Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction.

Heart failure with preserved ejection fraction (HFpEF) is a prevalent complex syndrome characterized by diastolic dysfunction with limited therapeutic options. While the renin-angiotensin system (RAS) is implicated in heart failure pathogenesis, the causal contribution of angiotensinogen (AGT), the unique precursor of the RAS, to HFpEF remains undefined. Using a two-hits mouse HFpEF model (high-fat diet + L-NAME), consistent upregulation of hepatic and plasma AGT  is identified in wild-type mice of both sexes.

Investigating the Function of TaUBX57 in Enhancing Abiotic Stress Tolerance in Wheat.

Wheat ( L.), a crucial global food crop, provides approximately 20% of daily protein and caloric intake globally. However, its production is increasingly threatened by abiotic stressors, especially drought and salinity, which are exacerbated by climate change.

Study on the residual dynamics of diazepam in freshwater fish of Zhejiang, China and its implications for human health.

This study provides an in-depth evaluation of diazepam (DZP) and its metabolites in freshwater fish from Zhejiang Province, China, during 2020-2024, with a focus on contamination trends, source attribution, bioaccumulation behavior, and potential human health risks. The results reveal a significant upward trend in DZP detection, rising from 0.33 % to 4.

Trends in the prevalence of steatotic liver disease among Chinese adults, 2015-2023: A nationwide cross-sectional study.

Background: Metabolic dysfunction-associated fatty liver disease and steatotic liver disease (SLD) have emerged as one of the fastest-growing liver complications over recent decades; this study evaluated trends in SLD prevalence among Chinese adults and its variation across demographic groups.

Methods: A multicenter, retrospective study analyzed health examination data from 600,536 Chinese adults across 10 provinces between 2015 and 2023. Participants (≥18 y) with complete data on age, sex, weight, waist circumference, ultrasound, and biochemical tests were included.

Liquid-Solid Interface Reactions Drive Enhanced Thermoelectric Performance in AgSe.

AgSe is a promising n-type thermoelectric material, but its performance is limited by excessive carrier concentration, compositional inhomogeneity, and phase instability, challenges rooted in a narrow homogeneity range and uncontrolled Ag diffusion in the superionic phase. Here, we address these issues by exploiting liquid-solid interface reactions using CdSe complexes that remove surface excess Ag to yield stoichiometric AgSe and generate CdSe nanodomains that inhibit Ag diffusion and constrain grain growth. The resulting AgSe-CdSe nanocomposites exhibit a reproducible, stable figure of merit () of 1.

CuSbSe-Alloying-Induced High Thermoelectric Performance and Mechanical Robustness in BiTe-Based Thermoelectric Materials.

BiTe-based thermoelectric materials remain the only commercially viable candidates for low-grade waste heat recovery. However, their moderate thermoelectric performance and limited mechanical robustness constrain broader industrial applications. Here, a synergistic enhancement of both the thermoelectric and mechanical properties of BiSbTe is demonstrated by alloying with CuSbSe via high‑energy ball milling followed by hot pressing.

Fabrication and Characterization of Electrospun PCL/GelMA Composite Scaffolds for Muscle Tissue Engineering.

Background: Muscle tissue engineering seeks to develop biomimetic scaffolds capable of restoring or replacing damaged muscle by promoting cell alignment, proliferation, and differentiation within a controlled microenvironment. This study presents a novel hybrid scaffold combining electrospun polycaprolactone (PCL) fibers with gelatin methacryloly (GelMA) hydrogel. The scaffold integrates the topographical guidance of aligned PCL fibers with the supportive 3D matrix of GelMA to promote muscle tissue formation.

Room temperature quantum metric effect in TbMnSn.

Quantum geometry, including Berry curvature and the quantum metric, of the electronic Bloch bands has been studied via nonlinear responses in topological materials. Naturally, these material systems with intrinsic strong nonlinear responses also form the key component in nonlinear electronic devices. However, the previous reported quantum geometry effects are mainly observed at cryogenic temperatures, hindering their application in practical devices.

