Inhibition of DJ-1 protects from lupus onset and severity.

The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels.

Fundamental Understanding and Material Challenges in Rechargeable Magnesium-Sulfur Battery: Current Advances and Perspective.

Rechargeable magnesium-sulfur (Mg-S) batteries have recently aroused broad attention due to their large theoretical energy density, low cost and negligible safety concerns compared to lithium-ion and lithium-sulfur counterparts. Great research efforts have been devoted to exploiting and advancing this Mg-S batteries and endowing them as the competitive alternatives for next-generation energy storage systems. However, the insufficient reversible capacity and rapid capacity loss have severely hindered their practical application due to the inevitable Mg-anode passivation, low sulfur utilization efficiency, polysulfide shuttle effect, and electrode-electrolyte incompatibility.

EVA1A facilitates glycolysis in esophageal squamous cell carcinoma to boost PLAU histone lactylation and dampen CD8 T cell activity.

Background: Endogenous retrovirus group E member 1 (EVA1A) is expressed in various normal tissues and plays a role in tumor development. However, its function in esophageal squamous cell carcinoma (ESCC) and immune regulation remains unclear.

Research Design And Methods: Bioinformatics, clinical samples, and in vivo/in vitro experiments were used to evaluate EVA1A expression and function.

Spatially Engineered Ternary Schottky/S-Scheme Heterojunctions for Artificial Photosynthesis.

Photocatalytic CO reduction into solar fuels presents a promising strategy for carbon mitigation and sustainable energy conversion. However, single-component photocatalysts suffer from inefficient charge separation, while binary heterojunctions-even with cocatalysts assistance-often undergo rapid Coulombic recombination due to timescale mismatches between ultrafast charge transfer and slower surface reaction kinetics. To overcome these limitations, a spatially engineered NbC/NbO/ZnO ternary heterostructure is developed by anchoring ZnO quantum dots (QDs) onto NbO nanorods grown in situ from NbC MXene.

Ligament reconstruction combined with osteotomy: Case report.

Rationale: Valgus deformity of the knee joint is caused by congenital anatomical abnormalities. The occurrence of an anterior cruciate ligament (ACL) tear in conjunction with a medial patellofemoral ligament (MPFL), alongside knee valgus deformity, is exceedingly rare in clinical practice.

Patient Concerns: A 30-year-old female presented with congenital valgus knee.

Comparative transcriptomic analysis reveals breed-specific developmental characters of skin and feather follicles between Anser Cygnoides and Anser Anser.

Feather follicle development is essential for the phenotypic characteristics and economic value of domesticated geese. In this study, we conducted a comparative transcriptomic analysis to explore the breed-specific molecular mechanisms involved in feather follicle development in Zhedong white goose (Anser cygnoides) and Hungarian white goose (Anser anser) at five critical embryonic stages (E10, E13, E18, E23, and E28). A total of 19,622 differentially expressed genes (DEGs) were identified in geese feather follicles across the comparison groups, with significant enrichment in pathways associated with neuroactive ligand-receptor interaction, melanogenesis, tyrosine metabolism, metabolic pathways, PPAR, p53, VEGF, and Hedgehog signaling pathways.

Advanced strategy for cancer detection based on volatile organic compounds in breath.

The analysis of volatile organic compounds (VOCs) in exhaled breath has emerged as a promising non-invasive approach for cancer diagnosis, offering advantages in speed, safety, cost-effectiveness, and real-time monitoring. Two primary methodologies are employed for VOCs detection: mass spectrometry (MS)-based techniques, which provide high-precision identification and quantification of individual compounds, and sensor-based pattern recognition methods, which detect disease-specific VOC signatures. Despite their diagnostic potential, inconsistencies in accuracy highlight the need for a comprehensive evaluation of these techniques.

Dietary baking soda (NaHCO) therapy recovered urolithiasis-induced kidney injury in mice by inhibition of oxidative stress, pyroptosis, and inflammation through gut-kidney axis.

