Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review.

Cancer is characterized by abnormal cell proliferation. Cyclins and cyclin-dependent kinases (CDKs) have been recognized as essential regulators of the intricate cell cycle, orchestrating DNA replication and transcription, RNA splicing, and protein synthesis. Dysregulation of the CDK pathway is prevalent in the development and progression of human cancers, rendering cyclins and CDKs attractive therapeutic targets.

Prevalence of stroke cognition and health literacy in high-risk populations in Chengdu: a community-based cross-sectional study.

Objective: The purpose of this study is to evaluate the awareness of stroke among high-risk populations in Chengdu and explore the factors contributing to it.

Methods: A cross-sectional study was conducted involving 360 individuals identified as being at high risk for stroke, recruited from four community health service centers in Chengdu. Participants were first screened for stroke risk using a technical plan, followed by an assessment of socio-demographic factors and health education status through a pre-designed structured interview questionnaire.

Emodin promotes GSK-3β-mediated PD-L1 proteasomal degradation and enhances anti-tumor immunity in hepatocellular carcinoma.

Background: Programmed death-ligand 1 (PD-L1), a prominent immune checkpoint, interacts with programmed death protein-1 (PD-1) on cytotoxic T cells within tumors and promotes immune evasion. Emodin, which is known to destabilize PD-L1 in breast cancer, has great potential for enhancing anti-tumor immunity. However, whether emodin can modulate PD-L1 levels in hepatocellular carcinoma (HCC) and enhance anti-tumor immune response remains unclear.

Radiotherapy combined with anlotinib in locoregional recurrent esophageal squamous cell carcinoma after radical surgery: a prospective, Phase II clinical trial.

Background: Chemoradiotherapy is less tolerable for postoperative locoregional recurrent esophageal squamous cell carcinoma (ESCC).

Methods: ESCC patients with three or fewer locoregional recurrent lesions after radical surgery were enrolled. Anlotinib (12 mg, d1-14) was administered with radiotherapy (50.

Baicalin promotes anti-tumor immunity in hepatocellular carcinoma through HIF-1α/Lactate/CXCL9 axis.

Low immune response is a hallmark of several solid tumors, including hepatocellular carcinoma (HCC), highlighting the urgent need for effective immunotherapeutic strategies. Baicalin, a bioactive ingredient derived from traditional Chinese medicine, has exhibited significant anti-tumor activity in various cancer types, yet its effects on anti-tumor immunity remain largely unclear. In this study, we investigated the immunomodulatory role of baicalin in HCC and elucidated its underlying mechanisms.

Intelligent Optimization Control of Plate Plan-View Pattern Based on Intermediate Slab Pattern Vision Inspection and BWO-DNN Algorithm.

In the production process of plate, the main factors affecting the yield of plate are the crop-cutting and edge losses. It is very important to accurately predict the crop pattern of plates and effectively control the plan-view pattern. In this paper, a detection scheme is proposed to obtain the plan-view pattern of the intermediate slab and finished plate by placing detection devices after the roughing mill and finishing mill, respectively.

Toxicity, bioaccumulation and metabolism of fluopyram in zebrafish (Danio rerio).

Fluopyram, a novel kind of succinate dehydrogenase inhibitor fungicides, has widespread utilized to control plant diseases or nematodes. However, the potential toxicity risks to non-target aquatic organisms of fluopyram have aroused wide concern. In this study, fluopyram was indicated as low toxic pesticide with 96 h LC to adult zebrafish of 17.

[Biejiajian Pill Regulates Ferroptosis in Hepatocellular Carcinoma Cells via p62/Keap1/NRF2 Signaling Pathway: A Mechanism Study].

Objective: To investigate the mechanism by which Biejiajian Pill (BJJP) regulates ferroptosis in hepatocellular carcinoma (HCC) cells through the p62/Keap1/NRF2 pathway and to provide an experimental basis for its application in the prevention and treatment of HCC.

