Efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for chronic rhinosinusitis.

Background: Chronic rhinosinusitis (CRS) leads to a burden in life and economy. Better therapies need to be explored.

Objective: This stage I study aims to explore the efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for CRS.

A Replicable and Generalizable Neuroimaging-Based Indicator of Pain Sensitivity Across Individuals.

Revealing the neural underpinnings of pain sensitivity is crucial for understanding how the brain encodes individual differences in pain and advancing personalized pain treatments. Here, six large and diverse functional magnetic resonance imaging (fMRI) datasets (total N = 1046) are leveraged to uncover the neural mechanisms of pain sensitivity. Replicable and generalizable correlations are found between nociceptive-evoked fMRI responses and pain sensitivity for laser heat, contact heat, and mechanical pains.

CAFs promote immune evasion in gastric cancer through histone lactylation-mediated suppression of NCAPG ubiquitination.

Background: Cancer-associated fibroblasts (CAFs) can facilitate tumor progression through multiple approaches. Research indicates that CAFs in various tumors exhibit robust lactate metabolism, ultimately becoming the primary source of lactate in the tumor microenvironment. Emerging evidence has established that CAFs could orchestrate gastric cancer (GC) immune evasion.

A comprehensive EEG dataset of laser-evoked potentials for pain research.

Understanding the neural mechanisms of pain is key to the development of novel pain diagnostic and treatment strategies. Here, we present a large-scale, comprehensive electroencephalogram (EEG) dataset of laser-evoked potentials (LEPs) from 678 healthy participants. This dataset comprises high-density EEG recordings and single-trial self-reported pain ratings in response to nociceptive laser stimuli of varying intensities (from 2.

Comments on Two Controversial Oriental Assassin Bug Species of the Genus (Heteroptera: Reduviidae: Harpactorinae), with the Description of sp. nov. from China.

The two closely related Oriental species of the genus , (Stål, 1867) and (Fabricius, 1787), exhibit remarkable morphological similarity, particularly in their overall red and black body coloration, including the head, thorax, and abdomen. Based on the examination of type specimens and non-type material collected from various localities of southern China, we found these two congeners were misidentified in many previous publications. Due to the restricted distribution and limited population size of in China, most taxonomic, biological, and biocontrol studies conducted under the name or should be instead attributed to To address this confusion regarding these two species, the present study clarifies the taxonomic status of the two controversial species- and .

Hardening-off under fluctuating light enhances the photosystem I resistance to excessive fluctuating light in Enhalus acoroides.

Seagrass meadows of Enhalus acoroides are rapidly declining. Transplanting artificially cultured seedlings is considered an efficient method of seagrass restoration. However, excessive fluctuating light (eFL) in the wild is highly likely to be a major threat to the survival of transplanted seedlings of E.

Multiple high-order topological states with high-order resonant bands in kagome lattice phononic crystal with resonant cavitiesa).

The topological phase of phononic crystals has garnered significant attention in the design of systems for confining and manipulating acoustic waves due to the robustness of topological states within bandgaps. In this work, we propose a kagome tight-binding model phononic crystal that utilizes the resonant effect coupling between cavities for airborne sound. The topological phase transition within high-order resonant bandgaps is achieved by tuning the coupling strength with the nontrivial phase characterized by a shrunken lattice.

An hourly and localized optimization method for soil fugitive dust emission inventory based on machine learning.

Soil fugitive dust (SFD) is characterized by a variety of sources and considerable spatial-temporal variability, exerting a significant impact on environmental air quality and ecological systems in cities across northern China. Multiple factors can shape SFD emission. Nevertheless, the current comprehension of its critical impact factors and quantitative methodologies remains constrained.

First record of silk-loving genus (Hemiptera, Heteroptera, Plokiophilidae) from Asia, with description of a new species from China.

The silk-loving bug is described from Yunnan, southwestern China, representing the first record of the genus (Heteroptera, Plokiophilidae) from Asia. The new species can be distinguished from its congeners by the different number of the spines on the fore - and mid-femora, and the numbers of the corial glands on the hemelytra. Photographs of the habitus and diagnostic characters, as well as living individuals in natural habitats, are provided.

