"Four-in-One" Strategy to Functionalize a Multiple Resonance Skeleton for Narrowband Ultrapure Green Emitters with Circularly Polarized Luminescence.

Novel chiral emitters are constructed using a "four-in-one" strategy through attachment of an octahydro-binaphthol unit onto a boron/nitrogen multiple resonance skeleton. They manifest ultrapure green emission peaking at 511 nm, a full width at half maximum of 22 nm, a Commission Internationale de l'Eclairage coordinate of 0.73, a small Δ of 0.

Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state.

The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In the present study, we demonstrate that dormant breast cancer cells lodged in the lungs reside in a highly mesenchymal, nonproliferative phenotypic state. The awakening of these cells is not triggered by a cancer cell-autonomous process.

Time series analysis between platelet counts and 60-day mortality in sepsis patients with thrombocytopenia: a retrospective cohort study.

Background: Thrombocytopenia is a prevalent complication and an adverse prognostic factor in sepsis; however, there is a paucity of studies examining the dynamic changes in platelet counts and their association with the prognosis of sepsis patients with related thrombocytopenia. This study aims to retrospectively to investigate the relationship between the dynamic trajectories of platelet counts and early adverse prognostic outcomes in such patients.

Methods: A retrospective observational study was conducted using data from 946 sepsis patients with thrombocytopenia extracted from the Medical Information Mart for Intensive Care (MIMIC-IV) database.

Inconsistent capacity of potential HONO sources to enhance secondary pollutants: Evidence from WRF-Chem modeling.

Nitrous acid (HONO) is a crucial source of OH radicals in the troposphere, significantly enhancing secondary pollutants like secondary organic aerosols (SOA) and peroxyacetyl nitrates (PAN). While prior research has examined HONO sources and their total impacts on secondary pollution, the specific enhancement capacity of each individual HONO source remains underexplored. This study uses observational data from 2015 to 2018 for HONO, SOA, and PAN across six sites in China, combined with WRF-Chem model adding six potential HONO sources to evaluate their capacity: traffic emissions (E_traffic), soil emissions (E_soil), indoor-outdoor exchange (E_indoor), nitrate photolysis (P_nit), and NO heterogeneous reactions on aerosol and ground surfaces (Het_a, Het_g).

3D Microporous Structure with Tunable Surface Roughness Enables Fast Bubble Dynamics for Efficient Water Splitting.

Water splitting serves as a cornerstone technology in modern energy conversion and storage systems. However, its industrial-scale implementation remains constrained by dynamic interfacial destabilization caused by intense bubble evolution under high current densities. Herein, a laser-assisted fabrication strategy is dveloped utilizing selective laser melting to construct 3D metallic electrodes with macro-micro synergetic architectures, enabled by precise laser energy density control for simultaneous optimization of water splitting and bubble transport dynamics.

Boosting Quantification of N-Glycans by an Enhanced Isobaric Multiplex Reagents for Carbonyl-Containing Compound (SUGAR) Tagging Strategy.

Glycans are complex molecules composed of various monosaccharides and exhibit diverse, branched polymer structures. Extensive research has been conducted on mass spectrometry (MS)-based qualitative and quantitative glycan analysis due to their critical biological functions. However, traditional data-dependent acquisition (DDA) in MS analysis primarily selects a limited subset of abundant ions during MS1 scans for fragmentation in subsequent MS2 stages.

Associations between an inflammatory diet index and nonunion: a prospective study of 172,839 UK biobank participants.

Purposes: This study utilizes prospective cohort data from the UK Biobank to investigate the association between the energy-adjusted dietary inflammation index (E-DII) and the development of fracture nonunion.

Methods: In this study, COX regression was used to analyze the correlation between E-DII and nonunion. Among 172,839 participants free of prior nonunion at baseline, 2,341 (1.

Radiotherapy combined with anlotinib in locoregional recurrent esophageal squamous cell carcinoma after radical surgery: a prospective, Phase II clinical trial.

Background: Chemoradiotherapy is less tolerable for postoperative locoregional recurrent esophageal squamous cell carcinoma (ESCC).