Background: Urolithiasis is one of the most common urological diseases, and its incidence has increased globally in recent years. Multiple potential mechanisms are involved in urolithiasis, including renal oxidative stress, inflammatory response, fibrosis, pyroptosis, and gut microbiota disturbance. Sodium bicarbonate (NaHCO) is commonly used clinically to alkalize urine and slow the progression of chronic kidney disease, including urolithiasis.

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer.

Genetic testing for pathogenic germline variants is critical for the personalized management of high-risk breast cancers, guiding targeted therapies and cascade testing for at-risk families. In this study, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing) is proposed, a deep learning framework that integrates histopathological microenvironment features from whole-slide images with clinical phenotypes from electronic health records for precise prescreening of germline BRCA1/2 mutations. Leveraging a multi-scale Transformer-based deep generative architecture, MAIGGT employs a cross-modal latent representation unification mechanism to capture complementary biological insights from multimodal data.

Effects of Heat Treatment Cooling Methods on Precipitated Phase and Tensile Properties of Fe-18Mn-10Al-1C-5Ni Lightweight Steel.

This research focuses on Fe-18Mn-10Al-1C-5Ni lightweight steel and deeply explores the influences of three different cooling methods, namely, water quenching (WQ), air cooling (AQ), and furnace cooling (FQ), on the precipitation behavior of the B2 phases and κ-carbides in the lightweight steel. The intrinsic relationship among the precipitated phases, mechanical properties, and fracture behavior is revealed. Compared with the WQ sample, the size of the intragranular B2 phase in the AQ sample did not change significantly (an increment of 9 nm), but nano-sized κ-carbides appeared at the grain boundaries and inside the grains.

The support provision and self-support journey of partners in high-risk pregnancies with comorbidities: A meta-synthesis analysis.

Aims: To explore the support provision and self-support journey of partners in high-risk pregnancies with comorbidities by integrating qualitative findings.

Methods: This is a meta-synthesis of qualitative studies. We systematically reviewed six electronic databases for relevant studies published from inception to January 2025.

Can reconfiguring the band-edge states regulate excitonic states in two-dimensional superlattice perovskites?

Herein, the reconfiguration of band-edge states in two-dimensional superlattice perovskites is theoretically investigated, followed by analysing the nature of the excitonic states. The relationship between density distributions of excitons and band edges is explored. Our work provides new considerations for the design of low-dimensional perovskites as optoelectronic materials.

Prevalence of and risk factors for important comorbidities of systemic lupus erythematosus using data from a multicenter Chinese cohort registry: A cross-sectional study.

Objectives: Patients with systemic lupus erythematosus (SLE) are at high risk of cardiovascular disease (CVD), fragility fractures, and malignancies. However, data regarding these comorbidities among Chinese SLE patients are limited. We aimed to determine the prevalence of and risk factors for these three major comorbidities in a large cohort of Chinese SLE patients.

Dietary supplementation with antibacterial peptide microcin J25 improved antioxidant capacity and intestinal health of pigeons.

Introduction: The present study aimed to evaluate the potential of antimicrobial peptide microcin J25 (MccJ25) as a feed additive for pigeons.

Methods: A total of 28-day-old pigeons were allocated to four groups and fed a basal diet (CON) or a basal diet supplemented with 100, 200, or 300 mg/kg MccJ25 (ABP100, ABP200, and ABP300) for 8 weeks.

Results: Dietary MccJ25 supplementation significantly improved survival rates in the ABP200 group compared to the control ( < 0.

Inhibition of ACSL4 Attenuates Behavioral Deficits by Regulating Ferroptosis in a Murine Model of Systemic Lupus Erythematosus.

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a disorder with a poor prognosis characterized by psychiatric and neurological manifestations directly associated with systemic lupus erythematosus (SLE). Neutrophil ferroptosis has been identified as a significant contributor to neutropenia and disease progression in SLE, but its role in NPSLE remains unclear. Female MRL/lpr and MRL/Mpj mice were used.

Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancer.

Background: Breast cancer (BRCA) is a significant threat to women's health worldwide, and its progression is closely associated with the tumor microenvironment and gene regulation. Lactylation modification, as a key epigenetic mechanism in cancer biology, has not yet been fully elucidated in the context of BRCA. This study examines the regulatory mechanisms of lactylation-related genes (LRGs), specifically PRDX1, and their prognostic significance in BRCA.

