Iliac branch endoprosthesis for the treatment of a complex aneurysm.

Decisions pertaining to the management of an abdominal aortic aneurysm in combination with bilateral internal iliac aneurysms present quandaries during endovascular intervention. This report outlines an endovascular aortic repair method for endovascular aortic repair involving an abdominal aortic aneurysm with bilateral iliac aneurysms. The patient exhibited aneurysmal dilatation of the abdominal aorta, bilateral common iliac arteries, and bilateral internal iliac arteries.

Inhibition of DJ-1 protects from lupus onset and severity.

The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels.

Interaction between the brain and multiple organ systems in schizophrenia.

Schizophrenia is characterized by psychotic symptoms, negative symptoms, and cognitive deficits, profoundly affecting individuals and their families. The etiology is multifactorial, involving genetic, endocrine, and immunological risk factors. It is thought that schizophrenia is exclusively linked to alterations in brain structure and function, while the relationship between the brain and many organs may lack sufficient attention.

A biodegradable self-cascading copper-based nanozyme for augmented cancer catalytic therapy and cuproptosis.

Nanozyme-mediated catalytic therapy is a promising and potent approach for tumor treatment; however, its therapeutic efficiency is limited by insufficient HO and excess glutathione (GSH) within the complex tumor microenvironment. Herein, we propose a self-cascading nanozyme strategy that self-supplies HO, consumes GSH, and induces cuproptosis to address these challenges. This design features a triphenylphosphine-functionalized copper-doped mesoporous silica nanoplatform (denoted as DCM) that exhibits multi-enzymatic activity, degradability, and mitochondrial targeting capacity.

Assessment of cardiac dysfunction in COVID-19 patients using layer-specific strain echocardiography in short-axis and long-axis views.

Objectives: Cardiac dysfunction is commonly observed in COVID-19 patients, but its impact on different myocardial layers-endocardial, mid-myocardial, and epicardial remains insufficiently understood. This study aims to evaluate myocardial dysfunction in COVID-19 patients by assessing both the long-axis and short-axis function of the left ventricle (LV) using two-dimensional myocardial layer-specific strain imaging.

Methods: A total of 197 COVID-19 patients were enrolled and categorized into three subgroups: mild, moderate, and severe.

Autoimmune encephalitis associated with antibodies against α-enolase sequestrated from degenerating retina in retinitis pigmentosa.

Background: Retinitis pigmentosa is a group of inherited retinal degenerations resulting in photoreceptor cell dysfunction, death, and eventually vision loss. It can be a manifestation of Usher syndrome and has been linked with autoimmune retinopathy and systemic autoimmune diseases.

Case Presentation: We report the case of a 70-year-old woman with retinitis pigmentosa and Usher syndrome who presented with autoimmune encephalitis.

Transient decline and early recovery of noninvasive myocardial work after kidney transplantation: a prospective study.

Background: Patients with chronic kidney disease (CKD) are at a high risk of cardiovascular disease. This study aims to observe the short-term changes of left ventricular (LV) myocardial work in stage 5 CKD patients with successful kidney transplantation (KT).

Methods: 45 stage 5 CKD patients who are candidates for KT were enrolled.

Manganese-Catalyzed Asymmetric Transfer Hydrogenation of Heteroatom-Containing Imines and Diarylimines.

The efficient synthesis of chiral amines has garnered ongoing interest due to their prevalence in pharmaceuticals and biologically active compounds. However, most existing strategies for their synthesis primarily rely on asymmetric (transfer) hydrogenation (AH/ATH) using noble metal catalysts. Additionally, the AH/ATH of heteroatom-containing imines and diarylimines has posed a longstanding challenge.

Elephant Cathelicidin-Derived Peptides Inhibit Herpes Simplex Virus 1 Infection.

Herpes simplex virus type 1 (HSV-1) is a globally prevalent pathogen that can infect a variety of animal species as well as humans. However, existing antiviral therapies are constrained in their capacity to effectively target viral latency and prevent recurrent infections. Antimicrobial peptides (AMPs), particularly cathelicidins, as part of innate immune system have demonstrated broad-spectrum efficacy against viral pathogens.

Single-Nucleus Chromatin Accessibility and Epigenetic Study Uncover Cell States and Transcriptional Regulation of Epidermis in Hidradenitis Suppurativa.

