C2-Benzylic C(sp)-H Alkylation of Indoles Enabled by Photoinduced, EDA-Complex-Mediated Radical-Radical Cross-Coupling.

2-Alkylindoles are privileged motifs that serve as versatile intermediates and building blocks in synthetic and medicinal chemistry. Herein, we report a photoinduced, EDA-complex-enabled C2-benzylic C(sp)-H alkylation of indoles with bromides through radical cross-coupling. This developed protocol provides facile access to 2-alkylindoles from structurally varied 2-methylindoles and bromides under mild reaction conditions with simple operation.

Photoinduced, Pd-Catalyzed Enantioselective Cascade Carboamidation of Dienes to Access γ-Lactams.

Chiral γ-lactam scaffolds represent a privileged structural motif that is prominently featured in numerous biologically active natural products and pharmaceuticals. Notably, due to the intimidating challenges in the stereocontrol for the intramolecular amidation, the asymmetric cascade carboamidation of the C═C bond to access structurally diverse chiral γ-lactams from readily available 2-bromoamides remains unexplored. Herein, a photoinduced, Pd-catalyzed enantioselective cyclization of conjugated 1,3-dienes with 2-bromoamides has been accomplished.

Current status of transcriptome sequencing technology in ruminants.

In many parts of the world, safe ruminant production underpins food security, while ruminant meat and milk are important agricultural commodities and a major source of protein requirements in the human diet. In order to maintain the sustainability of such agricultural products, animal production should be made more efficient through better management and production techniques. Ruminating animals such as cows and sheep have been used for the synthesis of dairy products, the production of high-quality meat, and the study of reproductive mechanisms.

GPX8 as a potential prognostic marker in gastric and colorectal cancer.

Gastric and colorectal cancers are common malignancies with high incidence and mortality worldwide. Early detection and individualized treatment are crucial to improving patient outcomes. Glutathione peroxidase-8 (GPX8), a member of the glutathione peroxidase family, emerges as a potential target for intervention in the treatment of various cancers.

EDA-Enabled Three-Component Polarity-Crossover Cyclization: Modular Installation of Fully Substituted γ-Lactams.

A photoinduced three-component radical addition-aminalization cascade was accomplished, enabling rapid assembly of a wide range of densely functionalized γ-lactams. Key to this transformation is the electron-donor-acceptor (EDA) generation of enamine and in situ trapping of an iminium intermediate with bromodifluoroacetamide. This rationally designed protocol fully takes advantage of the polarity crossover (enamine-iminium) in the process, providing the modular assembly of previously inaccessible scaffolds.

Enantioselective 1,2-Carboamination of 1,3-Dienes with -Hydroxyphthalimide (NHP) Esters Enabled by a Photoinduced Pd Catalysis.

Herein, a photoinduced, Pd-catalyzed direct 1,2-carboamination of conjugated 1,3-dienes has been successfully achieved. Sequential regioselective C-C bond and enantioselective C-N bond formation allows rapid assembly of a wide range of value-added chiral allylic amines from readily available -hydroxyphthalimide (NHP) esters and 1,3-dienes under mild conditions. This developed protocol further demonstrates the versatility and potency of the photoexcited Pd catalytic system with a bifunctional reagent in the streamlined difunctionalization of C═C bonds.

Progress in the application of Enterococcus faecium in animal husbandry.

As a probiotic, enterococcus faecium (E. faecium) has the characteristics of high temperature resistance, gastric acid resistance, bile salt resistance, etc. It can also effectively improve animal performance and immunity and improve the animal's intestinal environment, so in recent years it has been more widely used in the livestock industry.

Visible-light-driven oxidation of organosilanes by a charge-transfer complex.

Direct oxidation of organosilanes is one of the most straightforward ways to access silanols. Herein, we describe a novel photo-induced strategy for oxidation of organosilanes to access silanols, promoted by a photoactive charge-transfer complex (CTC) between sodium benzenesulfinate and molecular O. A streamlined sequence transformation of organosilanes to silyl ethers was also readily achieved.

