Visual Quantitative Characterization of External Corrosion in 3LPE Coated Pipes Based on Microwave Near-Field Reflectometry and Phase Unwrapping.

Three-layer polyethylene (3LPE) coated steel pipelines are currently the preferred solution for global oil and gas transmission. However, external corrosion beneath the 3LPE coating poses a serious threat to pipeline operations. The pressing concern for pipeline safety and integrity involves non-destructive evaluation techniques for the non-invasive and quantitative interrogation of such defects.

Consumption behavior of sugar-sweetened beverages among primary and secondary school students: a qualitative study based on teachers' perspectives.

This study investigates the factors influencing the consumption of sugar-sweetened beverages among primary and secondary school students in China from the perspective of teachers. A total of 56 teachers participated in face-to-face interviews, including both individual interviews and focus group discussions. Data were analyzed using the grounded theory approach with three levels of coding.

Sugar content and health risk assessment in freshly made sugary commercial beverages: A cross-sectional study.

Excessive sugar intake from beverages has become a growing concern due to its links to various health problems, such as obesity and diabetes. This study aims to evaluate the sugar content in commercial beverages and assess the associated health risks based on WHO guidelines. A cross-sectional analysis was conducted on 366 samples, where high-performance liquid chromatography was used to measure the presence of five types of sugars.

Poor Collateralization in T2DM: Role of SLC4A10+ MAIT Cells.

Background: Type 2 diabetes is strongly associated with impaired collateralization, which increases the risk of cardiovascular complications, such as myocardial infarction and heart failure. This study explored the immune cell dynamics in patients with type 2 diabetes with chronic total occlusion and their impact on collateralization.

Methods: Peripheral blood mononuclear cells were extracted from patients with type 2 diabetes with chronic total occlusion, exhibiting either good or poor collateralization.

Direction independent flipped spin splitting controlled by linearly polarized light.

Spin splitting, arising from spin-orbit interaction of light, has garnered increasing attention due to its potential applications in polarization detection, optical metrology, optical sensing, and optical computing. Here, we demonstrate a direction independent flipped spin splitting, which is realized through orthogonal linearly polarized incidences on conjugate particles. Specifically, the flipped spin splitting is achieved by constructing opposite spin dipoles, leveraging the electric field coupling of the conjugate particle.

AdaptiveGS: an explainable genomic selection framework based on adaptive stacking ensemble machine learning.

We developed an adaptive and unified stacking genomic selection framework and designed a model interpretation strategy to identify the candidate significant SNPs of target traits. Genomic selection (GS) is an important technique in modern molecular breeding. As a powerful machine learning (ML) GS approach, stacking ensemble learning (SEL) combines multiple basic models (base learners, BLs) and effectively blends the strengths of different models to precisely depict the complex relationships between phenotypes and genotypes.

Sijunzi Decoction treatment improved depression with qi deficiency/fatigue in the strain-dependent manner, involved in anti-inflammation in the hippocampus and muscles.

Ethnopharmacological Relevance: In the traditional Chinese medicine (TCM) clinic, qi deficiency is a common syndrome pattern in major depressive disorder (MDD). Sijunzi decoction (SJZD), a classic muti-herbal formula to replenish qi and nourish blood, is widely used to treat qi deficiency syndrome. The symptoms of qi deficiency are very similar to fatigue.

Effect of intraoperative mitomycin C application at different concentrations on corneal densitometry after SmartSurf transepithelial photorefractive keratectomy.

Purpose: This study aimed to investigate corneal densitometry (CD), visual, and refractive outcomes after transepithelial photorefractive keratectomy (TPRK) using smart pulse technology (SPT), known as the SmartSurface procedure, in patients treated with or without mitomycin C (MMC) at concentrations of 0.01% and 0.02%.

Inhibition of VEGFR-3 by SAR131675 decreases renal inflammation and lymphangiogenesis in the murine lupus nephritis model.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune-complex deposits and inflammatory cell infiltrations in multiple organs. Approximately half of lupus patients have nephritis. Lymphangiogenesis is the proliferation of lymphatic vessels (LVs), which regulate tissue fluid homeostasis and immune cell trafficking, responding to the tissue environment.

A Study on Distributed Multi-Sensor Fusion for Nonlinear Systems Under Non-Overlapping Fields of View.

To explore how varying viewpoints influence the accuracy of distributed fusion in asynchronous, nonlinear visual-field systems, this study investigates fusion strategies for multi-target tracking. The primary focus is on how different sensor perspectives affect the fusion of nonlinear moving-target data and the spatial segmentation of such targets. We propose a differential-view nonlinear multi-target tracking approach that integrates the Gaussian mixture, jump Markov nonlinear system, and the cardinalized probability hypothesis density (GM-JMNS-CPHD).

Exploring the potential association and experimental validation of disrupted circadian rhythms with polycystic ovary syndrome via meta-analysis and bioinformatics: a possible pathogenic mechanism.

Background: Polycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature of this connection remains unclear. The aim of this study was to explore further links between circadian rhythm and PCOS and to identify potential mediators of the pathogenesis of PCOS.

Ice-related flooding in the lower Yellow River driven by atmospheric teleconnections over the past 160 years.

Ice-jam floods are a unique yet understudied hydrological hazard, occurring in cold-region rivers when upstream thawing and downstream freezing create ice blockages. Despite their severe impacts, their atmospheric drivers and future trends remain unclear. Using a 160-year documentary record, historical reanalysis datasets, and statistical modeling, we examine the climatic and hydrological controls of ice-jam floods in the lower Yellow River, one of the world's most flood-prone rivers.

Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO).

