Monitoring and molecular mechanisms of resistance to complex III inhibitors in Tetranychus urticae populations from Türkiye.

Acequinocyl and bifenazate are widely used acaricides that inhibit mitochondrial electron transport at complex III, due to their high efficacy and low side effects. However, resistance development has been reported in Tetranychus urticae populations worldwide, likely as a result of frequent applications. This study assessed the phenotypic resistance levels of T.

Evaluation of Kienböck's Disease through Distal Radius Sagittal Plane Analysis.

Background: Kienböck's disease poses challenges in plate placement during radial shortening osteotomy due to steep metaphyseal inclinations of the distal radius. While coronal plane analyses have been extensively studied, sagittal plane deformities remain underexplored. This study addresses the anatomical variations in the sagittal plane associated with Kienböck's disease.

Prognostic immunotherapy score (PIS) in patients with advanced urothelial carcinoma treated with pembrolizumab: real-world data and validation from ARON-2 dataset.

Recent years have seen the development and advent of novel combinatorial strategies based on immunotherapy, and immune checkpoint inhibitor (ICI) - based treatment has established itself as a mainstay in the treatment of metastatic urothelial carcinoma (UC). Herein, we aimed to validate the prognostic value of a previously developed score, the Prognostic Immunotherapy Score (PIS), including female sex, Eastern Cooperative Oncology Group Performance Status (ECOG-PS) and liver metastases, in patients treated with pembrolizumab for advanced UC from the ARON-2 dataset. We retrospectively analyzed clinical data from Metastatic UC patients diagnosed at age ≥ 18 years.

Sensorimotor Cortical Integration Remains Unchanged After Dorsal Root Ganglion Pulsed Radiofrequency.

Background: Dorsal root ganglion (DRG) pulsed radiofrequency (PRF) is a minimally invasive neuromodulation technique used for the management of chronic radicular pain. While its analgesic effects are well-documented, its impact on sensorimotor integration at the cortical level remains unclear. This study aimed to investigate whether DRG PRF modulates sensorimotor integration via the cholinergic system using the Short-Latency Afferent Inhibition (SAI) paradigm.

The association between chronotype and dietary nutrient patterns.

This study examines how dietary nutrient patterns vary among individuals with different chronotypes. In other words, this research explores the potential connections between nutrient intake and circadian rhythm. In this secondary data analysis, we used data from 3,072 adult participants (mean age: 30.

A new characteristıc of systemic lupus erythematosus: subclinical vein involvement-an in-depth biochemical and imaging study.

Objectives: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder often complicated by vascular events, with or without antiphospholipid antibody syndrome (APS). This study aimed to explore subclinical venous involvement in SLE using biochemical and imaging modalities, focusing on vein wall thickness (VWT) and inflammation-related biomarkers.

Methods: In this cross-sectional study, 68 SLE patients were categorized based on antiphospholipid antibody (APA) status and clinical APS.

In vitro/in vivo evaluation of 3D bioprinted silk fibroin hydrogels for IBD: A dual mesalazine and TNF-α siRNA approach.

Inflammatory bowel disease (IBD) is a chronic, relapsing disease that poses significant challenges in treatment. This study aimed to develop silk fibroin-based mesalazine and chitosan:TNF-α siRNA polyplex-loaded, 3D bioprinted hydrogels for the oral treatment of IBD. For this purpose, bioink formulations composed of silk fibroin, hyaluronic acid, and sodium alginate were optimized.

Benchmarking deep learning-designed inlay restorations across operator experience: An in vitro comparison of time efficiency, contact intensity, and contour quality.

Objectives: This in vitro study aimed to evaluate the performance of a deep learning (DL)-based workflow for designing inlays, in terms of time efficiency, contact intensity, and contour quality, by comparing it with human-based workflows. The impact of operator experience was also assessed to examine whether the DL-based workflow could reduce experience-related variability.

Methods: A total of 25 digital scans of maxillary and mandibular arches, including posterior abutments prepared for mesial-occlusal (MO) or distal-occlusal (DO) cavities, were used to design inlays using five different workflows.

Hypoxia Disrupted Serotonin Levels in the Prefrontal Cortex and Striatum, Leading to Depression-like Behavior.

Hypoxia can adversely affect multiple organ systems. This study investigated the impact of intermittent hypoxia on serotonin levels and depression-like behaviors across distinct neuroanatomical regions. Sixteen adult female Wistar albino rats were divided into two groups: control ( = 8) and hypoxia ( = 8).

Investigating the Chemical-Biological Link in Extracts for the Discovery of Novel Raw Materials via and In Vitro Assays.

This study examined the impact of the extraction methods (70% ethanolic extraction, infusion) on the overall biological profile and concentration of phenolic compounds of . Infusion yielded significantly higher phenolics and flavonoids (75.73 ± 0.

Quantifying the correlation of ocular manifestations and macular pigment optical density in albinism: a prospective cross-sectional study.

Aims: To demonstrate the presence of macular pigments in patients with albinism using colour perimetry and to evaluate the relationship between macular pigment optical density (MPOD) and ocular findings.

Methods: 50 patients were included. Best-corrected visual acuities (BCVAs) were measured at 2 meters (Early Treatment Diabetic Retinopathy Study charts) and recorded as logMAR.

Pharmacological and toxicological profile of the Vahl: a comprehensive review.

Medicinal plants play a vital role in traditional medicine. They offer remedies for various ailments and contribute significantly to human health. Vahl is herbaceous plant from the Lamiaceae family, native to Türkiye, Iran, and the Caucasus.

