Sensorimotor Cortical Integration Remains Unchanged After Dorsal Root Ganglion Pulsed Radiofrequency.

Background: Dorsal root ganglion (DRG) pulsed radiofrequency (PRF) is a minimally invasive neuromodulation technique used for the management of chronic radicular pain. While its analgesic effects are well-documented, its impact on sensorimotor integration at the cortical level remains unclear. This study aimed to investigate whether DRG PRF modulates sensorimotor integration via the cholinergic system using the Short-Latency Afferent Inhibition (SAI) paradigm.

A new characteristıc of systemic lupus erythematosus: subclinical vein involvement-an in-depth biochemical and imaging study.

Objectives: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder often complicated by vascular events, with or without antiphospholipid antibody syndrome (APS). This study aimed to explore subclinical venous involvement in SLE using biochemical and imaging modalities, focusing on vein wall thickness (VWT) and inflammation-related biomarkers.

Methods: In this cross-sectional study, 68 SLE patients were categorized based on antiphospholipid antibody (APA) status and clinical APS.

Potential Role of SGLT-2 Inhibitors in Improving Allograft Function and Reducing Rejection in Kidney Transplantation.

Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have demonstrated renoprotective and cardioprotective benefits beyond their antiglycemic effects. Their potential utility in kidney transplant recipients (KTRs) for preserving graft function and reducing rejection risk is currently under active investigation. Preliminary studies indicate that SGLT-2i therapy stabilizes estimated glomerular filtration rate (eGFR), decreases glomerular hyperfiltration, and improves metabolic outcomes in KTRs.

Primary repair versus reconstruction of the anterior cruciate ligament: Functional outcomes and postural stability compared with healthy controls.

Purpose: To compare functional outcomes and postural stability in patients undergoing primary anterior cruciate ligament (ACL) repair or hamstring tendon reconstruction, using healthy individuals as a reference. We hypothesized that primary ACL repair would result in superior subjective knee function and postural stability.

Methods: This comparative case-control study assessed pain, function, single-leg hop performance and postural stability were assessed using the Visual Analogue Scale (VAS), Lysholm Knee Score, International Knee Documentation Committee (IKDC) Score and Biodex Biosway indices (OSI: overall stability index, API: anteroposterior index, MLI: mediolateral index) in bipedal and single-leg stance.

Long-Term Neurodevelopmental Outcomes of the SAFE Early Intervention in Infants at Risk: A Randomised Controlled Trial.

Background: Early intervention for infants at risk of cerebral palsy (CP) plays a critical role in improving neurodevelopmental outcomes. Recently, approaches emphasising infant active participation and family collaboration have shown greater effectiveness compared to traditional methods.

Aims: This study aimed to evaluate the effects of the SAFE early intervention approach on cognitive, language, and motor development in infants at risk for CP, in comparison to conventional neurodevelopmental treatment (NDT) practices.

Hidden blood loss in dega osteotomy with varus derotation osteotomy is more pronounced than in varus derotation alone.

Level III - case-control study.

Bronchiectasis in Children: A Comparative Analysis of Cystic Fibrosis and Non-Cystic Fibrosis Etiologies Using the Bhalla Score.

Background: Childhood bronchiectasis (BE) is a chronic lung condition that remains under recognized, marked by irreversible widening of the bronchi, frequent respiratory infections, a persistent wet cough, and progressive lung damage, often leading to significant health burdens.

Aims: To evaluate children with cystic fibrosis (CF) and non-CF BE and to examine the association between clinical presentation and radiological severity of BE using the Bhalla scoring system.

Study Design: Retrospective observational study.

Executive functioning difficulties in relation to food addiction, disordered eating attitudes, and metabolic syndrome markers among adolescents seeking obesity treatment: a cross-sectional analysis.

Background: Executive functioning (EF) difficulties may play a significant role in the vicious cycle of overeating and metabolic disturbances. We aimed to investigate the correlates of EF difficulties in terms of food addiction symptoms, eating attitudes, and metabolic syndrome markers among adolescents seeking obesity treatment.

Methods: Thirty-five adolescents seeking obesity treatment were included.

Recent advances in vascular ultrasound imaging technology and their clinical implications.

A multiparametric ultrasound (US) approach, which is defined as the use of existing and new ultrasonographic technologies to enhance diagnostic accuracy, can be applied in vascular imaging. By incorporating techniques such as stiffness evaluation, elastography modalities, vector flow imaging, slow flow imaging, contrast-enhanced US, and three-dimensional imaging, this approach offers deeper insights into various vascular conditions, including vascular aging. Advancements in technology now make it possible to quickly obtain numerical values for various vessel properties on a screen or worksheet, simplifying and streamlining the multiparametric approach.

Effects of Different Application Routes of Ozone on Testicular Tissue in Rats with Spinal Cord Ischemia and Reperfusion Injury.

Background: Spinal cord ischemia-reperfusion injury (IRI) is a serious condition that can develop after spinal and thoracoabdominal surgeries or spinal cord traumas. The aim of this study was to investigate the effects of different administration routes of ozone on testicular tissue in rats with spinal cord ischemia and reperfusion injury.

Methods: Rats were divided into five groups (n:5): control (C), ischemia-reperfusion (IR), IR-rectal ozone (IR+RO), IR-intratechal ozone (IR+ITO), and IR-intraperitoneal (i.