Photochemical Organocatalytic Aerobic Cleavage of C═C Bonds Enabled by Charge-Transfer Complex Formation.

A novel visible-light-driven organocatalytic protocol to access aerobic oxidative cleavage of olefins, promoted by sodium benzene sulfinate, is described herein. An array of alkenes smoothly delivered the corresponding aldehydes and ketones under transition-metal-free conditions. Notably, α-halo-substituted styrenes proceeded with photoinduced oxidation to finally afford α-halo-acetophenones with halogen migration.

Propofol modulates glycolysis reprogramming of ovarian tumor via restraining circular RNA-zinc finger RNA-binding protein/microRNA-212-5p/superoxide dismutase 2 axis.

Metabolic reprogramming refers to the transformation of the whole metabolic network covering glycolysis and mitochondrial metabolism, which is primarily manifested as the Warburg effect and mitochondrial metabolic reprogramming. Propofol (Pro) has been testified to suppress the malignancy of diversified human cancers. Nevertheless, its role in glycolysis is still uncertain.

Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes.

Herein, a tunable iodization/deuterolysis protocol for phosphonium ylides by employing DO as the deuterium source was designed. Notably, this process could be manipulated by tuning the base, thus leading to two valuable deuterated building blocks - benzyl iodides and aromatic aldehydes with broad substrate scope, good functional group compatibility and excellent deuteration degree. Concise syntheses of a series of deuterated drug analogues have been achieved based on the developed deuteration reaction platform.

Visible-Light-Induced, Palladium-Catalyzed 1,4-Difunctionalization of 1,3-Dienes with Bromodifluoroacetamides.

A highly modular 1,4-difunctionalization of 1,3-dienes with bromodifluoroacetamides and sulfinates/amines through a photoinduced palladium-catalyzed radical relay process is described herein. This developed protocol offers a facile and general route to access a variety of value-added CF-incorporated alkenes in moderate to good yields. The versatility and flexibility of this approach have been well illustrated by readily accessible starting materials, synthetic convenience, and wide functional group compatibility.

[Aging Process and DOC Analysis of Four Different Types of Plastic Particles in Freshwater Systems].

Although the pollution of freshwater systems by microplastics and the resulting ecological effects have attracted widespread attention from scholars at home and abroad, the fragmentation of different types of microplastics in the natural environment has not yet received enough attention. To analyze the fragmentation processes and products of different types of microplastics, a 40 d natural light fragmentation experiment was carried out using four microplastics commonly found in water:polystyrene (PS), low-density polyethylene (LDPE), polypropylene (PP), and polyhydroxybutyrate (PHB). The pH, ORP, EC, and DO of the four types of plastic-aging liquids changed significantly during the aging process.

[Impacts of dominated landscape types on hydrogen and oxygen isotope effects of spring water in the Hani Rice Terraces].

Analysis of hydrogen and oxygen stable isotopes is an effective method to track the water cycle in watershed. Impact of landscape pattern on the isotope effects of spring water is a new interdisciplinary topic between landscape ecology and isotope hydrology. Taking the Quanfuzhuang River basin located in the core area of UNESCO World Cultural Heritage of Honghe Hani Rice Terrace as the object, collecting the monthly samples of 78 points of spring water and 39 precipitation at altitude of 1500 m (terraces), 1700 m (terraces) and 1900 m (forest) from March 2015 to March 2016, we analyzed the hydrogen and oxygen stable isotopes of water samples under the different landscape types.

[Extraction and purification of psoralen from Psoralea corylifolia L].

Objective: To establish a method for extracting psoralen from the seed of Psoralea corylifolia L.

Methods: Crushed seed of Psoralea corylifolia L. was soaked with 50% ethyl alcohol solution, and the leaching solution was filtrated and distilled to remove alcohol.