Lithium extraction by extractant confined in Pickering emulsion.

The global energy transformation towards electrification and decarbonization urgently requires a sustainable lithium supply. However, current solvent extraction technology suffers from extractant dissolution and low efficiency. Herein, we develop an oil-in-water (O/W) Pickering emulsion with high stability using amphipathic SiO nanoparticles to confine tributyl phosphate (TBP) extractant within the oil phase for enhancing lithium extraction from salt-lake brine.

First-line immunotherapy in advanced non-squamous non-small cell lung cancer patients with rare mutations: a retrospective cohort study.

Background: Immunotherapy has become the standard therapy for advanced non-small cell lung cancer (NSCLC), but its efficacy in patients with rare mutations remains unclear. This study aimed to evaluate the efficacy of first-line immunotherapy in NSCLC patients with rare mutations.

Methods: This study selected 2,107 advanced non-squamous NSCLC patients who underwent genetic testing between January 2016 and April 2024 at Peking University Cancer Hospital.

Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions.

Targeting DNA damage response (DDR) pathways has become a promising strategy for overcoming tumor drug resistance, particularly in cancers with DNA repair defects. DDR pathways, including homologous recombination (HR), non-homologous end joining (NHEJ), base excision repair (BER), and mismatch repair (MMR), are essential for maintaining genomic stability. However, resistance to DDR-targeted therapies, such as PARP inhibitors, often arises due to tumor adaptation through various mechanisms.

Recurrent mutations drive the rapid evolution of pesticide resistance in the two-spotted spider mite .

The genetic basis of pesticide resistance has been widely studied, but the exact nature of this evolutionary process in the field is often unclear, particularly when a limited number of populations is considered and when there is a lag between the evolutionary event and its investigation. We showed that an unprecedented number of recurrently evolved mutations in an arthropod pest, the two-spotted spider mite , drive the rapid evolution of resistance to a recently commercialized acaricide, cyetpyrafen. We first observed high levels of resistance that appeared and became widespread within three years.

Solution-Processed Multivalent Molybdenum Oxide Tailoring Band Alignment for Efficient SbS Solar Cells.

Owing to its outstanding photoelectric characteristics, SbS has witnessed rapid development as a light-absorbing material for solar cells. However, the traditional utilization of Spiro-OMeTAD and PbS as hole transport layers (HTLs) in SbS solar cells poses significant challenges regarding stability and environmental toxicity. In this work, a solution-processed high-quality and smooth molybdenum oxide (MoO, 2 ≤ x ≤ 3) HTL is successfully applied in SbS solar cells, boosting the fill factor from 15.

Novel and Highly Potent Therapeutic Agent, Trametes Robiniophila Murr (Huaier), Mitigates Pulmonary Vascular Remodeling in Rodents.

Background: Pulmonary hypertension (PH) is a critical disease causing right ventricular failure and early death. Conventional single-pathway treatments are inadequate, highlighting the need for new therapies. Trametes robiniophila Murr (Huaier), a traditional Chinese medicine, inhibits cancer cell proliferation.

Cognitive Change Associated with Anesthesia and Surgery: An Introduction to POCD for Neuroscientists.

Postoperative cognitive dysfunction (POCD) is a central nervous system (CNS) complication seen in elderly patients, characterized by a decline in memory, comprehension, and attention in patients after surgery and general anesthesia. The pathophysiologic mechanisms of postoperative cognitive dysfunction are not well understood and effective means of prevention and treatment are currently lacking. Basic and clinical research, including the use of pre-clinical animal models of POCD, is advancing rapidly.

Effect of Perioperative Subanesthetic Dose of Esketamine on Postoperative Recovery Quality in Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomised, Double-Blind, Controlled Trial.

Background: To evaluate the effect of perioperative subanesthetic dose of esketamine on the postoperative recovery quality in patients undergoing laparoscopic gastrointestinal surgery.

