Experiences of complete decongestive therapy for patients with lower limb lymphedema: A descriptive phenomenological study.

Background: Lower limb lymphedema can cause significant physical and psychological distress. Complete decongestive therapy is recognized as the gold standard for non-surgical management of this condition. However, the lived experiences of patients undergoing complete decongestive therapy have been largely overlooked in existing research.

Covalent Organic Framework-Derived Ion-Sieving Channels Enabling Stable Lithium Metal Anodes through Interfacial Engineering and Solvation Structure Modulation.

Lithium metal anodes, despite their ultrahigh capacity, suffer from severe interfacial instability due to uncontrolled parasitic reactions and dendritic growth, limiting practical applications. Herein, a 2D covalent organic framework (NUS-9) synthesized via cryogenic interfacial growth was engineered into a NUS-9@PP composite separator to enhance lithium metal battery performance. Its unique layered architecture establishes vertically aligned Li transport channels with ion-sieving functionality, while lithiophilic polar groups regulate Li solvation structures, suppressing electrolyte-Li parasitic reactions.

Anti-tumor immune modulation and favorable survival outcomes in uterine corpus endometrial carcinoma: insights from PIK3CA/ARID1A co-mutation analysis.

Background: Uterine corpus endometrial carcinoma (UCEC) is the most prevalent cancer of the female reproductive system, posing significant risks to women's reproductive health and imposing considerable economic burdens on families and society due to high treatment costs.

Methods: The study population comprised 529 UCEC patients who were selected and retrieved from the cBioPortal public database for a comprehensive integrated analysis. This study aims to explore the prognostic significance of co-mutation in PIK3CA/ARID1A genes in UCEC, utilizing various bioinformatics approaches, including differential expression genes (DEGs) analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, Gene Set Enrichment Analysis (GSEA), immune infiltration analysis, and the establishment of nomogram model.

Proteomics and lipidomics of human umbilical cord mesenchymal stem cells exposed to ionizing radiation.

Objectives: Mesenchymal stem cell (MSC)-based therapies exhibit beneficial effects on various forms of tissue damage, including ionizing radiation-induced lesions. However, whether ionizing radiation affects the functions of human umbilical cord mesenchymal stem cells (hucMSCs) remains unclear. This study aimed to investigate the effect and possible mechanisms of ionizing radiation on the proliferation and differentiation of hucMSCs.

Enhancing the Protein Stability of an Anticancer VHH-Fc Heavy Chain Antibody through Computational Modeling and Variant Design.

VHHs (also known as nanobodies) are important therapeutic antibodies. To prolong their half-life in bloodstream, VHHs are usually fused to the Fc fragment of full-length antibodies. However, stability is often the main challenge for their commercialization, and methods to improve stability are still lacking.

High-Molecular-Weight Biodegradable CO/Propylene Oxide/Epichlorohydrin Terpolymers with Outstanding Gas Barrier Performance Synthesized Using an Organoboron Catalyst.

As the sole commercial polycarbonate derived from CO, poly(propylene carbonate) (PPC) is still hindered by poor thermal stability and a low glass transition temperature. Herein, first, the terpolymerization of CO, propylene oxide (PO), and epichlorohydrin (ECH) to synthesize PPC-ECH terpolymers via one-pot and metal-free method using multinuclear organoboron catalysts is reported. The PPC-ECH terpolymers with well-rounded properties can be easily synthesized by adjusting reaction conditions, monomer ratios, catalyst types, and loading.

Comprehensive bioinformatics analysis of co-mutation of and reveals prognostic effect and influences on the immune infiltration in ovarian serous cystadenocarcinoma.

Background: Ovarian cancer remains one of the most lethal gynecological malignancies, characterized by late-stage diagnosis and high rates of recurrence. The present study aims to explore the prognostic and immunological implications of and , the two genes exhibiting a high mutation frequency across various cancer types, in the context of ovarian serous cystadenocarcinoma (OV).

Methods: The study systematically analyzed and discussed the potential implications of co-mutation of and on prognosis and immune response using a cohort of 585 ovarian cancer samples.

Yersiniabactin produced by promotes intestinal inflammation through lipid peroxidation and ferroptosis.

(), a major foodborne pathogen, poses significant risks to public health by causing gastrointestinal diseases. Among its virulence factors, Yersiniabactin (Ybt), a siderophore, plays a crucial role in iron acquisition and enhancing intestinal colonization. Despite previous studies highlighting -Ybt's involvement in inflammation, its exact mechanisms remain unclear.

New insights into nitrate sources and transformations in riparian groundwater of a sluice-controlled river: An integrated approach using major ions, stable isotopes and microbial gene methods.

Nitrate pollution in water environment is a serious problem worldwide. Identifying nitrate sources and transformations in the riparian aquifer is critical for effectively controlling and mitigating nitrate contamination, especially in sluice-controlled rivers. This study employs an integrated approach combining hydrochemical analysis, isotopes (δO-HO, δH-HO, δN-NO and δO-NO), quantification of nitrogen (N) functional genes and a Bayesian mixing model (MixSIAR) to comprehensively investigates nitrate sources and transformation processes in the riparian groundwater of a sluice-controlled Shaying River, China.

Efficient and green extraction of chitin from Hermetia illucens using deep eutectic solvents and its application for rapid hemostasis.

Hermetia illucens, with a short growth cycle, is promising as a valuable source of chitin. However, the optimal method for extracting chitin from this insect and its application for hemostasis has not been addressed. This work employed an environmentally friendly choline chloride-lactic acid deep eutectic solvent technology to extract chitin effectively from the Hermetia illucens pupae shells, realizing one-step removal of inorganic salts and proteins.

One-sided device-independent random number generation through fiber channels.