Methods: Huh7 HCC cells were divided into a normal control group, a BJJP drug serum group, an erastin (a ferroptosis inducer) group, a BJJP drug serum + erastin group, and BJJP drug serum + ferrostatin-1 (Fer-1) (a ferroptosis inhibitor) group. BJJP drug serum was prepared with animals treated with BJJP and CCK-8 assay was performed to determine the optimal concentration and duration of BJJP intervention.

Prognostic analysis and identification of M7G immune-related genes in lung squamous cell carcinoma.

Background: In recent years, the clinical application of targeted therapies and immunotherapy has significantly improved survival outcomes for patients with lung adenocarcinomas(LUAD). However, due to fewer mutations, lung squamous cell carcinomas(LUSC) shows limited efficacy with targeted and immunotherapy, resulting in a notably lower 5-year survival rate compared to lung adenocarcinoma. The m7G modification plays an important role in tumorigenesis, progression, immune evasion, and therapeutic response.

Correlation Between the Quality of Life of Stroke Caregivers and the Readiness of Patients and Caregivers for Hospital Discharge.

Objective: This study aimed to evaluate the quality of life of stroke caregivers and analyze its association with the discharge readiness of both caregivers and patients.

Methods: A total of 302 stroke patients and their primary caregivers were recruited from the neurology departments of three hospitals affiliated with Chengdu Medical College using a convenience sampling method. Sociodemographic data, the WHO Quality of Life Scale (WHOQOL-BREF), the Caregiver Preparedness Scale (CPS), and the Readiness for Hospital Discharge Scale (RHDS) were used.

Rectangular Improvement Method for Plan View Pattern of Plates During the Angular Rolling Process.

The effect of the angular rolling process on the plan view pattern of a plate was studied, and the rectangular influencing factors and improvement methods for this process were proposed in this paper. DEFORM (v11.0) finite element software was used to simulate the processes of conventional rolling and angular rolling, and the degree of rectangularity of plates under different rolling process conditions was compared.

Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells.

The heterogeneity of endothelial cells (ECs) across human tissues remains incompletely inventoried. We constructed an atlas of > 210,000 ECs derived from 38 regions across 24 human tissues. Our analysis reveals significant differences in transcriptome, phenotype, metabolism and transcriptional regulation among ECs from various tissues.

Unlocking the Potential of Disulfidptosis-Related LncRNAs in Lung Adenocarcinoma: A Promising Prognostic LncRNA Model for Survival and Immunotherapy Prediction.

Objective: Disulfidptosis was stimulated in high SLC7A11 expression cells starving to glucose. We attempted to identify disulfidptosis-related lncRNAs (DRLs), built a prognostic model to predict survival, and analyzed the tumor microenvironment.

Methods: The TCGA database was utilized to procure the pertinent data.

Risk factors and prognostic factors of brain metastasis of triple-negative breast cancer: A single-center retrospective study.

Objective: This retrospective study is to explore the risk factors and prognostic factors of brain metastases of triple-negative breast cancer (TNBC) in a single center.

Methods: Clinical data of patients with stages I-III TNBC were collected. The Kaplan-Meier method, log-rank test, and stepwise COX regression were performed.

Exploring ICOPE's Impact on Delaying Elderly Disability Management.

The purpose of this study was to explore the initial benefits of introducing the ICOPE (Integrated care for older people) information assessment system for the management of hospitalized elderly patients in a teaching hospital in Eastern Taiwan. The ICOPE information assessment system was set up for case screening and abnormal referral through clinical ICOPE, followed by follow-up and case management. The results showed a total of 3424 screened cases, an average of 311 ICOPE screenings per month, an average of 48 abnormal screenings per month (15%), a referral rate of 79%, a rescreening rate of 91%, and a case management completion rate of 71%.

Development and Validation of a Nomogram for Predicting Nutritional Risk Based on Frailty Scores in Older Stroke Patients.

Background: In older stroke patients with frailty, nutritional deficiencies can amplify their susceptibility, delay recovery, and deteriorate prognosis. A precise predictive model is crucial to assess their nutritional risk, enabling targeted interventions for improved clinical outcomes.