Peroxynitrite (ONOO) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored.

Multifunctional gold nanoclusters with red fluorescence as nanoantibiotics for imaging-guided infected wound healing.

The increasing emergence of multidrug-resistant (MDR) bacteria threatens the health of the global population by perpetuating microbial infections. Therefore, accelerating the development of nondrug-resistant antimicrobial substances is crucial to combat drug-resistant bacterial infections. Herein, we report a simple one-pot, microwave-assisted strategy for designing ultrasmall lysozyme-functionalized gold nanoclusters (L-Au NCs) through the one-step assembly of natural lysozyme and metal ions (e.

Psychometric Evaluation of the Malay Version of Weight Stigma Exposure Inventory (WeSEI) Among Malaysian Young Adults.

The present study translated the Weight Stigma Exposure Inventory (WeSEI), an instrument assessing observed weight stigma, into Malay, and evaluated its psychometric properties among Malaysian young adults. Young adults who were Malaysian university students provided their informed consent electronically and completed an online survey hosted on . Data were collected by recruiting participants via emails or between March and August 2024.

Text analysis of rehabilitation nursing policy in China from the perspective of policy tools.

Objective: This study aims to analyze the specific content and structural characteristics of rehabilitation nursing-related policies in China from 2007 to 2024, utilizing the perspective of policy tools. The goal is to provide insights for the subsequent optimization and enhancement of the rehabilitation nursing policy system.

Methods: According to the classification method of policy instruments proposed by public policy scholars Rothwell and Zegveld, this study identified the X dimension (basic policy instrument) and categorized the included policies into demand-oriented, supply-oriented, and environment-based policies.

LBA and LC-MS/MS based comprehensive bioanalytical methods for FDA018, a Trop-2 targeted antibody-drug conjugate.

Recently, the approval of Trop-2 targeted antibody drug conjugate (ADC) has changed the dilemma of patients with advanced triple-negative breast cancer who rely on chemotherapeutics to improve their survival. FDA018, an ADC consisting of an anti-Trop-2 antibody conjugated with a topoisomerase inhibitor SN-38 via an acid-cleavable linker, is currently being investigated in clinical trials. Based on the urgent demand to evaluate the clinical pharmacokinetics of FDA018, ligand binding assays (LBAs) for the determination of SN-38-conjugated antibody and total antibody and LC-MS/MS methods for the determination of the free SN-38, its metabolite SN-38G and total SN-38 were developed.

Knowledge mapping of posterior capsular opacification from 2011 to 2023: A bibliometric analysis.

This bibliometric analysis explores the current status and trends of global research on posterior capsular opacification (PCO). A search of the Web of Science Core Collection (WoSCC) database was conducted to identify publications on PCO from 2011 to 2023. Bibliometric analysis was used to explore publication trends in PCO-related research.

NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation.

Precise DNA replication is the basis for maintaining cell proliferation and genome stability. Current chemotherapy drugs and radiotherapy induce cell death by aggravating replication stress, albeit with poor efficacy. The replication stress response has been shown to play fundamental roles in resistance to radiotherapy and chemotherapy.

Diagnostic potential of pericoronary adipose tissue mean attenuation for coronary atherosclerotic heart disease: a comparative analysis with the fat attenuation index.

Background: The fat attenuation index (FAI), a threshold-based method for assessing pericoronary adipose tissue (PCAT) density, provides strong evidence for patient-specific coronary inflammation assessment. However, the reliance on fat thresholds may result in the omission of some critical information. Thus, this study aimed to explore the diagnostic potential of a novel method, pericoronary adipose tissue mean attenuation (PCAT), which is not constrained by fat threshold limitations, by investigating the relationships among PCAT, the FAI, and coronary artery plaque types.

The landscape of research on ferroptosis under hypoxic conditions: a bibliometric analysis.

Background: Ferroptosis is a newly identified type of iron-dependent cell death that characterized by an increase in intracellular iron ions, which disrupt the balance of the cellular lipid peroxidation system, causing lipid peroxidation and ultimately resulting in cell death. Interestingly, ferroptosis is modulated by hypoxia and plays a role in hypoxia-related diseases. Therefore, we performed a bibliometric review of the Web of Science Core Collection (WoSCC) database to investigate the link between ferroptosis and hypoxia from January 2013 to December 2023.

Flexible Formation of Nanoparticles: Selectively Self-Assembling with Glycoclusters to Form Nano-Photosensitizers for Multipurpose Bioimaging and Photodynamic Therapy.

The smart construction of nano-photosensitizers (PSs) is significant for multipurpose applications, such as bioimaging, efficient photodynamic anti-tumor or anti-bacterial studies. This work reports a flexible self-assembling strategy for the construction of nano-PSs, in which PSs spontaneously form amorphous aggregates for killing bacteria, or self-assemble with tetraphenylethene (TPE) based glycoclusters () to construct glyco-dots for cell imaging and photodynamic anti-tumor studies. Tricyanofuran (TCF) and TPE units were bridged with furan or thiophene moiety to construct two PSs ( and ) with NIR fluorescence in monomers, and a performance of the aggregation-induced generation of reactive oxygen species (AIG-ROS) in an aggregated state.

Excited-State-Altering Ratiometric Fluorescent Probes for the Response of -Galactosidase in Senescent Cells.

-galactosidase (-Gal) has emerged as a pivotal biomarker for the comprehensive investigation of diseases associated with cellular senescence. The development of a fluorescent sensor is of considerable importance for precisely detecting the activity and spatial distribution of -Gal. In this study, we developed two excited-state-altering responsive fluorescent sensors ( and ) for ratiometric detection of -Gal.