Optimal leading follicle size for final oocyte maturation in POSEIDON group 3 and 4 poor responders undergoing assisted reproductive technology cycles.

Objective: The aim of this retrospective cohort study was to evaluate the relationship between leading follicle size at the time of human chorionic gonadotropin (hCG) trigger and live birth rates in Patient-Oriented Strategies Encompassing Individualised Oocyte Number (POSEIDON) groups 3 and 4 undergoing assisted reproductive technology cycles using a gonadotropin releasing hormone (GnRH) antagonist protocol. The objective was to identify the optimal leading follicle size for maximizing live birth outcomes in this challenging patient population.

Material And Methods: This retrospective cohort study included POSEIDON groups 3 and 4 poor responders aged 20-42 years undergoing intracytoplasmic sperm injection with GnRH antagonist protocol between January 2015 and July 2021.

The effect of oral ferrous sulfate use in different posology on laboratory values and clinical findings related to iron metabolism in anemia due to iron deficiency.

Iron deficiency anemia (IDA) is a common general health problem in daily clinical practice. A large amount of iron in the body is used for hemoglobin (Hb) synthesis and iron is critical for many biological functions such as cell proliferation, energy production, DNA synthesis and respiration. In recent years, with a better understanding of iron metabolism; it has led to the need to review treatment regimens in the treatment of IDA.

Temporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis.

Objective: This study aimed to evaluate the diagnostic performance of biochemical markers in normocalcemic primary hyperparathyroidism (nPHPT), analyse their temporal variations, and assess their correlation with adenoma localisation and size.

Methods: In this multicenter retrospective study-the largest patient cohort reported in the literature to date (n = 474) we comprehensively profiled normocalcemic patients diagnosed with primary hyperparathyroidism nPHPT was diagnosed based on persistently elevated PTH levels with normal serum calcium after excluding secondary causes such as vitamin D deficiency, renal impairment, and other conditions. This retrospective multicenter study included a large cohort of patients whose biochemical markers-including serum calcium, phosphorus, magnesium, vitamin D, parathyroid hormone (PTH), and glomerular filtration rate (GFR)-were measured at three time points, using standardised laboratory protocols.

An insight of oil protection theory: Survival, structural and metabolic adaptation of Salmonella enterica Enteritidis Phage Type 30 in three triglycerides.

"Oil protection theory" posits that oil enhances microbial survival and heat resistance in low-moisture foods, yet the role of triglyceride composition remains poorly defined. This study investigates how Salmonella enterica Enteritidis PT 30 adapts during desiccation in peanut oil (mixed triglycerides, a = 0.30) and two representative components, namely, trilinolein and glyceryl trioleate.

Epidemiology and Outcomes of Candida-Associated Osteoarticular Infections: A Multicenter Retrospective Study from Turkey.

This multicentre retrospective study investigated the epidemiology, clinical characteristics, and fluconazole resistance rates of Candida species in osteoarticular infections across Turkey as well as the factors influencing complete recovery. Data were gathered from 73 adult patients diagnosed with proven or probable Candida-associated osteoarticular infections between 2015 and 2025 from 20 healthcare centres. The most common clinical presentation was spondylodiscitis, followed by the involvement of phalangeal bones in the hands and feet.

Impact of COVID-19 and lockdown on outcomes of COPD patients in Turkey: lessons for the future.

Background: The COVID-19 pandemic and related public health restrictions have substantially altered healthcare access and delivery, particularly for patients with chronic conditions such as chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the impact of the COVID-19 pandemic and lockdown measures on COPD-related symptoms and hospital admissions, and to compare these outcomes with the pre-pandemic period.

Methods: This multicenter cross-sectional study was conducted between July 2021 and February 2022 across ten tertiary pulmonary outpatient clinics in Turkey.

Management of acute variceal bleeding: updated APASL guidelines.

Acute variceal bleeding (AVB) is a common life-threatening complication of portal hypertension (PHT), having a six-week mortality of 10%-20%. Major advances in the hemodynamic management, risk stratification, pharmacotherapy, endoscopy techniques, hemostatic devices and radiological interventions have led to improved management and outcome of AVB patients in the recent past. Therefore, the APASL Portal Hypertension Working Party, chose a panel of experts, primarily from the Asia-Pacific region, to identify important developments and controversial areas in the field of AVB.

Death associated with wet cupping therapy (hijama): A case report.

The World Health Organization defines traditional medicine as the sum of knowledge and practices unique to different cultures. Wet cupping therapy (hijama), a traditional medicine practice, holds religious and cultural significance, particularly in Middle Eastern and Islamic societies. However, this practice can lead to serious complications when performed under inappropriate conditions or by unqualified individuals.

Benralizumab In Severe Eosinophilic Asthma: A Real-Life Data From Türkiye.

Background: Benralizumab, a monoclonal antibody targeting IL-5α receptors, is approved for the treatment of severe eosinophilic asthma (SEA). Despite proven efficacy in randomized controlled trials, real-life data remain limited. This study aimed to evaluate effectiveness of benralizumab in real-life settings.

Impact of in ovo and water supplementation of a postbiotic on intestinal integrity and immune responses in broiler chickens challenged with necrotic enteritis.

Necrotic enteritis (NE) is an enterotoxemic disease of poultry caused by and inflicts substantial economic losses in the poultry industry. Postbiotics have emerged as a promising mitigation approach for NE as they can improve birds' performance and nutrient absorption and reduce NE-associated pathology. This study evaluated the effects of in ovo and post-hatch application of a postbiotic on intestinal health and the response of broilers during a subclinical NE challenge.