Ultrafast Synthesis of MOF-Derived Magnetic Ni@C Catalyst for Efficient Photo-Enhanced Uranium Recovery in Real Nuclear Wastewater.

Photocatalytic reduction of uranium from wastewater containing high concentrations of fluoride is crucial from both environmental and sustainability perspectives. However, the coordination of fluorine and uranyl ions to U(VI)-F complexes with high bond strengths poses challenges for photocatalysts. Electrostatic interactions induced by photocatalysis to dissociate U(VI)-F complexes provide an effective method for the extraction of uranium from wastewater containing fluorine.

Early Identification of Pediatric Inflammatory Bowel Disease Based on a Noninvasive Multivariable Predictive Model.

Background: Early identification of pediatric inflammatory bowel disease (IBD) improves long-term outcomes; yet, significant diagnostic delays persist. This study aimed to establish and validate the optimal model of noninvasive evaluation tests to help clinicians with the early identification of pediatric IBD.

Methods: The study adopted a retrospective development and prospective temporal validation design within the same clinical center.

[Neuroprotective Effects of Anisodine Hydromide in a Rat Model of Vascular Dementia and the Antioxidative Stress Mechanisms Involved].

Objective: Vascular dementia (VD) is a common cognitive dysfunction associated with cerebrovascular disease. This study is aimed at investigating the therapeutic effect of anisodine hydromide (AH) on VD and the potential antioxidative stress mechanisms involved.

Methods: A VD model was established in Sprague-Dawley (SD) rats through permanent bilateral common carotid artery occlusion.

Emission characteristics of indoor HONO from residential natural gas cooking stoves in a household in Kunming, China.

Nitrous acid (HONO), a key precursor of hydroxyl radicals, significantly impacts outdoor and indoor air chemistry and poses health risks. Gas stove combustion is a major indoor HONO source, yet its emission factors (EFs) remain poorly quantified in China. This study quantified HONO emissions from natural gas (NG) stove combustion in a Kunming residential kitchen, yielding a HONO/NOx ratio of 5.

An integrated analysis revealing that Sirt1-mediated decreased autophagy in the hippocampus of animal models of depression.

Background: Depression is a complex and prevalent mental disorder. Numerous studies have reported there were significant metabolomic and proteomic changes in hippocampus of depressed patients. However, few researches have systematically integrated these two omics data to identify key molecular mechanisms underlying depression.

Design research on a smart infusion device to reduce medical workload and enhance patient safety.

In traditional infusion processes, issues such as untimely medication replacement and patients' difficulty in continuously monitoring their medication levels are prevalent. This study presents the design of a smart infusion automatic medication replacement device aimed at automating infusion management through three key modules: high-precision liquid level monitoring, automated medication replacement, and a smart control system. By monitoring liquid levels in real time, the system eliminates the need for patients to constantly check their medication levels, accurately controlling the amount of medication dispensed and transmitting monitoring signals within safe thresholds.

Beta-defensin 1 knockdown ameliorates the characteristics of intervertebral disc degeneration by altering nucleus pulposus and annulus fibrosus cell phenotypes via suppression of the extracellular signal-regulated kinase signaling pathway.

Objective: Beta-defensin 1 (DEFB1), is a member of the defensin family involved in inflammation, cell apoptosis and senescence. We hypothesized that DEFB1 is essential for intervertebral disc (IVD) homeostasis. Our objective was to elucidate the roles of DEFB1 in IVD degeneration (IDD).

Characterizing metabolomic and proteomic changes in depression: a systematic analysis.

Despite the widespread use of metabolomics and proteomics to explore the molecular landscape of depression, there is a lack of consensus regarding dysregulated molecules with replicable evidence. Thus, this study aimed to identify robust metabolomic and proteomic features in depression by integrating evidence from large-scale studies. In this study, a knowledge base-mining approach was adopted to compile a list of dysregulated molecules derived from metabolomic and proteomic studies.

HS-SPME-GC-MS untargeted metabolomics reveals key volatile compound changes during Liupao tea fermentation.

This study used headspace solid-phase microextraction-gas chromatography-mass spectrometry and multivariate statistical analysis to comprehensively analyze the volatile components in Liupao tea samples throughout fermentation. In total, 1009 volatile organic compounds were detected and identified, including terpenoids, heterocyclic compounds, esters, ketones, hydrocarbons, alcohols, aromatics, and acids. Principal component and hierarchical cluster analyses, characterize the volatile components of Liupao tea samples were characterized at various fermentation stages.

Lymphocyte Infiltration Score and Spatial Characteristics Refined the Prognosis and Denosumab Treatment Responsiveness Indicators for Giant Cell Tumor of Bone.

Purpose: The prognostic value of lymphocyte infiltration score (LIS) and its nearest neighbor distance to tumor cells (NNDTC) in giant cell tumor of bone (GCTB) is currently not well established. This study aims to characterize LIS and NNDTC and examine their correlation with denosumab treatment responsiveness, clinicopathologic features, and patient prognosis.

Methods: Using multiplexed quantitative immunofluorescence, LIS was evaluated in 253 tumor specimens, whereas NNDTC was computed using HALO software.

The tumor-stroma ratio in giant cell tumor of bone: associations with the immune microenvironment and responsiveness to denosumab treatment.

Background: Currently, there is limited understanding regarding the clinical significance of the tumor-stroma ratio (TSR) in giant cell tumor of bone (GCTB). Hence, we aimed to investigate the distribution of TSR in GCTB and explore its correlation with various clinicopathologic factors, immune microenvironment, survival prognosis, and denosumab treatment responsiveness.

