Emodin promotes GSK-3β-mediated PD-L1 proteasomal degradation and enhances anti-tumor immunity in hepatocellular carcinoma.

Background: Programmed death-ligand 1 (PD-L1), a prominent immune checkpoint, interacts with programmed death protein-1 (PD-1) on cytotoxic T cells within tumors and promotes immune evasion. Emodin, which is known to destabilize PD-L1 in breast cancer, has great potential for enhancing anti-tumor immunity. However, whether emodin can modulate PD-L1 levels in hepatocellular carcinoma (HCC) and enhance anti-tumor immune response remains unclear.

Baicalin promotes anti-tumor immunity in hepatocellular carcinoma through HIF-1α/Lactate/CXCL9 axis.

Low immune response is a hallmark of several solid tumors, including hepatocellular carcinoma (HCC), highlighting the urgent need for effective immunotherapeutic strategies. Baicalin, a bioactive ingredient derived from traditional Chinese medicine, has exhibited significant anti-tumor activity in various cancer types, yet its effects on anti-tumor immunity remain largely unclear. In this study, we investigated the immunomodulatory role of baicalin in HCC and elucidated its underlying mechanisms.

Developing a predictive model for lower extremity deep vein thrombosis in acute ischemic stroke using a nomogram.

Background: Deep vein thrombosis (DVT) is a prevalent complication among patients with acute ischemic stroke (AIS). However, there remains a deficiency of patient-specific predictive models. This study aims to develop a nomogram to estimate the risk of lower extremity DVT in AIS patients during the acute phase (within 14 days of onset).

The Impact of Social Support for Patients with COVID-19 in Post-Traumatic Growth: A Mediating Analysis Study.

Background: Although it is known that social support can promote post-traumatic growth (PTG) of trauma survivors, the specific mechanism is still unclear in the case of government policy intervention and large-scale population infection with COVID-19.

Methods: Through snowballing sampling from January 7 to February 13, 2023, we collected data from 1381 patients tested positive for COVID-19, excluding asymptomatic or undiagnosed cases. Participants completed effective scales measuring social support, PTG, and proactive coping behaviors.

Association between physical activity and risk of anxiety: a dose-response meta-analysis of 11 international cohorts.

Background: Anxiety disorders are the world's most common mental disorders and the risk of anxiety may be reduced by physical activity. However, the dose-response relationship between physical activity and the risk of anxiety remains uncertain.

Methods: Following Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guidelines, PubMed, Embase, Web of Science, and PsycINFO databases were searched for all prospective cohort studies on physical activity and the risk of anxiety up to 7 February 2025, with no language restrictions.

[Biejiajian Pill Regulates Ferroptosis in Hepatocellular Carcinoma Cells via p62/Keap1/NRF2 Signaling Pathway: A Mechanism Study].

Objective: To investigate the mechanism by which Biejiajian Pill (BJJP) regulates ferroptosis in hepatocellular carcinoma (HCC) cells through the p62/Keap1/NRF2 pathway and to provide an experimental basis for its application in the prevention and treatment of HCC.

Methods: Huh7 HCC cells were divided into a normal control group, a BJJP drug serum group, an erastin (a ferroptosis inducer) group, a BJJP drug serum + erastin group, and BJJP drug serum + ferrostatin-1 (Fer-1) (a ferroptosis inhibitor) group. BJJP drug serum was prepared with animals treated with BJJP and CCK-8 assay was performed to determine the optimal concentration and duration of BJJP intervention.

Prediction of pressure drop in heavy oil water ring based on modified two fluid model.

Accurate prediction of pressure drop of the heavy oil-water ring flow in pipeline is of great significance for establishing an optimal drag reduction model and ensuring safe production. The effects of different factors on the flow pattern and pressure drop of heavy oil-water annular two-phase flow were systematically analyzed, and a standard two-fluid pressure drop prediction model for annular flow was established. By modifying the shear stress equation of oil-water interface and introducing the wave-flow theory to modify the shear stress equation of water wall, a pressure drop prediction model for the generalized concentric water ring was obtained to calculate the periodic fluctuations of oil phase.

An Adaptive Weighted Residual-Guided Algorithm for Non-Uniformity Correction of High-Resolution Infrared Line-Scanning Images.

Gain and bias non-uniformities in infrared line-scanning detectors often result in horizontal streak noise, degrading image quality. This paper introduces a novel non-uniformity correction algorithm combining residual guidance and adaptive weighting, which achieves superior denoising and detail preservation compared to existing methods. The method combines residual and original images in a dual-guidance mechanism and significantly enhances denoising performance and detail preservation through iterative compensation strategies and locally weighted linear regression.

Statins and the incidence of post-stroke depression: a systematic review and meta-analysis.

Introduction: Post-stroke depression (PSD) can lead to poorer functional outcomes and prognosis. Brain inflammation is a risk factor for PSD. Statins might be beneficial due to their anti-inflammatory properties.

Short-term learning of the vestibulo-ocular reflex induced by a custom interactive computer game.

Retinal image slip during head rotation drives motor learning in the rotational vestibulo-ocular reflex (VOR) and forms the basis of gaze-stability exercises that treat vestibular dysfunction. Clinical exercises, however, are unengaging, cannot easily be titrated to the level of impairment, and provide neither direct feedback nor tracking of the patient's adherence, performance, and progress. To address this, we have developed a custom application for VOR training based on an interactive computer game.

Overcoming Periodic Stripe Noise in Infrared Linear Array Images: The Fourier-Assisted Correlative Denoising Method.