Hidradenitis suppurativa (HS) is a complicated chronic inflammatory skin disorder characterized by recurrent and painful deep-seated nodules, abscesses, fistulae, scarring, and sinus tracts. HS most commonly affects high-density hair follicles and apocrine gland-rich regions of the body, including the axillae, inguinal folds, breasts, and perianal areas. Although genetic predisposition and environmental factors are known to contribute to the development and the severity of HS, the molecular mechanisms of HS are largely unknown.

RNA Interference-Aided Functional Characterization of Juvenile Hormone Signaling During Vitellogenesis in Two Coleoptera Species.

In Tribolium castaneum, juvenile hormone (JH) signal, through Methoprene-tolerant (Met)/Taiman (Tai) heterodimer, regulates vitellogenesis. Considering that Coleoptera is by far the largest animal taxon, whether JH pathway controls vitellogenesis remains to be clarified in other Coleopteran species. In the current paper, temporal expression determination revealed that JH signal is triggered in the young female adults in two Henosepilachna species, consistent with active oogenesis and vitellogenesis in these beetles.

Effect of intraoperative mitomycin C application at different concentrations on corneal densitometry after SmartSurf transepithelial photorefractive keratectomy.

Purpose: This study aimed to investigate corneal densitometry (CD), visual, and refractive outcomes after transepithelial photorefractive keratectomy (TPRK) using smart pulse technology (SPT), known as the SmartSurface procedure, in patients treated with or without mitomycin C (MMC) at concentrations of 0.01% and 0.02%.

Proline-rich nuclear receptor coactivator (Pnrc), the Drosophila aaquetzalli homologue, is important in survival of Henosepilachna vigintioctopunctata.

To develop a novel control strategy via a combination of double stranded RNA (dsRNA)-based pesticide and biocontrol in Henosepilachna vigintioctopunctata, we endeavored to identify potential dsRNAs that can cause living and non-feeding beetles to provide food for predators and parasitoids. In this context, depletion of proline-rich nuclear receptor coactivator (Pnrc), the Drosophila melanogaster aaquetzalli homologue, damages cuticle integrity. In the current paper, RNA interference (RNAi) targeting Hvpnrc by an injection of 200, 500 or 1000 ng of dspnrc into the third instar larvae significantly reduced the level of corresponding transcript and repressed pupation and adult eclosion, in a dose-dependent manner.

Glycometabolic reprogramming of immune cells in autoimmune diseases.

Autoimmune diseases (ADs) are a classification of disorders that occur owing to the breakdown of immunological tolerance to self-antigens, leading to an immune response to these antigens and associated bodily harm. The pathogenesis and etiology of these diseases remain unclear. A growing body of research indicates that metabolic reprogramming of immune cells is crucial for immunological control.

A GaN Schottky Barrier Diode-Based Terahertz Metasurface for High-Precision Phase Control and High-Speed Beam Scanning.

Effective wavefront control in the terahertz (THz) regime is essential for achieving high-directionality beamforming, spatial multiplexing, and real-time wireless communication. However, low-loss, precise, and rapid THz phase modulation remains fundamentally constrained by material limitations and inherent device-level trade-offs. A programmable THz metasurface (GaNMS) is presented, employing a gallium nitride Schottky barrier diode with a high-mobility 2D electron gas, specifically designed to overcome these limitations by leveraging its low insertion loss, fast response, and continuously tunable junction capacitance.

Tumor-Boundary Response Index (TBRI)- A promising indicator for predicting outcomes in colorectal liver metastases receiving neoadjuvant therapy: Insights from a single-center retrospective study.

Background: Tumor regression grade (TRG) and histopathological growth pattern (HGP) reflect the response of colorectal liver metastases (CRLM) to neoadjuvant therapy (NAT) from the perspectives of the tumor and its microenvironment, respectively. Based on these two indicators, this study aimed to develop a prognostic index for CRLM undergoing surgery after NAT.

Materials And Methods: 237 patients who underwent curative-intent resection following NAT from 2012 to 2022 were selected.

Arbuscular mycorrhizal fungi colonization regulates root traits and soil carbon economic strategies.