Exosome-shuttled miR-5121 from A2 astrocytes promotes BSCB repair after traumatic SCI by activating autophagy in vascular endothelial cells.

Spinal cord injury (SCI) is a severe neurological disorder that significantly impacts patients' quality of life. Following SCI, the blood-spinal cord barrier (BSCB) is destroyed, leading to ischemia and hypoxia, which further exacerbates the imbalance in the spinal cord microenvironment. A2-type astrocytes, which arise under ischemic and hypoxic conditions, have been reported to promote SCI repair.

Integrated omics reveals the regulatory role of PKCα in Sertoli cell proliferation and apoptosis through the MAPK/ERK signaling pathway in goose testis.

Testicular development is essential for reproductive performance in geese, as the testes are the primary organs for sperm production and play a pivotal role in egg-laying physiology. Despite their importance, genes, proteins, and pathways regulating goose testicular development are poorly understood. This study employed integrative transcriptomic and proteomic analysis methods to identify critical regulators of testicular development in geese across three reproductive periods.

Galacto-oligosaccharides alleviate experimental lactose intolerance associated with gut microbiota in mice.

Introduction: Galacto-oligosaccharides (GOS) are beneficial for alleviating lactose intolerance (LI). GOS have the ability to modify the composition of the intestinal microbiota. The development of intestinal diseases could be influenced by the composition of the gut microbiota.

The causal relationship between obstructive sleep apnea and rheumatic disease: A bidirectional Mendelian randomization study.

Background And Objective: Multiple studies have shown a substantial association between obstructive sleep apnea (OSA) and rheumatic disease. However, traditional studies are susceptible to confounding factors or reverse causal relationships, and the exact causal relationship still needs to be clearly defined. This study aims to use a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal association between OSA and rheumatoid immune diseases.

Cell-free DNA Fragmentomics Assay to Discriminate the Malignancy of Breast Nodules and Evaluate Treatment Response.

The fragmentomics-based cell-free DNA (cfDNA) assays have recently illustrated prominent abilities to identify various cancers from non-conditional healthy controls, while their accuracy for identifying early-stage cancers from benign lesions with inconclusive imaging results remains uncertain. Especially for breast cancer, current imaging-based screening methods suffer from high false positive rates for women with breast nodules, leading to unnecessary biopsies, which add to discomfort and healthcare burden. Here, we enrolled 613 female participants in this multi-center study and demonstrated that cfDNA fragmentomics (cfFrag) is a robust non-invasive biomarker for breast cancer using whole-genome sequencing.

Risk factors and predictive model for pulmonary arterial hypertension in adult idiopathic-inflammatory-myopathy patients: A cross-sectional study.

Objective: To identify clinical and laboratory risk factors for Pulmonary Arterial Hypertension (PAH) in Idiopathic-Inflammatory-Myopathy (IIM) patients as well as construct a predicting model for PAH.

Methods: An IIM cohort in southeastern China was established, including 504 adult IIM patients who met the inclusion and exclusion criteria, and were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZJU) from January 1st, 2018, to April 30st 2022. Serum cytokine profiles, myositis-specific antibodies as well as other factors of patients who met the inclusion and exclusion criteria were collected and analyzed.

How to Break Stubborn Association Between Hearing Loss and Cognitive Impairment: A Systematic Review and Meta-Analysis of Moderators and Mediators.

BackgroundHearing loss has been related to impaired cognition among older adults. The cost effectiveness of existing hearing support tools is controversial. Other potential modifying strategies that could effectively intervene in this prevalent and far-reaching association between hearing loss and cognitive decline remain unclear.

Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance.

In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature of solid tumors and is strongly associated with poor prognosis in cancer patients. Another significant portion of the development of acquired drug resistance is attributed to tumor stemness.

Site-specific synergy in heterogeneous single atoms for efficient oxygen evolution.

Heterogeneous single-atom systems demonstrate potential to break performance limitations of single-atom catalysts through synergy interactions. The synergy in heterogeneous single atoms strongly dependes on their anchoring sites. Herein, we reveal the site-specific synergy in heterogeneous single atoms for oxygen evolution.