A Replicable and Generalizable Neuroimaging-Based Indicator of Pain Sensitivity Across Individuals.

Revealing the neural underpinnings of pain sensitivity is crucial for understanding how the brain encodes individual differences in pain and advancing personalized pain treatments. Here, six large and diverse functional magnetic resonance imaging (fMRI) datasets (total N = 1046) are leveraged to uncover the neural mechanisms of pain sensitivity. Replicable and generalizable correlations are found between nociceptive-evoked fMRI responses and pain sensitivity for laser heat, contact heat, and mechanical pains.

Sirtuin 3, a pivotal actor in liver diseases: research progress and implications.

The liver is very important in preserving physiological homeostasis via its immune response, detoxification, and metabolism functions. A multitude of factors, such as alcohol, can detrimentally impact liver function, resulting in acute or chronic liver injury, which may subsequently progress to liver cancer. Liver diseases comprise a broad range of disorders primarily characterized by damage to hepatocytes, inflammatory cell infiltration, and hepatic stellate cells activation.

"Three people make a tiger": Honeycomb nitrogen-doped carbon supported PtFe&FeC with ultralow Pt for oxygen reduction reaction.

Here, an ultralow Pt (∼2 wt%) catalyst, honeycomb NC-supported PtFe&FeC (PtFe&FeC/HNC), is prepared for oxygen reduction reaction (ORR). This catalyst contains three advantages: (1) a large number of mesopores in HNC is beneficial for the exposure of active sites and rapid diffusion of O; (2) the introduction of Fe into PtFe alloy can effectively alter the electronic structure of Pt, weaken the oxygen binding energy between Pt and reaction intermediates to enhance the intrinsic activity of Pt; (3) FeC not only further regulate the electronic structure of Pt by transferring electrons to Pt, but also serve as an active site to enhance the catalytic efficiency. A significant synergistic effect of HNC, PtFe and FeC makes the ORR catalytic activity of PtFe&FeC/HNC far superior to that of the commercial 20 wt% Pt/C.

Deficiency of β-arrestin2 ameliorates MASLD in mice by promoting the activation of TAK1/AMPK signaling.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a liver manifestation of metabolic syndrome characterized by excessive hepatic lipid accumulation and lipid metabolism disorders. It has become the most common chronic liver disease worldwide. β-arrestin2 is a multifunctional scaffold protein that is among the most important regulatory molecules, and it exerts key roles in regulating various cellular processes, such as immune response, cellular collagen production, and inflammation.

A Comprehensive Review: Advances in Mesenchymal Stem Cell Applications for Burn Wound Repair.

Tissue repair following skin injury is a complex process that encompasses hemostasis, inflammation, tissue cell proliferation, and structural remodeling. Mesenchymal stem cells (MSCs) are derived from the mesodermal layer of tissues and possess multidirectional differentiation potential and self-renewal capabilities. MSCs from various sources, including the bone marrow, adipose tissue, dental pulp, umbilical cord, and amniotic membrane, have demonstrated effectiveness in promoting skin injury repair.

FeP as cocatalyst for ultra-low Pt oxygen reduction reaction catalyst.

The preparation of low Pt catalysts for oxygen reduction reaction (ORR) has been the focus research in fuel cell. Here, Pt&FeP@NC with ultra-low Pt loading (∼2 wt% Pt, one tenth of the commercial 20 wt% Pt/C) is prepared by introducing FeP cocatalyst into Pt-based catalyst through a simple two-step pyrolysis method. Pt&FeP@NC shows excellent ORR electrocatalytic performance in 0.

Advances of Vanadium-based Cathodes forAqueous Zinc Ion Batteries.

Aqueous zinc-ion batteries (AZIBs) are promising for energy storage due to their high safety, low cost, and environmental friendliness. Vanadium-based materials, including vanadium oxides, vanadium sulfides, vanadate, and vanadium carbon composites, have gained attention for their diverse crystal structures, multiple oxidation states, and high theoretical capacities. This review summarizes recent advances in vanadium-based cathodes, focusing on structural design and modification strategies, such as amorphous structures, defect engineering, conductive carbon matrices, and cation pre-intercalation to enhance Zn storage.

[Effect of cisplatin combined with Guiqi Yiyuan Ointment on Lewis lung cancer-bearing mice by regulating EGFR/MAPK pathway].

Based on the epidermal growth factor receptor(EGFR)/mitogen-activated protein kinase(MAPK) signaling pathway-mediated cell proliferation, this study explores the effect of cisplatin combined with Guiqi Yiyuan Ointment on Lewis lung cancer-bearing mice. A total of 60 male C57BL/6 mice were randomly divided into a blank group with 10 mice and a modeling group with 50 mice. After modeling, they were randomly divided into the model group, cisplatin group, and low-, medium-, and high-dose groups of cisplatin combined with Guiqi Yiyuan Ointment, with 10 mice in each group.

Lactylation and human disease.

Background: Lactylation, a new epigenetic modification, is an important way in which lactate exerts physiological functions. There is a close relationship between increased lactylations caused by lactate and glycolysis, which can interact and play a role in disease through lactate as an intermediate mediator. Current research on lactylations has focused on histone lactylation, but non-histone lactylation also has greater research potential.

A nomogram model of spectral CT quantitative parameters and clinical characteristics predicting lymphovascular invasion of gastric cancer.