Methods: We conducted a multicenter cohort study comprising 426 GCTB patients treated at four centers.

Systematic analysis of innate immune-related genes in the silkworm: Application to antiviral research.

The silkworm, a crucial model organism of the Lepidoptera, offers an excellent platform for investigating the molecular mechanisms underlying the innate immune response of insects toward pathogens. Over the years, researchers worldwide have identified numerous immune-related genes in silkworms. However, these identified silkworm immune genes are not well classified and not well known to the scientific community.

Synergistic evolution of water-energy-food system resilience and efficiency in urban agglomerations.

With increasing internal and external risks to the WEF system, a single emphasis on efficiency or a lopsided pursuit of resilience can lead to difficulties in adapting to complex changes and resource redundancy. Revealing the synergistic evolutionary characteristics between efficiency and resilience of the WEF system is an effective method to deal with systemic internal and external risks. However, the current study of the WEF system lacks a synergistic perspective on resilience and efficiency.

Accuracy of gastric nodule combined with rapid urease test prediction in diagnosing Helicobacter pylori infection in children.

Background: The diagnosis of Helicobacter pylori (H. pylori) infection in children remains challenging with the lack of a rapid, cost-effective, and highly accurate diagnostic method. Consequently, this study aimed to investigate the accuracy of the combination of gastric nodule and rapid urease test (RUT) as a diagnostic method for H.

Single-nucleus sequencing of silkworm larval midgut reveals the immune escape strategy of BmNPV in the midgut during the late stage of infection.

The midgut is an important barrier against microorganism invasion and proliferation, yet is the first tissue encountered when a baculovirus naturally invades the host. However, only limited knowledge is available how different midgut cell types contribute to the immune response and the clearance or promotion of viral infection. Here, single-nucleus RNA sequencing (snRNA seq) was employed to analyze the responses of various cell subpopulations in the silkworm larval midgut to B.

Intestinal ultrasound score predicts therapeutic outcomes of infliximab in pediatric patients with Crohn's disease.

Background And Aims: Objective evaluation of treatment response is critical in the management of Crohn's disease (CD). Compared with endoscopy, intestinal ultrasound (IUS) is non-invasive and well-tolerated. This study is aimed to assess the predictive value of IUS score for treatment response in pediatric CD patients.

Clinicopathological characteristics and prognostic factors in axial chondroblastomas: a retrospective analysis of 61 cases and comparison with extra-axial chondroblastomas.

Background: A comprehensive understanding of the clinical characteristics and prognostic factors associated with axial chondroblastoma (ACB) is still lacking. This study aimed to understand the clinical characteristics and prognostic factors of axial chondroblastoma (ACB) and compare them with extra-axial chondroblastoma (EACB).

Methods: A retrospective review of our institution's local database was conducted, encompassing a total of 132 CB patients, of which 61 were diagnosed with ACB and 71 with EACB.

The effects of dimethyl fumarate on cytoplasmic LPS-induced noncanonical pyroptosis in periodontal ligament fibroblasts and dental pulp cells.

Aim: Pyroptosis is a type of inflammatory cell death and is related to pulpitis and apical periodontitis. In this study, the aim was to investigate how periodontal ligament fibroblasts (PDLFs) and dental pulp cells (DPCs) respond to pyroptotic stimuli and explore whether dimethyl fumarate (DMF) could block pyroptosis in PDLFs and DPCs.

Methodology: Three methods (stimulation with lipopolysaccharide [LPS] plus nigericin, poly(dA:dT) transfection and LPS transfection) were used to induce pyroptosis in PDLFs and DPCs, two types of fibroblasts related to pulpitis and apical periodontitis.

The local coupling and telecoupling of urbanization and ecological environment quality based on multisource remote sensing data.

Coordinating the relationship between urbanization and ecological environment quality (EEQ) is crucial to achieving sustainable development. With the development of globalization, the pattern of remote interaction between urbanization and EEQ has gradually increased. However, the current study on the coupling of urbanization and EEQ lacks a remote perspective, and the remote sensing ecological index (RSEI) model has not yet considered the environmental pollution caused by population agglomeration.

Decoupling of water resources utilization and coordinated economic development in China's Hexi Corridor based on ecological water resource footprint.

The rapid growth of population and economy leads to a further increase in demand for water resources. The contradiction between supply and demand of water resources has become the main bottleneck restricting sustainable development of a regional social economy. Accurate measurement of regional water usage and the harmonious balance between water consumption (WC) and economic growth (EG) are the premise of regional high-quality development.

Suppression of gap plasmon resonance for high-responsivity metal-insulator-metal near-infrared hot-electron photodetectors.

Binary metal layers composed of a grating and a thin film are designed for high-responsivity metal-insulator-metal (MIM) near-infrared hot-electron photodetectors (HEPDs). The binary metal grating structure HEPDs demonstrate a strong asymmetrical optical absorption and result in a high current responsivity. In our devices, the top and bottom absorption ratio is as high as 76:1, much higher than that in the traditional grating structure HEPDs.

Mycn deficiency underlies the development of orofacial clefts in mice and humans.

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is the most common subphenotype of non-syndromic orofacial clefts arising from genetic and/or environmental perturbations during embryonic development. We previously identified 2p24.2 as a risk locus associated with NSCL/P in the Chinese Han population, and MYCN is a candidate risk gene in this region.