Initial misdiagnosis of gastritis cystica profunda: Two case reports.

Background: Gastritis cystica profunda (GCP) is a rare gastric disorder. It is characterized by non-specific symptoms and diagnostic complexity. This case report enriches the medical literature by highlighting challenges in diagnosing and treating GCP.

Discovery and Characterization of Novel FGFR1 V561M Inhibitors via Virtual Screening and Molecular Dynamics Simulations.

The FGFR1 V561M mutation significantly reduces the efficacy of current FGFR1 inhibitors, creating an urgent need for targeted second-generation therapies. In this study, we developed a comprehensive virtual screening protocol that combines energy-based screening and machine learning techniques, leading to the identification of a novel compound, . This compound exhibited potent inhibitory activity against FGFR1 V561M with an IC of 90.

m6A Modified-CYP1B1 Promotes HCC Cell Proliferation by Inhibiting Ferroptosis.

Introduction: CYP1B1, a crucial drug-metabolizing enzyme, metabolizes both endogenous compounds and clinical drugs. The present study investigated the effects of CYP1B1 on the proliferation, migration, apoptosis, and ferroptosis of HCC cells. It further elucidated the regulatory role of m⁶A modification, particularly via the methyltransferase METTL14-in regulating CYP1B1 mRNA stability and translation efficiency.

Doxycycline post-exposure prophylaxis in China: current utilized situation among men who have sex with men in a cross-sectional online survey from two cites.

Background: Doxycycline post-exposure prophylaxis (Doxy-PEP) represents an emerging strategy for STI prevention. Self-administered use of Doxy-PEP has been empirically observed among men who have sex with men (MSM) in some countries, while little is known about current use of it in the Chinese population.

Methods: An online survey was conducted among MSM in two cities in China.

Radiotherapy combined with anlotinib in locoregional recurrent esophageal squamous cell carcinoma after radical surgery: a prospective, Phase II clinical trial.

Background: Chemoradiotherapy is less tolerable for postoperative locoregional recurrent esophageal squamous cell carcinoma (ESCC).

Methods: ESCC patients with three or fewer locoregional recurrent lesions after radical surgery were enrolled. Anlotinib (12 mg, d1-14) was administered with radiotherapy (50.

Inhibition of CYP1B1 by miR-200b-3p increases the sensitivity of paclitaxel in hepatocellular carcinoma treatment.

Liver cancer ranks as the third leading cause of cancer-related death worldwide, with hepatocellular carcinoma (HCC) accounting for approximately 90 % of primary liver cancer cases. Elevated expression of drug-metabolizing enzyme CYP1B1 in HCC has been identified as a potential contributor to primary paclitaxel (PTX) resistance. This study demonstrated that miR-200b-3p suppresses CYP1B1 expression in HCC cells.

Identification of an individualized immune-related miRNA pair signature for survival prediction of neoadjuvant chemoradiotherapy in esophageal squamous cell cancer.

Background: Immune-related microRNAs (ImiRNAs) have emerged as potential biomarkers owing to their universality and tissue-specificity. Although neoadjuvant chemoradiotherapy (NCRT) has been incorporated into standardized guidelines for esophageal squamous cell carcinoma (ESCC), its efficacy is hindered by tumor and individual heterogeneity. This study aimed to develop a specific ImiRNA pair signature to predict the long-term survival benefits of NCRT for ESCCs.

Activation of Kir4.1 Channels by 2-D08 Promotes Myelin Repair in Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory disease that leads to myelin loss and neurological dysfunction. Clinical studies show increased anti-Kir4.1 antibody levels in MS patients' serum, indicating its diagnostic potential.

SPOCK2 promotes the invasion and migration of ovarian cancer cells through FAK signaling pathway.

Objective: Ovarian cancer is one of the most prevalent malignancies worldwide, with the highest mortality rate among gynecological cancers. This study aims to investigate the molecular mechanisms of SPOCK2 in ovarian cancer progression and metastasis and evaluate its potential as a therapeutic target.

Methods: The expression levels of SPOCK2 in ovarian cancer tissues and normal tissues were analyzed using data from The Cancer Genome Atlas (TCGA) and immunohistochemistry experiments.

[Transcriptomic analysis of key genes involved in sex differences in intellectual development].

Intelligence encompasses various abilities, including logical reasoning, comprehension, self-awareness, learning, planning, creativity, and problem-solving. Extensive research and practical experience suggest that there are sex differences in intellectual development, with females typically maturing earlier than males. However, the key genes and molecular network mechanisms underlying these sex differences in intellectual development remain unclear.

