Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels. Moreover, DJ-1 deficiency provided protection against renal hypertrophy and decreased glomerular deposition of immunoglobulin, ultimately leading to reduced albuminuria and SLE activity. These findings demonstrate that DJ-1 expression critically influences the progression of lupus-like disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379229 | PMC |
| http://dx.doi.org/10.1038/s41598-025-15670-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Could a DJ-1/PARK7 pathogenic variant be a cause of cardiac hypertrophy?-a case report.
Eur Heart J Case Rep
June 2025
Faculty of Medicine Cardiology Department, Ankara University, Altindag 06230, Turkey.
Background: DJ-1, a protein encoded by the PARK7 gene, is crucial in the regulation of oxidative stress and mitochondrial function. Experimental studies in murine models suggest that DJ-1 deficiency results in pronounced cardiac hypertrophy and an elevated risk of heart failure, especially under conditions of oxidative stress. Nonetheless, this association had not yet been substantiated in human studies.
View Article and Find Full Text PDFInhibition of DJ-1 protects from lupus onset and severity.
Sci Rep
August 2025
Department of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels.
View Article and Find Full Text PDFDJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN.
Invest Ophthalmol Vis Sci
July 2025
Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, P. R. China.
Purpose: Diabetic keratopathy (DK) is characterized by delayed corneal epithelial wound healing and impaired nerve regeneration, primarily due to mitochondrial oxidative stress. DJ-1 plays a key role in redox regulation. This study explores the effects of DJ-1 downregulation on DK and its mechanisms.
View Article and Find Full Text PDFDJ-1 protein ameliorates nonalcoholic fatty liver disease via ER-stress pathway and reduces inflammation.
Biochem Biophys Res Commun
August 2025
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China. Electronic address:
Originally identified in Parkinson's disease (PD), DJ-1 is a multifunctional protein increasingly recognized for its role in gastrointestinal and hepatic disorders. This study aimed to elucidate the potential mechanisms of DJ-1 in Nonalcoholic fatty liver disease (NAFLD), which is the early stage of various hepatic disorders. We examined the effects of DJ-1 protein in high-fat diet (HFD) and methionine-choline deficient diet (MCD) feeding mice.
View Article and Find Full Text PDFWe have previously extensively characterized the role of DJ-1 in oxidative stress regulation in the retina and RPE during aging. However, the DJ-1 protein also plays a role in regulating mitochondria's response to oxidative stress by translocating to the mitochondria where it helps clear generated reactive oxygen species (ROS). To study the effects of aging and oxidative stress in the retina, the DJ-1 KO mouse was analyzed.
View Article and Find Full Text PDF