Objective: To develop and externally validate a nutritional risk prediction model integrating general demographics, physical parameters, psychological indicators, and biochemical markers.

Covalent Organic Frameworks: Linkage Chemistry and Its Critical Role in The Evolution of π Electronic Structures and Functions.

Covalent organic frameworks (COFs) provide a molecular platform for designing a novel class of functional materials with well-defined structures. A crucial structural parameter is the linkage, which dictates how knot and linker units are connected to form two-dimensional polymers and layer frameworks, shaping ordered π-array and porous architectures. However, the roles of linkage in the development of ordered π electronic structures and functions remain fundamental yet unresolved issues.

Consolidation chemotherapy after definitive concurrent chemoradiotherapy in patients with inoperable esophageal squamous cell carcinoma: a multicenter non-inferiority phase III randomized clinical trial.

Background: Definitive concurrent chemoradiotherapy (dCCRT) is the gold standard for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC). However, the potential benefits of consolidation chemotherapy after dCCRT in patients with esophageal cancer remain debatable. Prospective randomized controlled trials comparing the outcomes of dCCRT with or without consolidation chemotherapy in patients with ESCC are lacking.

Multiomics Reveals Mechanisms of Inhibiting Pathogenic Fungi in .

Endophytic fungi can benefit the host plant and increase the plant resistance. Now, there is no in-depth study of how () is enhancing the ability of inhibiting pathogenic fungi in (). In this study, the fungal community and metabolites associated with endophyte-infected (EI) and endophyte-free (EF) were compared by multiomics.

Combining microbiome and pseudotargeted metabolomics revealed the alleviative mechanism of Cupriavidus sp. WS2 on the cadmium toxicity in Vicia unijuga A.Br.

Cadmium (Cd) pollution is one of the most severe toxic metals pollution in grassland. Vicia unijuga (V. unijuga) A.

Prediction models for post-thrombectomy brain edema in patients with acute ischemic stroke: a systematic review and meta-analysis.

Objective: The objective of this study is to systematically evaluate prediction models for post-thrombectomy brain edema in acute ischemic stroke (AIS) patients. This analysis aims to equip clinicians with evidence-based guidance for the selection of appropriate prediction models, thereby facilitating the early identification of patients at risk of developing brain edema post-surgery.

Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, Embase, The Cochrane Library, CNKI, Wanfang, and Vip, aiming to identify studies on prediction models for post-thrombectomy brain edema in AIS patients up to January 2023.

New-designed measurement device for radon and thoron activity concentration based on gas direct detection.

A new-designed measurement device for radon and thoron activity concentration is developed based on gas direct measurement to support their in-situ calibration. It consists of a 2000 mm Passivated Implanted Planar Silicon (PIPS) detector, a Multi-Channel Analyzer (MCA), a Micro Controller Unit (MCU), and a small electrostatic chamber with a volume of nearly 23 ml. The device records those alpha particles emitted from radon and thoron gas, and the detection efficiency and the crosstalk factor of Po/Po are determined by Monte Carlo simulation.

Molecular regulatory mechanisms of erythropoiesis and related diseases.

The metabolism of cells and blood circulation allow for the constant production and destruction of red blood cells. Erythrocyte formation allows red blood cells to regenerate, which is crucial for maintaining the equilibrium of the organism. Erythrocyte formation is a multi-step, intricate process with distinct structural and functional characteristics at each stage.

Paeoniflorin Coordinates Macrophage Polarization and Mitigates Liver Inflammation and Fibrogenesis by Targeting the NF-[Formula: see text]B/HIF-1α Pathway in CCl-Induced Liver Fibrosis.

Liver fibrosis is a disease largely driven by resident and recruited macrophages. The phenotypic switch of hepatic macrophages can be achieved by chemo-attractants and cytokines. During a screening of plants traditionally used to treat liver diseases in China, paeoniflorin was identified as a potential drug that affects the polarization of macrophages.

Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling.

Hepatocellular carcinoma (HCC) is a common malignancy affecting many people worldwide. Baicalin is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi. It can effectively inhibit the occurrence and development of HCC.