Mechanism-Guided Thermoelectric Strategies for Smart Fire Prevention.

Fire prevention and early warning systems are essential to minimize fire risks. Thermoelectric (TE) materials that convert temperature gradients into electrical signals offer a promising pathway for designing self-powered fire-warning technologies and devices; however, their practical applications are often impeded by their low output power, inefficient charge transport, and poor interfacial compatibility. Despite several relevant reviews focusing on material types, it has remained underexplored from a mechanism-driven perspective to enhance the fire prevention performance of TE strategies to date.

Serum Pharmacology Combined with Network Pharmacology Reveals the Effects and Mechanisms of Ganmai Dazao Decoction in the Treatment of Depression.

Ganmai Dazao Decoction (GMZ) is a famous classic traditional Chinese medicine compound prescription for the treatment of depression and has a good clinical effect. However, its specific components and molecular mechanisms are still unclear. The chronic unpredictable mild stress (CUMS) mouse model was employed in this study, and the antidepressant effect of GMZ was evaluated via behavioral and serum corticosterone level assessment.

Characterization and functional evaluation of JS207, a novel bispecific antibody against human PD-1 and VEGFA.

Introduction: Cancer immunotherapy has been revolutionized by targeting PD-1 to restore antitumor T-cell activity and blocking VEGF to attenuate immunosuppressive tumor angiogenesis. While combining PD-1 and VEGF inhibition has shown promise in enhancing antitumor responses, co-administration of two or more monoclonal antibodies face several challenges, including distinct pharmacokinetics, complex dosing, and toxicity. A bispecific antibody (BsAb) targeting both PD-1 and VEGF pathways could overcome these limitations by enabling simultaneous, localized blockades of PD-1 and VEGF signaling within the tumor microenvironment (TME) as both PD-1 and VEGF are usually co-expressed in the TME.

Smart traceable framework for transportation of transplantable organs using IPFS, iot, and smart contracts.

Existing organ transportation management systems face significant limitations as they do not allow patients to monitor the condition of the transplantable organ during its transportation from the donor's place to the recipient's venue. This undermines patients' confidence that the organ allotted to them remains uncontaminated, healthy, and unaffected by fluctuations in parameters including temperature, humidity, and the container's vibration, and orientation. Additionally, there is a lack of technology to ensure that the organ container remains securely closed throughout the shipment.

Commentary: Real-World Insights into Adjuvant Immunotherapy after Esophagectomy.

See Article page 134.

Augmented electronic metal-support interaction of single-atomic NiNC supported PtRu nanoalloys and their boosted activity and durability for hydrogen evolution and oxygen reduction reactions in both alkaline and acidic media.

PtRu nanoalloys anchored on conductive carbon supports have attracted attention for their promising hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) electrocatalytic activity, holding significant promising applications in hydrogen fuel cells, it is still challenging to develop highly efficient and durable catalysts for catalyzing HER/ORR in both alkaline and acidic media. However, it is still challenging to develop highly active and durable catalysts toward HER and ORR in both alkaline and acidic media. In this work, PtRu nanoalloys are uniformly anchored onto the surface of Ni single atoms embedded porous nitrogen carbon (NiNC) via a simple annealing approach.

Construction of Graphene Oxide Probes Loaded with Antisense Peptide Nucleic Acid and Doxorubicin for Regulating Telomerase Activity and Inducing Apoptosis of Cancer Cells.

In this study, we developed a multifunctional graphene oxide (GO)-based nanoprobe co-loaded with antisense peptide nucleic acid (PNA) and the chemotherapeutic agent doxorubicin (DOX). The nanoplatform was strategically functionalized with folic acid ligands to enable folate receptor-mediated tumor targeting. Upon cellular internalization, the antisense PNA component selectively hybridized with human telomerase reverse transcriptase (hTERT) mRNA through sequence-specific recognition, inducing structural detachment from the GO surface.

Magnetic Field-Driven Catalysis: Revealing Enhanced Oxygen Reactions in Li-O Batteries Using Tailored Magnetic Nanocatalysts.