Background: The symbiotic interaction between arbuscular mycorrhizal fungi (AMF) and roots can change root traits, soil carbon - nitrogen processes and crop yield. However, the precise mechanisms by which AMF affect soil carbon economic strategies and crop yield remain unclear. A two - factor pot experiment was done with cotton.

Modulating Macrophage-Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration.

Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM). Improving nucleus pulposus cells (NPCs) condition first requires a supportive surrounding environment. However, how to provide an excellent microenvironment before regulating the function of the NPCs is not yet a complete strategy.

Ventricular-arterial coupling derived from arterial velocity pulse index to global longitudinal strain ratio in hypertension.

Objective: Ventricular-arterial coupling (VAC) evaluates the relationship between the left ventricle (LV) and the arterial system. This study aimed to assess VAC using the ratio of arterial stiffness (arterial velocity pulse index [AVI]) to myocardial deformation (global longitudinal strain [GLS]) in hypertension, and to determine whether it is more closely associated with vascular and cardiac damage than the conventional arterial elastance/left ventricular elastance (Ea/Ees) index.

Methods: AVI, GLS, arterial elastance (Ea), left ventricular end-systolic elastance (Ees), left ventricular ejection fraction (LVEF), and markers of left ventricular diastolic function (E/A and E') were measured by echocardiography in 141 healthy controls and 141 hypertensive subjects.

Hyaluronic acid-based hydrogel for cadmium removal and enhanced sorghum growth under cadmium stress.

Cadmium (Cd) is a highly toxic heavy metal that poses a threat to environmental and human health. The hydrophilic and modifiable properties of hyaluronic acid (HA) render it well-suited for advanced environmental absorbent technologies. However, the potential of HA-based hydrogels in environmental applications remains largely unexplored.

Comparison of a novel gamified binocular therapy and standard monocular patching therapy in treating unilateral amblyopia in young children: a prospective, multicenter, randomized controlled trial.

Background: Amblyopia is a leading cause of visual impairment in children, and conventional treatments often encounter challenges related to poor compliance and adverse psychosocial effects. Recent advancements in treatment approaches have evolved beyond merely suppressing the dominant eye, now focusing on improving binocular visual function. Binocular therapy has emerged as a promising and innovative approach.

Efficacy and Safety of Ivarmacitinib, a Selective JAK1 Inhibitor, in Patients With Active Ankylosing Spondylitis: Results From an Adaptive Seamless Phase 2/3 Trial.

Objective: This randomized, double-blind, adaptive phase 2/3 trial aimed to evaluate the efficacy and safety of ivarmacitinib, a novel selective JAK1 inhibitor, in patients with active ankylosing spondylitis (AS).

Methods: In phase 2, patients were randomized (1:1:1:1) to receive ivarmacitinib at a dose of 2, 4, or 8 mg or placebo once daily for 12 weeks. Based on interim analysis, ivarmacitinib 4 mg was selected as the recommended dose.

In situ assessment of renal cortical microcirculation in septic acute kidney injury rats using contrast-enhanced ultrasound and sidestream dark-field imaging.

Purpose: To evaluate in situ assessment of renal cortical microcirculation (RCM) in S-AKI rats using CEUS and SDF imaging.

Methods: CLP was performed to induce S-AKI in Sprague-Dawley rats; Sham rats served as control. CEUS and SDF imaging were sequentially applied at postoperative 24 h and 48 h to investigate the RCM.

The impact of age, gender, and ocular parameters on corneal biomechanics in Chinese refractive candidates.

We aimed to quantify the distribution of corneal biomechanics in healthy, myopic Chinese candidates for refractive surgery using an ocular response analyzer, and explore factors that influence corneal biomechanics. In this retrospective cross-sectional study, 1,090 eyes from 1090 myopic patients scheduled for refractive surgery at the Refractive Center of Dalian Third People's Hospital between January 2021 and May 2022 were examined. Participants were categorized into three groups based on spherical equivalent power: low myopia (SE> -3.

2025 Chinese guideline for the imaging diagnosis and evaluation of Takayasu arteritis.

Background: Takayasu arteritis (TAK) presents as systemic vasculitis. Imaging is crucial for the diagnosis and evaluation of TAK, but the rational selection of imaging methods and interpretation of imaging results are major challenges in clinical practice, which can affect treatment decisions. This guideline aims to establish standardized protocols for selecting imaging modalities (as well as interpreting their findings) in TAK.