Preoperative prediction of microvascular invasion and relapse-free survival in hepatocellular Carcinoma ≥3 cm using CT radiomics: Development and external validation.

Objective: To preoperatively predict microvascular invasion (MVI) and relapse-free survival (RFS) in hepatocellular carcinoma (HCC) ≥3 cm by constructing and externally validating a combined radiomics model using preoperative enhanced CT images.

Methods: This retrospective study recruited adults who underwent surgical resection between September 2016 and August 2020 in our hospital with pathologic confirmation of HCC ≥3 cm and MVI status. For external validation, adults who underwent surgical resection between September 2020 and August 2021 in our hospital were included.

Proteomics and lipidomics of human umbilical cord mesenchymal stem cells exposed to ionizing radiation.

Objectives: Mesenchymal stem cell (MSC)-based therapies exhibit beneficial effects on various forms of tissue damage, including ionizing radiation-induced lesions. However, whether ionizing radiation affects the functions of human umbilical cord mesenchymal stem cells (hucMSCs) remains unclear. This study aimed to investigate the effect and possible mechanisms of ionizing radiation on the proliferation and differentiation of hucMSCs.

A Technologist's Vigilance: Identifying and Correcting a Cotton Ball-Induced MRI Artefact to Prevent Misdiagnosis in Pediatric Patients.

Wrap-around artefacts in magnetic resonance imaging (MRI) are common, typically caused by anatomical structures outside the Field of View (FOV) overlapping into the imaging area. This paper reports a rare source of wrap-around artifact, a wet cotton ball, whose image was inadvertently included in cranial imaging, potentially leading to misdiagnosis as pathological conditions such as otomastoiditis, postoperative changes, or intracranial hemorrhage. Hence, there is a need to enhance MRI technologists' awareness of such artifacts.

Flagellin FlaB3 Activates Inflammation and Inhibits Autophagy in HMC3 Cells via the TLR4 Pathway.

Neurosyphilis, a neurological manifestation of syphilis, is closely related to neuroinflammation. Autophagy, a fundamental cellular mechanism that mediates the degradation of intracellular components, plays a crucial role in immune regulation and inflammation. Microglia, resident immune cells in the brain, are central to these processes.

What Is the Optimal Position of Low Tibial Tunnel in Transtibial Posterior Cruciate Ligament Reconstruction? A Quantitative Analysis Based on 2D CT Images and 3D Knee Models.

Objectives: There is currently no consensus on the optimal placement of the low tibial tunnel for posterior cruciate ligament (PCL) reconstruction. This study aimed to perform the quantitative measurements of the optimal tangential low tibial-tunnel (OTLT) parameters based on 2D CT images and 3D virtual knee models and expect to provide reference data for clinical creation of the OTLT during the arthroscopic transtibial PCL reconstruction.

Methods: This was a retrospective CT image study.

Clinical features and outcomes of unresectable locally advanced lung adenocarcinoma with uncommon mutations: a retrospective multi-center Chinese study.

Background: Uncommon epidermal growth factor receptor () gene mutant locally advanced non-small cell lung cancer (NSCLC) has been poorly documented in the literature. Our study aimed to investigate the clinical features and outcomes associated with these mutations.

Methods: A multi-center retrospective study was conducted to review 511 patients with mutant unresectable stage III lung adenocarcinoma, treated between 2012 and 2018 across 12 Chinese institutions.

FHL1 as a prognostic biomarker and therapeutic target in acute promyelocytic leukaemia.

Acute myeloid leukemia (AML) has a poor prognosis and high heterogeneity. Most cases of leukemias are caused by environmental factors interacting with the cell's genetic material, but treatment is still dominated by cell cycle drugs. Therefore, there is an urgent need to find reliable biomarkers.

Regulating Organic Modifiers on Metal-Based Catalysts for Enhanced Electrocatalytic CO Reduction.

Electrochemical CO reduction reaction (CORR) has been proved as a promising pathway for valuable chemical production and sustainable carbon cycling. Various regulatory strategies have been explored to boost CORR performance. Among these, metal-based electrocatalytic CORR systems regulated by organic modifiers have been shown to play a pivotal role in regulating the complex catalytic processes.

Diagnostic features of pediatric testicular yolk sac tumors: a 13-year retrospective analysis.

Background: Testicular yolk sac tumor (YST) is a rare neoplasm with limited practical guidance for preoperative diagnostic assessment. This study aims to conduct a retrospective analysis of the value of clinical profiles and MRI parameters in accurately diagnosing pediatric testicular YST while exploring characteristic indicators for these patients.

Methods: This retrospective study analyzed eighty patients with a testicular mass who underwent surgical treatment and preoperative MRI.