Objective: The study established a nomogram based on quantitative parameters of spectral computed tomography (CT) and clinical characteristics, aiming to evaluate its predictive value for preoperative lymphovascular invasion (LVI) in gastric cancer (GC).

Methods: From December 2019 to December 2021, 171 patients with pathologically confirmed GC were retrospectively collected with corresponding clinical data and spectral CT quantitative data. Patients were divided into LVI-positive and LVI-negative groups based on their pathological results.

Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions.

The impact of mitochondrial dysfunction on the pathogenesis of cardiovascular disease is increasing. However, the precise underlying mechanism remains unclear. Mitochondria produce cellular energy through oxidative phosphorylation while regulating calcium homeostasis, cellular respiration, and the production of biosynthetic chemicals.

Protein Nanotubes as Advanced Material Platforms and Delivery Systems.

Protein nanotubes (PNTs) as state-of-the-art nanocarriers are promising for various potential applications both in the food and pharmaceutical industries. Derived from edible starting sources like α-lactalbumin, lysozyme, and ovalbumin, PNTs bear properties of biocompatibility and biodegradability. Their large specific surface area and hydrophobic core facilitate chemical modification and loading of bioactive substances, respectively.

The association between maternal urinary Bisphenol A levels and neurodevelopment at age 2 years in Chinese boys and girls: A prospective cohort study.

The impact of maternal exposure to Bisphenol A on child cognitive development as well as its sex dimorphism remains uncertain. This study used data of 215 mothers and their children from a birth cohort in Shanghai. Urinary BPA were measured in spot urine samples of mothers at late pregnancy and children at age 2 years.

N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis.

It has been reported that dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) exert therapeutic potential for the preservation of functional β-cell mass. However, the effect of dietary n-3 PUFA deficiency on pancreatic injury and whether the supplementation of n-3 PUFA could prevent the development of pancreatic injury are still not clear. In the present study, an n-3 PUFA deficiency mouse model was established by feeding them with n-3 PUFA deficiency diets for 30 days.

Research progress on effects of traditional Chinese medicine on myocardial ischemia-reperfusion injury: A review.

Ischemic heart disease (IHD) is a high-risk disease in the middle-aged and elderly population. The ischemic heart may be further damaged after reperfusion therapy with percutaneous coronary intervention (PCI) and other methods, namely, myocardial ischemia-reperfusion injury (MIRI), which further affects revascularization and hinders patient rehabilitation. Therefore, the investigation of new therapies against MIRI has drawn great global attention.

Effect of Serum Ferritin on the Prognosis of Patients with Sepsis: Data from the MIMIC-IV Database.

Background: The present study aimed to investigate the prognostic value of serum ferritin in critically ill patients with sepsis by using the MIMIC-IV database.

Methods: Data were extracted from the MIMIC-IV database. Adult patients who met the sepsis-3 criteria and had the test of ferritin were included.

Selective and replicable neuroimaging-based indicators of pain discriminability.

Neural indicators of pain discriminability have far-reaching theoretical and clinical implications but have been largely overlooked previously. Here, to directly identify the neural basis of pain discriminability, we apply signal detection theory to three EEG (Datasets 1-3, total N = 366) and two fMRI (Datasets 4-5, total N = 399) datasets where participants receive transient stimuli of four sensory modalities (pain, touch, audition, and vision) and two intensities (high and low) and report perceptual ratings. Datasets 1 and 4 are used for exploration and others for validation.

Downregulation of PDCD4 by deSUMOylation associates with the progression of gestational trophoblastic disease.

Introduction: Gestational trophoblastic disease (GTD) encompasses a range of trophoblastic disorders from hydatidiform mole (HM), to malignant gestational trophoblastic neoplasia (GTN). The exact molecular mechanisms of GTN remain unknown. Dysregulation and dysfunction of programmed cell death 4 (PDCD4)have been observed in many cancers.

Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

Oxidative stress (OS) induced activation of p38 mitogen-activated kinase (MAPK) and cell fate from p38 signaling was tested using the human fetal membrane's amnion epithelial cells (AEC). We created p38 KO AEC using the CRISPR/Cas9 approach and tested cell fate in response to OS on an AEC-free fetal membrane extracellular matrix (ECM). Screening using image CyTOF indicated OS causing epithelial-mesenchymal transition (EMT).

Hypertension Exacerbates Severity and Outcomes of COVID-19 in Elderly Patients: A Retrospective Observational Study.

Objective: To evaluate the impact of hypertension on the clinical outcome of COVID-19 patients aged 60 years old and older.

Methods: This single-center retrospective cohort study enrolled consecutive COVID-19 patients aged 60 years old and older, who were admitted to Liyuan Hospital from January 1, 2020 to April 25, 2020. All included patients were divided into two groups: hypertension and nonhypertension group.

6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response in mice through the NF-κB pathway.

Liver fibrosis is a global health problem caused by a number of diseases related to liver damage. 6-Shogaol is a biologically active substance derived from the rhizome of Zingiber officinale Roscoe with anti-tumor, anti-inflammatory, and antioxidant properties. To explore the effects of 6-Shogaol on liver fibrosis, we used a mouse model of the condition in which mice were injected intraperitoneally with carbon tetrachloride (CCl4) at a dose of 2 mL/kg three times per week for a period of 4 weeks.