless, current diagnostic approaches for assessing degradation conditions predominantly rely on either empirical or mechanistic approaches, leading to inconsistent findings across studies. Here, we proposed a geo-coding and abrupt analysis based (GAAB) method to identify the degradation conditions of grasslands.

Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial.

Background: Resistance training (RT) is a fundamental sarcopenia treatment, but its efficacy may be enhanced by nutritional strategies. This study investigated whether combining RT with vitamins C and E supplementation yields additive benefits in sarcopenia patients.

Methods: Sixty older women with sarcopenia (60-75 years) were randomized to an antioxidant supplementation group (AS; 1000 mg/d vitamin C and 335 mg/d vitamin E) or a placebo group (PLA) following the same elastic-band RT program.

Laparoscopic lateral suspension combined with uterosacral ligament folding and shortening versus laparoscopic sacrocolpopexy for the treatment of pelvic organ prolapse: a retrospective cohort study.

Background: Pelvic organ prolapse (POP) significantly impacts women's quality of life, with laparoscopic sacrocolpopexy (LSC) considered the gold standard for treatment. However, LSC carries risks of complications, prompting exploration of alternatives. This study compared the efficacy of Laparoscopic Lateral Suspension (LLS) combined with uterosacral ligament folding and shortening (LLS-ULFS) versus LSC for POP treatment.

Prenatal androgen exposure delays puberty onset in female offspring rats: possible roles of leptin and α-MSH.

Objective: To clarify the possible mechanism of leptin and α-MSH on the onset of puberty in female offspring rats after prenatal androgen exposure.

Methods: Sixteen 8-week-old specific pathogen free (SPF) healthy Sprague Dawley (SD) pregnant rats were randomly divided into the testosterone-treated group (TG, female offspring termed PNA group) or the olive oil control group (OOG, female offspring termed VEH group). The female offspring rats of two groups were raised to 21 days (PND21) and weaned.

Gut microbiota mediated the curvilinear association between dietary animal protein intake and bone mineral density in Chinese adults.

Dietary protein intake is closely related to bone health. However, it remains unclear how different dietary protein sources contribute to bone mass and how the gut microbiota affects these processes. This study investigated the relationships of dietary animal and plant protein intake with bone mineral density (BMD) and the mediating role of gut microbes in these associations.

Joint effect of hyperuricemia and severe Vitamin D deficiency on all-cause and cardiovascular mortality among individuals with diabetes.

Background: This study aims to investigate the individual and joint associations of hyperuricemia (HUA) and severe Vitamin D deficiency (SVDD) on the all-cause and cardiovascular disease (CVD) mortality among patients with diabetes mellitus (DM) by analyzing data from the National Health and Nutrition Examination Survey (NHANES).

Methods: Data of DM patients aged ≥20 years from the NHANES 2001-2018 were included in this study. Survey-weighted multivariable cox proportional hazards regression models, Kaplan-meier curve and restricted cubic spline analysis were employed to evaluate the individual and joint associations of HUA and SVDD with the all-cause and CVD mortality of DM patients.

Uric acid and sudden cardiac arrest: a more significant intermediate role of renal insufficiency than cardiac events.

Background: Although serum uric acid (SUA) has been frequently linked to a range of cardiorenal diseases, its potential role in disease trajectories leading to incident sudden cardiac arrest (SCA) has not been previously explored using a multistate modeling approach.

Objective: This study aimed to investigate the long-term effect of SUA on SCA and the possible intermediate diseases.

Methods: Based on the UK Biobank cohort, the Cox proportional hazard model was applied to explore associations between SUA and SCA.

Deep learning-based spatial analysis on tumor and immune cells of pathology images predicts MIBC prognosis.

Objective: Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. This study aims to explore the correlation between the spatial distribution of lymphocyte aggregates and the prognosis of MIBC using deep learning.

Methods: Whole-slide images (WSIs) and clinical information of MIBC patients were collected from The Cancer Genome Atlas (TCGA) and the HBlaU079Su01 microarray.

The impact of health emergencies on nurses' burnout: a systematic review and meta-analysis.

Background: Burnout is a prevalent occupational phenomenon among healthcare workers. To evaluate the current evidence on nurses' burnout and the impact of turnover intention during the pandemic is imperative.

Objective: We aimed to comprehensively synthesize and quantify the impact of health emergencies caused by the COVID-19 pandemic outbreak on nurses' burnout and identify factors associated with the negative impact.

Low-dose nicotine enhances arecoline-induced human oral mucosa fibroblast proliferation by stabilizing Egr-1 protein.

Oral submucous fibrosis (OSF) is a precancerous oral condition, with betel quid chewing and smoking identified as potential risk factors. However, the relationship between these factors, particularly their interaction, remains inconclusive. In this study, we observed that low-dose nicotine exposure (< 500 nM) increased arecoline-induced proliferation of human oral mucosa fibroblasts, whereas high doses of nicotine (1000 nM and 5000 nM) inhibited fibroblast proliferation.

Wuwei Ganlu and Myricetin alleviate rheumatoid arthritis by inhibiting M1 macrophage polarization through modulation of SHBG/SREBP1-mediated lipid metabolism.

Background: Rheumatoid arthritis (RA) is primarily characterized by imbalanced macrophage polarization. Wuwei Ganlu (WGL), a classical Tibetan topical formula, has been widely used in RA management.

Purpose: Nonetheless, the underlying mechanisms of WGL in protecting against RA and the bioactive components in WGL remain unclear.

Metabolomic insights into vitreous humor with therapy outcome in type 2 diabetic retinopathy.

Background: The therapeutic outcome for Type 2 Diabetic Retinopathy (T2DR) following vitrectomy has been unsatisfactory, with no definitive biomarker available to predict treatment response. Identifying a biomarker correlated with treatment efficacy is crucial, as the vitreous-situated between the lens and retina-may influence retinal metabolic perturbations.

Methods: Vitreous samples were collected during vitrectomy, and their metabolic profiles were analyzed using Ultraperformance Liquid Chromatography coupled with Tandem Mass Spectrometry (UPLC-MS/MS).