Methods: ESCC patients with three or fewer locoregional recurrent lesions after radical surgery were enrolled. Anlotinib (12 mg, d1-14) was administered with radiotherapy (50.

SeizeIT2: Wearable Dataset Of Patients With Focal Epilepsy.

The increasing technological advancements towards miniaturized physiological measuring devices have enabled continuous monitoring of epileptic patients outside of specialized environments. The large amounts of data that can be recorded with such devices hold significant potential for developing automated seizure detection frameworks. In this work, we present SeizeIT2, the first open dataset of wearable data recorded in patients with focal epilepsy.

Novel risk prediction model for major adverse cardiovascular events in minimally invasive mitral valve surgery: a retrospective study.

Background: Minimally invasive mitral valve surgery (MIMVS) has become the standard procedure for treating mitral valve pathologies. However, the existing cardiac risk model fails to consider the distinctive perfusion and ventilation techniques of MIMVS, leading to inaccurate prediction of perioperative risks. This study aimed to identify the perioperative risk factors for major adverse cardiovascular events (MACEs) in MIMVS and develop a predictive model based on these factors.

Laboratory Test of Industrial Waste Mud Treated by the Flocculation-Vacuum-Curing Integrated Method: Deep Dehydration and Preparation of Geopolymer Fluid Solidified Soil.

Resource reutilization of industrial waste mud has encountered challenges due to its high water content, enhanced fluidity, and inherent difficulty in segregating mud and water phases. The author first screened out efficient flocculants through flocculation dehydration tests and then adopted the technology of vacuum filtration combined with electroosmosis dehydration to conduct deep dehydration of waste mud. Among them, the independently designed vacuum filtration electroosmosis system effectively solves the problems of easy clogging and bending of the traditional system.

Research advances of amorphous metal oxides with the feature of Pseudocapacitance behavior in Lithium ion battery.

Amorphous metal oxides have emerged as a promising class of materials for advanced energy storage applications, owing to their unique structural characteristics including abundant defects/vacancies, highly permeable diffusion networks, and isotropic stress distribution. However, many studies have provided detailed descriptions and explanations of crystalline metal oxides, there is a lack of corresponding reviews on amorphous metal oxide materials, especially in terms of their applications in lithium-ion electrochemical energy storage and conversion. This comprehensive review systematically summarizes recent advancements in pseudocapacitive amorphous metal oxide anodes for high-performance lithium-ion batteries.

Rare Giant Cardiac Malignancy: Primary Cardiac Synovial Sarcoma.

We present a case of a primary cardiac synovial sarcoma, surrounding the right coronary artery and leaded to accelerate the blood flow of the tricuspid valve orifice.

Reprogramming of human urine cells into cardiomyocytes via a small molecule cocktail in xeno-free conditions.

Background: Cell therapy, particularly using cardiomyocytes, shows significant promise for treating heart failure. Direct reprogramming of somatic cells into cardiomyocytes using small molecules is advantageous due to its efficiency and cost-effectiveness.

Methods: Human urine-derived cells (hUCs) were transdifferentiated into functional cardiomyocyte-like cells (hCiCMs) using a cocktail of 15 small molecules under xeno-free conditions.

ERRα-Predictor: A Framework of Ensemble Models for Prediction of ERRα Binders, Antagonists, and Agonists Using Artificial Intelligence.

Estrogen-related receptor α (ERRα) is considered a promising target for the treatment of cancer and metabolic diseases. The development of comprehensive predictive models for ERRα binders, antagonists, and agonists is of significant importance. In this study, we collected and curated publicly available ERRα ligands from various databases (PubChem, ChEMBL, ExCAPE-DB, BindingDB, and IUPHAR).

Bio-Gel Formation Through Enzyme-Induced Carbonate Precipitation for Dust Control in Yellow River Silt.

This study explored the enzymatic formation of gel-like polymeric matrices through carbonate precipitation for dust suppression in Yellow River silt. The hydrogel-modified EICP method effectively enhanced the compressive strength and resistance to wind-rain erosion by forming a reinforced bio-cemented crust. The optimal cementation solution, consisting of urea and CaCl at equimolar concentrations of 1.

TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis.

Osteoarthritis (OA) is a degenerative disease with a series of metabolic changes accompanied by chondrocyte apoptosis. Chondrocytes express multiple receptors for neurotrophin, however, the role of neurotrophin receptor in chondrocyte metabolism remains unelucidated. Here, we first clarify the role of neurotrophin 3 (NT3) and its receptor tropomyosin receptor kinase C (TrkC) of chondrocytes in OA pathogenesis, using inducible TrkC-deficient mice (TrkC; Col2a1-CreER mice).

Different shapes of polylactic acid bioplastic initiate intestinal injury and gut microbiota dysbiosis of zebrafish.

Concerns about polylactic acid (PLA) bioplastic pollution have been growing, yet our understanding of how different shapes of PLA affect intestinal toxicity remains limited. In this study, four distinct shapes of PLA-film, fiber, particle and sphere-were prepared and exposed to zebrafish to investigate their effects. Results showed that PLA accumulation in the gut varied by shape, following film > fiber > particle > sphere.

NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition.

The human epidermal growth factor receptor 2 (HER2, also known as ERBB2) is a commonly over-expressed oncoprotein in oesophageal adenocarcinoma (OAC). Nonetheless, HER2-blocking agents have failed to significantly improve the outcome for OAC patients, despite achieving striking clinical success in breast cancer. To address this conundrum, we investigated how resistance progressively emerges when HER2 is targeted.

Association between Platelet Count and In-Hospital Mortality in Critical Patients with Multiple Myeloma: A Cohort Study.

Background: Multiple myeloma (MM) is a malignant blood disease characterized by the abnormal proliferation of immature plasma cells in the bone marrow. Changes in platelet counts (PLT) may significantly impact patient mortality. This study investigates the correlation between platelet counts and mortality rates in critically ill multiple myeloma patients admitted to the Intensive Care Unit (ICU).

AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition.

Debate regarding the premature aging of knee joints in acquired immune deficiency syndrome (AIDS) patients has remained contentious, with conjectures pointing towards its correlation with distinct antiviral regimes. Protease inhibitors (PIs) stand as a prominent class of antiviral agents frequently utilized in AIDS management and have been significantly linked to premature senescence. This study aimed to investigate whether PI-containing regimens would accelerate osteoarthritis (OA) development and explore the molecular mechanisms underlying this association.

Overexpression of colonic VIP ameliorates cognitive function and barrier system damage caused by sevoflurane anesthesia and surgery in aged rats with fragile brain functions.

Background: Surgery and anesthesia may compromise fragile brain function in the elderly, potentially precipitating cognitive decline or Alzheimer's disease (AD) following perioperative neurocognitive disorder (PND). Vasoactive intestinal peptide (VIP) exhibits anti-inflammatory properties via the gut-brain axis. Nevertheless, whether VIP regulation enhances cognitive function in the fragile brains of aged rat and the underlying mechanisms remain to be elucidated.

Liensinine Prevents Acute Myocardial Ischemic Injury via Inhibiting the Inflammation Response Mediated by the Wnt/β-Catenin Signaling Pathway.

Myocardial infarction (MI) is characterized by the sudden reduction in myocardial blood flow and remains the leading cause of death worldwide. Because MI causes irreversible damage to the heart, discovering drugs that can limit the extent of ischemic damage is crucial. Liensinine (LSN) is a natural alkaloid that has exhibited beneficial effects in various cardiovascular diseases, including MI; however, its molecular mechanisms of action remain largely unelucidated.

Emission characteristics of indoor HONO from residential natural gas cooking stoves in a household in Kunming, China.

Nitrous acid (HONO), a key precursor of hydroxyl radicals, significantly impacts outdoor and indoor air chemistry and poses health risks. Gas stove combustion is a major indoor HONO source, yet its emission factors (EFs) remain poorly quantified in China. This study quantified HONO emissions from natural gas (NG) stove combustion in a Kunming residential kitchen, yielding a HONO/NOx ratio of 5.