Lithium-oxygen (Li-O) batteries offer immense promise for next-generation energy storage technology due to their ultra-high theoretical energy density. However, their adoption faces challenges like large overpotential and slow oxygen reaction kinetics. This study introduces a novel strategy that leverages custom-designed magnetic nanocatalysts and external magnetic fields to boost electrochemical performance.

A Pooled Analysis of Datopotamab Deruxtecan in Patients With EGFR-Mutated NSCLC.

Background: This exploratory analysis assessed datopotamab deruxtecan (Dato-DXd) in pretreated patients with advanced or metastatic NSCLC and EGFR mutations.

Methods: Data were pooled from the phase II TROPION-Lung05 (NCT04484142) and phase III TROPION-Lung01 (NCT04656652) trials. Patients with EGFR-mutated advanced or metastatic NSCLC, who had received previous targeted therapies and platinum-based chemotherapy, received Dato-DXd 6 mg/kg (TROPION-Lung05) or were randomized to Dato-DXd 6 mg/kg or docetaxel 75 mg/m (TROPION-Lung01) once every 3 weeks.

Navigating advanced lung cancer care, patient-physician alliance, cancer stigma, and psychosocial support in Asia-Pacific: perspectives from patients, caregivers, and physicians.

Background: Factors influencing holistic lung cancer care among advanced/metastatic non-small cell lung cancer (NSCLC) patients in Asia-Pacific are understudied. We identified gaps in lung cancer care from patients, caregivers, and physicians in Australia, Japan, Mainland China, South Korea, and Taiwan.

Methods: Qualitative interviews and quantitative surveys were conducted among NSCLC patients with limited targeted treatment options, caregivers, and physicians.

Exhale-Focused Thermal Image Segmentation Using Optical Flow-Based Frame Filtering and Transformer-Aided Deep Networks.

Since the COVID-19 pandemic, interest in non-contact diagnostic technologies has grown, leading to increased research into remote biosignal monitoring. The respiratory rate, widely used in previous studies, offers limited insight into pulmonary volume. To redress this, we propose a thermal imaging-based framework for respiratory segmentation aimed at estimating non-invasive pulmonary function.

Mesoporous FeO Nanoparticles Loaded with IR-820 for Antibacterial Activity via Magnetic Hyperthermia Combined with Photodynamic Therapy.

The formation of bacterial biofilms presents a major challenge in infection treatments. Antimicrobial photodynamic therapy (aPDT) typically employs photosensitizers to generate reactive oxygen species (ROS) under irradiation, causing oxidative damage to both bacteria and biofilms. While prior studies have explored the integration of PDT with various other approaches, magnetic hyperthermia therapy (MHT) has not adequately addressed.

Combined compression and encryption of linear wireless sensor network data using autoencoders.

In a linear wireless sensor network (LWSN), sensor nodes are deployed in a linear fashion to monitor and gather data along a linear path or route. Generally, the base station collects the data from the contiguously placed nodes in the same order. When the sensors are deployed closely and with a gradual variation of sensor data along the route, a high degree of correlation exists among the sensed data.

From Sensors to Care: How Robotic Skin Is Transforming Modern Healthcare-A Mini Review.

In recent years, robotics has made notable progress, becoming an essential component of daily life by facilitating complex tasks and enhancing human experiences. While most robots have traditionally featured hard surfaces, the growing demand for more comfortable and safer human-robot interactions has driven the development of soft robots. One type of soft robot, which incorporates innovative skin materials, transforms rigid structures into more pliable and adaptive forms, making them better suited for interacting with humans.

Safety Evaluation of Contezolid (MRX-I) Versus Linezolid in Sprague-Dawley Rats.

Background & Objectives: Contezolid (MRX-I) is a novel ortho-fluorophenyl dihydropyridone developed by MicuRx Pharmaceuticals, Inc. It has been approved for the treatment of drug-resistant Gram-positive bacterial infections with relatively lower toxicity than other oxazolidinones such as linezolid. However, the toxicity profile has not yet been completely revealed.