The renoprotective anti-hyperuricemia effect of Cornus officinalis extract in hyperuricemia rats based on network pharmacology and multiple omics.

Ethnopharmacological Relevance: Corus officinalis Siebold & Zucc belongs to the genus Cornus in the Cornaceae family, and was first recorded in the "Shennong Herbal Classic", now has been included in "according to the tradition of both food and Chinese herbal medicines", consist of kidney and liver tonifying, antioxidant substances including cycloid glycosides, flavonoids, polyphenols, organic acids, etc. AIM OF THE STUDY: This study was aimed at discovering the mechanism underlying the anti-hyperemia effect of Cor in rats, particularly its protective effect against liver and kidney dysfunction caused by HUA.

Materials And Methods: In this study, the effect of Cor extract against HUA was verified in rats, subsequently, network pharmacology combined with non-targeted metabolomic were performed to investigate its composition characteristics, and further multi-omics studies and molecular validation were performed to reveal molecular mechanism both in vivo and in vitro.

Forty years of global research on WHO's four critical priority fungal pathogens: Advances and prospects.

Background: On October 25, 2022, the World Health Organization (WHO) released its first Fungal Priority Pathogen List (FPPL), classifying Cryptococcus neoformans (C. neoformans), Candida auris (C. auris), Aspergillus fumigatus (A.

Beyond top-hit nontarget screening: Diagnostic fragment analysis reveals nitrogen-containing heterocycles in iron and steel industry wastewater.

Nitrogen-containing heterocyclic compounds (NHCs), widely present in industrial wastewater, pose significant environmental and health risks, yet their identification and characterization remain poorly understood. Herein, we developed a diagnostic fragment list comprising 20 nitrogen-containing fragments for NHCs, by integrating chemical information from Pubchem with the NIST mass spectral library. Leveraging this list, we employed a diagnostic fragment-assisted nontarget screening approach and identified 151 NHCs in iron and steel industry wastewater.

Geographical flavor fingerprinting of morels: integrated analysis of volatile and non-volatile components with environmental drivers across Chinese regions.

Morel (Morchella spp.) is highly valued and increasingly widely cultivated in China. However, due to the limited analysis of its flavor components and origin, its full utilization is restricted.

Gut microbiota and metabolites related intra-patient variability of tacrolimus pharmacokinetics predicted adverse one-year outcomes following kidney transplantation.

Kidney transplantation (KT) is an effective treatment for end-stage renal disease, with over 90 % of recipients requiring lifelong tacrolimus (Tac). However, The Tac pharmacokinetics exhibit high intra-patient variability (IPV), posing significant challenges. This study included 102 KT recipients at our center from October 2022 to December 2023.

C2-Benzylic C(sp)-H Alkylation of Indoles Enabled by Photoinduced, EDA-Complex-Mediated Radical-Radical Cross-Coupling.

2-Alkylindoles are privileged motifs that serve as versatile intermediates and building blocks in synthetic and medicinal chemistry. Herein, we report a photoinduced, EDA-complex-enabled C2-benzylic C(sp)-H alkylation of indoles with bromides through radical cross-coupling. This developed protocol provides facile access to 2-alkylindoles from structurally varied 2-methylindoles and bromides under mild reaction conditions with simple operation.

Synthesis and Biological Evaluation of Platensimycin Analogues with Improved Antimycobacterial Activity.

KasA and KasB are promising drug targets against and infectious nontuberculous mycobacteria, while most lead compounds are in the preclinical development stage. Herein, a platensimycin (PTM) analogue library consisting of 340 members was first screened to identify 46 PTM thioethers with superior activity compared to that of PTM against . Next, 19 PTM thioethers were chosen and semisynthesized from PTM oxirane (), together with seven PTM ether derivatives and 6-ido, 6-bromo-, and 6-thiocyanato PTM.

Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against non-small cell lung cancer.

Lung cancer is the most common cancer and one of the leading causes of cancer-related deaths in the world, however, the treatment of non-small cell lung cancer (NSCLC) is still limited, and it is a clinically urgent problem. ROBO1 is an important surface receptor on tumor cells, but the role of humanized chimeric antigen receptor (CAR) modified natural killer (NK) cells targeting ROBO1 in NSCLC is rarely explored. Furthermore, the role of PD-1 in NK cell killing tumor cells remains controversial.

Machine learning for the prediction of blood transfusion risk during or after mitral valve surgery: a multicenter retrospective cohort study.

This study aimed to identify the optimal prediction method and key preoperative variables for red blood cell (RBC) transfusion risk in patients undergoing mitral valve surgery. We conducted a retrospective study involving 1477 patients from eight large tertiary hospitals in China who underwent mitral valve surgery with cardiopulmonary bypass. From thirty collected preoperative variables, the Max-Relevance and Min-Redundancy (mRMR) method was used for feature selection, and various machine learning models were evaluated.

Predictors of progression from pre-frailty to frailty in older people: a systematic review and meta-analysis protocol.

Introduction: Frailty is a global health issue, particularly among older adults, and is strongly associated with adverse health outcomes. The intermediate stage of pre-frailty, which represents a transition from robust health to frailty, has garnered growing concern due to its potential reversibility. This systematic review and meta-analysis will aim to identify predictors associated with the progression from pre-frailty to frailty in older adults.

STAT1-VAMP8 axis drives nasopharyngeal carcinoma progression via autophagy enhancement.

Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high risk of invasion and metastasis. Elucidating the molecular underpinnings of NPC may uncover new diagnostic and therapeutic targets. Vesicle associated membrane protein 8 (VAMP8) is overexpressed and plays an oncogenic role in various tumors.

Volatile organic compounds exposure with risk of thyroid function in U.S. general population: 2007-2012 NHANES.

Background: The link between exposure to environmental hazards and thyroid function has been relatively well established. However, evidence on environmental exposure to volatile organic compounds (VOCs) and thyroid function in the general population remains unclear.

Objectives: To assess the impact of individual and joint effects of VOCs exposure on thyroid function in a representative sample of U.

Consensus statement on the multidisciplinary treatment of nasopharyngeal carcinoma with immune checkpoint inhibitors in China.

Introduction: This study aims to establish a multidisciplinary consensus on the treatment of nasopharyngeal carcinoma (NPC) in China, with a particular focus on the guidelines for the use of immune checkpoint inhibitors (ICIs) to ensure scientific and rational treatment protocols.

Methods: The consensus was formulated based on the 'guidelines for the diagnosis and treatment of NPC (2024 edition)' issued by the Chinese Society of Clinical Oncology. The Delphi method was used to collect and consolidate expert opinions.

Efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for chronic rhinosinusitis.

Background: Chronic rhinosinusitis (CRS) leads to a burden in life and economy. Better therapies need to be explored.

Objective: This stage I study aims to explore the efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for CRS.

Latent profile analysis of healthcare-related regret coping among Master of Nursing specialist students during clinical internships: A multi-center cross-sectional study.

Background: Healthcare-related regret (HRR) is frequently encountered by healthcare professionals, even in the early clinical stages. Effective coping strategies are essential for mental well-being, professional performance, and career satisfaction. However, the specific coping mechanisms used by Master of Nursing specialist (MNS) students during clinical internships are not well understood.

Recaticimab in adult heterozygous familial hypercholesterolemia (REMAIN-3): A multicentre, randomised, double-blind, placebo-controlled phase 3 study.

Aims: Heterozygous familial hypercholesterolemia (HeFH) is a genetic disorder, characterised by high plasma concentrations of low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the efficacy and safety of recaticimab, a new humanised anti-PCSK9 antibody capable of reducing LDL-C levels in patients with poorly controlled HeFH.

Methods And Results: REMAIN-3 was a multicentre, randomised, double-blind, placebo-controlled phase 3 study done at 25 sites in China.

Acute kidney injury: pathogenesis and therapeutic interventions.

Acute kidney injury (AKI) is a prevalent clinical condition that is associated with unacceptably high morbidity and mortality, as well as the development of chronic kidney disease (CKD). The pathogenesis of AKI is highly complex and heterogeneous, primarily attributed to metabolic disturbances arising from the disease itself and the administration of medications related to treatment. In recent years, AKI in cancer patients is highly concerned.

[Influencing factors of fertility preservation decision-making in patients with testicular cancer： A qualitative study].

Objective: The aim of this study is to explore the influencing factors of fertility preservation decision-making in testicular cancer patient and provide a basis for clinical decision.

Methods: A descriptive qualitative study was conducted using purposive sampling in 18 testicular cancer patients. Semi-structured interviews were performed, and data were analyzed through content analysis.

Pharmacogenomic analysis of low-density lipoprotein receptor 3' untranslated region genetic variants influencing rosuvastatin efficacy in Chinese dyslipidemia patients.

Objectives: Dyslipidemia is a crucial risk factor for atherosclerotic cardiovascular disease. Although rosuvastatin is widely used, treatment response varies significantly due to genetic variation. This study investigated the pharmacogenomic impact of low-density lipoprotein receptor (LDLR) 3' untranslated region (UTR) variants on rosuvastatin efficacy in a Chinese Han adult cohort with dyslipidemia.

PLEKHF1 Induces Mitochondrial Dysfunction to Inhibit Osteosarcoma Growth and Metastasis.

Osteosarcoma (OS) is an uncommon malignancy with stagnant survival rates over the past four decades and early-stage metastasis, predominantly affecting children and adolescents. This study identified significant metabolic differences between metastatic and non-metastatic OS samples through bioinformatics analysis, highlighting key processes such as cell proliferation, mitochondrial assembly, and changes in mitochondrial membrane permeability. Among differentially expressed genes, Pleckstrin Homology And FYVE Domain Containing 1 (PLEKHF1) was the most significantly downregulated in metastatic OS samples.

Enhanced *COOH Adsorption over Edge-Rich Ni-N Sites for Efficient Acidic CO Electroreduction.

Single-atom Ni catalysts hold great promise for the acidic CO reduction reaction (CORR), owing to their high CO selectivity. However, their performance under industrially relevant high current conditions is limited by the weak interaction between isolated Ni-N sites and *COOH intermediates, restricting efficient CO conversion. Here, we introduced edge-rich Ni-N sites via support vacancy engineering to enhance *COOH adsorption, thereby boosting the CORR activity and selectivity in acidic media.

A dual-site doping strategy to enhance the sodium storage performance of an O3-type layered sodium oxide cathode.

The O3-type NaNiFeMnO material is modified by introducing Sr into the Na sites and Al into the transition metal (TM) sites. The inactive Sr and Al serve as structural pillars within the NaO and TMO slabs, respectively, expanding the interlayer spacing and boosting the stability of the structure. The optimized cathode demonstrates a good rate performance of 117.