GGT-normal cholestasis associated with LSR deficiency: A potential new subtype of PFIC.

Introduction: Hereditary cholestatic liver diseases are a group of disorders caused by different gene mutations encoding proteins involved in bile production, transport, or secretion. New genetic disorders have been identified in cholestatic patients through an increased understanding of these proteins, evolving genetic technology and more widespread genetic testing. Recently, mutations in the Lipolysis-Stimulated Lipoprotein Receptor (LSR) gene have been identified as a novel cause of infantile intrahepatic cholestasis.

Transcranial magnetic stimulation identifies early cortical abnormalities in radiologically isolated syndrome.

Background: Radiologically isolated syndrome (RIS) is a preclinical stage of multiple sclerosis, characterized by demyelinating lesions on MRI. Transcranial magnetic stimulation (TMS) can detect corticospinal dysfunction associated with demyelination and neuronal loss.

Objective: This study aimed to investigate motor cortical excitability in RIS using TMS and explore its relationship with cognition, fatigue and MRI lesion characteristics.

Associations of CRP and PCT levels with obstetric and neonatal outcomes: a prospective study.

Background: C-reactive protein (CRP) and procalcitonin (PCT) levels may be elevated under inflammatory conditions. The aim of this study was to determine the cutoff values for CRP and PCT levels during pregnancy and to evaluate the associations of any elevation with obstetric and neonatal outcomes.

Methods: This prospective study was conducted from June 2023 to December 2024.

Effect of ALPSA Tear Morphology on Redislocation Risk After Arthroscopic Repair.

Background: Recent studies have emphasized the importance of lesion location and tear structure for understanding Bankart lesions; however, knowledge on anterior labroligamentous periosteal sleeve avulsion (ALPSA) lesion characteristics in anterior shoulder instability remains limited.

Purpose: To evaluate the prevalence of various ALPSA lesion patterns and their effect on redislocation rates after labrum repair.

Study Design: Case-control study; Level of evidence, 3.

Stigmatization negatively affects exercise compliance in children with adolescent idiopathic scoliosis: a cross-sectional study.

Objective: Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity that can impact both physical and psychosocial well-being. Stigmatization, particularly during adolescence, may influence adherence to conservative treatment strategies, including exercise therapy. This study examines the relationship between scoliosis-related stigma and adherence to exercise therapy in AIS patients.

Endovascular treatment of vertebral artery ostial stenosis with second generation drug-eluting coronary stents: Long-term follow up.

Background And Purpose: To evaluate the patency and clinical outcomes of drug-eluting stents (DES) in patients with symptomatic and significant vertebral artery ostial stenosis (VAOS).

Methods: This single-center, retrospective observational study included 31 patients (21 males, 10 females; mean age: 64 ± 10.56 years) who underwent DES placement for severe (>70 %) symptomatic VAOS in our institution between 2013 and 2023.

Evaluation of Low Alkaline Phosphatase Levels in Clinical Practice: Implications for Diagnosing Hypophosphatasia.

Persistent low serum alkaline phosphatase (ALP) levels are crucial in identifying genetic disorders such as hypophosphatasia (HPP). This study investigates the causes of low ALP levels in children, aiming to evaluate the demographic and clinical characteristics of those diagnosed with HPP.We evaluated 2243 children and adolescents, ranging from 0 to 19 years old between September 2019 and July 2024, who exhibited at least two ALP levels below the age- and gender-specific lower limit.

Validation of the Turkish Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (Quip-Rs).

Background: Impulse control disorders and related behaviors (ICDs-RBs) significantly affect the quality of life of Parkinson's disease (PD) patients. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) was developed to identify and monitor these behaviors. This study aimed to translate and validate the Turkish version of QUIP-RS.

KRAS mutation subtypes in metastatic non-small cell lung cancer.

The aim of this study is to determine the clinicopathologic features of KRAS mutant metastatic non-small cell lung cancer (NSCLC) patients and to determine the clinical, prognostic and survival differences between subtypes and their relationship with response to treatment. A total of 101 patients with KRAS mutant metastatic non-small cell lung cancer treated in 3 oncology centers between 2013 and 2024 were included in this retrospective, multicenter study conducted in Turkey. Molecular analysis was confirmed by next generation sequencing (NGS; QIAGEN Clinical Insight Interpretation, United States).

Real-World Outcomes in BRAF-Mutant Non-small Cell Lung Cancer: A Multicenter Analysis From the Turkish Oncology Group.

Background: Real-world data on BRAF-mutant non-small cell lung cancer (NSCLC) remain limited, particularly regarding outcomes with dabrafenib plus trametinib (D + T).

Methods: This multicenter retrospective study included 88 patients with advanced BRAF-mutant NSCLC treated across 30 centers. Clinicopathologic characteristics, treatment outcomes, and safety data were collected and analyzed.

How early is early for JIA? Insights from the infantile-onset juvenile idiopathic arthritis patients of the PERA research group cohort.

Objective: Juvenile idiopathic arthritis (JIA) is the most common chronic childhood arthritis, with distinct categories based on pathophysiology and clinical manifestations. The age of onset varies by category but is reported to be approximately six years. This study aimed to evaluate the clinical, laboratory, and outcome characteristics of patients with the infantile-onset JIA.