Randomness is an essential resource and plays important roles in various applications ranging from cryptography to simulation of complex systems. Certified randomness from quantum process is ensured to have the element of privacy but usually relies on the device's behavior. To certify randomness without the characterization for device, it is crucial to realize the one-sided device-independent random number generation based on quantum steering, which guarantees security of randomness and relaxes the demands of one party's device.

Cyano and Fluorine-Enhanced Copolymer Electrolytes: Synergistically Boosting High-Voltage Lithium Metal Batteries.

In high-voltage lithium metal batteries, designing electrolytes with low salt concentrations to achieve stable electrode interfaces presents a formidable challenge. High-concentration electrolytes stabilize the interface through an anion-derived LiF-rich interphase; however, their anion-rich solvation structures compromise the ionic conductivity. This study introduces a polymer-derived interphase that maintains interface stability at low lithium salt concentrations (∼1 M).

Occurrence, migration, and assessment of human health and ecological risks of PFASs and EDCs in groundwater of Northeast China.

Northeast China as an important base of grain production in China, has been suffering from potential groundwater pollution due to the excessive and prolonged application of fertilizers and pesticides. However, exploration of emerging contaminants pollution in groundwater and assessment of human health and ecological risks caused by large-scale agricultural activities have been relatively scarce. This study collected groundwater samples from typical agricultural areas in Northeast China to investigate the extent of contamination by nitrate, per- and polyfluoroalkyl substances (PFASs) and endocrine-disrupting compounds (EDCs), and then compared the levels of these pollutants with those in other regions of China.

One-pot synthesis of crystalline polycarbonate--polyesters.

We herein describe a simple and efficient one-pot synthesis approach to prepare crystalline polycarbonate-polyester diblock copolymers by copolymerizing tetrachlorophthalic anhydride, CO, and ethylene oxide using a metal-free catalyst. The block copolymers possess a melting point as high as 169 °C and two distinct glass transition temperatures. It is also possible to control the length and composition of the copolymers, thereby customizing their crystallinity and physical performance.

Effects of Postharvest SO Treatment on Longan Aril Flavor and Glucosinolate Metabolites.

SO fumigation treatment (commonly known as sulfur treatment, ST) is a key method in the postharvest preservation of imported and exported fresh longan fruits, effectively reducing pericarp browning and enhancing color. Nonetheless, distinctive aromas, often referred to as "sulfur flavor", may develop in the aril during the extended preservation period. This study employed "Caopu" longan as the test material and patented SO-releasing paper (ZL201610227848.

Zinc Oxide Nanoparticles Treatment Maintains the Postharvest Quality of Litchi Fruit by Inducing Antioxidant Capacity.

Pericarp browning and fruit decay severely reduce the postharvest quality of litchi. Improving the antioxidant capacity of the fruit is an effective way to solve these problems. In our study, the appropriate zinc oxide nanoparticles (ZnO NPs) treatment and its mechanism of action on the storability of litchi was investigated.

The role of in liver cancer: a bioinformatics analysis.

Background: Liver hepatocellular carcinoma (LIHC) is a prevalent malignancy globally, exhibiting substantial incidence and mortality rates. Early diagnosis and prevention of metastasis are crucial for the benefit of patients with liver cancer. The present study aimed to elucidate the involvement of in liver cancer through the utilization of bioinformatics.

Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors.

Chronic stress often has deleterious effects leading to the development of psychiatric diseases. The gut-brain axis represents a novel avenue for stress research. The negative effects of stress on the gut physiology have been well-described, whereas the pathways whereby stress controls microbial composition to modulate behaviors remains mainly unknown.

Strategies for Mitigating Phosphoric Acid Leaching in High-Temperature Proton Exchange Membrane Fuel Cells.

High-temperature proton exchange membrane fuel cells (HT-PEMFCs) have become one of the important development directions of PEMFCs because of their outstanding features, including fast reaction kinetics, high tolerance against impurities in fuel, and easy heat and water management. The proton exchange membrane (PEM), as the core component of HT-PEMFCs, plays the most critical role in the performance of fuel cells. Phosphoric acid (PA)-doped membranes have showed satisfied proton conductivity at high-temperature and anhydrous conditions, and significant advancements have been achieved in the design and development of HT-PEMFCs based on PA-doped membranes.

Self-Healable, Transparent, Biodegradable, and Shape Memorable Polyurethanes Derived from Carbon Dioxide-Based Diols.

A series of CO-based thermoplastic polyurethanes (TPUs) were prepared using CO-based poly(polycarbonate) diol (PPCDL), 4,4'-methylenebis (cyclohexyl isocyanate) (HMDI), and polypropylene glycol (PPG and 1,4-butanediol (BDO) as the raw materials. The mechanical, thermal, optical, and barrier properties shape memory behaviors, while biocompatibility and degradation behaviors of the CO-based TPUs are also systematically investigated. All the synthesized TPUs are highly transparent amorphous polymers, with one glass transition temperature at ~15-45 °C varying with hard segment content and soft segment composition.

A study on the correlation between hyperuricemia and TG/HDL-c ratio in the Naxi ethnic group at high-altitude regions of Yunnan.

Objective: The study aimed to explore the risk factors for hyperuricemia (HUA) in the Naxi ethnic population residing in high-altitude areas of Yunnan, China, and assess the clinical value of the triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio as a diagnostic marker.

Methods: In this cross-sectional study, clinical data were collected from the health checkup population in the People's Hospital of Yulong Naxi Autonomous County, Yunnan Province, from January 2021 to January 2023. Participants were divided into quartiles based on the TG/HDL-c ratio (Q1, Q2, Q3, and Q4) for group analysis using chi-square tests, -tests, and rank sum tests.