Methods: A total of 144 patients undergoing elective surgery for gastrointestinal tumors were selected and randomly assigned to either the esketamine group or the control group, with 72 patients in each group. Based on the standardized general anesthesia protocols, the esketamine group received an intravenous injection of esketamine at a dose of 0.

Cavitation erosion: An efficient method for promoting osteogenesis and immunomodulation of titanium surface.

Objectives: Surface treatments of titanium dental implants can improve osseointegration and reduce the incidence of peri-implantitis. This study provides a new approach for surface modification by utilizing the principle of cavitation(CAV), which can generate high temperature and pressure with micro-jets acting on the surface.

Methods: Titanium surfaces were treated by CAV, and compared with a control group (sandblasted, large grit, and acid-etched, SLA).

METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of mG- 3' tiRNA Met.

Methyltransferase 1 (METTL1) is currently regarded as a key tRNA mG writer. Recent studies indicate its potential role in carcinogenesis via increased mG modification to stabilize tRNA and upregulate tRNA expression. Cadmium-induced stress triggers the assembly of stress granules (SGs) and production of tRNA-derived stress-induced RNAs (tiRNAs).

Comparison of the perioperative complications of high intensity focused ultrasound vs. laparoscopic surgery for uterine fibroids: a retrospective study.

Objective: To compare the perioperative complications following high intensity focused ultrasound (HIFU) or laparoscopic surgery for uterine fibroids.

Methods: A retrospective cohort was conducted involving patients with uterine fibroids (UFs) who underwent HIFU or laparoscopic surgery. The primary outcome was the incidence of perioperative complications.

Downregulation of miR-127-5p promotes idiopathic epiretinal membrane development via GLUL-mediated Müller cell activation.

Idiopathic epiretinal membrane (iERM) represents a fibrocellular proliferation on retinal surface associated with vision loss, with underlying molecular mechanisms that remain undefined. The current work aimed to assess miR-127-5p for its role in the regulation of retinal Müller cell activity in iERM. We analyzed miRNA expression profiles in vitreous samples from iERM patients and controls.

Exploring the alterations in microstate dynamics during the migraine cycle and detecting pre-ictal phases.

Background: Microstate analysis captures brief but critical fluctuations in brain activity, making it a powerful tool for exploring the cyclic nature of migraine. In this study, we aimed to investigate microstate features during different migraine phases and develop a classification model to identify the pre-ictal phase.

Methods: From May 2023 to June 2024, we conducted a cross-sectional study with consecutive recruitment, collecting resting-state electroencephalography data from 174 individuals with migraine without aura and 50 healthy controls, followed by classification of migraine phases.

The impact of the Grain-for-Green Programme on carbon storage in the Upper Yangtze River Basin based on the PLUS-InVEST model.

Alterations in land use and land cover (LUCC) play a fundamental role in influencing the variability of ecosystem carbon storage. Evaluating how land use dynamics affect carbon sequestration and projecting future carbon storage scenarios are essential steps toward meeting China's dual carbon objectives. In this study, we integrated the Patch-generating Land Use Simulation (PLUS) model with the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) framework to investigate LUCC dynamics and their implications for carbon storage across the Upper Yangtze River Basin (UYRB) between 2000 and 2020.

Stabilizing Grain Boundaries by In Situ Formation of Robust Layered Metallo-Organic Complex toward High-Performance Inverted Perovskite Solar Cells.

The grain boundaries (GBs) instability induced by photodecomposition of residual PbI is long-standing challenge for further simultaneous improvement of stability and power conversion efficiency (PCE) of perovskite solar cells (PSCs). Herein, a novel GB stabilization strategy through managing unstable residual PbI within perovskite films is reported, which is realized by incorporating 2-iodoimidazole (2-IM) into perovskite precursor solution. The 2-IM can in situ convert unstable residual PbI at GBs into robust metallo-organic complex 2-IMPbI exhibiting an orderly hexagonal layered crystal structure.