Infrared linear array detectors frequently experience vertical, low-frequency, and periodic stripe noise during imaging, stemming from electro-mechanical interference. Unlike conventional periodic disturbances, this interference showcases long periodicities and is uniquely columnar in orientation. Its presence, especially within the low-frequency domain, renders conventional filtering techniques ineffective and, at times, detrimental to image quality.

Factors affecting colonoscopy screening among first-degree relatives of colorectal cancer patients: A mixed-method systematic review.

Background: First-degree relatives (FDRs) of colorectal cancer (CRC) patients have a higher risk of developing CRC than the general population. Ensuring that these at-risk populations receive colonoscopy screening is an effective strategy for reducing the increased risk, but the rates remain low. Colonoscopy screening behavior is influenced by factors at multiple levels.

Coptidis Rhizoma processed with Evodia Rutaecarpa improves the effect on ulcerative colitis by increasing intestinal energy metabolites alpha-ketoglutarate and Lactobacillus reuteri.

Background: Evodia Rutaecarpa-processed Coptidis Rhizoma (ECR) is a traditional Chinese medicine for the treatment of ulcerative colitis (UC) in China. However, the mechanisms underlying the ECR processing are not elucidated.

Purpose: Coptidis Rhizoma (CR) regulates the gut microbiota in the treatment of gastrointestinal diseases.

Paeoniflorin Coordinates Macrophage Polarization and Mitigates Liver Inflammation and Fibrogenesis by Targeting the NF-[Formula: see text]B/HIF-1α Pathway in CCl-Induced Liver Fibrosis.

Liver fibrosis is a disease largely driven by resident and recruited macrophages. The phenotypic switch of hepatic macrophages can be achieved by chemo-attractants and cytokines. During a screening of plants traditionally used to treat liver diseases in China, paeoniflorin was identified as a potential drug that affects the polarization of macrophages.

Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling.

Hepatocellular carcinoma (HCC) is a common malignancy affecting many people worldwide. Baicalin is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi. It can effectively inhibit the occurrence and development of HCC.

Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.

Ethnopharmacological Relevance: Gardenia jasminoides Ellis is a traditional Chinese medicine that has been used for treatment of various diseases, including atherosclerosis by clearing heat and detoxication. Geniposide is considered as the effective compounds responsible for the therapeutic efficacy of Gardenia jasminoides Ellis against atherosclerosis.

Aim Of The Study: To investigate the effect of geniposide on atherosclerosis burden and plaque macrophage polarization, with focus on its potential impact on CXCL14 expression by perivascular adipose tissue (PVAT).

SNS alleviates depression-like behaviors in CUMS mice by regluating dendritic spines via NCOA4-mediated ferritinophagy.

Ethnopharmacological Relevance: Depression is one of the most common mood disturbances worldwide. The Si-ni-san formula (SNS) is a famous classic Traditional Chinese Medicine (TCM) widely used to treat depression for thousands of years in clinics. However, the mechanism underlying the therapeutic effect of SNS in improving depression-like behaviors following chronic unpredictable mild stress (CUMS) remains unknown.

Translation and validation: standard Chinese version of the skin tear knowledge assessment instrument (OASES).

Objective: Skin tears (STs) are acute cutaneous trauma and have become an increasingly common global health problem. International studies have shown barriers to the prevention and management of ST and the relevance of the role of nurses in implementation. The purpose of this study was to adapt an existing tool to measure nurses' knowledge of the prevention, assessment, and management of STs.

Erratum: MicroRNA-30a-3p acts as a tumor suppressor in MHCC-97H hepatocellular carcinoma cells by targeting COX-2: Erratum.

[This corrects the article DOI: 10.7150/jca.52298.

Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblasts.

Ethnopharmacological Relevance: Biejiajian pill (BJJP) is a canonical formula that is clinically used to treat chronic liver disease, especially to decrease the incidence of hepatocellular carcinoma (HCC). However, the mechanisms underlying the prevention of HCC progression by BJJP remain unclear.

Aim Of The Study: This study aimed to determine whether BJJP inhibits HCC progression by downregulating platelet-derived growth factor receptor beta (PDGFRβ) signaling in cancer-associated fibroblasts (CAFs) in a mouse model of diethylnitrosamine (DEN)/carbon tetrachloride (CCl)-induced HCC.

Consequences of anthropogenic activities and beach dynamics on vertical distribution of microplastics in the mid-intertidal sediments of Donghai Island, China.

Microplastic accumulation and resulting degradation are significant threats to the coastal ecosystems around the world. Baseline information on microplastics and their sources is of great importance for a permanent waste management system. The present study focused on the vertical distribution and characteristics of microplastics in the mid-intertidal zone of Donghai Island, China.

Bayesian group testing with dilution effects.

A Bayesian framework for group testing under dilution effects has been developed, using lattice-based models. This work has particular relevance given the pressing public health need to enhance testing capacity for coronavirus disease 2019 and future pandemics, and the need for wide-scale and repeated testing for surveillance under constantly varying conditions. The proposed Bayesian approach allows for dilution effects in group testing and for general test response distributions beyond just binary outcomes.

Biejiajian Pill Promotes the Infiltration of CD8 T Cells in Hepatocellular Carcinoma by Regulating the Expression of CCL5.

Tumor-infiltrating CD8T lymphocytes are mostly associated with a favorable prognosis in numerous cancers, including hepatocellular carcinoma (HCC). Biejiajian Pill (BJJP) is a common type of traditional Chinese medicine that is widely used in the treatment of HCC in China. Previous studies showed that BJJP suppressed the growth of HCC cells both and , by exerting direct cytotoxic effects on tumor cells.